NO179615C - Monoklonale antistoffer eller fragmenter derav som reagerer med kakektin, cellelinjer som produserer dem, prövesett som omfatter dem, samt anvendelse derav in vitro - Google Patents

Monoklonale antistoffer eller fragmenter derav som reagerer med kakektin, cellelinjer som produserer dem, prövesett som omfatter dem, samt anvendelse derav in vitro

Info

Publication number
NO179615C
NO179615C NO901247A NO901247A NO179615C NO 179615 C NO179615 C NO 179615C NO 901247 A NO901247 A NO 901247A NO 901247 A NO901247 A NO 901247A NO 179615 C NO179615 C NO 179615C
Authority
NO
Norway
Prior art keywords
cell lines
cachectin
monoclonal antibodies
produce
assays
Prior art date
Application number
NO901247A
Other languages
English (en)
Norwegian (no)
Other versions
NO901247L (no
NO901247D0 (no
NO179615B (no
Inventor
George Kuo
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of NO901247L publication Critical patent/NO901247L/no
Publication of NO901247D0 publication Critical patent/NO901247D0/no
Priority to NO952509A priority Critical patent/NO180637C/no
Publication of NO179615B publication Critical patent/NO179615B/no
Publication of NO179615C publication Critical patent/NO179615C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
NO901247A 1988-07-18 1990-03-16 Monoklonale antistoffer eller fragmenter derav som reagerer med kakektin, cellelinjer som produserer dem, prövesett som omfatter dem, samt anvendelse derav in vitro NO179615C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO952509A NO180637C (no) 1988-07-18 1995-06-22 Fremgangsmåte for fremstilling av monoklonale antistoffer eller fragmenter derav

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22020688A 1988-07-18 1988-07-18
PCT/US1989/003025 WO1990000902A1 (en) 1988-07-18 1989-07-12 Monoclonal antibodies reactive with cachectin

Publications (4)

Publication Number Publication Date
NO901247L NO901247L (no) 1990-03-16
NO901247D0 NO901247D0 (no) 1990-03-16
NO179615B NO179615B (no) 1996-08-05
NO179615C true NO179615C (no) 1996-11-13

Family

ID=22822529

Family Applications (1)

Application Number Title Priority Date Filing Date
NO901247A NO179615C (no) 1988-07-18 1990-03-16 Monoklonale antistoffer eller fragmenter derav som reagerer med kakektin, cellelinjer som produserer dem, prövesett som omfatter dem, samt anvendelse derav in vitro

Country Status (16)

