NO20013941L - Polynukleotider med forkortet kjede og fremgangsmåte ved fremstillingen derav - Google Patents

Polynukleotider med forkortet kjede og fremgangsmåte ved fremstillingen derav

Info

Publication number
NO20013941L
NO20013941L NO20013941A NO20013941A NO20013941L NO 20013941 L NO20013941 L NO 20013941L NO 20013941 A NO20013941 A NO 20013941A NO 20013941 A NO20013941 A NO 20013941A NO 20013941 L NO20013941 L NO 20013941L
Authority
NO
Norway
Prior art keywords
preparation
short
chain polynucleotides
chain
same
Prior art date
Application number
NO20013941A
Other languages
English (en)
Other versions
NO20013941D0 (no
Inventor
Shinji Matsuyama
Kouichi Ishiyama
Junzo Seki
Tadaaki Ohgi
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of NO20013941L publication Critical patent/NO20013941L/no
Publication of NO20013941D0 publication Critical patent/NO20013941D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Den foreliggende oppfinnelse tilveiebringer et polynukleotid med forkortet kjede hvori proporsjonen av en 2'-5•-fosfodiesterbinding er opp til 3% basert på helheten av fosfodiesterbindinger eller et salt derav og en farmasøytisk sammensetning inneholdende det samme og en fremgangsmåte for å fremstille det samme.
NO20013941A 1999-02-15 2001-08-14 Polynukleotider med forkortet kjede og fremgangsmate ved fremstillingen derav NO20013941D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3596399 1999-02-15
PCT/JP2000/000778 WO2000047601A1 (fr) 1999-02-15 2000-02-14 Polynucleotides a chaine raccourcie et procede de preparation correspondant

Publications (2)

Publication Number Publication Date
NO20013941L true NO20013941L (no) 2001-08-14
NO20013941D0 NO20013941D0 (no) 2001-08-14

Family

ID=12456623

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013941A NO20013941D0 (no) 1999-02-15 2001-08-14 Polynukleotider med forkortet kjede og fremgangsmate ved fremstillingen derav

Country Status (14)

Country Link
US (2) US6780429B1 (no)
EP (1) EP1153931B1 (no)
KR (1) KR100455814B1 (no)
CN (1) CN1194002C (no)
AT (1) ATE299885T1 (no)
AU (1) AU2460900A (no)
BR (1) BR0008227A (no)
CA (1) CA2359674A1 (no)
DE (1) DE60021354T2 (no)
ID (1) ID29546A (no)
NO (1) NO20013941D0 (no)
RU (1) RU2238279C2 (no)
WO (1) WO2000047601A1 (no)
ZA (1) ZA200106701B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010053763A1 (en) * 1998-12-02 2001-12-20 Andrew Salzman Method and composition for modulating an immune response
US6958324B2 (en) 1998-12-02 2005-10-25 Inotek Pharmaceuticals Corporation Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease
EP1582584A4 (en) * 2002-12-26 2006-05-31 Nippon Shinyaku Co Ltd PROCESS FOR PRODUCING PNPASE
CA2587676A1 (en) * 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer by double-stranded rna
EP2281043B1 (en) 2008-04-25 2013-03-13 Innate Pharma Improved tlr3 agonist compositions
EP2116602A1 (en) 2008-05-07 2009-11-11 Institut Gustave Roussy Combination products for treating cancer
CN101352422B (zh) * 2008-09-17 2011-04-20 厦门朝阳生物工程有限公司 河豚毒素冻干粉针制剂及其制备方法
US20130195919A1 (en) 2010-03-05 2013-08-01 President And Fellows Of Harvard College Induced dendritic cell compositions and uses thereof
US9814740B2 (en) 2010-12-21 2017-11-14 Duke University Methods and compositions combining immunotherapy with monocyte activation
SG11201407875UA (en) 2012-06-08 2014-12-30 Aduro Biotech Compostions and methods for cancer immunotherapy
EP2930180B1 (en) * 2012-12-06 2021-11-10 Kyowa Hakko Bio Co., Ltd. Double-stranded ribonucleic acid for adjuvants
WO2014093936A1 (en) 2012-12-13 2014-06-19 Aduro Biotech, Inc. Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
CN105358158A (zh) 2013-04-29 2016-02-24 纪念斯隆-凯特琳癌症中心 用于改变第二信使信号传导的组合物和方法
JP2016518140A (ja) 2013-05-03 2016-06-23 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｉ型インターフェロンの環状ジヌクレオチド誘導法
US9549944B2 (en) 2013-05-18 2017-01-24 Aduro Biotech, Inc. Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
RS59500B1 (sr) 2013-05-18 2019-12-31 Aduro Biotech Inc Sastavi i metode za aktiviranje signaliziranja koje je zavisno od „stimulatora gena za interferon“
WO2015017652A1 (en) 2013-07-31 2015-02-05 Memorial Sloan-Kettering Cancer Center Sting crystals and modulators
EP3554515A4 (en) 2016-12-15 2020-08-26 Duke University B10 REGULATORY CELL DEPLETION ANTIBODIES AND METHODS AND THEIR USE IN COMBINATION WITH IMMUNITY CHECKPOINT INHIBITORS
TW202308629A (zh) 2021-04-28 2023-03-01 法商Ｅｎｙｏ製藥公司 使用fxr激動劑作為組合治療以增強tlr3激動劑之療效

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692899A (en) * 1969-12-17 1972-09-19 Us Health Education & Welfare Inhibition of transplanted tumor growth by polyinosinic-polycytidylic acid in mice
US3666646A (en) * 1970-05-15 1972-05-30 Merck & Co Inc Reduction of molecular weight in polynucleotides using ultrasonic radiation
US5298614A (en) * 1986-01-06 1994-03-29 Nippon Shinyaku Co. Ltd. Size limited double stranded poly I poly(cytidylate/4-thiouridylate)
GB2207138B (en) * 1987-07-03 1992-02-05 Nippon Shinyaku Co Ltd Preparation of nucleic acid derivatives.
EP0685234B1 (en) * 1993-02-19 2000-05-10 Nippon Shinyaku Company, Limited Drug composition containing nucleic acid copolymer
US5795587A (en) * 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US5886165A (en) * 1996-09-24 1999-03-23 Hybridon, Inc. Mixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segments

Also Published As

Publication number Publication date
ATE299885T1 (de) 2005-08-15
RU2238279C2 (ru) 2004-10-20
ID29546A (id) 2001-09-06
EP1153931A1 (en) 2001-11-14
US6780429B1 (en) 2004-08-24
CN1340055A (zh) 2002-03-13
EP1153931B1 (en) 2005-07-20
US20040235044A1 (en) 2004-11-25
CN1194002C (zh) 2005-03-23
BR0008227A (pt) 2001-10-30
US7223857B2 (en) 2007-05-29
KR20020013500A (ko) 2002-02-20
CA2359674A1 (en) 2000-08-17
KR100455814B1 (ko) 2004-11-06
NO20013941D0 (no) 2001-08-14
ZA200106701B (en) 2002-11-14
WO2000047601A1 (fr) 2000-08-17
DE60021354D1 (de) 2005-08-25
DE60021354T2 (de) 2006-04-27
AU2460900A (en) 2000-08-29
EP1153931A4 (en) 2002-07-17

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