NO177967C - Fremgangsmåte ved fremstilling av aprotinin og aprotinin homologer i gjær, og en gjærstamme som anvendes i fremgangsmåten - Google Patents
Fremgangsmåte ved fremstilling av aprotinin og aprotinin homologer i gjær, og en gjærstamme som anvendes i fremgangsmåtenInfo
- Publication number
- NO177967C NO177967C NO900920A NO900920A NO177967C NO 177967 C NO177967 C NO 177967C NO 900920 A NO900920 A NO 900920A NO 900920 A NO900920 A NO 900920A NO 177967 C NO177967 C NO 177967C
- Authority
- NO
- Norway
- Prior art keywords
- aprotinin
- yeast
- homologues
- preparation
- strain used
- Prior art date
Links
- 108010039627 Aprotinin Proteins 0.000 title abstract 5
- 229960004405 aprotinin Drugs 0.000 title abstract 5
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title abstract 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 3
- 125000000539 amino acid group Chemical group 0.000 abstract 3
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK450187A DK450187D0 (da) | 1987-08-28 | 1987-08-28 | Fremgangsmaade til fremstilling af proteiner |
| PCT/DK1988/000138 WO1989001968A1 (en) | 1987-08-28 | 1988-08-26 | Aprotinin homologues and process for the production of aprotinin and aprotinin homologues in yeast |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO900920D0 NO900920D0 (no) | 1990-02-27 |
| NO900920L NO900920L (no) | 1990-04-25 |
| NO177967B NO177967B (no) | 1995-09-18 |
| NO177967C true NO177967C (no) | 1995-12-27 |
Family
ID=8134111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO900920A NO177967C (no) | 1987-08-28 | 1990-02-27 | Fremgangsmåte ved fremstilling av aprotinin og aprotinin homologer i gjær, og en gjærstamme som anvendes i fremgangsmåten |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0375718B1 (da) |
| JP (1) | JP2806958B2 (da) |
| AT (1) | ATE113986T1 (da) |
| DE (1) | DE3852105T2 (da) |
| DK (1) | DK450187D0 (da) |
| FI (1) | FI104428B (da) |
| NO (1) | NO177967C (da) |
| WO (1) | WO1989001968A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5591603A (en) * | 1987-08-28 | 1997-01-07 | Novo Nordisk A/S | Process for preparing aprotinin and aprotinin analogs in yeast cells |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| US7413537B2 (en) | 1989-09-01 | 2008-08-19 | Dyax Corp. | Directed evolution of disulfide-bonded micro-proteins |
| DE3930522A1 (de) * | 1989-09-13 | 1991-03-21 | Bayer Ag | Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben |
| US5258302A (en) * | 1990-07-03 | 1993-11-02 | The Salk Institute Biotechnology/Industrial Associates, Inc. | DNA for expression of aprotinin in methylotrophic yeast cells |
| IL99585A0 (en) * | 1990-10-01 | 1992-08-18 | Novo Nordisk As | Aprotinin analogues,their production and pharmaceutical compositions containing them |
| EP1820858B1 (en) | 1991-03-01 | 2009-08-12 | Dyax Corporation | Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof |
| DE4417353A1 (de) * | 1994-05-18 | 1996-01-25 | Bayer Ag | Verfahren zur Herstellung von rekombinantem Aprotinin und rekombinanten Aprotinin Varianten mit der natürlichen N-terminlaen Sequenz |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK58285D0 (da) * | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| US5219569A (en) * | 1985-04-22 | 1993-06-15 | Genentech, Inc. | Protease resistant urokinase |
| DE3930522A1 (de) * | 1989-09-13 | 1991-03-21 | Bayer Ag | Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben |
-
1987
- 1987-08-28 DK DK450187A patent/DK450187D0/da not_active Application Discontinuation
-
1988
- 1988-08-26 JP JP63507339A patent/JP2806958B2/ja not_active Expired - Fee Related
- 1988-08-26 EP EP88907646A patent/EP0375718B1/en not_active Expired - Lifetime
- 1988-08-26 AT AT88907646T patent/ATE113986T1/de not_active IP Right Cessation
- 1988-08-26 DE DE3852105T patent/DE3852105T2/de not_active Expired - Fee Related
- 1988-08-26 WO PCT/DK1988/000138 patent/WO1989001968A1/en not_active Ceased
-
1990
- 1990-02-27 FI FI900991A patent/FI104428B/fi not_active IP Right Cessation
- 1990-02-27 NO NO900920A patent/NO177967C/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO177967B (no) | 1995-09-18 |
| NO900920L (no) | 1990-04-25 |
| JPH03502519A (ja) | 1991-06-13 |
| WO1989001968A1 (en) | 1989-03-09 |
| EP0375718A1 (en) | 1990-07-04 |
| FI900991A0 (fi) | 1990-02-27 |
| JP2806958B2 (ja) | 1998-09-30 |
| FI104428B (fi) | 2000-01-31 |
| DE3852105T2 (de) | 1995-03-23 |
| DE3852105D1 (de) | 1994-12-15 |
| EP0375718B1 (en) | 1994-11-09 |
| NO900920D0 (no) | 1990-02-27 |
| DK450187D0 (da) | 1987-08-28 |
| ATE113986T1 (de) | 1994-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |