NO20005303L - Solid phase synthesis of sulfonated 2-oxopiperazines - Google Patents
Solid phase synthesis of sulfonated 2-oxopiperazinesInfo
- Publication number
- NO20005303L NO20005303L NO20005303A NO20005303A NO20005303L NO 20005303 L NO20005303 L NO 20005303L NO 20005303 A NO20005303 A NO 20005303A NO 20005303 A NO20005303 A NO 20005303A NO 20005303 L NO20005303 L NO 20005303L
- Authority
- NO
- Norway
- Prior art keywords
- oxopiperazines
- sulfonated
- solid phase
- resin
- phase synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Foreliggende oppfinnelse involverer fremgangsmåter for å lage 2-oksopiperazin og homologe forbindelser anvendende en fast bærerharpiks ved (a) å fjerne den beskyttende gruppe fra en N-beskyttet aminosyre-ester av harpiksen (dersom tilstede), (b) å reagere den resulterende ubeskyttede har- piksester med et sulfonylklorid, (c) å reagere det resul- terende intermediat med en N-beskyttet aminoalkohol, (d) å fjerne den N-beskyttende gruppe fra N'en fra aminoalko- holen, og (e) å dele/cyklisere produktet fra harpiksen.The present invention involves methods for making 2-oxopiperazine and homologous compounds using a solid support resin by (a) removing the protecting group from an N-protected amino acid ester of the resin (if present), (b) reacting the resulting unprotected - peak ester with a sulfonyl chloride, (c) reacting the resulting intermediate with an N-protected amino alcohol, (d) removing the N-protecting group from the N from the amino alcohol, and (e) dividing / cyclizing the product from the resin.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8346898P | 1998-04-29 | 1998-04-29 | |
PCT/US1999/009091 WO1999055684A1 (en) | 1998-04-29 | 1999-04-27 | Solid supported synthesis of sulfonated 2-oxopiperazines |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20005303D0 NO20005303D0 (en) | 2000-10-20 |
NO20005303L true NO20005303L (en) | 2000-12-20 |
Family
ID=22178551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20005303A NO20005303L (en) | 1998-04-29 | 2000-10-20 | Solid phase synthesis of sulfonated 2-oxopiperazines |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1073644A1 (en) |
JP (1) | JP2002513010A (en) |
AU (1) | AU3764399A (en) |
CA (1) | CA2328934A1 (en) |
IL (1) | IL139121A0 (en) |
NO (1) | NO20005303L (en) |
WO (1) | WO1999055684A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7964181B2 (en) | 2006-03-30 | 2011-06-21 | Palatin Technologies, Inc. | Amino acid surrogates for peptidic constructs |
US8114844B2 (en) | 2006-03-30 | 2012-02-14 | Palatin Technologies, Inc. | Linear and cyclic melanocortin receptor-specific peptidomimetics |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5811241A (en) * | 1995-09-13 | 1998-09-22 | Cortech, Inc. | Method for preparing and identifying N-substitued 1,4-piperazines and N-substituted 1,4-piperazinediones |
-
1999
- 1999-04-27 CA CA002328934A patent/CA2328934A1/en not_active Abandoned
- 1999-04-27 JP JP2000545844A patent/JP2002513010A/en not_active Withdrawn
- 1999-04-27 EP EP99920061A patent/EP1073644A1/en not_active Withdrawn
- 1999-04-27 AU AU37643/99A patent/AU3764399A/en not_active Abandoned
- 1999-04-27 WO PCT/US1999/009091 patent/WO1999055684A1/en not_active Application Discontinuation
- 1999-04-27 IL IL13912199A patent/IL139121A0/en unknown
-
2000
- 2000-10-20 NO NO20005303A patent/NO20005303L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2002513010A (en) | 2002-05-08 |
WO1999055684A1 (en) | 1999-11-04 |
IL139121A0 (en) | 2001-11-25 |
CA2328934A1 (en) | 1999-11-04 |
EP1073644A1 (en) | 2001-02-07 |
NO20005303D0 (en) | 2000-10-20 |
AU3764399A (en) | 1999-11-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |