NO176306C - Fremgangsmåte for fremstilling av stjerneformede konjugater - Google Patents

Fremgangsmåte for fremstilling av stjerneformede konjugater

Info

Publication number
NO176306C
NO176306C NO881639A NO881639A NO176306C NO 176306 C NO176306 C NO 176306C NO 881639 A NO881639 A NO 881639A NO 881639 A NO881639 A NO 881639A NO 176306 C NO176306 C NO 176306C
Authority
NO
Norway
Prior art keywords
star
preparation
conjugates
shaped
dendrimer
Prior art date
Application number
NO881639A
Other languages
English (en)
Norwegian (no)
Other versions
NO881639L (no
NO176306B (no
NO881639D0 (no
Inventor
Donald A Tomalia
Donald A Kaplan
William J Kruper
Roberta C Cheng
Ian A Tomlinson
Michael J Fazio
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25407923&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO176306(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of NO881639D0 publication Critical patent/NO881639D0/no
Publication of NO881639L publication Critical patent/NO881639L/no
Publication of NO176306B publication Critical patent/NO176306B/no
Publication of NO176306C publication Critical patent/NO176306C/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A61K47/6885—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/005—Dendritic macromolecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Environmental Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Luminescent Compositions (AREA)
NO881639A 1986-08-18 1988-04-15 Fremgangsmåte for fremstilling av stjerneformede konjugater NO176306C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89745586A 1986-08-18 1986-08-18
PCT/US1987/002074 WO1988001178A1 (en) 1986-08-18 1987-08-18 Starburst conjugates

Publications (4)

Publication Number Publication Date
NO881639D0 NO881639D0 (no) 1988-04-15
NO881639L NO881639L (no) 1988-06-15
NO176306B NO176306B (no) 1994-12-05
NO176306C true NO176306C (no) 1995-03-15

Family

ID=25407923

Family Applications (1)

Application Number Title Priority Date Filing Date
NO881639A NO176306C (no) 1986-08-18 1988-04-15 Fremgangsmåte for fremstilling av stjerneformede konjugater

Country Status (21)

Country Link
EP (1) EP0271180B2 (fi)
JP (6) JPH0757735B2 (fi)
KR (1) KR970011151B1 (fi)
AT (1) ATE89743T1 (fi)
AU (2) AU609051B2 (fi)
BR (3) BR8707433A (fi)
DE (1) DE3786000T3 (fi)
DK (1) DK174053B1 (fi)
ES (1) ES2054678T5 (fi)
FI (2) FI103410B (fi)
GR (1) GR3024215T3 (fi)
HK (1) HK54396A (fi)
HU (2) HU209252B (fi)
IE (1) IE61356B1 (fi)
IL (1) IL83567A (fi)
MX (1) MX169992B (fi)
MY (1) MY102878A (fi)
NO (1) NO176306C (fi)
NZ (1) NZ221484A (fi)
WO (3) WO1988001178A1 (fi)
ZA (1) ZA876114B (fi)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5560929A (en) * 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
US5914095A (en) * 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
DK0429644T3 (da) * 1989-05-26 1996-01-22 Ramaswamy Subramanian Chelat-dannende midler til binding af metalioner til proteiner
US5292868A (en) * 1989-05-26 1994-03-08 Akzo N.V. Chelating agents for attaching metal ions to proteins
US5808003A (en) * 1989-05-26 1998-09-15 Perimmune Holdings, Inc. Polyaminocarboxylate chelators
DE3930674A1 (de) * 1989-09-11 1991-03-21 Diagnostikforschung Inst Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie
DE3938992A1 (de) 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
AU642980B2 (en) * 1990-03-21 1993-11-04 Quest International B.V. Ultilization of enzymes
GB9021671D0 (en) * 1990-10-05 1990-11-21 Unilever Plc Delivery of agents
AU642979B2 (en) * 1990-03-21 1993-11-04 Quest International B.V. Utilization and delivery of enzymes
AU641736B2 (en) * 1990-03-21 1993-09-30 Quest International B.V. Delivery of agents
IL99234A (en) * 1990-08-27 1994-05-30 Michigan Molecular Inst Non-cross-linked multi-branch polymers and their preparation
GB9112536D0 (en) * 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
US5871713A (en) * 1991-12-04 1999-02-16 Guerbet S.A. Macromolecular polyamine iodine-containing compound, process for its preparation and its use as a contrast agent
WO1993010824A1 (fr) * 1991-12-04 1993-06-10 Guerbet S.A. Nouveau compose macromoleculaire polyamine iode, son procede de preparation et son utilisation comme agent de contraste
FR2688508A1 (fr) * 1992-03-13 1993-09-17 Guerbet Sa Nouveau produit de contraste iode, son procede de preparation et son utilisation comme agent de contraste.
WO1993021259A1 (en) 1992-04-14 1993-10-28 Cornell Research Foundation Inc. Dendritic based macromolecules and method of production
US5387617A (en) * 1993-01-22 1995-02-07 The Dow Chemical Company Small cell foams and blends and a process for their preparation
US6121056A (en) * 1993-02-24 2000-09-19 Dade Behring Inc. Random detection of antigens with antibodies immobilized on soluble submicron particles
ES2132392T3 (es) * 1993-02-24 1999-08-16 Dade Behring Inc Inmovilizacion de reactivos de ensayo de enlace especifico.
US5898005A (en) * 1993-02-24 1999-04-27 Dade Behring Inc. Rapid detection of analytes with receptors immobilized on soluble submicron particles
FR2703055B1 (fr) * 1993-03-22 1995-07-07 Guerbet Sa Nouveaux composés polyiodés, leur préparation et leur utilisation en tant que produits de contraste pour la radiologie .
US7097839B1 (en) 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
AU750411B2 (en) * 1994-03-07 2002-07-18 Dendritic Nanotechnologies, Inc. Bioactive and/or targeted dendrimer conjugates
MX9504664A (es) * 1994-03-07 1997-05-31 Dow Chemical Co Conjugados de dendrimeros bioactivos y/o dirigidos.
GB9407812D0 (en) * 1994-04-20 1994-06-15 Nycomed Salutar Inc Compounds
NL9401886A (nl) * 1994-05-27 1996-01-02 Dsm Nv Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijgeven van de actieve stof.
NL9400880A (nl) * 1994-05-27 1996-01-02 Dsm Nv Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijstellen van de actieve stof.
