NO20013963L - Aromatiske sulfonhydroksaminsyre-metallproteaseinhibitor - Google Patents
Aromatiske sulfonhydroksaminsyre-metallproteaseinhibitorInfo
- Publication number
- NO20013963L NO20013963L NO20013963A NO20013963A NO20013963L NO 20013963 L NO20013963 L NO 20013963L NO 20013963 A NO20013963 A NO 20013963A NO 20013963 A NO20013963 A NO 20013963A NO 20013963 L NO20013963 L NO 20013963L
- Authority
- NO
- Norway
- Prior art keywords
- protease inhibitor
- acid metal
- hydroxamic acid
- aromatic sulfonic
- metal protease
- Prior art date
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/256,948 US20010039287A1 (en) | 1997-11-14 | 1999-02-24 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
PCT/US2000/002518 WO2000050396A1 (en) | 1999-02-24 | 2000-02-22 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20013963D0 NO20013963D0 (no) | 2001-08-15 |
NO20013963L true NO20013963L (no) | 2001-10-23 |
Family
ID=22974260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20013963A NO20013963L (no) | 1999-02-24 | 2001-08-15 | Aromatiske sulfonhydroksaminsyre-metallproteaseinhibitor |
Country Status (19)
Country | Link |
---|---|
US (2) | US20010039287A1 (xx) |
EP (1) | EP1230219A1 (xx) |
JP (1) | JP2002537378A (xx) |
KR (1) | KR20020092157A (xx) |
CN (1) | CN1370144A (xx) |
AR (1) | AR043676A1 (xx) |
AU (1) | AU3478500A (xx) |
BR (1) | BR0008491A (xx) |
CA (1) | CA2371876A1 (xx) |
CZ (1) | CZ20013038A3 (xx) |
EA (1) | EA200100804A1 (xx) |
HU (1) | HUP0200239A3 (xx) |
IL (1) | IL144945A0 (xx) |
MX (1) | MXPA01008568A (xx) |
NO (1) | NO20013963L (xx) |
NZ (1) | NZ513648A (xx) |
PL (1) | PL351204A1 (xx) |
WO (1) | WO2000050396A1 (xx) |
ZA (1) | ZA200106780B (xx) |
Families Citing this family (29)
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US6747027B1 (en) | 1996-07-22 | 2004-06-08 | Pharmacia Corporation | Thiol sulfonamide metalloprotease inhibitors |
US6696449B2 (en) | 1997-03-04 | 2004-02-24 | Pharmacia Corporation | Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors |
WO1998039315A1 (en) | 1997-03-04 | 1998-09-11 | Monsanto Company | Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds |
US7115632B1 (en) | 1999-05-12 | 2006-10-03 | G. D. Searle & Co. | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
US6794511B2 (en) | 1997-03-04 | 2004-09-21 | G. D. Searle | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
CA2306460A1 (en) * | 1997-11-14 | 1999-05-27 | G.D. Searle & Co. | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
BR0008440A (pt) | 1999-02-08 | 2002-03-26 | Searle & Co | Inibidor de metaloprotease de sulfamato do ácido hidroxâmico |
US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
US20010049449A1 (en) * | 1999-12-23 | 2001-12-06 | Becker Daniel P. | Aromatic sulfonyl alpha-cycloamino hydroxamates and their use as MMP inhibitors |
US6683093B2 (en) * | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
US20040024024A1 (en) * | 2001-05-11 | 2004-02-05 | Freskos John N. | Aromatic sulfone hydroxamates and their use as protease inhibitors |
EP1385836A2 (en) * | 2001-05-11 | 2004-02-04 | Pharmacia Corporation | Aromatic sulfone hydroxamates and their use as protease inhibitors |
US20030139332A1 (en) * | 2001-07-09 | 2003-07-24 | The Regents Of The University Of California | Use of matrix metalloproteinase inhibitors to mitigate nerve damage |
US6683078B2 (en) | 2001-07-19 | 2004-01-27 | Pharmacia Corporation | Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors |
WO2003042176A1 (fr) * | 2001-11-13 | 2003-05-22 | Shiseido Co., Ltd. | Compose azabicyclo, inhibiteur de metalloprotease matricielle et preparation cutanee |
MXPA04010555A (es) * | 2002-04-25 | 2005-02-17 | Pharmacia Corp | Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa. |
US20050209278A1 (en) * | 2002-04-25 | 2005-09-22 | Mcdonald Joseph J | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
JP2006502980A (ja) * | 2002-06-25 | 2006-01-26 | ファルマシア・コーポレーション | アリールスルホニルヒドロキサム酸およびアミド誘導体、ならびにプロテアーゼ阻害薬としてのそれらの使用 |
WO2004007444A2 (en) | 2002-07-11 | 2004-01-22 | Vicuron Pharmaceuticals, Inc. | N-hydroxyamide derivatives possessing antibacterial activity |
US20050043533A1 (en) * | 2003-03-25 | 2005-02-24 | Babiak Kevin A. | Process for making alpha-substituted hydroxamic acids |
GB0319069D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Therapeutically useful compounds |
DE102004031620A1 (de) * | 2004-06-30 | 2006-02-02 | Sanofi-Aventis Deutschland Gmbh | 4-Trifluormethoxyphenoxybenzol-4`-sulfonsäuren, Verfahren zu ihrer Herstellung und Verwendung in Arzneimitteln |
WO2007141029A1 (en) * | 2006-06-08 | 2007-12-13 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Specific protease inhibitors and their use in cancer therapy |
ITTO20060575A1 (it) * | 2006-08-02 | 2008-02-03 | Univ Pisa | Inibitori di zinco proteinasi tioaril sostituiti e loro usi |
WO2013039851A1 (en) | 2011-09-12 | 2013-03-21 | Mallinckrodt Llc | Optical agents for imaging and visualization of matrix metalloproteinase enzymes |
CA2896053A1 (en) | 2012-12-21 | 2014-06-26 | Ocata Therapeutics, Inc. | Methods for production of platelets from pluripotent stem cells and compositions thereof |
US11590226B2 (en) | 2018-06-29 | 2023-02-28 | Loyola University Of Chicago | Carborane hydroxamic acid matrix metalloproteinase inhibitors and agents for boron neutron capture therapy |
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US4882434A (en) * | 1986-10-29 | 1989-11-21 | Takeda Chemical Industries, Ltd. | Gamma-lactonecarboxylic acid derivatives and their use as antibacterial agents or intermediates |
GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
JP3122161B2 (ja) | 1991-05-16 | 2001-01-09 | 武田薬品工業株式会社 | γ−ラクトン免疫抑制剤 |
WO1993020047A1 (en) | 1992-04-07 | 1993-10-14 | British Bio-Technology Limited | Hydroxamic acid based collagenase and cytokine inhibitors |
US5376664A (en) | 1992-07-27 | 1994-12-27 | The Du Pont Merck Pharmaceutical Company | Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents |
US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
GB9307956D0 (en) | 1993-04-17 | 1993-06-02 | Walls Alan J | Hydroxamic acid derivatives |
GB9320660D0 (en) | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
AU687921B2 (en) | 1993-11-04 | 1998-03-05 | Liposome Company, Inc., The | Multilamellar liposomal arachidonic acid metabolite formulations |
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WO1995029892A1 (en) | 1994-04-28 | 1995-11-09 | The Du Pont Merck Pharmaceutical Company | Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents |
GB9416897D0 (en) | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
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JP2000502330A (ja) | 1995-12-08 | 2000-02-29 | アグロン・ファーマシュウティカルズ・インコーポレーテッド | メタロプロテイナーゼ阻害薬、それらを含有する薬剤組成物および薬剤としてのそれらの使用、ならびにそれらの製造に有用な方法および中間体 |
EP0780386B1 (en) * | 1995-12-20 | 2002-10-02 | F. Hoffmann-La Roche Ag | Matrix metalloprotease inhibitors |
JP4358908B2 (ja) * | 1996-01-02 | 2009-11-04 | アヴェンティス ファーマシューティカルズ インコーポレイテッド | 置換(アリール、ヘテロアリール、アリールメチル又はヘテロアリールメチル)ヒドロキサム酸化合物 |
EP0994104A4 (en) | 1996-06-27 | 2001-09-12 | Ono Pharmaceutical Co | ARYL SULFIDE, SULFOXIDE AND SULPHONE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM AS AN ACTIVE INGREDIENT |