Country Link
US (1) US5658803A (un)
EP (1) EP0351789B1 (un)
JP (1) JP2638652B2 (un)
AT (1) ATE173766T1 (un)
AU (1) AU626572B2 (un)
CA (1) CA1340018C (un)
DE (1) DE68928857T2 (un)
DK (1) DK69890A (un)
ES (1) ES2124209T3 (un)
FI (1) FI101937B1 (un)
IL (1) IL90990A (un)
NO (1) NO179615C (un)
NZ (1) NZ229922A (un)
PT (1) PT91201B (un)
WO (1) WO1990000902A1 (un)
ZA (1) ZA895372B (un)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3443119B2 (ja) * 1989-08-07 2003-09-02 ペプテック リミテッド 腫瘍壊死因子結合リガンド
US20030225254A1 (en) * 1989-08-07 2003-12-04 Rathjen Deborah Ann Tumour necrosis factor binding ligands
US5959087A (en) * 1989-08-07 1999-09-28 Peptide Technology, Ltd. Tumour necrosis factor binding ligands
US6451983B2 (en) 1989-08-07 2002-09-17 Peptech Limited Tumor necrosis factor antibodies
GB8918232D0 (en) * 1989-08-10 1989-09-20 Opal Stephen M Pharmaceutical product for the treatment of septic shock
JPH05501351A (ja) * 1989-08-16 1993-03-18 カイロン コーポレイション プロホルモンタンパク質に対する開裂部位阻止抗体及びその使用
DE4037604A1 (de) * 1990-04-25 1991-10-31 Bayer Ag Verwendung von anti-tnf-antikoerpern als arzneimittel bei der behandlung von ischaemien und deren folgen
EP0592423B1 (en) * 1990-08-06 2000-11-15 Chiron Corporation Methods for the identification of cytokine convertase inhibitors
US5958413A (en) * 1990-11-01 1999-09-28 Celltech Limited Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor
GB9028123D0 (en) * 1990-12-28 1991-02-13 Erba Carlo Spa Monoclonal antibodies against human tumor necrosis factor alpha
CA2100084A1 (en) * 1991-01-11 1992-07-12 James R. Rusche Method of preventing inflammatory damage
DK1097945T3 (da) * 1991-03-18 2007-11-05 Univ New York Monoklonale og kimære antistoffer, der er specifikke for human tumornekrosefaktor
US5656272A (en) * 1991-03-18 1997-08-12 New York University Medical Center Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
US5698195A (en) * 1991-03-18 1997-12-16 New York University Medical Center Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies
US6277969B1 (en) 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
US7192584B2 (en) 1991-03-18 2007-03-20 Centocor, Inc. Methods of treating psoriasis with anti-TNF antibodies
US5919452A (en) * 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
US6284471B1 (en) * 1991-03-18 2001-09-04 New York University Medical Center Anti-TNFa antibodies and assays employing anti-TNFa antibodies
EP0525570A3 (en) * 1991-07-31 1993-10-06 Miles Inc. Anti-idiotypic antibodies that mimic tnf
ATE172880T1 (de) * 1992-08-28 1998-11-15 Bayer Ag Verwendung von monoklonalen anti-tnf-antikörpern für die behandlung von bakteriellen meningitiden
GB2294267B (en) * 1993-06-03 1996-11-20 Therapeutic Antibodies Inc Anti-TNFalpha Fab fragments derived from polyclonal IgG antibodies
NZ278607A (en) * 1994-02-07 1999-05-28 Knoll Ag Use of tnf antagonists for treating disorders involving elevated serum levels of il-6 wherein the serum levels are 500pg/ml or above
AU3632595A (en) * 1994-09-15 1996-03-29 Verigen, Inc Porcine antibodies to tnf-alpha(alpha)
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
BRPI9715219B8 (pt) 1996-02-09 2015-07-07 Abbvie Biotechnology Ltd Vetor recombinante de expressão, e célula hospedeira procariótica.
DE19746868A1 (de) * 1997-10-23 1999-04-29 Knoll Ag Verwendung von TNF-Antagonisten als Arzneimittel zur Behandlung von septischen Erkrankungen
UA81743C2 (uk) 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
CA2868614A1 (en) 2001-06-08 2002-12-08 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
TWI327597B (en) 2001-08-01 2010-07-21 Centocor Inc Anti-tnf antibodies, compositions, methods and uses
MY150740A (en) 2002-10-24 2014-02-28 Abbvie Biotechnology Ltd Low dose methods for treating disorders in which tnf? activity is detrimental
JP4754219B2 (ja) 2002-12-02 2011-08-24 アムジエン・フレモント・インコーポレイテツド 腫瘍壊死因子を対象とする抗体、およびそれらの使用
US20050045635A1 (en) * 2003-09-03 2005-03-03 Jane Dong Containers for storing articles
TW201705980A (zh) 2004-04-09 2017-02-16 艾伯維生物技術有限責任公司 用於治療TNFα相關失調症之多重可變劑量療法
BRPI0610058A2 (pt) 2005-05-16 2010-05-25 Abbott Biotech Ltd uso de inibidor de tnf para tratamento da poliartrite erosiva
EP1963367A4 (en) * 2005-12-06 2009-05-13 Amgen Inc POLISHING STEPS IN MULTI-STAGE PROTEIN PURIFICATION TREATMENTS
EP2004689A4 (en) 2006-04-05 2010-06-02 Abbott Biotech Ltd PURIFICATION OF ANTIBODIES
EP2010214A4 (en) 2006-04-10 2010-06-16 Abbott Biotech Ltd USES AND COMPOSITIONS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
EP2666472A3 (en) 2006-04-10 2014-04-02 Abbott Biotechnology Ltd Uses and compositions for treatment of psoriatic arthritis
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
US8999337B2 (en) 2007-06-11 2015-04-07 Abbvie Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis by inhibition of TNFα
SG2013054218A (en) 2008-01-15 2014-10-30 Abbott Gmbh & Co Kg Powdered protein compositions and methods of making same
US8415291B2 (en) 2008-10-31 2013-04-09 Centocor Ortho Biotech Inc. Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
WO2014035475A1 (en) 2012-09-02 2014-03-06 Abbvie Inc. Methods to control protein heterogeneity
AU2014215639B2 (en) 2013-01-25 2017-03-23 Thymon, Llc Compositions for selective reduction of circulating bioactive soluble TNF and methods for treating TNF-mediated disease
AU2013381687A1 (en) 2013-03-12 2015-09-24 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
US10465003B2 (en) 2016-02-05 2019-11-05 Janssen Biotech, Inc. Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes
KR20240038146A (ko) 2017-01-30 2024-03-22 얀센 바이오테크 인코포레이티드 활성 건선성 관절염의 치료를 위한 항-tnf 항체, 조성물, 및 방법
WO2018147915A1 (en) 2017-02-07 2018-08-16 Janssen Biotech, Inc. Anti-tnf antibodies, compositions, and methods for the treatment of active ankylosing spondylitis
AU2020279987A1 (en) 2019-05-23 2021-11-18 Janssen Biotech, Inc. Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603106A (en) * 1982-02-22 1986-07-29 The Rockefeller University Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay)
US4684623A (en) * 1985-05-02 1987-08-04 The Board Of Trustees Of The Cetus Corporation Use of tumor necrosis factor as a weight regulator
US4870163A (en) * 1985-08-29 1989-09-26 New York Blood Center, Inc. Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor
EP0249618A1 (en) * 1985-12-05 1987-12-23 Biogen N.V. Combinations of tumor necrosis factors and antibiotics and methods for treating tumors
US4834976A (en) * 1986-07-03 1989-05-30 Genetic Systems Corporation Monoclonal antibodies to pseudomonas aeruginosa flagella
DE3631229A1 (de) * 1986-09-13 1988-03-24 Basf Ag Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung

