NO994209L - Process for Preparation of 2-Ä (2-Pyridinyl) MethylÜsulfinylÜ-1H-benzimidazoles and New Compounds for Use for This Purpose - Google Patents

Process for Preparation of 2-Ä (2-Pyridinyl) MethylÜsulfinylÜ-1H-benzimidazoles and New Compounds for Use for This Purpose

Info

Publication number
NO994209L
NO994209L NO994209A NO994209A NO994209L NO 994209 L NO994209 L NO 994209L NO 994209 A NO994209 A NO 994209A NO 994209 A NO994209 A NO 994209A NO 994209 L NO994209 L NO 994209L
Authority
NO
Norway
Prior art keywords
benzimidazoles
pyridinyl
preparation
och3
methylüsulfinylü
Prior art date
Application number
NO994209A
Other languages
Norwegian (no)
Other versions
NO994209D0 (en
Inventor
Finn Priess Clausen
Original Assignee
Gea Farmaceutisk Fabrik As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gea Farmaceutisk Fabrik As filed Critical Gea Farmaceutisk Fabrik As
Publication of NO994209D0 publication Critical patent/NO994209D0/en
Publication of NO994209L publication Critical patent/NO994209L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Fremgangsmåte for fremstilling av 2-[[(2-pyridinyl)metyl]sulfinyl]-lH- bcnzimidazoler og nye forbindelser til anvendelse for dette formål Fremgangsmåte for fremstilling av 2-[[2- pyridinyl)metyl]sulfinyl]-l-H- benzimidazolderivater med generell formel (1), hvor R2 betegner H, OCH3, OCHF2 eller CF3; R3 betegner H, CH3 eller OCH3; R' betegner H, OCH3, OCH2CF3, eller halogen, slik som Cl, Br eller F; og R5 betegner H, CH3 eller OCH3, eller salter derav, omfattende reduksjon av en forbindelse med generell formel (II), eller et salt derav, hvor R2, R3, R4 og R5 er som definert ovenfor, i et alkoholisk løsningsmiddel, idet reduksjonen utføres ved anvendelse av et tiobisamin som reduksjonsmiddel i nærvær av en mineralsyre, og hvis ønskelig, omdannelse av en forbindelse oppnådd i fri form til et salt derav, eller vice versa. Nye mellomprodukter med formel (II) er også beskrevet. Forbindelsene med formel (I) er biologisk aktive og/eller kan anvendes som mellomprodukter ved syntese av biologisk aktive forbindelser.Process for the preparation of 2 - [[(2-pyridinyl) methyl] sulfinyl] -1H-benzimidazoles and novel compounds for use in this process. general formula (1) wherein R 2 represents H, OCH 3, OCHF 2 or CF 3; R3 represents H, CH3 or OCH3; R 'represents H, OCH3, OCH2CF3, or halogen, such as Cl, Br or F; and R5 represents H, CH3 or OCH3, or salts thereof, comprising reduction of a compound of general formula (II), or a salt thereof, wherein R2, R3, R4 and R5 are as defined above, in an alcoholic solvent, the reduction is carried out using a thiobisamine as reducing agent in the presence of a mineral acid and, if desired, conversion of a compound obtained in free form into a salt thereof, or vice versa. New intermediates of formula (II) are also described. The compounds of formula (I) are biologically active and / or can be used as intermediates in the synthesis of biologically active compounds.

NO994209A 1997-03-07 1999-08-31 Process for Preparation of 2-Ä (2-Pyridinyl) MethylÜsulfinylÜ-1H-benzimidazoles and New Compounds for Use for This Purpose NO994209L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK25197 1997-03-07
PCT/DK1998/000058 WO1998040377A1 (en) 1997-03-07 1998-02-16 Process for the preparation of 2-[[(2-pyridinyl)methyl]sulfinyl]-1h-benzimidazoles and novel compounds of use for such purpose

Publications (2)

Publication Number Publication Date
NO994209D0 NO994209D0 (en) 1999-08-31
NO994209L true NO994209L (en) 1999-08-31

Family

ID=8091443

Family Applications (1)

Application Number Title Priority Date Filing Date
NO994209A NO994209L (en) 1997-03-07 1999-08-31 Process for Preparation of 2-Ä (2-Pyridinyl) MethylÜsulfinylÜ-1H-benzimidazoles and New Compounds for Use for This Purpose

Country Status (6)

Country Link
EP (1) EP0968204A1 (en)
AU (1) AU5982198A (en)
HR (1) HRP980116A2 (en)
NO (1) NO994209L (en)
WO (1) WO1998040377A1 (en)
ZA (1) ZA981733B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE510643C2 (en) * 1997-06-27 1999-06-14 Astra Ab Thermodynamically stable omeprazole sodium form B
DK173431B1 (en) 1998-03-20 2000-10-23 Gea Farmaceutisk Fabrik As Pharmaceutical formulation comprising a 2 - [[(2-pyridinyl) methyl] sulfinyl] benzimidazole with anti-ulcer activity and progress
US6191148B1 (en) 1998-08-11 2001-02-20 Merck & Co., Inc. Omerazole process and compositions thereof
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
US7507829B2 (en) 2002-12-19 2009-03-24 Teva Pharmaceuticals Industries, Ltd Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
WO2004111029A2 (en) 2003-06-10 2004-12-23 Teva Pharmaceutical Industries Ltd. Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
SE0400410D0 (en) * 2004-02-20 2004-02-20 Astrazeneca Ab New compounds
ATE459617T1 (en) 2006-10-30 2010-03-15 Dipharma Francis Srl METHOD FOR PRODUCING PYRIDINE METHYLSULPHINYL COMPOUNDS
ES2343935B1 (en) * 2008-12-29 2011-04-28 Laboratorios Viñas S.A. USEFUL INTERMEDIATES FOR OBTAINING 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOLES AND CORRESPONDING PROCEDURES.
CN102964336B (en) * 2012-11-29 2014-08-06 寿光富康制药有限公司 Refining method of proton pump inhibitor and reducing method of N-oxide of proton pump inhibitor
CN114163419A (en) * 2021-12-24 2022-03-11 辰欣药业股份有限公司 Preparation method of lansoprazole

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2026761A6 (en) * 1990-10-31 1992-05-01 Genesis Para La Investigacion A process for the preparation of omeprazol.

Also Published As

Publication number Publication date
NO994209D0 (en) 1999-08-31
ZA981733B (en) 1998-09-04
HRP980116A2 (en) 1999-02-28
EP0968204A1 (en) 2000-01-05
WO1998040377A1 (en) 1998-09-17
AU5982198A (en) 1998-09-29

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