NO174342C - Analogifremgangsmåte for fremstilling av terapeutisk aktive aryloksyfenylpropylaminer - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive aryloksyfenylpropylaminer

Info

Publication number
NO174342C
NO174342C NO902338A NO902338A NO174342C NO 174342 C NO174342 C NO 174342C NO 902338 A NO902338 A NO 902338A NO 902338 A NO902338 A NO 902338A NO 174342 C NO174342 C NO 174342C
Authority
NO
Norway
Prior art keywords
alkyl
cycloalkyl
alkoxy
aryloxy
cyano
Prior art date
Application number
NO902338A
Other languages
English (en)
Norwegian (no)
Other versions
NO902338D0 (no
NO174342B (no
NO902338L (no
Inventor
Palle Jakobsen
Joergen Drejer
Original Assignee
Novo Nordisk As
Ferrosan As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As, Ferrosan As filed Critical Novo Nordisk As
Publication of NO902338D0 publication Critical patent/NO902338D0/no
Publication of NO902338L publication Critical patent/NO902338L/no
Publication of NO174342B publication Critical patent/NO174342B/no
Publication of NO174342C publication Critical patent/NO174342C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Luminescent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
NO902338A 1989-05-26 1990-05-25 Analogifremgangsmåte for fremstilling av terapeutisk aktive aryloksyfenylpropylaminer NO174342C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK258389A DK258389D0 (da) 1989-05-26 1989-05-26 Aryloxyphenylpropylaminer, deres fremstilling og anvendelse

Publications (4)

Publication Number Publication Date
NO902338D0 NO902338D0 (no) 1990-05-25
NO902338L NO902338L (no) 1990-11-27
NO174342B NO174342B (no) 1994-01-10
NO174342C true NO174342C (no) 1994-04-20

Family

ID=8113376

Family Applications (1)

Application Number Title Priority Date Filing Date
NO902338A NO174342C (no) 1989-05-26 1990-05-25 Analogifremgangsmåte for fremstilling av terapeutisk aktive aryloksyfenylpropylaminer

Country Status (16)

Country Link
US (2) US5145870A (fr)
EP (1) EP0399504B1 (fr)
JP (1) JPH0317046A (fr)
AT (1) ATE122031T1 (fr)
AU (1) AU641653B2 (fr)
CA (1) CA2017468A1 (fr)
DE (1) DE69019060T2 (fr)
DK (2) DK258389D0 (fr)
ES (1) ES2071699T3 (fr)
FI (1) FI902629A0 (fr)
IE (1) IE70070B1 (fr)
IL (1) IL94452A (fr)
NO (1) NO174342C (fr)
NZ (1) NZ233809A (fr)
PT (1) PT94167B (fr)
ZA (1) ZA904072B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0576766A1 (fr) * 1992-06-29 1994-01-05 Novo Nordisk A/S Dérivés de propanolamine, leur préparation et utilisation
US6750244B2 (en) 1993-02-08 2004-06-15 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6211245B1 (en) 1993-02-08 2001-04-03 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6071970A (en) * 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6017965A (en) * 1993-02-08 2000-01-25 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US7087765B2 (en) 1995-06-07 2006-08-08 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
DE69434889D1 (de) 1994-02-08 2007-01-11 Nps Pharma Inc An einer neuen Stelle von Rezeptorabhängigen Kalziumkanälen wirkende Verbindungen zur Behandlung von neurologischen Erkrankungen
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
IT1304874B1 (it) * 1998-07-17 2001-04-05 Univ Firenze Amminoalcoli,amminochetoni e loro derivati,loro preparazione ed usocome farmaci per le patologie del sistema nervoso centrale (snc) e
GB0004153D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
GB0004152D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
GB0004151D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
SE0102641D0 (sv) * 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
SE0102640D0 (sv) * 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
SE0102639D0 (sv) 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
US6846957B2 (en) * 2002-11-22 2005-01-25 Board Of Regents, The University Of Texas System Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor
WO2005063707A1 (fr) * 2003-12-26 2005-07-14 Natco Pharma Limited Procede enantiospecifique permettant de preparer un intermediaire de paroxetine
ITMI20061987A1 (it) * 2006-10-16 2008-04-17 Archimica Srl Processo per la sintesi di arilossipropilammine ed eteroarilossipropilammine.
WO2008081477A1 (fr) * 2007-01-04 2008-07-10 Natco Pharma Limited Propanamines à 3-substitution 3-aryloxy
JP5246715B2 (ja) * 2009-01-27 2013-07-24 独立行政法人科学技術振興機構 蛋白質架橋阻害剤およびその用途
DE102009036164B4 (de) 2009-05-28 2011-06-09 Schott Ag Verfahren zum Biegen und thermischen Vorspannen von Strahlenschutzglas
WO2014046544A1 (fr) * 2012-09-21 2014-03-27 Aapa B.V. 3-hétéroaryloxy-3-(hétéro)aryl-propylamines substituées comme modulateurs de transporteur de la sérotonine et du récepteur ht2c de la sérotonine

