NO20004144L - Heterocykliske forbindelser, deres fremstilling og anvendelse som takykininreseptorantagonister - Google Patents
Heterocykliske forbindelser, deres fremstilling og anvendelse som takykininreseptorantagonisterInfo
- Publication number
- NO20004144L NO20004144L NO20004144A NO20004144A NO20004144L NO 20004144 L NO20004144 L NO 20004144L NO 20004144 A NO20004144 A NO 20004144A NO 20004144 A NO20004144 A NO 20004144A NO 20004144 L NO20004144 L NO 20004144L
- Authority
- NO
- Norway
- Prior art keywords
- ring
- optionally substituted
- heterocyclic ring
- tachykinin receptor
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Det beskrives en forbindelse representert ved formelen hvor ring M er en heterocyklisk ring, hvor ¿X = Y < er en av -N=C<, -CO-N< eller - CS-N<; Ra og Rb er bundet til hverandre for å danne ring A, eller de er like eller forskjellige og representerer uavhengig et hydrogenatom eller en substituent på ringen M; ring A og ring B representerer uvhengig en eventuelt substituert homocyklisk eller he- terocyklisk ring, med det forbehold at minst en av dem er en eventuelt substituert he- terocyklisk ring; ring C er en eventuelt substituert homocyklisk eller heterocyklisk ring; ring Z er en eventuelt substituert nitrogenholdig heterocyklisk ring; og n er et heltall fra l til 6, eller et salt herav som har en takykininreseptorantagonistisk virkning in vitro og er nyttig for hindring eller behandling av depressjon, angst, manisk depressiv sykdom eller psykopati.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6999998 | 1998-03-19 | ||
PCT/JP1999/001358 WO1999047132A2 (en) | 1998-03-19 | 1999-03-18 | Heterocyclic compounds, their production and use as tachykinin receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20004144D0 NO20004144D0 (no) | 2000-08-18 |
NO20004144L true NO20004144L (no) | 2000-10-10 |
Family
ID=13418890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20004144A NO20004144L (no) | 1998-03-19 | 2000-08-18 | Heterocykliske forbindelser, deres fremstilling og anvendelse som takykininreseptorantagonister |
Country Status (12)
Country | Link |
---|---|
EP (2) | EP1061926A2 (no) |
KR (1) | KR20010041991A (no) |
CN (1) | CN1291099A (no) |
AR (1) | AR018772A1 (no) |
AU (1) | AU751114B2 (no) |
BR (1) | BR9908895A (no) |
CA (1) | CA2321155A1 (no) |
HU (1) | HUP0100934A3 (no) |
ID (1) | ID25818A (no) |
IL (1) | IL136950A0 (no) |
NO (1) | NO20004144L (no) |
WO (1) | WO1999047132A2 (no) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI287003B (en) | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
US20040023843A1 (en) * | 2000-09-26 | 2004-02-05 | Takayuki Doi | Preventives/remedies for emotional disorders |
CA2514547A1 (en) * | 2003-01-28 | 2004-08-12 | Takeda Pharmaceutical Company Limited | Receptor agonists |
JPWO2010016552A1 (ja) | 2008-08-07 | 2012-01-26 | 武田薬品工業株式会社 | 過敏性腸症候群治療薬 |
CA2938311C (en) | 2014-02-03 | 2023-03-07 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ror-gamma |
TWI675032B (zh) | 2014-10-14 | 2019-10-21 | 美商維它藥物公司 | ROR-γ之二氫吡咯并吡啶抑制劑 |
US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
DK3331876T3 (da) | 2015-08-05 | 2021-01-11 | Vitae Pharmaceuticals Llc | Modulators of ror-gamma |
KR20180086221A (ko) | 2015-11-20 | 2018-07-30 | 비타이 파마슈티컬즈, 인코포레이티드 | Ror-감마의 조절물질 |
TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
RU2020107919A (ru) | 2017-07-24 | 2021-08-25 | Вайтаи Фармасьютиклз, Ллк. | Ингибиторы rorϒ |
WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU217548B (hu) * | 1991-05-31 | 2000-02-28 | Pfizer Inc. | Kinuklidinszármazékok és ilyen származékokat tartalmazó gyógyászati készítmények |
DE69628484T2 (de) * | 1995-03-24 | 2004-05-19 | Takeda Chemical Industries, Ltd. | Zyklische Verbindungen, ihre Herstellung und ihre Verwendung als Tachykininrezeptorantagonisten |
-
1999
- 1999-03-18 EP EP99909233A patent/EP1061926A2/en not_active Withdrawn
- 1999-03-18 AR ARP990101177A patent/AR018772A1/es unknown
- 1999-03-18 HU HU0100934A patent/HUP0100934A3/hu unknown
- 1999-03-18 CA CA002321155A patent/CA2321155A1/en not_active Abandoned
- 1999-03-18 CN CN99803086A patent/CN1291099A/zh active Pending
- 1999-03-18 AU AU28532/99A patent/AU751114B2/en not_active Ceased
- 1999-03-18 KR KR1020007010318A patent/KR20010041991A/ko not_active Application Discontinuation
- 1999-03-18 EP EP01127194A patent/EP1184036A2/en not_active Withdrawn
- 1999-03-18 ID IDW20001579A patent/ID25818A/id unknown
- 1999-03-18 IL IL13695099A patent/IL136950A0/xx unknown
- 1999-03-18 BR BR9908895-9A patent/BR9908895A/pt not_active IP Right Cessation
- 1999-03-18 WO PCT/JP1999/001358 patent/WO1999047132A2/en not_active Application Discontinuation
-
2000
- 2000-08-18 NO NO20004144A patent/NO20004144L/no unknown
Also Published As
Publication number | Publication date |
---|---|
KR20010041991A (ko) | 2001-05-25 |
CA2321155A1 (en) | 1999-09-23 |
WO1999047132A2 (en) | 1999-09-23 |
ID25818A (id) | 2000-11-09 |
IL136950A0 (en) | 2001-06-14 |
AR018772A1 (es) | 2001-12-12 |
EP1061926A2 (en) | 2000-12-27 |
NO20004144D0 (no) | 2000-08-18 |
EP1184036A2 (en) | 2002-03-06 |
WO1999047132A3 (en) | 1999-11-11 |
AU751114B2 (en) | 2002-08-08 |
HUP0100934A2 (hu) | 2001-09-28 |
BR9908895A (pt) | 2000-12-05 |
HUP0100934A3 (en) | 2002-09-30 |
CN1291099A (zh) | 2001-04-11 |
AU2853299A (en) | 1999-10-11 |
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