NO20004580L - Chemical process for the preparation of sulfinyl derivatives by oxidation of the corresponding CO derivatives with perborates - Google Patents

Chemical process for the preparation of sulfinyl derivatives by oxidation of the corresponding CO derivatives with perborates

Info

Publication number
NO20004580L
NO20004580L NO20004580A NO20004580A NO20004580L NO 20004580 L NO20004580 L NO 20004580L NO 20004580 A NO20004580 A NO 20004580A NO 20004580 A NO20004580 A NO 20004580A NO 20004580 L NO20004580 L NO 20004580L
Authority
NO
Norway
Prior art keywords
derivatives
och
preparation
perborates
oxidation
Prior art date
Application number
NO20004580A
Other languages
Norwegian (no)
Other versions
NO20004580D0 (en
Inventor
James Patrick Brennan
Andrew Timothy Turner
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of NO20004580L publication Critical patent/NO20004580L/en
Publication of NO20004580D0 publication Critical patent/NO20004580D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Fremgangsmåte for fremstilling av en forbindelse med formel l hvor RL R2, R3 og R4 representerer henholdsvis a) (Ri=CH3; R2=OCH3; R3=CH3; R4=OCH3) eller b) (Ri=CH3; R2=OCH2CF3; R3=H; R4=H) eller c) (Ri=OCH3; R2=OCH3; R3=H og R4=OCHF2) og farmasøytisk akseptable salter derav, omfattende omsetning av en forbindelse med formel II hvor RI, R2, R3 og FM representerer henholdsvis a) (R!=CH3; R2=OCH3; R3=CH3; R4=OCH3) eller b) (R,=CH3; R2=OCH2CF3; R3=H; F<4=H) eller c) (Ri=OCH3; R2=OCH3; R3=H og R4= med et perboratsalt i et flytende fortynningsmiddel ved en pH i området 7,5 til 14 ved en temperatur i området 0°C til kokepunktet til det anvendte flytende fortynningsmiddel.Process for Preparation of a Compound of Formula 1 wherein RL R2, R3 and R4 represent a) (R 1 = CH 3; R 2 = OCH 3; R 3 = CH 3; R 4 = OCH 3) or b) (R 1 = CH 3; R 2 = OCH 2 CF 3; R 3 = H; R4 = H) or c) (R 1 = OCH 3; R 2 = OCH 3; R 3 = H and R 4 = OCHF 2) and pharmaceutically acceptable salts thereof, comprising reacting a compound of formula II wherein R 1, R 2, R 3 and FM represent respectively (a) (R 1 = CH 3; R 2 = OCH 3; R 3 = CH 3; R 4 = OCH 3) or b) (R 1 = CH 3; R 2 = OCH 2 CF 3; R 3 = H; F <4 = H) or c) (R 1 = OCH3; R2 = OCH3; R3 = H and R4 = with a perborate salt in a liquid diluent at a pH in the range of 7.5 to 14 at a temperature in the range 0 ° C to the boiling point of the liquid diluent used.

NO20004580A 1998-03-17 2000-09-14 Chemical process for the preparation of sulfinyl derivatives by oxidation of the corresponding CO derivatives with perborates NO20004580D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9805558.5A GB9805558D0 (en) 1998-03-17 1998-03-17 Chemical process`
PCT/EP1999/001574 WO1999047514A1 (en) 1998-03-17 1999-03-11 Chemical process for the production of sulphinyl derivatives by oxidation of the corresponding co-derivatives with perborates

Publications (2)

Publication Number Publication Date
NO20004580L true NO20004580L (en) 2000-09-14
NO20004580D0 NO20004580D0 (en) 2000-09-14

Family

ID=10828629

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20004580A NO20004580D0 (en) 1998-03-17 2000-09-14 Chemical process for the preparation of sulfinyl derivatives by oxidation of the corresponding CO derivatives with perborates

Country Status (15)

