NO20050068L - New carboxamide compounds having a mch antagonist effect, drugs containing these compounds, and methods of preparing them - Google Patents

New carboxamide compounds having a mch antagonist effect, drugs containing these compounds, and methods of preparing them

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Publication number
NO20050068L
NO20050068L NO20050068A NO20050068A NO20050068L NO 20050068 L NO20050068 L NO 20050068L NO 20050068 A NO20050068 A NO 20050068A NO 20050068 A NO20050068 A NO 20050068A NO 20050068 L NO20050068 L NO 20050068L
Authority
NO
Norway
Prior art keywords
compounds
preparing
methods
drugs containing
antagonist effect
Prior art date
Application number
NO20050068A
Other languages
Norwegian (no)
Inventor
Heike-Andrea Wieland
Martin Lenter
Klaus Rudolf
Thorsten Lehmann-Lintz
Stephan Georg Mueller
Ralf Richard Hermann Lotz
Dirk Stenkamp
Philipp Lustenberger
Original Assignee
Boehringer Ingelheim Pharma
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Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20050068L publication Critical patent/NO20050068L/en

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    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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Abstract

Foreliggende oppfinnelse angår karboksamid-forbindelser med den generelle formel I a r'¿n'' v n a-^w^itB ' hvor gruppene og restene A, B, W, X, Y, Z, R', R^, R' og k har betydningene som er oppgitt i krav 1. Videre angår oppfinnelsen en fremgangsmåte for fremstilling av de ovennevnte karboksamider, så vel som farmasøytiske preparater som inneholder minst ett karboksamid ifølge oppfinnelsen. På bakgrunn av deies MCH-reseptorantagonistiske virkning er de farmasøytiske preparater ifølge oppfinnelsen egnet for behandling av metabolske lidelser og/eller spiseforstyrrelser, spesielt fedme, bulimi, anoreksi, hyperfagi og diabetes.BACKGROUND OF THE INVENTION The present invention relates to carboxamide compounds of the general formula I in which the groups and residues A, B, W, X, Y, Z, R ', R and k has the meanings given in claim 1. Furthermore, the invention relates to a process for the preparation of the above carboxamides, as well as pharmaceutical compositions containing at least one carboxamide according to the invention. In view of these MCH receptor antagonistic effects, the pharmaceutical compositions of the invention are suitable for the treatment of metabolic disorders and / or eating disorders, especially obesity, bulimia, anorexia, hyperphagia and diabetes.

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