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3095449A (en) * 1957-08-06 1963-06-25 Bayer Ag 1-(gamma-dimethylaminopropoxy)-2-alkoxy alkenylbenzenes
CH609331A5 (en) * 1974-01-10 1979-02-28 Lilly Co Eli Process for the preparation of 3-aryloxy-3-phenyl-propylamines
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
US4194009A (en) * 1974-01-10 1980-03-18 Eli Lilly And Company Aryloxyphenylpropylamines for obtaining a psychotropic effect
FR2432500A1 (fr) * 1978-02-24 1980-02-29 Roussel Uclaf Nouveaux derives de la benzene propanamine et leurs sels, procede de preparation et application a titre de medicaments
DE2940765A1 (de) * 1979-10-08 1981-04-23 Basf Ag, 6700 Ludwigshafen Substituierte alkylammoniumsalze, ihre herstellung, ihre verwendung zur regulierung des pflanzenwachstums und mittel dafuer
DE2950135A1 (de) * 1979-12-13 1981-06-19 Merck Patent Gmbh, 6100 Darmstadt Basischer aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
GR75395B (fr) * 1980-11-14 1984-07-13 Lilly Co Eli
US4956388A (en) * 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
IL85988A (en) * 1987-04-09 1992-08-18 Lilly Co Eli 1-phenyl-3-naphthalenyloxy-propanamines,process for their preparation and pharmaceutical compositions containing them
DK630987D0 (da) * 1987-12-01 1987-12-01 Ferrosan As Aryloxyphenylpropylaminer, deres fremstilling og anvendelse

Also Published As

Publication number Publication date
DE69019060D1 (de) 1995-06-08
PT94167A (pt) 1991-01-08
PT94167B (pt) 1996-12-31
IL94452A (en) 1995-11-27
NZ233809A (en) 1993-04-28
IE901790L (en) 1990-11-26
ES2071699T3 (es) 1995-07-01
EP0399504A3 (fr) 1992-02-12
NO902338D0 (no) 1990-05-25
IL94452A0 (en) 1991-03-10
NO174342B (no) 1994-01-10
EP0399504A2 (fr) 1990-11-28
ATE122031T1 (de) 1995-05-15
DK258389D0 (da) 1989-05-26
IE70070B1 (en) 1996-10-30
AU5582190A (en) 1990-11-29
EP0399504B1 (fr) 1995-05-03
US5310756A (en) 1994-05-10
US5145870A (en) 1992-09-08
FI902629A0 (fi) 1990-05-25
JPH0317046A (ja) 1991-01-25
DK0399504T3 (da) 1995-09-04
CA2017468A1 (fr) 1990-11-26
DE69019060T2 (de) 1995-08-31
ZA904072B (en) 1991-03-27
AU641653B2 (en) 1993-09-30
NO902338L (no) 1990-11-27

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