NO20001049L - Kondenserte tiofenforbindelser og farmasøytisk anvendelse derav - Google Patents
Kondenserte tiofenforbindelser og farmasøytisk anvendelse deravInfo
- Publication number
- NO20001049L NO20001049L NO20001049A NO20001049A NO20001049L NO 20001049 L NO20001049 L NO 20001049L NO 20001049 A NO20001049 A NO 20001049A NO 20001049 A NO20001049 A NO 20001049A NO 20001049 L NO20001049 L NO 20001049L
- Authority
- NO
- Norway
- Prior art keywords
- compound
- condensed thiophene
- pharmaceutical use
- useful
- formula
- Prior art date
Links
- 150000003577 thiophenes Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 208000024891 symptom Diseases 0.000 abstract 2
- 201000010000 Agranulocytosis Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000019430 Motor disease Diseases 0.000 abstract 1
- 239000000164 antipsychotic agent Substances 0.000 abstract 1
- 208000028683 bipolar I disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
- -1 thiophene compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
En kondensert tiofenforbindelse med formel (I) Rb hvor i hvert symbol er som definert i beskrivelsen, et farmasøytisk akseptabelt salt derav og hydrat derav. Forbindelsen med formel (I) ifølge oppfinnelsen er anvendelig som et nytt antipsykotisk middel som er effektivt både for pisitive symptomer og negative symptomer av scizofreni, som er tilknyttet færre bivirkninger slik som ekstrapyramidal motorisk forstyrrelse og lignende og som er mindre tilknyttet alvorlige bivirkninger slik som agranulocytosi og lignende. I tillegg er denne forbindelsen også anvendelig som et terapeutisk middel for Alzheimers sykdom og manisk depressiv sykdom.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23670097 | 1997-09-02 | ||
JP27777197 | 1997-10-09 | ||
JP16572598 | 1998-06-12 | ||
PCT/JP1998/003915 WO1999011647A1 (fr) | 1997-09-02 | 1998-08-31 | Composes thiophene condenses et leur utilisation en medecine |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20001049D0 NO20001049D0 (no) | 2000-03-01 |
NO20001049L true NO20001049L (no) | 2000-04-03 |
Family
ID=27322564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20001049A NO20001049L (no) | 1997-09-02 | 2000-03-01 | Kondenserte tiofenforbindelser og farmasøytisk anvendelse derav |
Country Status (16)
Country | Link |
---|---|
US (2) | US6271225B1 (no) |
EP (1) | EP1016664B1 (no) |
JP (2) | JP3156933B2 (no) |
KR (1) | KR20010021989A (no) |
CN (1) | CN1268949A (no) |
AT (1) | ATE244245T1 (no) |
AU (1) | AU739385B2 (no) |
BR (1) | BR9814042A (no) |
CA (1) | CA2302409A1 (no) |
DE (1) | DE69816102D1 (no) |
HU (1) | HUP0003718A3 (no) |
IL (1) | IL134812A0 (no) |
NO (1) | NO20001049L (no) |
NZ (1) | NZ503484A (no) |
RU (1) | RU2197491C2 (no) |
WO (1) | WO1999011647A1 (no) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
IL145976A0 (en) | 1999-04-16 | 2002-07-25 | Ortho Mcneil Pharm Inc | Ketolide antibacterials |
US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
US6751036B2 (en) * | 2000-08-04 | 2004-06-15 | Seagate Technology Llc | Tuning track density for data storage device |
US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
ATE438637T1 (de) * | 2001-06-11 | 2009-08-15 | Virochem Pharma Inc | Thiophenderivate als antivirale mittel gegen flavivirus-infektion |
AU2003264915A1 (en) | 2002-08-05 | 2004-02-25 | Eli Lilly And Company | Piperazine substituted aryl benzodiazepines |
US7402608B2 (en) * | 2002-12-10 | 2008-07-22 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
US20040236181A1 (en) * | 2003-04-01 | 2004-11-25 | Olympus Corporation | In-body information acquiring apparatus and power-supply circuit |
EP1664063A1 (en) * | 2003-09-09 | 2006-06-07 | Eli Lilly And Company | Substituted piperazines of azepines, oxazepines, and thiazepines |
EP1713486A4 (en) * | 2003-12-02 | 2009-04-29 | Sheldon Leslie James | COMBINED THERAPY FOR THE TREATMENT OF DEMENTIA, DEPRESSION AND APATHY |
DE602004014264D1 (de) * | 2003-12-22 | 2008-07-17 | Teva Pharma | Verfahren zur herstellung von olanzapin |
US7807828B2 (en) * | 2005-08-11 | 2010-10-05 | Hypnion, Inc. | Olanzapine analogs and methods of use thereof |
CA2670260A1 (en) | 2006-11-15 | 2008-05-22 | Virochem Pharma Inc. | Thiophene analogues for the treatment or prevention of flavivirus infections |
PL395468A1 (pl) | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego |
JP6551671B2 (ja) * | 2015-08-11 | 2019-07-31 | 国立大学法人 熊本大学 | アルツハイマー治療薬 |
