NO20050068L - New carboxamide compounds having a mch antagonist effect, drugs containing these compounds, and methods of preparing them - Google Patents
New carboxamide compounds having a mch antagonist effect, drugs containing these compounds, and methods of preparing themInfo
- Publication number
- NO20050068L NO20050068L NO20050068A NO20050068A NO20050068L NO 20050068 L NO20050068 L NO 20050068L NO 20050068 A NO20050068 A NO 20050068A NO 20050068 A NO20050068 A NO 20050068A NO 20050068 L NO20050068 L NO 20050068L
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- compounds
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- methods
- drugs containing
- antagonist effect
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Abstract
Foreliggende oppfinnelse angår karboksamid-forbindelser med den generelle formel I a r'¿n'' v n a-^w^itB ' hvor gruppene og restene A, B, W, X, Y, Z, R', R^, R' og k har betydningene som er oppgitt i krav 1. Videre angår oppfinnelsen en fremgangsmåte for fremstilling av de ovennevnte karboksamider, så vel som farmasøytiske preparater som inneholder minst ett karboksamid ifølge oppfinnelsen. På bakgrunn av deies MCH-reseptorantagonistiske virkning er de farmasøytiske preparater ifølge oppfinnelsen egnet for behandling av metabolske lidelser og/eller spiseforstyrrelser, spesielt fedme, bulimi, anoreksi, hyperfagi og diabetes.BACKGROUND OF THE INVENTION The present invention relates to carboxamide compounds of the general formula I in which the groups and residues A, B, W, X, Y, Z, R ', R and k has the meanings given in claim 1. Furthermore, the invention relates to a process for the preparation of the above carboxamides, as well as pharmaceutical compositions containing at least one carboxamide according to the invention. In view of these MCH receptor antagonistic effects, the pharmaceutical compositions of the invention are suitable for the treatment of metabolic disorders and / or eating disorders, especially obesity, bulimia, anorexia, hyperphagia and diabetes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE10238865A DE10238865A1 (en) | 2002-08-24 | 2002-08-24 | New carboxamides are melanin-concentrating hormone receptor antagonists, useful for treating e.g. metabolic diseases, diabetes, eating disorders, cardiovascular disease, emotional disorders, reproductive and memory disorders |
PCT/EP2003/009099 WO2004024702A1 (en) | 2002-08-24 | 2003-08-16 | Novel carboxamide compounds having an mch-antagonistic effect, medicaments containing said compounds, and methods for the production thereof |
Publications (1)
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NO20050068L true NO20050068L (en) | 2005-03-04 |
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ID=31501914
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NO20050068A NO20050068L (en) | 2002-08-24 | 2005-01-06 | New carboxamide compounds having a mch antagonist effect, drugs containing these compounds, and methods of preparing them |
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EP (1) | EP1534689A1 (en) |
JP (1) | JP2006507246A (en) |
KR (1) | KR20050040928A (en) |
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AR (1) | AR043046A1 (en) |
AU (1) | AU2003258620A1 (en) |
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CA (1) | CA2496563A1 (en) |
DE (1) | DE10238865A1 (en) |
EA (1) | EA012834B1 (en) |
EC (1) | ECSP055615A (en) |
HR (1) | HRP20050179A2 (en) |
MX (1) | MXPA05002158A (en) |
NO (1) | NO20050068L (en) |
PE (1) | PE20040974A1 (en) |
PL (1) | PL375344A1 (en) |
RS (1) | RS20050173A (en) |
TW (1) | TW200413332A (en) |
UA (1) | UA82853C2 (en) |
WO (1) | WO2004024702A1 (en) |
ZA (1) | ZA200500086B (en) |
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AR075401A1 (en) | 2009-02-13 | 2011-03-30 | Sanofi Aventis | SUBSTITUTED INDANS, PROCESSES FOR THEIR PREPARATION AND USE OF THE SAME AS A MEDICINAL PRODUCT |
CA2796419C (en) | 2010-04-16 | 2018-11-06 | Kinex Pharmaceuticals, Llc | Compositions and methods for the prevention and treatment of cancer |
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WO2001087834A1 (en) * | 2000-05-16 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
EP1299362A4 (en) * | 2000-07-05 | 2004-11-03 | Synaptic Pharma Corp | Selective melanin concentrating hormone-1 (mch1) receptor antagonists and uses thereof |
US20030022891A1 (en) * | 2000-12-01 | 2003-01-30 | Anandan Palani | MCH antagonists and their use in the treatment of obesity |
CA2431953A1 (en) * | 2000-12-22 | 2002-07-04 | Schering Corporation | Piperidine mch antagonists and their use in the treatment of obesity |
GB0124627D0 (en) * | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
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- 2003-08-16 EP EP03794886A patent/EP1534689A1/en not_active Withdrawn
- 2003-08-16 BR BR0313790-2A patent/BR0313790A/en not_active Expired - Fee Related
- 2003-08-16 MX MXPA05002158A patent/MXPA05002158A/en unknown
- 2003-08-16 UA UAA200502601A patent/UA82853C2/en unknown
- 2003-08-21 PE PE2003000849A patent/PE20040974A1/en not_active Application Discontinuation
- 2003-08-22 AR ARP030103034A patent/AR043046A1/en unknown
- 2003-08-22 TW TW092123197A patent/TW200413332A/en unknown
-
2005
- 2005-01-05 ZA ZA200500086A patent/ZA200500086B/en unknown
- 2005-01-06 NO NO20050068A patent/NO20050068L/en not_active Application Discontinuation
- 2005-02-18 EC EC2005005615A patent/ECSP055615A/en unknown
- 2005-02-23 HR HR20050179A patent/HRP20050179A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
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ECSP055615A (en) | 2005-05-30 |
CA2496563A1 (en) | 2004-03-25 |
KR20050040928A (en) | 2005-05-03 |
BR0313790A (en) | 2005-07-12 |
AU2003258620A1 (en) | 2004-04-30 |
DE10238865A1 (en) | 2004-03-11 |
EP1534689A1 (en) | 2005-06-01 |
ZA200500086B (en) | 2006-07-26 |
JP2006507246A (en) | 2006-03-02 |
AR043046A1 (en) | 2005-07-13 |
HRP20050179A2 (en) | 2006-05-31 |
MXPA05002158A (en) | 2005-05-23 |
EA200500301A1 (en) | 2006-02-24 |
EA012834B1 (en) | 2009-12-30 |
RS20050173A (en) | 2007-09-21 |
CN1678591A (en) | 2005-10-05 |
UA82853C2 (en) | 2008-05-26 |
PL375344A1 (en) | 2005-11-28 |
WO2004024702A1 (en) | 2004-03-25 |
TW200413332A (en) | 2004-08-01 |
PE20040974A1 (en) | 2005-01-12 |
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