ID17851A - HETEROSICLIC COMPOUNDS, PRODUCTION AND USAGE - Google Patents

HETEROSICLIC COMPOUNDS, PRODUCTION AND USAGE

Info

Publication number
ID17851A
ID17851A IDP972526A ID972526A ID17851A ID 17851 A ID17851 A ID 17851A ID P972526 A IDP972526 A ID P972526A ID 972526 A ID972526 A ID 972526A ID 17851 A ID17851 A ID 17851A
Authority
ID
Indonesia
Prior art keywords
stands
heterosiclic
usage
compounds
production
Prior art date
Application number
IDP972526A
Other languages
Indonesian (id)
Inventor
Yu Momose
Etsuya Matsutani
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ID17851A publication Critical patent/ID17851A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Heterocyclic compounds represented by general formula (I): <CHEM> wherein R stands for an optionally substituted aromatic heterocyclic group; X stands for oxygen atom, an optionally oxidized sulfur atom, -C(=O) or - CH(OH)-; Y stands for CH or N; m denotes an integer of 0 to 10; n denotes an integer of 1 to 5; the cyclic group: <CHEM> stands for an optionally substituted aromatic azole group; and ring A may be further substituted, or salts thereof. The compound (I) possesses action of inhibiting tyrosine kinase and is useful as an antitumor agent.
IDP972526A 1996-07-19 1997-07-21 HETEROSICLIC COMPOUNDS, PRODUCTION AND USAGE ID17851A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19110096 1996-07-19
JP15517797 1997-06-12

Publications (1)

Publication Number Publication Date
ID17851A true ID17851A (en) 1998-01-29

Family

ID=26483246

Family Applications (1)

Application Number Title Priority Date Filing Date
IDP972526A ID17851A (en) 1996-07-19 1997-07-21 HETEROSICLIC COMPOUNDS, PRODUCTION AND USAGE

Country Status (10)

Country Link
US (1) US6211215B1 (en)
EP (2) EP1270571B1 (en)
KR (1) KR20000065227A (en)
CN (2) CN1077107C (en)
AT (1) ATE338754T1 (en)
AU (1) AU3461697A (en)
CA (1) CA2260999C (en)
DE (1) DE69736642T2 (en)
ID (1) ID17851A (en)
WO (1) WO1998003505A2 (en)

Families Citing this family (50)