CA2260859A1 (en) | 1996-07-22 | 1998-01-29 | Monsanto Company | Thiol sulfone metalloprotease inhibitors |
GEP20022626B (en) * | 1997-02-27 | 2002-02-25 | American Cyanamid Company Us | N-Hydroxy-2-(Alkyl, Aryl, or Heteroaryl Sulfanyl, Sulfinil or Sulfonyl)-3-Substituted Alkyl, Aryl or Heteroarylamides as Matrix Metalloproteinase Inhibitors |
US6300514B1 (en) | 1997-06-25 | 2001-10-09 | Ono Pharmaceutical Co., Ltd. | Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient |
US6576664B1 (en) | 1997-08-18 | 2003-06-10 | Bristol-Myers Squibb Pharma Company | Inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis |
CA2306460A1 (en) * | 1997-11-14 | 1999-05-27 | G.D. Searle & Co. | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
IL127496A0 (en) | 1997-12-19 | 1999-10-28 | Pfizer Prod Inc | The use of MMP inhibitors for the treatment of ocular angiogenesis |
IL137566A0 (en) * | 1998-02-19 | 2001-07-24 | American Cyanamid Co | N-hydroxy-2-(alkyl, aryl or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted-alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
BR0008440A (pt) | 1999-02-08 | 2002-03-26 | Searle & Co | Inibidor de metaloprotease de sulfamato do ácido hidroxâmico |
WO2000059874A1 (en) | 1999-04-02 | 2000-10-12 | Du Pont Pharmaceuticals Company | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE |
-
1999
- 1999-02-24 US US09/256,948 patent/US20010039287A1/en not_active Abandoned
-
2000
- 2000-02-22 EA EA200100804A patent/EA200100804A1/ru unknown
- 2000-02-22 IL IL14494500A patent/IL144945A0/xx unknown
- 2000-02-22 MX MXPA01008568A patent/MXPA01008568A/es unknown
- 2000-02-22 NZ NZ513648A patent/NZ513648A/xx unknown
- 2000-02-22 JP JP2000600979A patent/JP2002537378A/ja active Pending
- 2000-02-22 CN CN00806608A patent/CN1370144A/zh active Pending
- 2000-02-22 CA CA002371876A patent/CA2371876A1/en not_active Abandoned
- 2000-02-22 BR BR0008491-3A patent/BR0008491A/pt not_active Application Discontinuation
- 2000-02-22 HU HU0200239A patent/HUP0200239A3/hu unknown
- 2000-02-22 EP EP00913317A patent/EP1230219A1/en not_active Withdrawn
- 2000-02-22 AU AU34785/00A patent/AU3478500A/en not_active Abandoned
- 2000-02-22 WO PCT/US2000/002518 patent/WO2000050396A1/en not_active Application Discontinuation
- 2000-02-22 PL PL00351204A patent/PL351204A1/xx not_active Application Discontinuation
- 2000-02-22 KR KR1020017010886A patent/KR20020092157A/ko not_active Application Discontinuation
- 2000-02-22 CZ CZ20013038A patent/CZ20013038A3/cs unknown
- 2000-02-24 AR ARP000100800A patent/AR043676A1/es unknown
-
2001
- 2001-08-15 NO NO20013963A patent/NO20013963L/no not_active Application Discontinuation
- 2001-08-16 ZA ZA200106780A patent/ZA200106780B/en unknown
- 2001-09-17 US US09/954,451 patent/US6750233B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EA200100804A1 (ru) | 2002-04-25 |
EP1230219A1 (en) | 2002-08-14 |
AR043676A1 (es) | 2005-08-10 |
IL144945A0 (en) | 2002-06-30 |
NZ513648A (en) | 2004-02-27 |
HUP0200239A2 (en) | 2002-06-29 |
US6750233B2 (en) | 2004-06-15 |
WO2000050396A1 (en) | 2000-08-31 |
ZA200106780B (en) | 2002-08-16 |
MXPA01008568A (es) | 2002-04-08 |
NO20013963D0 (no) | 2001-08-15 |
AU3478500A (en) | 2000-09-14 |
BR0008491A (pt) | 2002-09-17 |
JP2002537378A (ja) | 2002-11-05 |
CN1370144A (zh) | 2002-09-18 |
CA2371876A1 (en) | 2000-08-31 |
CZ20013038A3 (cs) | 2002-07-17 |
US20010039287A1 (en) | 2001-11-08 |
US20020177588A1 (en) | 2002-11-28 |
PL351204A1 (en) | 2003-03-24 |
HUP0200239A3 (en) | 2003-04-28 |
KR20020092157A (ko) | 2002-12-11 |
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