NO178660C - Analogifremgangsmåte for fremstilling av N-aryl-piperazinalkanamidforbindelser - Google Patents

Analogifremgangsmåte for fremstilling av N-aryl-piperazinalkanamidforbindelser

Info

Publication number
NO178660C
NO178660C NO881407A NO881407A NO178660C NO 178660 C NO178660 C NO 178660C NO 881407 A NO881407 A NO 881407A NO 881407 A NO881407 A NO 881407A NO 178660 C NO178660 C NO 178660C
Authority
NO
Norway
Prior art keywords
6alkyl
aminocarbonyl
optionally substituted
piperazine
aryl
Prior art date
Application number
NO881407A
Other languages
English (en)
Norwegian (no)
Other versions
NO881407D0 (no
NO178660B (no
NO881407L (no
Inventor
Georges Henri Paul Van Daele
Freddy Francois Vlaeminck
Marc Gustaaf Celine Verdonck
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO881407D0 publication Critical patent/NO881407D0/no
Publication of NO881407L publication Critical patent/NO881407L/no
Publication of NO178660B publication Critical patent/NO178660B/no
Publication of NO178660C publication Critical patent/NO178660C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO881407A 1987-04-01 1988-03-29 Analogifremgangsmåte for fremstilling av N-aryl-piperazinalkanamidforbindelser NO178660C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3412987A 1987-04-01 1987-04-01

Publications (4)

Publication Number Publication Date
NO881407D0 NO881407D0 (no) 1988-03-29
NO881407L NO881407L (no) 1988-10-03
NO178660B NO178660B (no) 1996-01-29
NO178660C true NO178660C (no) 1996-05-08

Family

ID=21874492

Family Applications (1)

Application Number Title Priority Date Filing Date
NO881407A NO178660C (no) 1987-04-01 1988-03-29 Analogifremgangsmåte for fremstilling av N-aryl-piperazinalkanamidforbindelser

Country Status (21)

Country Link
EP (2) EP0285219B1 (de)
JP (1) JP2574377B2 (de)
KR (1) KR960016539B1 (de)
AT (2) ATE142627T1 (de)
AU (1) AU609790B2 (de)
CA (1) CA1315790C (de)
DE (2) DE3855520T2 (de)
DK (1) DK174878B1 (de)
ES (2) ES2167510T3 (de)
FI (1) FI97617C (de)
GR (1) GR3020983T3 (de)
HK (1) HK1006020A1 (de)
HU (2) HUT57740A (de)
IE (1) IE81057B1 (de)
IL (1) IL85919A (de)
NO (1) NO178660C (de)
NZ (1) NZ223847A (de)
PH (1) PH25507A (de)
PT (1) PT87118B (de)
RU (1) RU2014328C1 (de)
ZA (1) ZA882352B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840896A (en) * 1989-11-22 1998-11-24 Janssen Pharmaceutica, N.V. Method of preventing or limiting reperfusion damage
KR0165686B1 (ko) * 1989-11-22 1999-01-15 디르크 반테 재관류 손상을 예방 또는 억제용 조성물
JP2660086B2 (ja) * 1990-07-03 1997-10-08 明治製菓株式会社 脳及び心機能障害改善剤
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
SE9202266D0 (sv) * 1992-07-31 1992-07-31 Kabi Pharmacia Ab Novel piperazine carboxamides
EP0582164B1 (de) * 1992-07-31 1998-12-23 Bristol-Myers Squibb Company Diphenyl Oxazole-, Thiazole- und Imidazole-Derivate als Inhibitoren der Wiederaufnahme des Adenosins
PT756593E (pt) * 1994-04-20 2001-01-31 Lonza Ag Processo para a producao de derivados de acido 2-piperazinocarboxilico
US5866574A (en) * 1997-04-10 1999-02-02 Kyowa Hakko Kogyo Co., Ltd. Pancreatitis remedy
JP2002504134A (ja) * 1997-06-16 2002-02-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 疼痛を治療するためのドラフラジン類似体の使用
UA89503C2 (uk) 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
AR055831A1 (es) 2004-12-30 2007-09-12 Janssen Pharmaceutica Nv Pepirazinilureas y piperidinilureas como moduladores de hidrolasa de amida de acidos grasos
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
CN110511220B (zh) * 2018-05-22 2022-04-01 上海挚盟医药科技有限公司 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795375A1 (de) * 1968-09-21 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia

Also Published As

Publication number Publication date
NO881407D0 (no) 1988-03-29
EP0285219A3 (de) 1991-07-03
DE3856501D1 (de) 2001-11-29
PT87118B (pt) 1992-07-31
NO178660B (no) 1996-01-29
IL85919A0 (en) 1988-09-30
PH25507A (en) 1991-07-24
KR960016539B1 (ko) 1996-12-14
EP0727421A1 (de) 1996-08-21
PT87118A (pt) 1988-04-01
NZ223847A (en) 1989-12-21
JPS63290869A (ja) 1988-11-28
DK174878B1 (da) 2004-01-12
NO881407L (no) 1988-10-03
FI881525A (fi) 1988-10-02
AU609790B2 (en) 1991-05-09
DE3856501T2 (de) 2004-04-29
ES2091183T3 (es) 1996-11-01
ES2167510T3 (es) 2002-05-16
AU1384788A (en) 1988-10-06
CA1315790C (en) 1993-04-06
HUT57740A (en) 1991-12-30
KR880012566A (ko) 1988-11-28
FI97617B (fi) 1996-10-15
ZA882352B (en) 1989-12-27
EP0727421B1 (de) 2001-10-24
RU2014328C1 (ru) 1994-06-15
DE3855520T2 (de) 1997-02-06
IE880989L (en) 1988-10-01
ATE142627T1 (de) 1996-09-15
FI97617C (fi) 1997-01-27
EP0285219B1 (de) 1996-09-11
IE81057B1 (en) 1999-12-29
DK179788A (da) 1988-10-02
FI881525A0 (fi) 1988-03-31
HU211129A9 (en) 1995-10-30
DE3855520D1 (de) 1996-10-17
HK1006020A1 (en) 1999-02-05
EP0285219A2 (de) 1988-10-05
ATE207474T1 (de) 2001-11-15
GR3020983T3 (en) 1996-12-31
JP2574377B2 (ja) 1997-01-22
IL85919A (en) 1992-12-01
DK179788D0 (da) 1988-03-30

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