NO20004980L - Particulate articles of active ingredients for pulmonary use - Google Patents

Particulate articles of active ingredients for pulmonary use

Info

Publication number
NO20004980L
NO20004980L NO20004980A NO20004980A NO20004980L NO 20004980 L NO20004980 L NO 20004980L NO 20004980 A NO20004980 A NO 20004980A NO 20004980 A NO20004980 A NO 20004980A NO 20004980 L NO20004980 L NO 20004980L
Authority
NO
Norway
Prior art keywords
active ingredients
particulate
pulmonary use
particulate articles
pulmonary
Prior art date
Application number
NO20004980A
Other languages
Norwegian (no)
Other versions
NO20004980D0 (en
Inventor
Holger Bengs
Juergen Grande
Original Assignee
Axiva Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axiva Gmbh filed Critical Axiva Gmbh
Publication of NO20004980D0 publication Critical patent/NO20004980D0/en
Publication of NO20004980L publication Critical patent/NO20004980L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Abstract

Oppfinnelsen angår tilveiebringelse av en partikulær virkestoffbærer og dens farmasøytiske sammensetning med depotvirkning for pulmonal applikasjon. Den tønformulerbare biokompatible, partikulære virkestoffbæreren fremstilles helt eller til dels av lineære vannuoppløselige polysakkarider, fortrinnsvis poly(l,4-a-D-glukan), med homogen enhetlig størrelse fra fortrinnsvis biotransformatorisk fremstilling med evnen til å kluster- og/eller agglomeratdannelse. De derav resulterende fordeler benyttes fortrinnsvis i rammen av den tørre pulverinhaleringen.The invention relates to the provision of a particulate active substance and its pharmaceutical composition with depot effect for pulmonary application. The barrel-formulated biocompatible particulate carrier is prepared wholly or in part by linear water-insoluble polysaccharides, preferably poly (1,4-a-D-glucan), of homogeneous uniform size, preferably from biotransformational preparation with the ability to cluster and / or agglomerate formation. The resulting advantages are preferably used in the frame of the dry powder inhalation.

NO20004980A 1998-04-09 2000-10-03 Particulate articles of active ingredients for pulmonary use NO20004980L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19816085 1998-04-09
PCT/EP1999/002385 WO1999052506A1 (en) 1998-04-09 1999-04-08 Particulate active agent support for pulmonary application

Publications (2)

Publication Number Publication Date
NO20004980D0 NO20004980D0 (en) 2000-10-03
NO20004980L true NO20004980L (en) 2000-12-08

Family

ID=7864224

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20004980A NO20004980L (en) 1998-04-09 2000-10-03 Particulate articles of active ingredients for pulmonary use

Country Status (12)

Country Link
EP (1) EP1069889B1 (en)
JP (1) JP2002511399A (en)
KR (1) KR20010034755A (en)
CN (1) CN1423553A (en)
AT (1) ATE270097T1 (en)
AU (1) AU3421099A (en)
CA (1) CA2340340A1 (en)
DE (1) DE59909854D1 (en)
HU (1) HUP0101912A2 (en)
NO (1) NO20004980L (en)
PL (1) PL343342A1 (en)
WO (1) WO1999052506A1 (en)

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DE19847593A1 (en) * 1998-10-15 2000-04-20 Aventis Res & Tech Gmbh & Co Parenteral drug administration composition with depot and controlled release comprises active agent and water soluble polysaccharide microparticles as carrier
PT1808438E (en) * 1999-06-29 2015-01-14 Mannkind Corp Purification and stabilization of peptide and proteins in pharmaceutical agents
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
JP5078014B2 (en) 2004-08-20 2012-11-21 マンカインド コーポレイション Catalytic reaction of diketopiperazine synthesis.
HUE026797T2 (en) 2004-08-23 2016-07-28 Mannkind Corp Diketopiperazine salts for drug delivery
KR20120060245A (en) 2005-09-14 2012-06-11 맨카인드 코포레이션 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US8084420B2 (en) 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
EP2497484A3 (en) * 2006-02-22 2012-11-07 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
EP3281663B8 (en) 2008-06-13 2022-09-21 MannKind Corporation Breath powered dry powder inhaler for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
TWI494123B (en) 2008-08-11 2015-08-01 Mannkind Corp Use of ultrarapid acting insulin
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
EP3556356B1 (en) 2009-06-12 2021-05-05 MannKind Corporation Diketopiperazine microparticles with defined isomer content
WO2010144789A2 (en) 2009-06-12 2010-12-16 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
AU2011271097B2 (en) 2010-06-21 2014-11-27 Mannkind Corporation Dry powder drug delivery system and methods
CN105667994B (en) 2011-04-01 2018-04-06 曼金德公司 Blister package for pharmaceutical kit
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
KR20140095483A (en) 2011-10-24 2014-08-01 맨카인드 코포레이션 Methods and compositions for treating pain
DK2872205T3 (en) 2012-07-12 2017-02-27 Mannkind Corp DRY POWDER FORMAL ADMINISTRATION SYSTEM
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
WO2014074797A1 (en) * 2012-11-09 2014-05-15 Civitas Therapeutics, Inc. Ultra low density pulmonary powders
KR102499439B1 (en) 2013-03-15 2023-02-13 맨카인드 코포레이션 Microcrystalline diketopiperazine compositions and methods
WO2015010092A1 (en) 2013-07-18 2015-01-22 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
JP2016530930A (en) 2013-08-05 2016-10-06 マンカインド コーポレイション Ventilation device and method
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2018222581A1 (en) * 2017-05-29 2018-12-06 Resinnate Therapeutics Llc Methods and formulations for administering beta glucan

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB937303A (en) * 1959-01-02 1963-09-18 Benger Lab Ltd Improvements in and relating to the application of drugs in finely divided condition
US6428771B1 (en) * 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
GB9606188D0 (en) * 1996-03-23 1996-05-29 Danbiosyst Uk Pollysaccharide microspheres for the pulmonary delivery of drugs
DE19737481A1 (en) * 1997-08-28 1999-03-04 Hoechst Ag Microparticles containing spherical linear polysaccharides

Also Published As

Publication number Publication date
CN1423553A (en) 2003-06-11
ATE270097T1 (en) 2004-07-15
WO1999052506B1 (en) 1999-11-25
JP2002511399A (en) 2002-04-16
PL343342A1 (en) 2001-08-13
DE59909854D1 (en) 2004-08-05
KR20010034755A (en) 2001-04-25
HUP0101912A2 (en) 2001-10-28
NO20004980D0 (en) 2000-10-03
WO1999052506A1 (en) 1999-10-21
CA2340340A1 (en) 1999-10-21
EP1069889A1 (en) 2001-01-24
EP1069889B1 (en) 2004-06-30
AU3421099A (en) 1999-11-01

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application