EP3965803A4 (en) * | 2019-05-10 | 2022-11-30 | Dana-Farber Cancer Institute, Inc. | SMALL MOLECULAR FOCUS ADHESION KINASE (FAK) INHIBITORS |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL140242B (nl) | 1963-03-01 | 1973-11-15 | Wander Ag Dr A | Werkwijze voor het bereiden van op de 11-plaats door een basische groep gesubstitueerde dibenz (b.f.)(1.4) oxazepinen. |
CH468400A (de) | 1965-12-23 | 1969-02-15 | Sandoz Ag | Verfahren zur Herstellung neuer Thieno(2,3-b)(1,5)benzothiazepin-4-on-Verbindungen |
US3726977A (en) | 1969-02-06 | 1973-04-10 | Sandoz Ag | 2-NITRO-11-(1-PIPERAZINYL)-DIBENZ (b,f) (1,4) OXAZEPINES COMPOSITIONS IN THE TREATMENT OF DEPRESSION |
US3683084A (en) | 1969-02-06 | 1972-08-08 | Jean Schmutz | Basically substituted heterocycles as anti-emetics |
US3962248A (en) * | 1972-04-04 | 1976-06-08 | Sandoz, Inc. | Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines |
SU629879A3 (ru) * | 1974-11-26 | 1978-10-25 | Лилли Индастриз Лимитед, (Фирма) | Способ получени тиено(1,5) бензодиазепинов или их солей |
US4115568A (en) | 1974-11-26 | 1978-09-19 | Lilly Industries Limited | Thieno[3,2-b]-[1,5]benzodiazepines |
US4172831A (en) | 1974-11-26 | 1979-10-30 | Lilly Industries Limited | Thieno-benzodiazepines |
GB1533236A (en) | 1975-11-24 | 1978-11-22 | Lilly Industries Ltd | Thieno(1,5)benzodiazepine intermediates |
US4157444A (en) | 1978-03-13 | 1979-06-05 | American Cyanamid Company | 10-(Piperazinyl)thieno[3,4-b][1,5]benzoxazepines and 10-(piperazinyl)thieno[3,4-b][1,5]benzothiazepines |
GB9009229D0 (en) * | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
US5538965A (en) | 1993-12-23 | 1996-07-23 | Allelix Biopharmaceuticals Inc. | Dopamine receptor ligands |
US5602124A (en) | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | 5-HT2 receptor ligands |
US5602120A (en) | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | Benzyl-substituted compounds having dopamine receptor affinity |
US5700445A (en) | 1994-12-12 | 1997-12-23 | Allelix Biopharmaceuticals, Inc. | N-methyl piperazine compounds having dopamine receptor affinity |
US5602121A (en) | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | Alkyl-substituted compounds having dopamine receptor affinity |
US5576314A (en) | 1994-12-12 | 1996-11-19 | Allelix Biopharmaceuticals Inc. | Bicyclic nonane and decane compounds having dopamine receptor affinity |
US5561127A (en) | 1994-12-19 | 1996-10-01 | Allelix Biopharmaceuticals, Inc. | Muscarinic receptor ligands |
-
1998
- 1998-08-31 HU HU0003718A patent/HUP0003718A3/hu unknown
- 1998-08-31 KR KR1020007000556A patent/KR20010021989A/ko not_active Application Discontinuation
- 1998-08-31 DE DE69816102T patent/DE69816102D1/de not_active Expired - Lifetime
- 1998-08-31 WO PCT/JP1998/003915 patent/WO1999011647A1/ja not_active Application Discontinuation
- 1998-08-31 RU RU2000108433/04A patent/RU2197491C2/ru not_active IP Right Cessation
- 1998-08-31 AT AT98940666T patent/ATE244245T1/de not_active IP Right Cessation
- 1998-08-31 JP JP51595799A patent/JP3156933B2/ja not_active Expired - Fee Related
- 1998-08-31 EP EP98940666A patent/EP1016664B1/en not_active Expired - Lifetime
- 1998-08-31 CN CN98808681A patent/CN1268949A/zh active Pending
- 1998-08-31 AU AU88890/98A patent/AU739385B2/en not_active Ceased
- 1998-08-31 US US09/341,317 patent/US6271225B1/en not_active Expired - Lifetime
- 1998-08-31 CA CA002302409A patent/CA2302409A1/en not_active Abandoned
- 1998-08-31 NZ NZ503484A patent/NZ503484A/en unknown
- 1998-08-31 IL IL13481298A patent/IL134812A0/xx unknown
-
1999
- 1999-07-08 BR BR9814042-6A patent/BR9814042A/pt not_active IP Right Cessation
-
2000
- 2000-03-01 NO NO20001049A patent/NO20001049L/no unknown
- 2000-09-22 JP JP2000289527A patent/JP4354106B2/ja not_active Expired - Fee Related
-
2001
- 2001-04-19 US US09/837,424 patent/US6455521B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6455521B1 (en) | 2002-09-24 |
US6271225B1 (en) | 2001-08-07 |
JP3156933B2 (ja) | 2001-04-16 |
CA2302409A1 (en) | 1999-03-11 |
IL134812A0 (en) | 2001-04-30 |
EP1016664B1 (en) | 2003-07-02 |
WO1999011647A1 (fr) | 1999-03-11 |
KR20010021989A (ko) | 2001-03-15 |
RU2197491C2 (ru) | 2003-01-27 |
CN1268949A (zh) | 2000-10-04 |
AU8889098A (en) | 1999-03-22 |
ATE244245T1 (de) | 2003-07-15 |
BR9814042A (pt) | 2000-10-03 |
NO20001049D0 (no) | 2000-03-01 |
NZ503484A (en) | 2001-10-26 |
JP2001072684A (ja) | 2001-03-21 |
HUP0003718A2 (hu) | 2001-09-28 |
US20020042411A1 (en) | 2002-04-11 |
EP1016664A4 (en) | 2001-01-24 |
DE69816102D1 (de) | 2003-08-07 |
HUP0003718A3 (en) | 2002-11-28 |
EP1016664A1 (en) | 2000-07-05 |
JP4354106B2 (ja) | 2009-10-28 |
AU739385B2 (en) | 2001-10-11 |
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