NO175097C - Analogous Process for Preparation of Therapeutically Active Hydrazones - Google Patents

Analogous Process for Preparation of Therapeutically Active Hydrazones

Info

Publication number
NO175097C
NO175097C NO911777A NO911777A NO175097C NO 175097 C NO175097 C NO 175097C NO 911777 A NO911777 A NO 911777A NO 911777 A NO911777 A NO 911777A NO 175097 C NO175097 C NO 175097C
Authority
NO
Norway
Prior art keywords
independently
hydrazones
preparation
hydrogen
therapeutically active
Prior art date
Application number
NO911777A
Other languages
Norwegian (no)
Other versions
NO911777L (en
NO175097B (en
NO911777D0 (en
Inventor
Jaroslav Stanek
Jorg Frei
Giorgio Caravatti
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO911777D0 publication Critical patent/NO911777D0/en
Publication of NO911777L publication Critical patent/NO911777L/en
Publication of NO175097B publication Critical patent/NO175097B/en
Publication of NO175097C publication Critical patent/NO175097C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06Compounds containing any of the groups, e.g. thiosemicarbazides
    • C07C337/08Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10Hydrazines
    • C07C243/20Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C07C281/12Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being part of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Photolithography (AREA)
  • Wire Bonding (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of the formula I <IMAGE> in which A denotes a direct bond or -(CH2)n-, in which n represents 1, 2 or 3; X represents a -C(=Y)-NR6R7 radical; Y represents NR8, O or S; Z represents NR9, O or S; R1 and R2, independently of one another, denote hydrogen or one or more substituents other than hydrogen; the radicals R3, R4, R6, R8 and R9 independently of one another denote hydrogen or lower alkyl; and R5 and R7 independently of one another represent hydrogen, lower alkyl, hydroxyl, etherified or esterified hydroxyl or unsubstituted or mono- or disubstituted amino; tautomers thereof, and salts thereof. They have useful pharmaceutical properties and are particularly active against tumours. They are prepared in a manner known per se.
NO911777A 1990-05-07 1991-05-06 Analogous Process for Preparation of Therapeutically Active Hydrazones NO175097C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH153890 1990-05-07

Publications (4)

Publication Number Publication Date
NO911777D0 NO911777D0 (en) 1991-05-06
NO911777L NO911777L (en) 1991-11-08
NO175097B NO175097B (en) 1994-05-24
NO175097C true NO175097C (en) 1994-08-31

Family

ID=4212764

Family Applications (1)

Application Number Title Priority Date Filing Date
NO911777A NO175097C (en) 1990-05-07 1991-05-06 Analogous Process for Preparation of Therapeutically Active Hydrazones

Country Status (26)

Country Link
EP (1) EP0456133B1 (en)
JP (1) JP2565602B2 (en)
KR (1) KR100203234B1 (en)
AT (1) ATE119878T1 (en)
AU (1) AU645799B2 (en)
CA (1) CA2041832C (en)
CY (1) CY2080B1 (en)
CZ (1) CZ279340B6 (en)
DE (1) DE59104930D1 (en)
DK (1) DK0456133T3 (en)
ES (1) ES2069768T3 (en)
FI (1) FI107916B (en)
GR (1) GR3015574T3 (en)
HK (1) HK1000919A1 (en)
HU (1) HU218221B (en)
ID (1) ID1040B (en)
IE (1) IE66157B1 (en)
IL (1) IL98008A (en)
NO (1) NO175097C (en)
NZ (1) NZ238033A (en)
PT (1) PT97571B (en)
RU (2) RU2057748C1 (en)
SA (1) SA91120283B1 (en)
SK (1) SK279136B6 (en)
TW (1) TW202428B (en)
ZA (1) ZA913391B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395855A (en) * 1990-05-07 1995-03-07 Ciba-Geigy Corporation Hydrazones
RU2081108C1 (en) * 1991-10-16 1997-06-10 Циба-Гейги АГ Additive salts of acids with the base and pharmaceutical composition showing antitumor activity
ATE133939T1 (en) * 1992-04-03 1996-02-15 Innothera Lab Sa INDAN-1,3-DIONE AND INDAN-1,2,3-TRION DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE
ES2103166B1 (en) * 1992-08-26 1998-04-01 Ciba Geigy Ag PROCEDURE FOR OBTAINING BICYCLE AMIDINOHYDRAZONES.
FR2710639B1 (en) * 1993-10-01 1995-12-22 Innothera Lab Sa Ketone indane derivatives, their process of obtaining, their therapeutic application.
DE69633557T2 (en) * 1995-01-26 2005-10-13 Novartis Ag IMDAZOL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONES DECARBOXYLASE (= SAMDC) INHIBITORS
EP1408028A1 (en) * 2002-10-09 2004-04-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) S-adenosyl methionine decarboxylase inhibition for the treatment of a herpes simplex virus infection
EP1834669A1 (en) * 2006-03-15 2007-09-19 Heinrich-Pette-Institut Use of specific hydrazone compounds for the treatment of viral infections
EP1884515A1 (en) 2006-07-31 2008-02-06 Laboratorios del Dr. Esteve S.A. Substituted indanyl sulfonamide compounds, their preparation and use as medicaments
CN102627593A (en) * 2012-02-23 2012-08-08 河南师范大学 1,4-dihydroxy-2-formyl-9,10 anthraquinone thiosemicarbazone new compound with anticancer activity and preparation method thereof
RS59400B1 (en) * 2014-07-02 2019-11-29 Inflectis Bioscience O-alkyl-benzylideneguanidine derivatives and therapeutic use for the treatment of disorders associated an accumulation of misfolded proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7407469A (en) * 1974-06-01 1975-12-03 Akzo Nv NEW AMIDINOHYDRAZONE COMPOUNDS.
DE3416695A1 (en) * 1984-05-05 1985-11-07 Bayer Ag, 5090 Leverkusen AMIDINOHYDRAZONE OF TETRALINE, CHROMONE, THIOCHROMONE AND TRETRAHYDROQUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
BR8907842A (en) * 1988-12-27 1991-12-03 Du Pont REPLACED SEMICARBAZONE ARTROPODICIDES

Also Published As

Publication number Publication date
EP0456133B1 (en) 1995-03-15
NO911777L (en) 1991-11-08
CA2041832C (en) 2002-09-17
FI107916B (en) 2001-10-31
IL98008A0 (en) 1992-06-21
JPH04225946A (en) 1992-08-14
RU2066311C1 (en) 1996-09-10
FI912164A0 (en) 1991-05-03
CY2080B1 (en) 1998-10-16
FI912164A (en) 1991-11-08
DE59104930D1 (en) 1995-04-20
CZ279340B6 (en) 1995-04-12
IE66157B1 (en) 1995-12-13
JP2565602B2 (en) 1996-12-18
AU645799B2 (en) 1994-01-27
IL98008A (en) 1996-08-04
NZ238033A (en) 1993-01-27
HUT57183A (en) 1991-11-28
AU7596791A (en) 1991-11-07
HK1000919A1 (en) 1998-05-08
GR3015574T3 (en) 1995-06-30
RU2057748C1 (en) 1996-04-10
SK279136B6 (en) 1998-07-08
ES2069768T3 (en) 1995-05-16
ATE119878T1 (en) 1995-04-15
NO175097B (en) 1994-05-24
NO911777D0 (en) 1991-05-06
TW202428B (en) 1993-03-21
ID1040B (en) 1996-10-25
HU218221B (en) 2000-06-28
PT97571B (en) 1999-04-30
ZA913391B (en) 1991-12-24
SA91120283B1 (en) 2005-12-17
CA2041832A1 (en) 1991-11-08
EP0456133A1 (en) 1991-11-13
PT97571A (en) 1992-01-31
DK0456133T3 (en) 1995-05-22
KR100203234B1 (en) 1999-06-15
CS131791A3 (en) 1992-03-18
KR910019964A (en) 1991-12-19
IE911530A1 (en) 1991-11-20

Similar Documents

Publication Publication Date Title
DE19775091I2 (en) Therapeutic heterocyclic compounds
MX9602837A (en) Cosmetic or pharmaceutical compositions containing mangiferin or derivatives thereof.
NO175097C (en) Analogous Process for Preparation of Therapeutically Active Hydrazones
IT1250749B (en) HETEROCYCLIC COMPOUNDS ACTIVATED IN II ANTAGONIST
FI922459A (en) FRAMEWORK FOR THE FRAMEWORK OF SUBSTITUTES DIAMINOFTALIMIDER AND DERAS ANALOGER
IL106387A (en) Indole derivatives, their preparation and pharmaceutical compositions containing them
ES2104682T3 (en) FLUORINE-COMPOUNDS.
CA2220140A1 (en) (2-morpholinylmethyl)benzamide derivatives
ATE278676T1 (en) IMDAZOLE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS
ATE154010T1 (en) 2-PHENYL AND 2-THIENYL-(2)-PIPERIDINE DERIVATIVES WITH NEUROPROTECTIVE PROPERTIES
IE850128L (en) Guanidine derivatives
FI934016A (en) FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT AKTIVA KINOLIN- ELLER NAFTYRIDINKARBOXYLSYRADERIVAT SOM INNEHAOLLER EN SPIROSUBSTITUENT

Legal Events

Date Code Title Description
MK1K Patent expired