FI912164A - FOERFARANDE FOER FRAMSTAELLNING AV HYDRAZONER. - Google Patents

FOERFARANDE FOER FRAMSTAELLNING AV HYDRAZONER. Download PDF

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Publication number
FI912164A
FI912164A FI912164A FI912164A FI912164A FI 912164 A FI912164 A FI 912164A FI 912164 A FI912164 A FI 912164A FI 912164 A FI912164 A FI 912164A FI 912164 A FI912164 A FI 912164A
Authority
FI
Finland
Prior art keywords
independently
hydrogen
another
hydrazoner
lower alkyl
Prior art date
Application number
FI912164A
Other languages
Finnish (fi)
Other versions
FI107916B (en
FI912164A0 (en
Inventor
Jaroslav Stanek
Joerg Frei
Giorgio Caravatti
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI912164A0 publication Critical patent/FI912164A0/en
Publication of FI912164A publication Critical patent/FI912164A/en
Application granted granted Critical
Publication of FI107916B publication Critical patent/FI107916B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
    • C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C07C281/12—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being part of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Photolithography (AREA)
  • Wire Bonding (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compounds of the formula I <IMAGE> in which A denotes a direct bond or -(CH2)n-, in which n represents 1, 2 or 3; X represents a -C(=Y)-NR6R7 radical; Y represents NR8, O or S; Z represents NR9, O or S; R1 and R2, independently of one another, denote hydrogen or one or more substituents other than hydrogen; the radicals R3, R4, R6, R8 and R9 independently of one another denote hydrogen or lower alkyl; and R5 and R7 independently of one another represent hydrogen, lower alkyl, hydroxyl, etherified or esterified hydroxyl or unsubstituted or mono- or disubstituted amino; tautomers thereof, and salts thereof. They have useful pharmaceutical properties and are particularly active against tumours. They are prepared in a manner known per se.
FI912164A 1990-05-07 1991-05-03 A process for the preparation of hydrazone derivatives FI107916B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH153890 1990-05-07
CH153890 1990-05-07

Publications (3)

Publication Number Publication Date
FI912164A0 FI912164A0 (en) 1991-05-03
FI912164A true FI912164A (en) 1991-11-08
FI107916B FI107916B (en) 2001-10-31

Family

ID=4212764

Family Applications (1)

Application Number Title Priority Date Filing Date
FI912164A FI107916B (en) 1990-05-07 1991-05-03 A process for the preparation of hydrazone derivatives

Country Status (26)

