BR9908835A - Process for the preparation of a compound - Google Patents
Process for the preparation of a compoundInfo
- Publication number
- BR9908835A BR9908835A BR9908835-5A BR9908835A BR9908835A BR 9908835 A BR9908835 A BR 9908835A BR 9908835 A BR9908835 A BR 9908835A BR 9908835 A BR9908835 A BR 9908835A
- Authority
- BR
- Brazil
- Prior art keywords
- och
- compound
- preparation
- ochf
- represent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"PROCESSO PARA A PREPARAçãO DE UM COMPOSTO" Processo para a preparação de um composto de fórmula (I) na qual R~ 1~, R~ 2~, R~ 3~, e R~ 4~ representam: a) (R~ 1~=CH~ 3~; R~ 2~=OCH~ 3~; R~ 3~=CH~ 3~; R~ 4~=OCH~ 3~) ou b) (R~ 1~=CH~ 3~; R~ 2~=OCH~ 2~CF~ 3~; R~ 3~=H; R~ 4~=H) ou c) (R~ 1~=OCH~ 3~; R~ 2~=OCH~ 3~; R~ 3~=H; e R~ 4~=OCHF~ 2~) respectivamente e seus sais farmaceuticamente aceitáveis, compreendendo reagir um composto de fórmula (II) em que R~ 1~, R~ 2~, R~ 3~ e R~ 4~ representam a) (R~ 1~=CH~ 3~; R~ 2~=OCH~ 3~; R~ 3~=CH~ 3~; R~ 4~=OCH~ 3~) ou b) (R~ 1~=CH~ 3~; R~ 2~=OCH~ 2~CF~ 3~; R~ 3~=H; e R~ 4~=H) ou c) (R~ 1~=OCH~ 3~; R~ 2~=OCH~ 3~; R~ 3~=H; e R~ 4~=OCHF~ 2~) respectivamente, com um sal perborato em um diluente líquido em um pH na faixa de 7,5 a 14 em uma temperatura na faixa de 0°C até o ponto de ebulição do diluente líquido empregado."PROCESS FOR THE PREPARATION OF A COMPOUND" Process for the preparation of a compound of formula (I) in which R ~ 1 ~, R ~ 2 ~, R ~ 3 ~, and R ~ 4 ~ represent: a) (R ~ 1 ~ = CH ~ 3 ~; R ~ 2 ~ = OCH ~ 3 ~; R ~ 3 ~ = CH ~ 3 ~; R ~ 4 ~ = OCH ~ 3 ~) or b) (R ~ 1 ~ = CH ~ 3 ~; R ~ 2 ~ = OCH ~ 2 ~ CF ~ 3 ~; R ~ 3 ~ = H; R ~ 4 ~ = H) or c) (R ~ 1 ~ = OCH ~ 3 ~; R ~ 2 ~ = OCH ~ 3 ~; R ~ 3 ~ = H; and R ~ 4 ~ = OCHF ~ 2 ~) respectively and their pharmaceutically acceptable salts, comprising reacting a compound of formula (II) in which R ~ 1 ~, R ~ 2 ~, R ~ 3 ~ and R ~ 4 ~ represent a) (R ~ 1 ~ = CH ~ 3 ~; R ~ 2 ~ = OCH ~ 3 ~; R ~ 3 ~ = CH ~ 3 ~; R ~ 4 ~ = OCH ~ 3 ~) or b) (R ~ 1 ~ = CH ~ 3 ~; R ~ 2 ~ = OCH ~ 2 ~ CF ~ 3 ~; R ~ 3 ~ = H; and R ~ 4 ~ = H) or c) ( R ~ 1 ~ = OCH ~ 3 ~; R ~ 2 ~ = OCH ~ 3 ~; R ~ 3 ~ = H; and R ~ 4 ~ = OCHF ~ 2 ~) respectively, with a perborate salt in a liquid diluent in a pH in the range of 7.5 to 14 at a temperature in the range of 0 ° C to the boiling point of the liquid diluent used.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9805558.5A GB9805558D0 (en) | 1998-03-17 | 1998-03-17 | Chemical process` |
| PCT/EP1999/001574 WO1999047514A1 (en) | 1998-03-17 | 1999-03-11 | Chemical process for the production of sulphinyl derivatives by oxidation of the corresponding co-derivatives with perborates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908835A true BR9908835A (en) | 2000-11-21 |
Family
ID=10828629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908835-5A BR9908835A (en) | 1998-03-17 | 1999-03-11 | Process for the preparation of a compound |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1071678A1 (en) |
| JP (1) | JP2002506862A (en) |
| KR (1) | KR20010041948A (en) |
| CN (1) | CN1293670A (en) |
| AU (1) | AU3410699A (en) |
| BR (1) | BR9908835A (en) |
| CA (1) | CA2323422A1 (en) |
| GB (1) | GB9805558D0 (en) |
| HU (1) | HUP0101230A3 (en) |
| IL (1) | IL138001A0 (en) |
| NO (1) | NO20004580L (en) |
| SK (1) | SK13452000A3 (en) |
| TR (1) | TR200002670T2 (en) |
| TW (1) | TW473476B (en) |
| WO (1) | WO1999047514A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19951960C2 (en) * | 1999-10-28 | 2002-06-27 | Gruenenthal Gmbh | Process for the preparation of benzimidazole derivatives suitable as ulcer therapeutics |
| MXPA03006904A (en) * | 2001-02-02 | 2004-12-06 | Teva Pharma | Processes for the production of substituted 2-(2-pyridylmethyl) sulfinyl-1h-benzimidazoles. |
| KR100547824B1 (en) | 2001-12-29 | 2006-02-01 | 삼성전자주식회사 | Method for transmitting emergency call in mobile communication terminal having bluetooth |
