IL98008A0 - Hydrazones - Google Patents

Hydrazones

Info

Publication number
IL98008A0
IL98008A0 IL98008A IL9800891A IL98008A0 IL 98008 A0 IL98008 A0 IL 98008A0 IL 98008 A IL98008 A IL 98008A IL 9800891 A IL9800891 A IL 9800891A IL 98008 A0 IL98008 A0 IL 98008A0
Authority
IL
Israel
Prior art keywords
independently
hydrogen
another
lower alkyl
hydroxyl
Prior art date
Application number
IL98008A
Other versions
IL98008A (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IL98008A0 publication Critical patent/IL98008A0/en
Publication of IL98008A publication Critical patent/IL98008A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C07C281/12—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being part of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
    • C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Photolithography (AREA)
  • Wire Bonding (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of the formula I <IMAGE> in which A denotes a direct bond or -(CH2)n-, in which n represents 1, 2 or 3; X represents a -C(=Y)-NR6R7 radical; Y represents NR8, O or S; Z represents NR9, O or S; R1 and R2, independently of one another, denote hydrogen or one or more substituents other than hydrogen; the radicals R3, R4, R6, R8 and R9 independently of one another denote hydrogen or lower alkyl; and R5 and R7 independently of one another represent hydrogen, lower alkyl, hydroxyl, etherified or esterified hydroxyl or unsubstituted or mono- or disubstituted amino; tautomers thereof, and salts thereof. They have useful pharmaceutical properties and are particularly active against tumours. They are prepared in a manner known per se.
IL9800891A 1990-05-07 1991-04-30 Amidino-, carbamoyl or thiocarbamoyl-1-indanone-2'-amidinohydrazone derivatives and analogues thereof that inhibit s-adenoylmethionine decarboxylase IL98008A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH153890 1990-05-07

Publications (2)

Publication Number Publication Date
IL98008A0 true IL98008A0 (en) 1992-06-21
IL98008A IL98008A (en) 1996-08-04

Family

ID=4212764

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9800891A IL98008A (en) 1990-05-07 1991-04-30 Amidino-, carbamoyl or thiocarbamoyl-1-indanone-2'-amidinohydrazone derivatives and analogues thereof that inhibit s-adenoylmethionine decarboxylase

Country Status (26)

Country Link
EP (1) EP0456133B1 (en)
JP (1) JP2565602B2 (en)
KR (1) KR100203234B1 (en)
AT (1) ATE119878T1 (en)
AU (1) AU645799B2 (en)
CA (1) CA2041832C (en)
CY (1) CY2080B1 (en)
CZ (1) CZ279340B6 (en)
DE (1) DE59104930D1 (en)
DK (1) DK0456133T3 (en)
ES (1) ES2069768T3 (en)
FI (1) FI107916B (en)
GR (1) GR3015574T3 (en)
HK (1) HK1000919A1 (en)
HU (1) HU218221B (en)
ID (1) ID1040B (en)
IE (1) IE66157B1 (en)
IL (1) IL98008A (en)
NO (1) NO175097C (en)
NZ (1) NZ238033A (en)
PT (1) PT97571B (en)
RU (2) RU2057748C1 (en)
SA (1) SA91120283B1 (en)
SK (1) SK279136B6 (en)
TW (1) TW202428B (en)
ZA (1) ZA913391B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395855A (en) * 1990-05-07 1995-03-07 Ciba-Geigy Corporation Hydrazones
RU2081108C1 (en) * 1991-10-16 1997-06-10 Циба-Гейги АГ Additive salts of acids with the base and pharmaceutical composition showing antitumor activity
JPH06508375A (en) * 1992-04-03 1994-09-22 イノテラ Derivatives of indan-1,3-dione and indan-1,2,3-trione, processes for their preparation and their therapeutic uses
ES2103166B1 (en) * 1992-08-26 1998-04-01 Ciba Geigy Ag PROCEDURE FOR OBTAINING BICYCLE AMIDINOHYDRAZONES.
FR2710639B1 (en) * 1993-10-01 1995-12-22 Innothera Lab Sa Ketone indane derivatives, their process of obtaining, their therapeutic application.
JP3989543B2 (en) * 1995-01-26 2007-10-10 ノバルティス・アクチエンゲゼルシャフト Imidazole derivatives, their preparation and their use as S-adenosylmethionine decarboxylase (= SAMDC) inhibitors
EP1408028A1 (en) * 2002-10-09 2004-04-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) S-adenosyl methionine decarboxylase inhibition for the treatment of a herpes simplex virus infection
EP1834669A1 (en) * 2006-03-15 2007-09-19 Heinrich-Pette-Institut Use of specific hydrazone compounds for the treatment of viral infections
EP1884515A1 (en) * 2006-07-31 2008-02-06 Laboratorios del Dr. Esteve S.A. Substituted indanyl sulfonamide compounds, their preparation and use as medicaments
CN102627593A (en) * 2012-02-23 2012-08-08 河南师范大学 1,4-dihydroxy-2-formyl-9,10 anthraquinone thiosemicarbazone new compound with anticancer activity and preparation method thereof
RU2706002C2 (en) * 2014-07-02 2019-11-13 Инфлектис Байосайенс O-alkyl-benzylidene guanidine derivatives and their therapeutic use for treating diseases associated with accumulation of misfolded proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7407469A (en) * 1974-06-01 1975-12-03 Akzo Nv NEW AMIDINOHYDRAZONE COMPOUNDS.
DE3416695A1 (en) * 1984-05-05 1985-11-07 Bayer Ag, 5090 Leverkusen AMIDINOHYDRAZONE OF TETRALINE, CHROMONE, THIOCHROMONE AND TRETRAHYDROQUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
RU2067092C1 (en) * 1988-12-27 1996-09-27 Е.И.Дюпон Де Немур Энд Компани Semicarbazone derivatives, method of controlling arthropodes, and arthropocidal composition

Also Published As

Publication number Publication date
ES2069768T3 (en) 1995-05-16
CY2080B1 (en) 1998-10-16
EP0456133B1 (en) 1995-03-15
NZ238033A (en) 1993-01-27
NO911777L (en) 1991-11-08
FI912164A0 (en) 1991-05-03
EP0456133A1 (en) 1991-11-13
IE66157B1 (en) 1995-12-13
ZA913391B (en) 1991-12-24
NO911777D0 (en) 1991-05-06
HU218221B (en) 2000-06-28
JPH04225946A (en) 1992-08-14
PT97571A (en) 1992-01-31
NO175097B (en) 1994-05-24
ID1040B (en) 1996-10-25
GR3015574T3 (en) 1995-06-30
TW202428B (en) 1993-03-21
CA2041832C (en) 2002-09-17
RU2066311C1 (en) 1996-09-10
DE59104930D1 (en) 1995-04-20
CZ279340B6 (en) 1995-04-12
SK279136B6 (en) 1998-07-08
AU7596791A (en) 1991-11-07
KR100203234B1 (en) 1999-06-15
IE911530A1 (en) 1991-11-20
HUT57183A (en) 1991-11-28
HK1000919A1 (en) 1998-05-08
AU645799B2 (en) 1994-01-27
CS131791A3 (en) 1992-03-18
FI912164A (en) 1991-11-08
IL98008A (en) 1996-08-04
DK0456133T3 (en) 1995-05-22
SA91120283B1 (en) 2005-12-17
KR910019964A (en) 1991-12-19
JP2565602B2 (en) 1996-12-18
ATE119878T1 (en) 1995-04-15
PT97571B (en) 1999-04-30
NO175097C (en) 1994-08-31
CA2041832A1 (en) 1991-11-08
RU2057748C1 (en) 1996-04-10
FI107916B (en) 2001-10-31

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