Country Link
EP (1) EP0456133B1 (en)
JP (1) JP2565602B2 (en)
KR (1) KR100203234B1 (en)
AT (1) ATE119878T1 (en)
AU (1) AU645799B2 (en)
CA (1) CA2041832C (en)
CY (1) CY2080B1 (en)
CZ (1) CZ279340B6 (en)
DE (1) DE59104930D1 (en)
DK (1) DK0456133T3 (en)
ES (1) ES2069768T3 (en)
FI (1) FI107916B (en)
GR (1) GR3015574T3 (en)
HK (1) HK1000919A1 (en)
HU (1) HU218221B (en)
ID (1) ID1040B (en)
IE (1) IE66157B1 (en)
IL (1) IL98008A (en)
NO (1) NO175097C (en)
NZ (1) NZ238033A (en)
PT (1) PT97571B (en)
RU (2) RU2057748C1 (en)
SA (1) SA91120283B1 (en)
SK (1) SK279136B6 (en)
TW (1) TW202428B (en)
ZA (1) ZA913391B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395855A (en) * 1990-05-07 1995-03-07 Ciba-Geigy Corporation Hydrazones
RU2081108C1 (en) * 1991-10-16 1997-06-10 Циба-Гейги АГ Additive salts of acids with the base and pharmaceutical composition showing antitumor activity
EP0566445B1 (en) * 1992-04-03 1996-02-07 Innothera Derivatives of indane 1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy
ES2103166B1 (en) * 1992-08-26 1998-04-01 Ciba Geigy Ag PROCEDURE FOR OBTAINING BICYCLE AMIDINOHYDRAZONES.
FR2710639B1 (en) * 1993-10-01 1995-12-22 Innothera Lab Sa Ketone indane derivatives, their process of obtaining, their therapeutic application.
ES2229260T3 (en) * 1995-01-26 2005-04-16 Novartis Ag DERIVATIVES OF IMIDAZOL, ITS PREPARATION AND ITS USE AS INHIBITORS OF S-ADENOSILMETIONINA DESCARBOXYLASE (= SAMDC).
EP1408028A1 (en) * 2002-10-09 2004-04-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) S-adenosyl methionine decarboxylase inhibition for the treatment of a herpes simplex virus infection
EP1834669A1 (en) * 2006-03-15 2007-09-19 Heinrich-Pette-Institut Use of specific hydrazone compounds for the treatment of viral infections
EP1884515A1 (en) * 2006-07-31 2008-02-06 Laboratorios del Dr. Esteve S.A. Substituted indanyl sulfonamide compounds, their preparation and use as medicaments
CN102627593A (en) * 2012-02-23 2012-08-08 河南师范大学 1,4-dihydroxy-2-formyl-9,10 anthraquinone thiosemicarbazone new compound with anticancer activity and preparation method thereof
KR20170027737A (en) * 2014-07-02 2017-03-10 인플렉티스 바이오사이언스 O-alkyl-benzylideneguanidine derivatives and therapeutic use for the treatment of disorders associated an accumulation of misfolded proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7407469A (en) * 1974-06-01 1975-12-03 Akzo Nv NEW AMIDINOHYDRAZONE COMPOUNDS.
DE3416695A1 (en) * 1984-05-05 1985-11-07 Bayer Ag, 5090 Leverkusen AMIDINOHYDRAZONE OF TETRALINE, CHROMONE, THIOCHROMONE AND TRETRAHYDROQUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
ATE102606T1 (en) * 1988-12-27 1994-03-15 Du Pont SUBSTITUTED SEMICARBAZONE ARTHROPODICIDES.

Also Published As

Publication number Publication date
EP0456133A1 (en) 1991-11-13
CZ279340B6 (en) 1995-04-12
NO175097B (en) 1994-05-24
JPH04225946A (en) 1992-08-14
IE911530A1 (en) 1991-11-20
ID1040B (en) 1996-10-25
RU2057748C1 (en) 1996-04-10
JP2565602B2 (en) 1996-12-18
ES2069768T3 (en) 1995-05-16
HK1000919A1 (en) 1998-05-08
CA2041832A1 (en) 1991-11-08
PT97571A (en) 1992-01-31
GR3015574T3 (en) 1995-06-30
IL98008A (en) 1996-08-04
FI107916B (en) 2001-10-31
FI912164A0 (en) 1991-05-03
KR100203234B1 (en) 1999-06-15
EP0456133B1 (en) 1995-03-15
DK0456133T3 (en) 1995-05-22
SA91120283B1 (en) 2005-12-17
IE66157B1 (en) 1995-12-13
NO911777L (en) 1991-11-08
TW202428B (en) 1993-03-21
NO175097C (en) 1994-08-31
HU218221B (en) 2000-06-28
RU2066311C1 (en) 1996-09-10
CA2041832C (en) 2002-09-17
CY2080B1 (en) 1998-10-16
NZ238033A (en) 1993-01-27
CS131791A3 (en) 1992-03-18
ZA913391B (en) 1991-12-24
NO911777D0 (en) 1991-05-06
AU645799B2 (en) 1994-01-27
KR910019964A (en) 1991-12-19
HUT57183A (en) 1991-11-28
IL98008A0 (en) 1992-06-21
SK279136B6 (en) 1998-07-08
AU7596791A (en) 1991-11-07
PT97571B (en) 1999-04-30
DE59104930D1 (en) 1995-04-20
ATE119878T1 (en) 1995-04-15

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