NO180046C - Markerte fibrinogen-reseptor-antagonister, og deres anvendelse - Google Patents

Markerte fibrinogen-reseptor-antagonister, og deres anvendelse

Info

Publication number
NO180046C
NO180046C NO931528A NO931528A NO180046C NO 180046 C NO180046 C NO 180046C NO 931528 A NO931528 A NO 931528A NO 931528 A NO931528 A NO 931528A NO 180046 C NO180046 C NO 180046C
Authority
NO
Norway
Prior art keywords
fibrinogen
receptor antagonists
fibrinogen receptor
receptor
labelled
Prior art date
Application number
NO931528A
Other languages
English (en)
Other versions
NO931528L (no
NO180046B (no
NO931528D0 (no
Inventor
Johannes Weisenberger
Hans-Dieter Schubert
Karl-Heinz Switek
Guenter Linz
Frank Himmelsbach
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4214245A external-priority patent/DE4214245A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO931528D0 publication Critical patent/NO931528D0/no
Publication of NO931528L publication Critical patent/NO931528L/no
Publication of NO180046B publication Critical patent/NO180046B/no
Publication of NO180046C publication Critical patent/NO180046C/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
NO931528A 1992-04-28 1993-04-27 Markerte fibrinogen-reseptor-antagonister, og deres anvendelse NO180046C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4213930 1992-04-28
DE4214245A DE4214245A1 (de) 1992-04-30 1992-04-30 Tritiummarkierte fibrinogen-rezeptor-antagonisten, deren verwendung und verfahren zu ihrer herstellung

Publications (4)

Publication Number Publication Date
NO931528D0 NO931528D0 (no) 1993-04-27
NO931528L NO931528L (no) 1993-10-29
NO180046B NO180046B (no) 1996-10-28
NO180046C true NO180046C (no) 1997-02-05

Family

ID=25914315

Family Applications (1)

Application Number Title Priority Date Filing Date
NO931528A NO180046C (no) 1992-04-28 1993-04-27 Markerte fibrinogen-reseptor-antagonister, og deres anvendelse

Country Status (16)

Country Link
US (1) US5677466A (no)
EP (1) EP0567967B1 (no)
JP (1) JPH0650977A (no)
KR (1) KR940005271A (no)
AT (1) ATE140225T1 (no)
AU (1) AU670778B2 (no)
CA (1) CA2094963A1 (no)
DE (1) DE59303178D1 (no)
DK (1) DK0567967T3 (no)
ES (1) ES2092170T3 (no)
FI (1) FI931881A (no)
GR (1) GR3020740T3 (no)
IL (1) IL105519A0 (no)
MX (1) MX9302446A (no)
NO (1) NO180046C (no)
NZ (1) NZ247511A (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4304650A1 (de) * 1993-02-16 1994-08-18 Thomae Gmbh Dr K Kondensierte 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4324580A1 (de) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5925635A (en) * 1996-04-17 1999-07-20 Dupont Pharmaceuticals Company N-(amidinophenyl) cyclourea analogs as factor XA inhibitors
NZ504324A (en) 1997-11-20 2002-02-01 Teijin Ltd Biphenylamidine derivatives and pharmaceutical compositions thereof; which can be useful as anticoagulant inhibitors, and thrombus or embolus preventing agents
UA52797C2 (uk) 1997-11-20 2003-01-15 Тейдзін Лімітед Похідне біфеніламідину, проліки, інгібітор коагуляції крові, агент для профілактики тромбозу або емболії та агент для терапії тромбозу або емболії
AU773156B2 (en) * 1999-01-28 2004-05-20 Teijin Limited Release-regulating preparations
WO2004024707A2 (en) * 2002-09-16 2004-03-25 Abbott Laboratories Process for preparing amine type substituted benzofurans
US6822101B2 (en) 2002-09-16 2004-11-23 Abbott Laboratories Process for preparing amine-substituted benzofurans
EP3489692A1 (de) * 2017-11-28 2019-05-29 Siemens Healthcare Diagnostics Products GmbH Prothrombinzeit-reagenz enthaltend einen eisenchelator

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
DE4134467A1 (de) * 1991-10-18 1993-04-22 Thomae Gmbh Dr K Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4107857A1 (de) * 1991-03-12 1992-09-17 Thomae Gmbh Dr K Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4124942A1 (de) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4127404A1 (de) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4129603A1 (de) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
JPH0650977A (ja) 1994-02-25
EP0567967A1 (de) 1993-11-03
NO931528L (no) 1993-10-29
IL105519A0 (en) 1993-08-18
DE59303178D1 (de) 1996-08-14
MX9302446A (es) 1994-03-31
NZ247511A (en) 1995-02-24
AU3715393A (en) 1993-11-04
EP0567967B1 (de) 1996-07-10
DK0567967T3 (da) 1996-11-18
GR3020740T3 (en) 1996-11-30
FI931881A (fi) 1993-10-29
NO180046B (no) 1996-10-28
ES2092170T3 (es) 1996-11-16
US5677466A (en) 1997-10-14
ATE140225T1 (de) 1996-07-15
KR940005271A (ko) 1994-03-21
FI931881A0 (fi) 1993-04-27
CA2094963A1 (en) 1993-10-29
NO931528D0 (no) 1993-04-27
AU670778B2 (en) 1996-08-01

Similar Documents

Publication Publication Date Title
Mandle et al. Identification of prekallikrein and high-molecular-weight kininogen as a complex in human plasma.
Leyte et al. The interaction between human blood-coagulation factor VIII and von Willebrand factor. Characterization of a high-affinity binding site on factor VIII
Terkeltaub et al. Plasma protein binding by monosodium urate crystals
DK0397633T3 (da) Fibronectinbindende protein samt fremstilling deraf
DK0590071T3 (da) Hovedsagelig rene receptor-lignende TGF-BETA-1 bindende molekyler samt anvendelse deraf
ATE128237T1 (de) Test für hepatitis-c.
NO180046C (no) Markerte fibrinogen-reseptor-antagonister, og deres anvendelse
DK0407813T3 (da) Oxidativ denaturering af proteinanalytter
Karamanolis et al. Characterization of cryofibrinogen isolated from patients’ plasma
DE68921371D1 (de) Verfahren zur Herstellung einer an Faktor-VIIa angereicherten Fraktion und ihre Verwendung als Arzneimittel.
Kelm et al. Human platelet osteonectin: release, surface expression, and partial characterization
Pihko et al. Rabbit α-fetoprotein: Immunochemical purification and partial characterization
Gralnick et al. Characterization of the defect of the factor VIII/von Willebrand factor protein in von Willebrand's disease
ATE345381T1 (de) Neue polypeptide aus bienengift und verfahren zu deren verwendung
ATE196775T1 (de) Gereinigte flt3 liganden von saeugentieren, agonisten und antagonisten davon
Muntz et al. Properties of post-infusion factor VIII in von Willebrand's disease
SE8801723D0 (sv) Fibronectin binding protein as well as its preparation
DE69629976D1 (de) Typ I Prokollagen aminoterminales Propeptid, dessen Antikörper und Testverfahren unter Verwendung davon
Weinstein et al. Two distinct forms of Factor VIII coagulant protein in human plasma. Cleavage by thrombin, and differences in coagulant activity and association with von Willebrand factor.
DE69434118D1 (de) Klonierung und rekombinante herstellung des crf-rezeptors (crf=corticotropin ausloese faktor)
Suzuki et al. The influence of 2-mercaptoethanol on von Willebrand factor and bovine platelet aggregating factor
DE3582504D1 (de) Waermedefibrinogenierung eines ahf-praeparates.
Banovac et al. Local conformational changes of vitronectin upon adsorption on glass and silane surfaces
Lane et al. Affinity chromatography of human factor VIII using human and rabbit antibodies to factor VIII
Chataway et al. Studies on the iodination of a ras protein and the detection of ras polymers