AR014960A1 - DERIVATIVES OF CARBOXILICO ACID PIRIMIDIN 5-REPLACED, ITS USE, PHARMACEUTICAL COMBINATIONS THAT UNDERSTAND AND PHARMACEUTICAL COMPOSITIONS CONTAINING DERIVATIVES - Google Patents

DERIVATIVES OF CARBOXILICO ACID PIRIMIDIN 5-REPLACED, ITS USE, PHARMACEUTICAL COMBINATIONS THAT UNDERSTAND AND PHARMACEUTICAL COMPOSITIONS CONTAINING DERIVATIVES

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Publication number
AR014960A1
AR014960A1 ARP990100634A ARP990100634A AR014960A1 AR 014960 A1 AR014960 A1 AR 014960A1 AR P990100634 A ARP990100634 A AR P990100634A AR P990100634 A ARP990100634 A AR P990100634A AR 014960 A1 AR014960 A1 AR 014960A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
radical
halogenoalkyl
mercapto
Prior art date
Application number
ARP990100634A
Other languages
Spanish (es)
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of AR014960A1 publication Critical patent/AR014960A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Derivados de 2-pirimidin ácido carboxílico de la formula (I) en la que los sustituyentes tienen los significados siguientes: R1 significa tetrazol o ungrupo de formula (II), R significa a) un radical OR7, donde R7 significa: hidrogeno, el cation deu n metal alcalino, el cation de un metal alcolinotérreo, union amonio orgánico fisiologicamente tolerado, como por ej.C1-C4-alquilamonio terciario o el ion amonio. C3-8-cicloalquilo, C1-8-alquilo, CH2-fenilo, que puedeestar sustituido por uno ovarios de los radicales siguientes: hidrogeno, nitro, ciano, C1-4-alquilo, C1-4-halogenoalquilo, hidroxi, C1-4-alcoxi, mercapto, C1-4-alquiltio, amino NH(C1-4alquilo), N(C1-4-alquilo)2, un grupo C3-6-alquenilo o un grupo C3-6-alquinilo, cuyos grupospueden por su parte llevar de uno a cincoátomos de halogeno, R7 puede ser además, un radical fenilo que puede llevar de uno a cinco átomos de halogeno y/o de uno a tres de los radicales siguientes:nitro, ciano, C1-4-alquilo, C1-4 halogenoalquilo,hidroxi, C1-4-alcoxi, mercapto, C1-4alquiltio, amino, NH(C1-4-alquilo)2, b) un heteroaromático de cincomiembros ligado por vía de un átomo de nitrogeno, como por ej. pirrolilo, pirazolilo, imidazolilo y triazolilo, que puede llevar uno o dos átomosde halogen o,o uno a dos grupos C1-4-alquilo o uno a dos grupos C1-4-alcoxi, c) un grupo de formula (III) en la que k puede tener los valores 0, 1 y 2, p los valores 1, 2,3 y 4 y R8 significa C1-4-alquilo, C3-8-cicloalquilo, C3-6-alquenilo, C3-6alquinilo o fen ilo, que puede estar sustituido por uno o varios, por ej. uno a tresde los radicales siguientes: hidrogeno, nitro, ciano, C1-4-alquilo, C1-4-halogenoalquilo, hidroxi, C1-4 alcoxi, C1-4-alquiltio, mercapto, amino, NH(C1-C4-alquilo),N(C1-C4-alquilo)2, d) un radical de formula (IV), donde R9 significa: C1-4-alquilo, C3-6-alquenilo, C3-6-alquinilo, C3-8-cicloalquilo, pudiendo estosradicales llevar un radical C1-4-alcoxi, C1-4-alquiltio y/o un radical fenilo, como los mencionadosen c), fenilo que p uede estar sustituido por uno a tres delos radicales siguientes: hidrogeno, nitro, ciano, C1-4-alquilo, C1-4-halogenoalquilo, hidroxi, C1-4-alcoxi, C1-4-alquiltio, mercapto, amino, NH(C1-4-alquilo)2-Pyrimidine carboxylic acid derivatives of the formula (I) in which the substituents have the following meanings: R1 means tetrazol or a group of formula (II), R means a) an OR7 radical, where R7 means: hydrogen, the cation With an alkali metal, the cation of an alkaline earth metal, physiologically tolerated organic ammonium bond, such as C1-C4-tertiary alkylammonium or the ammonium ion. C3-8-cycloalkyl, C1-8-alkyl, CH2-phenyl, which may be substituted by one ovaries of the following radicals: hydrogen, nitro, cyano, C1-4-alkyl, C1-4-halogenoalkyl, hydroxy, C1-4 -alkoxy, mercapto, C1-4-alkylthio, amino NH (C1-4alkyl), N (C1-4-alkyl) 2, a C3-6-alkenyl group or a C3-6-alkynyl group, the groups of which can in turn carrying from one to five halogen atoms, R7 can also be a phenyl radical that can carry one to five halogen atoms and / or one to three of the following radicals: nitro, cyano, C1-4-alkyl, C1- 4 halogenoalkyl, hydroxy, C1-4-alkoxy, mercapto, C1-4alkylthio, amino, NH (C1-4-alkyl) 2, b) a heteroaromatic of cincomiembros linked by way of a nitrogen atom, as for example. pyrrolyl, pyrazolyl, imidazolyl and triazolyl, which can carry one or two halogen atoms or, or one to two C1-4-alkyl groups or one to two C1-4-alkoxy groups, c) a group of formula (III) in the that k can have the values 0, 1 and 2, p the values 1, 2,3 and 4 and R8 means C1-4-alkyl, C3-8-cycloalkyl, C3-6-alkenyl, C3-6alkynyl or phenyl, which may be substituted by one or more, e.g. one to three of the following radicals: hydrogen, nitro, cyano, C1-4-alkyl, C1-4-halogenoalkyl, hydroxy, C1-4 alkoxy, C1-4-alkylthio, mercapto, amino, NH (C1-C4-alkyl) , N (C1-C4-alkyl) 2, d) a radical of formula (IV), where R9 means: C1-4-alkyl, C3-6-alkenyl, C3-6-alkynyl, C3-8-cycloalkyl, being able These radicals carry a C1-4-alkoxy, C1-4-alkylthio radical and / or a phenyl radical, such as those mentioned in c), which may be substituted by one to three of the following radicals: hydrogen, nitro, cyano, C1- 4-alkyl, C1-4-halogenoalkyl, hydroxy, C1-4-alkoxy, C1-4-alkylthio, mercapto, amino, NH (C1-4-alkyl)