AUPM623994A0 (en) * 1994-06-15 1994-07-07 Biomolecular Research Institute Limited Antiviral dendrimers
AU4344696A (en) * 1994-12-21 1996-07-10 Novartis Ag Oligonucleotide-dendrimer conjugates
FR2734268B1 (fr) * 1995-05-19 1997-07-04 Centre Nat Rech Scient Nouveaux dendrimeres fonctionnels a terminaisons phosphorees et leur procede de preparation
US6051429A (en) 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
US6083708A (en) * 1995-08-11 2000-07-04 Dade Behring Inc. Polypeptide: dendrimer complexes
US5658574A (en) * 1995-10-13 1997-08-19 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Cleansing compositions with dendrimers as mildness agents
NL1001753C2 (nl) * 1995-11-28 1997-05-30 Dsm Nv Samenstelling omvattende een kunststof en een additief.
DE19625982A1 (de) * 1996-06-28 1998-01-02 Wella Ag Kosmetisches Mittel zur Haarbehandlung mit Dendrimeren
EP0951486B1 (en) * 1997-01-13 2006-01-11 The Dow Chemical Company Nanocomposites of dendritic polymers
WO1998056427A1 (fr) * 1997-06-12 1998-12-17 Mitsubishi Chemical Corporation Agent de contrast
DE19728954C1 (de) * 1997-06-30 1999-04-22 Schering Ag Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung
FR2790642A1 (fr) 1999-03-08 2000-09-15 Aventis Cropscience Sa Nouvelles compositions pesticides et/ou regulatrices de croissance
CA2376619A1 (en) * 1999-06-29 2001-01-11 Dako A/S Detection using dendrimers bearing labels and probes
HUP0202635A3 (en) 1999-07-29 2006-03-28 Epix Medical Inc Cambridge Targeting multimeric imaging agents through multilocus binding
FI19991705A (fi) * 1999-08-11 2001-02-12 Neste Chemicals Oy Antimikrobinen hyperhaaroittunut polymeerikoostumus
FR2797563A1 (fr) * 1999-08-18 2001-02-23 Rhodianyl Composes biocides et leur utilisation dans des polymeres thermoplastiques
EP1241986B1 (en) * 1999-12-10 2009-02-11 Gerald M. Rosen Use of poly-nitroxyl-functionalized dendrimers as contrast enhancing agents in mri imaging of joints
RU2252929C2 (ru) 2000-04-07 2005-05-27 Шелл Интернэшнл Рисерч Маатсхаппий Б.В. Способ ингибирования закупоривания труб газовыми гидратами
US6471968B1 (en) * 2000-05-12 2002-10-29 Regents Of The University Of Michigan Multifunctional nanodevice platform
CU23011A1 (es) * 2000-11-03 2004-12-17 Ct Ingenieria Genetica Biotech Método de obtención de estructuras antigénicas quemétodo de obtención de estructuras antigénicas que potencian la reactividad cruzada específica y su potencian la reactividad cruzada específica y su uso en formulaciones uso en formulaciones
EP1401988B1 (en) 2001-06-14 2008-06-04 Shell Internationale Researchmaatschappij B.V. Method for solubilising asphaltenes in a hydrocarbon mixture
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
GB0209022D0 (en) 2002-04-19 2002-05-29 Imp College Innovations Ltd Compounds
RU2314413C2 (ru) 2002-09-03 2008-01-10 Шелл Интернэшнл Рисерч Маатсхаппий Б.В. Способ и композиции для ингибирования образования гидратов углеводородов
EP1525890A1 (en) 2003-10-02 2005-04-27 Complex Biosystems GmbH Protein-Proteophore complexes
US7754500B2 (en) * 2003-11-21 2010-07-13 Anp Technologies, Inc. Asymmetrically branched polymer conjugates and microarray assays
CN1946772B (zh) 2004-04-20 2013-01-02 德瑞迪克纳米科技公司 具有增强的扩增性和内部官能度的树枝状聚合物
US7985424B2 (en) 2004-04-20 2011-07-26 Dendritic Nanotechnologies Inc. Dendritic polymers with enhanced amplification and interior functionality
US7919570B2 (en) 2004-08-13 2011-04-05 Nippon Soda Co., Ltd. Multibranched polymer and method for producing the same
US20090104119A1 (en) * 2004-08-25 2009-04-23 Majoros Istvan J Dendrimer Based Compositions And Methods Of Using The Same
EP1656840B1 (en) 2004-11-08 2008-05-14 FUJIFILM Corporation Use of an active oxygen eliminator
BRPI0518254A2 (pt) 2004-11-24 2008-11-11 Shell Int Research mÉtodo para melhorar a escoabilidade de uma mistura que contÉm cera e outros hidrocarbonetos, e, mistura de hidrocarboneto contendo cera e outros hidrocarbonetos
MX2007010402A (es) * 2005-04-20 2008-01-22 Dendritic Nanotechnologies Inc Polimeros dendriticos con amplificacion mejorada y funcionalidad interior.
US7575687B2 (en) * 2005-08-16 2009-08-18 Ge Osmonics, Inc. Membranes and methods useful for caustic applications
WO2007029794A1 (ja) 2005-09-07 2007-03-15 Nippon Soda Co., Ltd. スターポリマー及びその製造方法
CA2629300C (en) 2005-11-17 2014-07-08 Zogenix, Inc. Delivery of viscous formulations by needle-free injection
CN101484488B (zh) 2006-07-11 2012-02-01 日本曹达株式会社 星形聚合物及其制造方法
US20080020043A1 (en) * 2006-07-20 2008-01-24 Marc Gingras Dendrimer-Drug Conjugates
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8658148B2 (en) 2007-06-22 2014-02-25 Genzyme Corporation Chemically modified dendrimers
KR101176813B1 (ko) 2007-08-31 2012-08-24 닛뽕소다 가부시키가이샤 스타 폴리머의 제조 방법
US8252834B2 (en) 2008-03-12 2012-08-28 The Regents Of The University Of Michigan Dendrimer conjugates
CA2722743A1 (en) 2008-04-28 2009-11-05 Zogenix, Inc. Novel formulations for treatment of migraine
WO2010039861A2 (en) 2008-09-30 2010-04-08 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010054321A2 (en) 2008-11-07 2010-05-14 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
CN102917699A (zh) 2009-10-13 2013-02-06 密执安大学评议会 树枝状聚合物组合物和合成方法
BR112012009847B1 (pt) * 2009-10-26 2021-04-13 Dendritc Nanotechnologies, Inc. Formulação compreendendo dendrímeros peham para uso em agricultura, e método para tratamento de plantas ou sementes
US8912323B2 (en) 2009-10-30 2014-12-16 The Regents Of The University Of Michigan Multifunctional small molecules
WO2011105520A1 (ja) * 2010-02-26 2011-09-01 国立大学法人 長崎大学 抗原または薬物送達複合体
US9402911B2 (en) 2011-12-08 2016-08-02 The Regents Of The University Of Michigan Multifunctional small molecules
US9921205B2 (en) 2012-11-13 2018-03-20 Chevron U.S.A. Inc. Method for determining the effectiveness of asphaltene dispersant additives for inhibiting or preventing asphaltene precipitation in a hydrocarbon-containing material subjected to elevated temperature and presssure conditions
GB201405660D0 (en) 2014-03-28 2014-05-14 Gama Healthcare Ltd A liquid disinfecting composition
BR112018012244B1 (pt) * 2015-12-16 2022-02-01 Priostar Pty Ltd Formulação, método para controlar uma praga, e, uso
US10907473B2 (en) 2017-11-14 2021-02-02 Chevron U.S.A., Inc. Low volume in-line filtration methods for analyzing hydrocarbon-containing fluid to evaluate asphaltene content and behavior during production operations
CN109287624A (zh) * 2018-10-08 2019-02-01 威海晨源分子新材料有限公司 一种树枝状聚酰胺-胺在农药中的应用
WO2020142664A1 (en) 2019-01-03 2020-07-09 Ionpath, Inc. Compositions and reagents for ion beam imaging
CN114292217A (zh) * 2021-12-31 2022-04-08 安源基因科技(上海)有限公司 生物活性交联剂、生物交联物、试剂盒及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289872A (en) * 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
IL64277A0 (en) * 1981-11-11 1982-02-28 Basht Ltd Apparatus for removal of integrated circuits from circuit boards
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
CA1225930A (en) * 1982-06-07 1987-08-25 Otto A. Gansow Metal chelate conjugated monoclonal antibodies
US4507466A (en) * 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US4631337A (en) * 1983-01-07 1986-12-23 The Dow Chemical Company Hydrolytically-stable dense star polyamine
US4558120A (en) * 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
US4606907A (en) * 1984-07-02 1986-08-19 The Dow Chemical Company Bone seeking Tc-99m complexes of phosphonate derivatives of polyamidoamines
US4599400A (en) * 1984-12-18 1986-07-08 The Dow Chemical Company Star/comb-branched polyamide
US4694064A (en) * 1986-02-28 1987-09-15 The Dow Chemical Company Rod-shaped dendrimer

Also Published As

Publication number Publication date
JPH069778A (ja) 1994-01-18
JPS63501876A (ja) 1988-07-28
HU209252B (en) 1994-04-28
KR880701564A (ko) 1988-11-03
DE3786000T3 (de) 1997-08-21
AU8139191A (en) 1991-10-03
IL83567A (en) 1992-02-16
JPH0757736B2 (ja) 1995-06-21
DE3786000D1 (de) 1993-07-01
FI105693B (fi) 2000-09-29
FI881768A (fi) 1988-04-15
MX169992B (es) 1993-08-04
NZ221484A (en) 1991-01-29
GR3024215T3 (en) 1997-10-31
JPH07108860B2 (ja) 1995-11-22
FI103410B1 (fi) 1999-06-30
NO881639L (no) 1988-06-15
HU220205B (hu) 2001-11-28
AU638153B2 (en) 1993-06-17
WO1988001179A1 (en) 1988-02-25
JP2848218B2 (ja) 1999-01-20
HU9303379D0 (en) 1994-03-28
JP2771404B2 (ja) 1998-07-02
DK205388D0 (da) 1988-04-14
NO176306B (no) 1994-12-05
DK174053B1 (da) 2002-05-13
BR8707432A (pt) 1988-11-01
FI881768A0 (fi) 1988-04-15
JPH06219966A (ja) 1994-08-09
ES2054678T3 (es) 1994-08-16
HUT55245A (en) 1991-05-28
HK54396A (en) 1996-04-03
WO1988001178A1 (en) 1988-02-25
IE872210L (en) 1988-02-18
FI103410B (fi) 1999-06-30
NO881639D0 (no) 1988-04-15
BR8707431A (pt) 1988-11-01
FI981807A0 (fi) 1998-08-24
FI981807A (fi) 1998-08-24
IL83567A0 (en) 1988-01-31
DK205388A (da) 1988-06-14
BR8707433A (pt) 1988-11-01
JPH0757735B2 (ja) 1995-06-21
JPH072840B2 (ja) 1995-01-18
ZA876114B (en) 1989-04-26
IE61356B1 (en) 1994-11-02
ES2054678T5 (es) 1997-09-16
AU609051B2 (en) 1991-04-26
AU7715987A (en) 1988-03-03
JPS63501878A (ja) 1988-07-28
WO1988001180A1 (en) 1988-02-25
ATE89743T1 (de) 1993-06-15
MY102878A (en) 1993-03-31
EP0271180B2 (en) 1997-06-18
EP0271180A1 (en) 1988-06-15
EP0271180B1 (en) 1993-05-26
JPH06220190A (ja) 1994-08-09
DE3786000T2 (de) 1993-09-02
JPS63502350A (ja) 1988-09-08
KR970011151B1 (ko) 1997-07-07

Similar Documents

Publication Publication Date Title
NO176306C (no) Fremgangsmåte for fremstilling av stjerneformede konjugater
ATE2667T1 (de) Antidepressiv wirkende derivate des trans-4phenyl-1,2,3,4-tetrahydro-1-naphthalin-amins und pharmazeutische zusammensetzungen daraus.
DE3877406D1 (de) Benzothiazolinon-derivate, ihre herstellung und pharmazeutische zusammensetzung.
FI883251A (fi) Substituerade bensimidazoler, foerfarande foer deras framstaellnig, dessa innehaollande farmaceutiska preparat och deras anvaendning.
IT1212043B (it) Tetraalchilpiperidine,loro preparazione e loro impiego come stabilizzanti delle materie polimere
FI883266A (fi) 4-aminosubstituerade 1,2-dihydronaftalenderivat.
DE3578597D1 (de) 4-phenylphthalazin-derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen.
IT8919524A0 (it) Derivati dal 1 arilsolfonil 2 piperidone, loro procedimento di preparazione e loro impiego come farmaci.
IT1212044B (it) Ossalammidi,loro preparazione e loro impiego come stabilizzanti delle materie polimere
ES8607016A1 (es) Preparado solido de nifedipina
DE3782698D1 (de) 5-fluoruridin-derivat und dessen herstellung.
DE58902310D1 (de) Tetrahydropyridin-derivate.
IT8720179A0 (it) 2-sulfinil-acetil-1,3-tiazolidine, loro preparazione e composizioni farmaceutiche.
FI894347A (fi) 2,3,4,5-tetrahydro-1-benzoxepiner, foerfarande foer deras framstaellning, deras anvaendning och dessa foereningar innehaollande farmaceutiska preparat.
ATE10496T1 (de) Dibenzazepinderivate, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Legal Events

Date Code Title Description
MK1K Patent expired