Also Published As

Publication number Publication date
FI101937B (fi) 1998-09-30
DE68928857T2 (de) 1999-08-05
JPH03501330A (ja) 1991-03-28
FI101937B1 (fi) 1998-09-30
JP2638652B2 (ja) 1997-08-06
DK69890D0 (da) 1990-03-16
EP0351789B1 (en) 1998-11-25
EP0351789A2 (en) 1990-01-24
DE68928857D1 (de) 1999-01-07
ES2124209T3 (es) 1999-02-01
NO901247L (no) 1990-03-16
DK69890A (da) 1990-05-15
ATE173766T1 (de) 1998-12-15
NZ229922A (en) 1992-04-28
FI901344A0 (fi) 1990-03-16
AU626572B2 (en) 1992-08-06
NO901247D0 (no) 1990-03-16
IL90990A (en) 1994-10-21
AU3970389A (en) 1990-02-19
CA1340018C (en) 1998-09-01
PT91201A (pt) 1990-02-08
US5658803A (en) 1997-08-19
WO1990000902A1 (en) 1990-02-08
PT91201B (pt) 1996-12-31
IL90990A0 (en) 1990-02-09
EP0351789A3 (en) 1990-08-01
ZA895372B (en) 1990-04-25
NO179615B (no) 1996-08-05

Similar Documents

Publication Publication Date Title
NO179615C (no) Monoklonale antistoffer eller fragmenter derav som reagerer med kakektin, cellelinjer som produserer dem, prövesett som omfatter dem, samt anvendelse derav in vitro
DE68923027D1 (de) Antigene.
NO167185C (no) Absorpsjonslegeme av fibre beregnet til bruk i engangsprodukter, samt fremgangsmaate for fremstilling av slike legemer.
NO171223C (no) Monoklonalt reseptormolekyl eller del derav som omfatter det antistoffbindende sete, for in vitro bruk, samt in vitro anvendelse derav
DE3886760T2 (de) Monoklonale antikörper gegen menschliche interleukin-4 und die sie erzeugenden hybridomen.
DK115189A (da) Sulfateret k5-antigen og sulfaterede k5-antigenfragmenter og fremgangsmaade til fremstilling deraf samt middel indeholdende det sulfaterede k5-antigen eller fragmenter deraf
EP0341684A3 (en) Human monoclonal antibody, hybridoma producing the same and pharmaceutical
IT8820023A0 (it) Struttura di braccialetti, anelli, cinturini e simili, dotata di mezzi indicatori.
ATE71149T1 (de) Monoklonale antikoerper.
FR2689904B1 (fr) Test de bronzage épidermique in vitro.
ES2046187T3 (es) Anticuerpos para uso en la determinacion de la glucoalbumina humana.
DE69034209D1 (de) 2'-deoxy-4'-thioribonucleoside als antivirale und antikrebsmittel
NO894378L (no) Blandeapparat, samt tilhoerende fremgangsmaate.
ES2103017T3 (es) Sueros estandares y de control para empleo en ensayos para anticuerpos.
TR25221A (tr) ISLAH EDILMIS YUMUSAKLIGA SAHIP YAGLANMIS DERILER VE BUNLARIN üRETILMESINE MAHSUS USUL.
ATE51894T1 (de) Spezifische mycoplasma-membran-antigene und antik¯rper sowie deren klinische verwendungen.
NO864742D0 (no) Dna-sekvens som koder for human vevsplasminogenaktivator, rekombinant dna-sekvens, vertcelle transformert med denne samt fremgangsmaate for fremstilling av plasminogenaktivatoren.
ATE99332T1 (de) Monoklonale antikoerper gegen menschliche interleukin-4 und die sie erzeugenden hybridomen.
IT8848161A0 (it) Dispositivo per la trasformazione di motociclette e simili, in mezzi aerei
ES241072Y (es) Mejoras introducidas en las cabinas de granallado.
FI880188A0 (fi) Wobbler med flere funktioner.
NO911715L (no) Forbedrede polyoler, fremgangsmaate for deres fremstilling, samt anvendelse.
ES243582Y (es) Mejoras introducidas en la aireacion de cabinas y similares.
ES1007529Y (es) Dispositivo de acoplamiento para la constitucion de estufas en botellas de gas.
IT1219095B (it) Procedimento e impianto di climatizzazione per serre e simili

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN JANUARY 2003