NO20053745L - Polymeriserte hemoglobin losninger med redusert mengde tetramer og fremgangsmate for fremstilling derav - Google Patents

Polymeriserte hemoglobin losninger med redusert mengde tetramer og fremgangsmate for fremstilling derav

Info

Publication number
NO20053745L
NO20053745L NO20053745A NO20053745A NO20053745L NO 20053745 L NO20053745 L NO 20053745L NO 20053745 A NO20053745 A NO 20053745A NO 20053745 A NO20053745 A NO 20053745A NO 20053745 L NO20053745 L NO 20053745L
Authority
NO
Norway
Prior art keywords
tetramer
preparation
methods
reduced amount
polymerized hemoglobin
Prior art date
Application number
NO20053745A
Other languages
English (en)
Other versions
NO20053745D0 (no
Inventor
Richard E Dewoskin
Marc D Doubleday
Anthony Avella
Original Assignee
Northfield Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northfield Lab filed Critical Northfield Lab
Publication of NO20053745D0 publication Critical patent/NO20053745D0/no
Publication of NO20053745L publication Critical patent/NO20053745L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Det beskrives en tilnærmet tetramer-fri hemoglobinløsning og en fremgangsmåte for fremstilling av en tilnærmet tetramer-fri hemoglobinløsning. Fremgangsmåten omfatter polymerisering av en løsning av hemoglobin, behandling av den polymeriserte hemoglobinløsning for delvis å nedbryte polymeren til tetramer og fjerning av tetramer fra hemoglobinløsningen.
NO20053745A 2003-01-29 2005-08-04 Polymeriserte hemoglobin losninger med redusert mengde tetramer og fremgangsmate for fremstilling derav NO20053745L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44343603P 2003-01-29 2003-01-29
PCT/US2004/002512 WO2004066953A2 (en) 2003-01-29 2004-01-29 Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing

Publications (2)

Publication Number Publication Date
NO20053745D0 NO20053745D0 (no) 2005-08-04
NO20053745L true NO20053745L (no) 2005-10-03

Family

ID=32825331

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053745A NO20053745L (no) 2003-01-29 2005-08-04 Polymeriserte hemoglobin losninger med redusert mengde tetramer og fremgangsmate for fremstilling derav

Country Status (14)

Country Link
US (2) US7135553B2 (no)
EP (1) EP1592437A4 (no)
JP (1) JP2006516994A (no)
KR (1) KR20050095636A (no)
CN (1) CN100431602C (no)
AU (1) AU2004207595B2 (no)
BR (1) BRPI0407106A (no)
CA (1) CA2512169A1 (no)
MX (1) MXPA05007885A (no)
NO (1) NO20053745L (no)
NZ (1) NZ541340A (no)
RU (1) RU2337705C2 (no)
WO (1) WO2004066953A2 (no)
ZA (1) ZA200505814B (no)

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CN100431602C (zh) * 2003-01-29 2008-11-12 北原实验室有限公司 具有低量四聚体的聚合血红蛋白溶液及制备方法
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US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
RU2361608C1 (ru) * 2008-03-18 2009-07-20 Общество С Ограниченной Ответственностью "Научно-Производственная Компания "Медбиофарм" Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты)
US8273857B2 (en) 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
US7989593B1 (en) 2010-05-27 2011-08-02 Bing Lou Wong Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
US7932356B1 (en) 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition
US8048856B1 (en) 2010-06-23 2011-11-01 Billion King, Ltd. Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
US8889830B2 (en) 2011-03-01 2014-11-18 Chuo University Hemoglobin-albumin complex, and artificial plasma expander and artificial oxygen carrier containing the complex
US8084581B1 (en) 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
US20130052232A1 (en) 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
CN103690978B (zh) * 2013-12-19 2017-01-25 陕西佰美基因股份有限公司 一种用于血红蛋白及血红蛋白氧载体灭活病毒的方法
JP7016124B2 (ja) 2016-07-06 2022-02-04 学校法人 中央大学 虚血性疾患の治療剤
CA3070172A1 (en) 2017-07-18 2019-01-24 VirTech Bio, Inc. Blood substitutes comprising hemoglobin and methods of making
JP2021134199A (ja) * 2020-02-28 2021-09-13 学校法人 中央大学 ヘモグロビン微粒子及び人工酸素運搬体

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Also Published As

Publication number Publication date
US20040186047A1 (en) 2004-09-23
US7135553B2 (en) 2006-11-14
US20060287222A1 (en) 2006-12-21
CN100431602C (zh) 2008-11-12
AU2004207595B2 (en) 2009-02-05
CN1741813A (zh) 2006-03-01
BRPI0407106A (pt) 2006-01-24
NZ541340A (en) 2008-04-30
ZA200505814B (en) 2006-05-31
CA2512169A1 (en) 2004-08-12
JP2006516994A (ja) 2006-07-13
RU2337705C2 (ru) 2008-11-10
AU2004207595A1 (en) 2004-08-12
WO2004066953A3 (en) 2005-04-07
EP1592437A2 (en) 2005-11-09
EP1592437A4 (en) 2007-12-26
KR20050095636A (ko) 2005-09-29
RU2005127050A (ru) 2006-01-20
WO2004066953A2 (en) 2004-08-12
MXPA05007885A (es) 2005-09-21
NO20053745D0 (no) 2005-08-04
US7411044B2 (en) 2008-08-12

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