| AU2003258335A1 (en) | 2002-08-21 | 2004-03-11 | Teva Pharmaceutical Industries Ltd. | A method for the purification of lansoprazole |
| EP1465890B1 (en) | 2002-11-18 | 2007-04-04 | Teva Pharmaceutical Industries Ltd. | Stable lansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol |
| DK1575941T3 (en) | 2002-12-06 | 2012-07-09 | Nycomed Gmbh | Process for Preparation of (S) -Pantoprazole |
| EP1572680A2 (en) | 2002-12-19 | 2005-09-14 | Eva Pharmaceutical Industries Ltd. | Solid states of pantoprazole sodium, known pantoprazole sodium hydrates, processes for their preparation. |
| US7678816B2 (en) | 2003-02-05 | 2010-03-16 | Teva Pharmaceutical Industries Ltd. | Method of stabilizing lansoprazole |
| US7683177B2 (en) | 2003-06-10 | 2010-03-23 | Teva Pharmaceutical Industries Ltd | Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole |
| PL1802584T3 (en) | 2004-10-11 | 2010-03-31 | Ranbaxy Laboratories Ltd | Processes for the preparation of substituted sulfoxides |
| CN102603621B (en) * | 2012-02-07 | 2013-09-04 | 成都苑东药业有限公司 | Novel chiral sulfoxide compound and method for preparing esomeprazole by using novel chiral sulfoxide compound |
| CN107365300B (en) * | 2017-07-26 | 2019-08-02 | 桂林华信制药有限公司 | A method of effectively removing impurity in Lansoprazole crude product |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE416649B (en) * | 1974-05-16 | 1981-01-26 | Haessle Ab | PROCEDURE FOR THE PREPARATION OF SUBSTANCES WHICH PREVENT Gastric acid secretion |
| SE8500996D0 (en) * | 1985-03-01 | 1985-03-01 | Haessle Ab | METHOD OF TREATMENT |
| JPH0352887A (en) * | 1989-07-20 | 1991-03-07 | Yoshitomi Pharmaceut Ind Ltd | Pyridine compound |
| ATE184602T1 (en) * | 1990-06-20 | 1999-10-15 | Astra Ab | DIALKOXYPYRIDINYLBENZIMIDAZOLE DERIVATIVES, PROCESS FOR PRODUCTION AND PHARMACEUTICAL USE THEREOF |
| ES2026761A6 (en) * | 1990-10-31 | 1992-05-01 | Genesis Para La Investigacion | A process for the preparation of omeprazol. |
| DE69826900T2 (en) * | 1997-07-11 | 2005-11-24 | Eisai Co., Ltd. | Process for the preparation of pyridine derivatives |
-
1998
- 1998-03-17 GB GBGB9805558.5A patent/GB9805558D0/en not_active Ceased
-
1999
- 1999-03-11 TR TR2000/02670T patent/TR200002670T2/en unknown
- 1999-03-11 BR BR9908835-5A patent/BR9908835A/en not_active Application Discontinuation
- 1999-03-11 SK SK1345-2000A patent/SK13452000A3/en unknown
- 1999-03-11 HU HU0101230A patent/HUP0101230A3/en unknown
- 1999-03-11 CA CA002323422A patent/CA2323422A1/en not_active Abandoned
- 1999-03-11 EP EP99915569A patent/EP1071678A1/en not_active Withdrawn
- 1999-03-11 AU AU34106/99A patent/AU3410699A/en not_active Abandoned
- 1999-03-11 IL IL13800199A patent/IL138001A0/en unknown
- 1999-03-11 WO PCT/EP1999/001574 patent/WO1999047514A1/en not_active Application Discontinuation
- 1999-03-11 JP JP2000536710A patent/JP2002506862A/en active Pending
- 1999-03-11 CN CN99804078A patent/CN1293670A/en active Pending
- 1999-03-11 KR KR1020007010261A patent/KR20010041948A/en not_active Application Discontinuation
- 1999-03-17 TW TW088104130A patent/TW473476B/en active
-
2000
- 2000-09-14 NO NO20004580A patent/NO20004580L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0101230A2 (en) | 2001-10-28 |
| CN1293670A (en) | 2001-05-02 |
| JP2002506862A (en) | 2002-03-05 |
| WO1999047514A1 (en) | 1999-09-23 |
| KR20010041948A (en) | 2001-05-25 |
| GB9805558D0 (en) | 1998-05-13 |
| AU3410699A (en) | 1999-10-11 |
| CA2323422A1 (en) | 1999-09-23 |
| TR200002670T2 (en) | 2000-11-21 |
| EP1071678A1 (en) | 2001-01-31 |
| TW473476B (en) | 2002-01-21 |
| NO20004580D0 (en) | 2000-09-14 |
| SK13452000A3 (en) | 2001-04-09 |
| IL138001A0 (en) | 2001-10-31 |
| NO20004580L (en) | 2000-09-14 |
| HUP0101230A3 (en) | 2002-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |