NO20005303L - Fastfase syntese av sulfonerte 2-oksopiperaziner - Google Patents

Fastfase syntese av sulfonerte 2-oksopiperaziner

Info

Publication number
NO20005303L
NO20005303L NO20005303A NO20005303A NO20005303L NO 20005303 L NO20005303 L NO 20005303L NO 20005303 A NO20005303 A NO 20005303A NO 20005303 A NO20005303 A NO 20005303A NO 20005303 L NO20005303 L NO 20005303L
Authority
NO
Norway
Prior art keywords
oxopiperazines
sulfonated
solid phase
resin
phase synthesis
Prior art date
Application number
NO20005303A
Other languages
English (en)
Other versions
NO20005303D0 (no
Inventor
Adam Golebiowski
Sean Rees Klopfenstein
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO20005303D0 publication Critical patent/NO20005303D0/no
Publication of NO20005303L publication Critical patent/NO20005303L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Foreliggende oppfinnelse involverer fremgangsmåter for å lage 2-oksopiperazin og homologe forbindelser anvendende en fast bærerharpiks ved (a) å fjerne den beskyttende gruppe fra en N-beskyttet aminosyre-ester av harpiksen (dersom tilstede), (b) å reagere den resulterende ubeskyttede har- piksester med et sulfonylklorid, (c) å reagere det resul- terende intermediat med en N-beskyttet aminoalkohol, (d) å fjerne den N-beskyttende gruppe fra N'en fra aminoalko- holen, og (e) å dele/cyklisere produktet fra harpiksen.
NO20005303A 1998-04-29 2000-10-20 Fastfase syntese av sulfonerte 2-oksopiperaziner NO20005303L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8346898P 1998-04-29 1998-04-29
PCT/US1999/009091 WO1999055684A1 (en) 1998-04-29 1999-04-27 Solid supported synthesis of sulfonated 2-oxopiperazines

Publications (2)

Publication Number Publication Date
NO20005303D0 NO20005303D0 (no) 2000-10-20
NO20005303L true NO20005303L (no) 2000-12-20

Family

ID=22178551

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005303A NO20005303L (no) 1998-04-29 2000-10-20 Fastfase syntese av sulfonerte 2-oksopiperaziner

Country Status (7)

Country Link
EP (1) EP1073644A1 (no)
JP (1) JP2002513010A (no)
AU (1) AU3764399A (no)
CA (1) CA2328934A1 (no)
IL (1) IL139121A0 (no)
NO (1) NO20005303L (no)
WO (1) WO1999055684A1 (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7964181B2 (en) 2006-03-30 2011-06-21 Palatin Technologies, Inc. Amino acid surrogates for peptidic constructs
US8114844B2 (en) 2006-03-30 2012-02-14 Palatin Technologies, Inc. Linear and cyclic melanocortin receptor-specific peptidomimetics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811241A (en) * 1995-09-13 1998-09-22 Cortech, Inc. Method for preparing and identifying N-substitued 1,4-piperazines and N-substituted 1,4-piperazinediones

Also Published As

Publication number Publication date
JP2002513010A (ja) 2002-05-08
WO1999055684A1 (en) 1999-11-04
IL139121A0 (en) 2001-11-25
CA2328934A1 (en) 1999-11-04
EP1073644A1 (en) 2001-02-07
NO20005303D0 (no) 2000-10-20
AU3764399A (en) 1999-11-16

Similar Documents

Publication Publication Date Title
ATE290014T1 (de) Festphasen-peptidsynthese
CA2104909A1 (en) Decahydroisoquinolines as excitatory amino acid receptor antagonists
NO982850L (no) Ny syntese
UA50730C2 (uk) Спосіб одержання 1-(тіометил)циклопропаноцтової кислоти та проміжних сполук для її одержання
MX203057B (es) Procedimiento para la sintesis electroquimica directa de fosgeno en fase gaseosa.
AU5969396A (en) Novel N-(4-oxo-2,3,4,5-tetrahydro-1H-1, 5-benzodiazepin-3yl)-3-amides
ATE245435T1 (de) Totalsynthese des amino hip analogen von didemnin a
Carlström et al. Palladium-catalyzed synthesis of didehydroamino acid derivatives
CA2290252A1 (en) Process and intermediates for growth hormone secretagogues
CA2180283A1 (fr) Procede de fabrication du difluoromethane
NO20005303L (no) Fastfase syntese av sulfonerte 2-oksopiperaziner
WO1997031016A3 (en) New inhibitors of sh2-mediated processes
WO1999048872A3 (de) Verfahren zur abtrennung eines azepin-derivats aus einer mischung enthaltend ein amin und ein azepin-derivat
Lowik et al. Synthesis of α‐and β‐substituted aminoethane sulfonamide arginine‐glycine mimics
DK0871612T3 (da) Kondenserede isoindoloner som proteinkinase C-inhibitorer
DE69637941D1 (de) Modifizierte hämoglobinähnliche verbindungen und verfahren zu deren reinigung
ATE243678T1 (de) Verfahren zur herstellung von methylcarbazat
NO20004278L (no) Fremstilling av 2-oksopiperaziner pÕ en fast bærer
Schumann et al. Synthesis of different types of dipeptide building units containing N‐or C‐terminal arginine for the assembly of backbone cyclic peptides
SE9800865D0 (sv) New Process
WO1995017418A3 (en) NOVEL INTERMEDIATES FOR THE SYNTHESIS OF L-ASPARTYL-D-α-AMINOALKANOYL-(S)-N-α-ALKYLBENZYL AMIDES USEFUL AS ARTIFICIAL SWEETENERS
DE69724216D1 (de) Pyridin-Zwischenprodukte, verwendbar zur Herstellung von Beta-adrenergischen Rezeptor-Agonisten
DE69900214D1 (de) Herstellung von (s)-n-tert-butyl-1,2,3,4-tetrahydroisoquinolin-3-carboxamid
AU1779088A (en) Guanidine-related compounds comprising a tetraphenylborate ion, process for obtaining these compounds and use of the compounds in peptide synthesis
NO20042469L (no) N-metylhomocysteiner, anvendelse derav og fremgangsmate for fremstilling derav

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application