Country Link
EP (1) EP1071678A1 (en)
JP (1) JP2002506862A (en)
KR (1) KR20010041948A (en)
CN (1) CN1293670A (en)
AU (1) AU3410699A (en)
BR (1) BR9908835A (en)
CA (1) CA2323422A1 (en)
GB (1) GB9805558D0 (en)
HU (1) HUP0101230A3 (en)
IL (1) IL138001A0 (en)
NO (1) NO20004580D0 (en)
SK (1) SK13452000A3 (en)
TR (1) TR200002670T2 (en)
TW (1) TW473476B (en)
WO (1) WO1999047514A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19951960C2 (en) * 1999-10-28 2002-06-27 Gruenenthal Gmbh Process for the preparation of benzimidazole derivatives suitable as ulcer therapeutics
JP2004524303A (en) * 2001-02-02 2004-08-12 テバ ファーマシューティカル インダストリーズ リミティド Method for producing substituted 2- (2-pyridylmethyl) sulfinyl-1H-benzimidazoles
KR100547824B1 (en) 2001-12-29 2006-02-01 삼성전자주식회사 Method for transmitting emergency call in mobile communication terminal having bluetooth
EP1501824B1 (en) 2002-08-21 2007-10-10 Teva Pharmaceutical Industries Ltd A method for the purification of lansoprazole
PT1465890E (en) 2002-11-18 2007-05-31 Teva Pharma Stable lansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
PL375695A1 (en) * 2002-12-06 2005-12-12 Altana Pharma Ag Process for preparing (s)-pantoprazole
WO2004056804A2 (en) 2002-12-19 2004-07-08 Teva Pharmaceutical Industries Ltd. Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
WO2004072061A1 (en) 2003-02-05 2004-08-26 Teva Pharmaceutical Industries Ltd. Method of stabilizing lansoprazole
EP1615913A2 (en) 2003-06-10 2006-01-18 Teva Pharmaceutical Industries Limited Process for preparing 2-(pyridinyl)methyl sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
PL1802584T3 (en) 2004-10-11 2010-03-31 Ranbaxy Laboratories Ltd Processes for the preparation of substituted sulfoxides
CN102603621B (en) * 2012-02-07 2013-09-04 成都苑东药业有限公司 Novel chiral sulfoxide compound and method for preparing esomeprazole by using novel chiral sulfoxide compound
CN107365300B (en) * 2017-07-26 2019-08-02 桂林华信制药有限公司 A method of effectively removing impurity in Lansoprazole crude product

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE416649B (en) * 1974-05-16 1981-01-26 Haessle Ab PROCEDURE FOR THE PREPARATION OF SUBSTANCES WHICH PREVENT Gastric acid secretion
SE8500996D0 (en) * 1985-03-01 1985-03-01 Haessle Ab METHOD OF TREATMENT
JPH0352887A (en) * 1989-07-20 1991-03-07 Yoshitomi Pharmaceut Ind Ltd Pyridine compound
DE69131627T2 (en) * 1990-06-20 2000-04-27 Astra Ab Soedertaelje DIALKOXYPYRIDINYLBENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION AND THEIR PHARMACEUTICAL USE
ES2026761A6 (en) * 1990-10-31 1992-05-01 Genesis Para La Investigacion A process for the preparation of omeprazol.
WO1999002521A1 (en) * 1997-07-11 1999-01-21 Eisai Co., Ltd. Processes for the preparation of pyridine derivatives

Also Published As

Publication number Publication date
EP1071678A1 (en) 2001-01-31
WO1999047514A1 (en) 1999-09-23
AU3410699A (en) 1999-10-11
CN1293670A (en) 2001-05-02
HUP0101230A2 (en) 2001-10-28
HUP0101230A3 (en) 2002-10-28
SK13452000A3 (en) 2001-04-09
TR200002670T2 (en) 2000-11-21
BR9908835A (en) 2000-11-21
IL138001A0 (en) 2001-10-31
NO20004580D0 (en) 2000-09-14
TW473476B (en) 2002-01-21
CA2323422A1 (en) 1999-09-23
KR20010041948A (en) 2001-05-25
JP2002506862A (en) 2002-03-05
GB9805558D0 (en) 1998-05-13

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