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US6180632B1 (en) 1997-05-28 2001-01-30 Aventis Pharmaceuticals Products Inc. Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
CA2291750A1 (en) * 1997-05-28 1998-12-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
FR2766822B1 (en) * 1997-07-30 2001-02-23 Adir NOVEL DERIVATIVES OF BENZIMIDAZOLE, BENZOXAZOLE AND BENZOTHIAZOLE, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU737092B2 (en) † 1997-08-15 2001-08-09 Cephalon, Inc. Combination of tyrosine kinase inhibitor and chemical castration to treat prostate cancer
KR20010080007A (en) * 1998-10-08 2001-08-22 다케다 야쿠힌 고교 가부시키가이샤 Agents for retarding change of hormone-dependent cancer into hormone-independent cancer
US6867203B2 (en) 1998-12-29 2005-03-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
WO2001035955A1 (en) * 1999-11-16 2001-05-25 Toray Industries, Inc. Benzene derivatives and use thereof as drugs
PE20011178A1 (en) * 2000-04-07 2001-11-19 Takeda Chemical Industries Ltd HETEROCYCLIC COMPOUNDS AND THEIR PRODUCTION
AU6871801A (en) 2000-06-29 2002-01-14 Abbott Lab Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
KR20030013360A (en) * 2000-07-19 2003-02-14 다케다 야쿠힌 고교 가부시키가이샤 Production method of 1-substituted-1,2,3-triazole derivatives
PL362172A1 (en) * 2000-12-11 2004-10-18 Takeda Chemical Industries, Ltd. Medicinal compositions having improved absorbability
EP1712550A3 (en) * 2000-12-22 2009-07-15 Ortho-McNeil Pharmaceutical, Inc. Substituted triazole diamine derivatives as kinase inhibitors
DE60139025D1 (en) 2000-12-28 2009-07-30 Takeda Pharmaceutical ALKANIC ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE
SE0100567D0 (en) * 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
WO2002087618A1 (en) * 2001-04-27 2002-11-07 Takeda Chemical Industries, Ltd. Preventive/therapeutic method for cancer
WO2002087619A1 (en) * 2001-04-27 2002-11-07 Takeda Chemical Industries, Ltd. Preventive/therapeutic method for cancer
MXPA03011558A (en) 2001-06-12 2004-03-26 Wellstat Therapeutics Corp Compounds for the treatment of metabolic disorders.
US6984653B2 (en) * 2001-10-05 2006-01-10 Takeda Pharmaceutical Company Limited Heterocyclic compounds, oxazole derivatives, process for preparation of the same and use thereof
CA2466659A1 (en) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Anticancer agents
WO2003045929A1 (en) * 2001-11-26 2003-06-05 Takeda Chemical Industries, Ltd. Bicyclic derivative, process for producing the same, and use
WO2003059907A1 (en) * 2002-01-17 2003-07-24 Takeda Chemical Industries, Ltd. Nitrogenous heterocyclic compounds, process for preparation of the same and use thereof
DE10258168B4 (en) * 2002-12-12 2005-07-07 Infineon Technologies Ag Integrated DRAM semiconductor memory and method of operating the same
PL377712A1 (en) 2003-02-13 2006-02-06 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
TW200505913A (en) * 2003-03-28 2005-02-16 Hoffmann La Roche Novel oxazole derivatives, their manufacture and use as pharmaceutical agents
AR044098A1 (en) * 2003-04-30 2005-08-24 Hoffmann La Roche DERIVATIVES OF ANILINA, ITS ELABORATION, PHARMACEUTICAL COMPOSITIONS AND ITS USE TO PREPARE MEDICATIONS FOR THE TREATMENT OF CANCER
US7247649B2 (en) 2003-08-13 2007-07-24 Hoffmann-La Roche Inc. Oxazoles, their manufacture and use as pharmaceutical agents
DE602004004156T2 (en) 2003-08-20 2007-10-11 Eli Lilly And Co., Indianapolis COMPOUNDS, METHODS AND FORMULATIONS FOR THE ORAL ADMINISTRATION OF A GLUCAGON LIKE PEPTIDE (GLP) -1 COMPOUNDS OR A MEPANOLORTIN-4-RECEPTOR (MC4) AS AGONIST PEPTIDES
ES2286679T3 (en) * 2003-08-20 2007-12-01 Eli Lilly And Company COMPOUNDS, PROCEDURES AND FORMULATIONS FOR ORAL RELEASE OF A GLUCAGON TYPE PEPTIDE COMPOSITE (LPG) -1 OR AGONIST PEPTIDE OF THE MELANOCORTINE RECEIVER 4 (MC4).
US7259262B2 (en) 2003-10-24 2007-08-21 Hoffmann-La Roche Inc. Arylazole derivatives, their manufacture and use as pharmaceutical agents
TW200531688A (en) 2004-03-05 2005-10-01 Hoffmann La Roche Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents
TW200612914A (en) 2004-03-05 2006-05-01 Hoffmann La Roche Novel oxidized thioether derivatives, their manufacture and use as pharmaceutical agents
TW200533346A (en) 2004-03-18 2005-10-16 Hoffmann La Roche Novel ether derivatives, their manufacture and use as pharmaceutical agents
AU2005231937A1 (en) 2004-04-02 2005-10-20 F. Hoffmann-La Roche Ag Novel diazine derivatives, their manufacture and use as pharmaceutical agents
US7163953B2 (en) 2004-05-25 2007-01-16 Hoffmann-La Roche Inc. Benzylether derivatives
US7005526B2 (en) 2004-05-25 2006-02-28 Hoffmann-La Roche Inc. Thioether derivatives
US7288557B2 (en) 2004-09-21 2007-10-30 Hoffmann-La Roche Inc. Triazole derivatives
TW200616951A (en) * 2004-09-22 2006-06-01 Hoffmann La Roche Indole derivatives, their manufacture and use as pharmaceutial agents
TW200626589A (en) * 2004-09-24 2006-08-01 Hoffmann La Roche Azole derivatives, their manufacture and use as pharmaceutical agents
US20060116407A1 (en) * 2004-11-22 2006-06-01 Birgit Bossenmaier Amide derivatives
ZA200801150B (en) 2005-07-22 2010-05-26 Takeda Pharmaceutical Premature ovulation preventive agent
US7429605B2 (en) 2005-08-04 2008-09-30 Hoffmann-La Roche Inc. Phenylpyridine derivatives
US20090264485A1 (en) * 2005-08-08 2009-10-22 Hans-Willi Krell Pyrazole Derivatives, Their Manufacture and Their Use as Pharmaceutical Agents
WO2007075852A2 (en) 2005-12-22 2007-07-05 Icagen, Inc. Calcium channel antagonists
WO2008034579A1 (en) * 2006-09-20 2008-03-27 F. Hoffmann-La Roche Ag 2-heterocyclyl-5-phenoxymethylpyridine derivatives as anticancer agents
WO2008151437A1 (en) * 2007-06-14 2008-12-18 Osta Biotechnologies Heme-oxygenase inhibitors and use of the same in the treatment of cancer and diseases of the central nervous system
EP2329823A4 (en) 2008-09-03 2013-04-03 Takeda Pharmaceutical Method for improving absorbability of preparation, and preparation having improved absorbability
US9364438B2 (en) 2012-09-26 2016-06-14 Takeda Pharmaceutical Company Limited Process for producing solid particles
CA2995617A1 (en) * 2017-11-03 2019-05-03 Universite De Montreal Heterocyclic mitochondrial activity inhibitors and uses thereof
CN117624052B (en) * 2024-01-26 2024-04-12 四川益能康生环保科技有限公司 Ionic liquid for capturing carbon dioxide and preparation method thereof
CN117820251B (en) * 2024-03-01 2024-05-03 南京桦冠生物技术有限公司 Bis-alpha-keto acid amide compound and composition thereof

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US5359078A (en) * 1989-05-19 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Signal transduction inhibitor compounds
HUT70153A (en) 1990-08-23 1995-09-28 Pfizer Hypoglycemic hydroxyurea derivatives
AU672224B2 (en) 1992-08-06 1996-09-26 Warner-Lambert Company 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and whichhave antitumor properties
IT1266582B1 (en) 1993-07-30 1997-01-09 Recordati Chem Pharm (DI) AZACYLO-HEXANIC AND DIAZACYLO-HEPTANIC DERIVATIVES
US5466610A (en) 1993-09-07 1995-11-14 Eli Lilly And Company Immunoassays for insulin sensitivity enhancers, insulin sensitivity enhancer antibodies, and non-thiazolidinedione insulin sensitivity enhancer compositions
US5480896A (en) 1994-01-27 1996-01-02 American Home Products Corporation Aralkyl-1,2,4-oxadiazolidine-3,5-diones as antihyperglycemic agents
DK0783505T3 (en) * 1994-09-29 2001-07-02 Novartis Ag Pyrrolo [2,3-d] pyrimidines and their use

Also Published As

Publication number Publication date
CA2260999A1 (en) 1998-01-29
CN1077107C (en) 2002-01-02
DE69736642D1 (en) 2006-10-19
WO1998003505A2 (en) 1998-01-29
AU3461697A (en) 1998-02-10
EP1270571A1 (en) 2003-01-02
DE69736642T2 (en) 2007-09-20
ATE338754T1 (en) 2006-09-15
CN1349990A (en) 2002-05-22
EP0912562A1 (en) 1999-05-06
CA2260999C (en) 2006-07-11
KR20000065227A (en) 2000-11-06
EP1270571B1 (en) 2006-09-06
US6211215B1 (en) 2001-04-03
CN1223653A (en) 1999-07-21
WO1998003505A3 (en) 1998-06-25

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