ARP990100634A 1998-02-17 1999-02-16 DERIVATIVES OF CARBOXILICO ACID PIRIMIDIN 5-REPLACED, ITS USE, PHARMACEUTICAL COMBINATIONS THAT UNDERSTAND AND PHARMACEUTICAL COMPOSITIONS CONTAINING DERIVATIVES AR014960A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19806438A DE19806438A1 (en) 1998-02-17 1998-02-17 New pyrimidinyloxy-propionic acid derivatives useful as endothelin receptor antagonists in treatment of e.g. cardiac insufficiency, restenosis, hypertension, kidney failure, asthma and prostate cancer

Publications (1)

Publication Number Publication Date
AR014960A1 true AR014960A1 (en) 2001-04-11

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ID=7857948

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990100634A AR014960A1 (en) 1998-02-17 1999-02-16 DERIVATIVES OF CARBOXILICO ACID PIRIMIDIN 5-REPLACED, ITS USE, PHARMACEUTICAL COMBINATIONS THAT UNDERSTAND AND PHARMACEUTICAL COMPOSITIONS CONTAINING DERIVATIVES

Country Status (20)

Country Link
EP (1) EP1066268A1 (en)
JP (1) JP2002503726A (en)
KR (1) KR20010086247A (en)
CN (1) CN1291190A (en)
AR (1) AR014960A1 (en)
AU (1) AU3027199A (en)
BG (1) BG104577A (en)
BR (1) BR9907911A (en)
CA (1) CA2321182A1 (en)
DE (1) DE19806438A1 (en)
HR (1) HRP20000602A2 (en)
HU (1) HUP0100957A3 (en)
IL (1) IL137038A0 (en)
NO (1) NO20004075L (en)
PL (1) PL342311A1 (en)
SK (1) SK11512000A3 (en)
TR (1) TR200002376T2 (en)
TW (1) TW579376B (en)
WO (1) WO1999042453A1 (en)
ZA (1) ZA991214B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19924892A1 (en) * 1999-06-01 2000-12-07 Basf Ag New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists
US8217155B2 (en) 2007-07-31 2012-07-10 Gilead Colorado, Inc. Metabolites and derivatives of ambrisentan
ES2549379T3 (en) 2008-01-22 2015-10-27 Dow Agrosciences Llc 4-amino5-fluoropyrimidine derivatives as fungicides
CA2731332A1 (en) * 2008-08-01 2010-04-29 Zoltan L. Benko Use of 5-fluorocytosine as a fungicide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4411225A1 (en) * 1994-03-31 1995-10-05 Basf Ag Use of carboxylic acid derivatives as a drug
DE19533023B4 (en) * 1994-10-14 2007-05-16 Basf Ag New carboxylic acid derivatives, their preparation and use
DE19614533A1 (en) * 1996-04-12 1997-10-16 Basf Ag New alpha-hydroxy acid derivatives, their production and use
DE19614534A1 (en) * 1996-04-12 1997-10-16 Basf Ag New carboxylic acid derivatives, their production and use
IL130251A0 (en) * 1996-12-18 2000-06-01 Basf Ag Heterocyclic carboxylic acid derivatives the production and use thereof as endothelin receptor antagonists
DE19726146A1 (en) * 1997-06-19 1998-12-24 Basf Ag New ß-amino and ß-azidopcarboxylic acid derivatives, their preparation and use as endothelin receptor antagonists
EP1027338A2 (en) * 1997-10-31 2000-08-16 Basf Aktiengesellschaft New carboxylic acid derivatives, carrying amido side-chains; production and use as endothelin receptor antagonists

Also Published As

Publication number Publication date
KR20010086247A (en) 2001-09-10
NO20004075D0 (en) 2000-08-15
EP1066268A1 (en) 2001-01-10
CA2321182A1 (en) 1999-08-26
TR200002376T2 (en) 2000-12-21
WO1999042453A1 (en) 1999-08-26
JP2002503726A (en) 2002-02-05
HRP20000602A2 (en) 2001-06-30
BG104577A (en) 2001-03-30
BR9907911A (en) 2000-10-24
HUP0100957A2 (en) 2002-02-28
HUP0100957A3 (en) 2002-03-28
SK11512000A3 (en) 2001-04-09
AU3027199A (en) 1999-09-06
DE19806438A1 (en) 1999-08-19
TW579376B (en) 2004-03-11
IL137038A0 (en) 2001-06-14
PL342311A1 (en) 2001-06-04
ZA991214B (en) 2000-08-16
NO20004075L (en) 2000-08-15
CN1291190A (en) 2001-04-11

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