NO20004075L - Substituted pyrimidin-2-yloxy-carboxylic acid derivatives, their preparation and their use as endothelin antagonists - Google Patents

Substituted pyrimidin-2-yloxy-carboxylic acid derivatives, their preparation and their use as endothelin antagonists

Info

Publication number
NO20004075L
NO20004075L NO20004075A NO20004075A NO20004075L NO 20004075 L NO20004075 L NO 20004075L NO 20004075 A NO20004075 A NO 20004075A NO 20004075 A NO20004075 A NO 20004075A NO 20004075 L NO20004075 L NO 20004075L
Authority
NO
Norway
Prior art keywords
preparation
carboxylic acid
acid derivatives
yloxy
endothelin antagonists
Prior art date
Application number
NO20004075A
Other languages
Norwegian (no)
Other versions
NO20004075D0 (en
Inventor
Wilhelm Amberg
Rolf Jansen
Andreas Kling
Dagmar Klinge
Hartmut Riechers
Stefan Hergenroeder
Manfred Raschack
Liliane Unger
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of NO20004075D0 publication Critical patent/NO20004075D0/en
Publication of NO20004075L publication Critical patent/NO20004075L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Karboksylsyre derivater med formelen hvor R1-R6, X og Z er som definert i beskrivelsen og deres fremstilling er beskrevet. De nye forbindelsene er egnet for bekjempelse av lidelser, spesielt som endotelinantagonister.Carboxylic acid derivatives of the formula wherein R 1 -R 6, X and Z are as defined in the specification and their preparation are described. The new compounds are suitable for combating disorders, especially as endothelin antagonists.

NO20004075A 1998-02-17 2000-08-15 Substituted pyrimidin-2-yloxy-carboxylic acid derivatives, their preparation and their use as endothelin antagonists NO20004075L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19806438A DE19806438A1 (en) 1998-02-17 1998-02-17 New pyrimidinyloxy-propionic acid derivatives useful as endothelin receptor antagonists in treatment of e.g. cardiac insufficiency, restenosis, hypertension, kidney failure, asthma and prostate cancer
PCT/EP1999/000776 WO1999042453A1 (en) 1998-02-17 1999-02-05 5-substituted pyrimidine-2-yloxy carboxylic acid derivatives, the production of the same and their utilization as endothelin antagonists

Publications (2)

Publication Number Publication Date
NO20004075D0 NO20004075D0 (en) 2000-08-15
NO20004075L true NO20004075L (en) 2000-08-15

Family

ID=7857948

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20004075A NO20004075L (en) 1998-02-17 2000-08-15 Substituted pyrimidin-2-yloxy-carboxylic acid derivatives, their preparation and their use as endothelin antagonists

Country Status (20)

Country Link
EP (1) EP1066268A1 (en)
JP (1) JP2002503726A (en)
KR (1) KR20010086247A (en)
CN (1) CN1291190A (en)
AR (1) AR014960A1 (en)
AU (1) AU3027199A (en)
BG (1) BG104577A (en)
BR (1) BR9907911A (en)
CA (1) CA2321182A1 (en)
DE (1) DE19806438A1 (en)
HR (1) HRP20000602A2 (en)
HU (1) HUP0100957A3 (en)
IL (1) IL137038A0 (en)
NO (1) NO20004075L (en)
PL (1) PL342311A1 (en)
SK (1) SK11512000A3 (en)
TR (1) TR200002376T2 (en)
TW (1) TW579376B (en)
WO (1) WO1999042453A1 (en)
ZA (1) ZA991214B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19924892A1 (en) * 1999-06-01 2000-12-07 Basf Ag New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists
MX2010001255A (en) 2007-07-31 2010-12-06 Gilead Colorado Inc Metabolites and derivatives of ambrisentan.
HUE026200T2 (en) 2008-01-22 2016-05-30 Dow Agrosciences Llc 5-fluoro pyrimidine derivatives as fungicides
MX2011001091A (en) * 2008-08-01 2011-03-15 Dow Agrosciences Llc Use of 5-fluorocytosine as a fungicide.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4411225A1 (en) * 1994-03-31 1995-10-05 Basf Ag Use of carboxylic acid derivatives as a drug
DE19533023B4 (en) * 1994-10-14 2007-05-16 Basf Ag New carboxylic acid derivatives, their preparation and use
DE19614534A1 (en) * 1996-04-12 1997-10-16 Basf Ag New carboxylic acid derivatives, their production and use
DE19614533A1 (en) * 1996-04-12 1997-10-16 Basf Ag New alpha-hydroxy acid derivatives, their production and use
US6448248B1 (en) * 1996-12-18 2002-09-10 Abbott Laboratories Heterocyclic carboxylic acid derivatives, the production and use thereof as endothelin receptor antagonists
DE19726146A1 (en) * 1997-06-19 1998-12-24 Basf Ag New ß-amino and ß-azidopcarboxylic acid derivatives, their preparation and use as endothelin receptor antagonists
EP1027338A2 (en) * 1997-10-31 2000-08-16 Basf Aktiengesellschaft New carboxylic acid derivatives, carrying amido side-chains; production and use as endothelin receptor antagonists

Also Published As

Publication number Publication date
CA2321182A1 (en) 1999-08-26
SK11512000A3 (en) 2001-04-09
BR9907911A (en) 2000-10-24
AR014960A1 (en) 2001-04-11
HRP20000602A2 (en) 2001-06-30
PL342311A1 (en) 2001-06-04
BG104577A (en) 2001-03-30
TR200002376T2 (en) 2000-12-21
NO20004075D0 (en) 2000-08-15
TW579376B (en) 2004-03-11
AU3027199A (en) 1999-09-06
HUP0100957A3 (en) 2002-03-28
KR20010086247A (en) 2001-09-10
DE19806438A1 (en) 1999-08-19
CN1291190A (en) 2001-04-11
JP2002503726A (en) 2002-02-05
EP1066268A1 (en) 2001-01-10
ZA991214B (en) 2000-08-16
IL137038A0 (en) 2001-06-14
WO1999042453A1 (en) 1999-08-26
HUP0100957A2 (en) 2002-02-28

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