NO20005303L - Solid phase synthesis of sulfonated 2-oxopiperazines - Google Patents

Solid phase synthesis of sulfonated 2-oxopiperazines

Info

Publication number
NO20005303L
NO20005303L NO20005303A NO20005303A NO20005303L NO 20005303 L NO20005303 L NO 20005303L NO 20005303 A NO20005303 A NO 20005303A NO 20005303 A NO20005303 A NO 20005303A NO 20005303 L NO20005303 L NO 20005303L
Authority
NO
Norway
Prior art keywords
oxopiperazines
sulfonated
solid phase
resin
phase synthesis
Prior art date
Application number
NO20005303A
Other languages
Norwegian (no)
Other versions
NO20005303D0 (en
Inventor
Adam Golebiowski
Sean Rees Klopfenstein
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO20005303D0 publication Critical patent/NO20005303D0/en
Publication of NO20005303L publication Critical patent/NO20005303L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Foreliggende oppfinnelse involverer fremgangsmåter for å lage 2-oksopiperazin og homologe forbindelser anvendende en fast bærerharpiks ved (a) å fjerne den beskyttende gruppe fra en N-beskyttet aminosyre-ester av harpiksen (dersom tilstede), (b) å reagere den resulterende ubeskyttede har- piksester med et sulfonylklorid, (c) å reagere det resul- terende intermediat med en N-beskyttet aminoalkohol, (d) å fjerne den N-beskyttende gruppe fra N'en fra aminoalko- holen, og (e) å dele/cyklisere produktet fra harpiksen.The present invention involves methods for making 2-oxopiperazine and homologous compounds using a solid support resin by (a) removing the protecting group from an N-protected amino acid ester of the resin (if present), (b) reacting the resulting unprotected - peak ester with a sulfonyl chloride, (c) reacting the resulting intermediate with an N-protected amino alcohol, (d) removing the N-protecting group from the N from the amino alcohol, and (e) dividing / cyclizing the product from the resin.

NO20005303A 1998-04-29 2000-10-20 Solid phase synthesis of sulfonated 2-oxopiperazines NO20005303L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8346898P 1998-04-29 1998-04-29
PCT/US1999/009091 WO1999055684A1 (en) 1998-04-29 1999-04-27 Solid supported synthesis of sulfonated 2-oxopiperazines

Publications (2)

Publication Number Publication Date
NO20005303D0 NO20005303D0 (en) 2000-10-20
NO20005303L true NO20005303L (en) 2000-12-20

Family

ID=22178551

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005303A NO20005303L (en) 1998-04-29 2000-10-20 Solid phase synthesis of sulfonated 2-oxopiperazines

Country Status (7)

Country Link
EP (1) EP1073644A1 (en)
JP (1) JP2002513010A (en)
AU (1) AU3764399A (en)
CA (1) CA2328934A1 (en)
IL (1) IL139121A0 (en)
NO (1) NO20005303L (en)
WO (1) WO1999055684A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7964181B2 (en) 2006-03-30 2011-06-21 Palatin Technologies, Inc. Amino acid surrogates for peptidic constructs
US8114844B2 (en) 2006-03-30 2012-02-14 Palatin Technologies, Inc. Linear and cyclic melanocortin receptor-specific peptidomimetics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811241A (en) * 1995-09-13 1998-09-22 Cortech, Inc. Method for preparing and identifying N-substitued 1,4-piperazines and N-substituted 1,4-piperazinediones

Also Published As

Publication number Publication date
JP2002513010A (en) 2002-05-08
WO1999055684A1 (en) 1999-11-04
IL139121A0 (en) 2001-11-25
CA2328934A1 (en) 1999-11-04
EP1073644A1 (en) 2001-02-07
NO20005303D0 (en) 2000-10-20
AU3764399A (en) 1999-11-16

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application