NO171904C - Analogifremgangsmaate til fremstilling av en terapeutisk aktiv nitratester - Google Patents

Analogifremgangsmaate til fremstilling av en terapeutisk aktiv nitratester

Info

Publication number
NO171904C
NO171904C NO893686A NO893686A NO171904C NO 171904 C NO171904 C NO 171904C NO 893686 A NO893686 A NO 893686A NO 893686 A NO893686 A NO 893686A NO 171904 C NO171904 C NO 171904C
Authority
NO
Norway
Prior art keywords
tester
preparing
therapeutic active
analogy procedure
active nitrate
Prior art date
Application number
NO893686A
Other languages
English (en)
Norwegian (no)
Other versions
NO171904B (no
NO893686L (no
NO893686D0 (no
Inventor
Jan Bron
Geert Jan Sterk
Jan Fetze Van Der Werf
Hendrik Timmerman
Original Assignee
Cedona Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedona Pharm Bv filed Critical Cedona Pharm Bv
Publication of NO893686D0 publication Critical patent/NO893686D0/no
Publication of NO893686L publication Critical patent/NO893686L/no
Publication of NO171904B publication Critical patent/NO171904B/no
Publication of NO171904C publication Critical patent/NO171904C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/08—Esters of nitric acid having nitrate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO893686A 1988-09-15 1989-09-14 Analogifremgangsmaate til fremstilling av en terapeutisk aktiv nitratester NO171904C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8802276A NL8802276A (nl) 1988-09-15 1988-09-15 Geneesmiddel met relaxerende werking, dat als aktieve stof een nitraatester bevat.

Publications (4)

Publication Number Publication Date
NO893686D0 NO893686D0 (no) 1989-09-14
NO893686L NO893686L (no) 1990-03-16
NO171904B NO171904B (no) 1993-02-08
NO171904C true NO171904C (no) 1993-05-19

Family

ID=19852906

Family Applications (1)

Application Number Title Priority Date Filing Date
NO893686A NO171904C (no) 1988-09-15 1989-09-14 Analogifremgangsmaate til fremstilling av en terapeutisk aktiv nitratester

Country Status (13)

Country Link
US (1) US5049694A (da)
EP (1) EP0359335A3 (da)
JP (1) JPH02134316A (da)
KR (1) KR900004331A (da)
AU (1) AU638413B2 (da)
DK (1) DK453089A (da)
FI (1) FI894349A (da)
IL (1) IL91602A0 (da)
NL (1) NL8802276A (da)
NO (1) NO171904C (da)
NZ (1) NZ230631A (da)
PT (1) PT91701B (da)
ZA (1) ZA896982B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
NL9001955A (nl) * 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.
JP3454531B2 (ja) * 1991-11-07 2003-10-06 三共株式会社 ニトロキシアルキルアミド誘導体
US5646181A (en) * 1992-07-02 1997-07-08 Research Foundation Of State University Of New York Method and compositions for treating impotence
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
AU6376894A (en) * 1993-03-15 1994-10-11 Byk Nederland Bv Use of substituted alkyl nitrates for the treatment of pathologically increased intra-ocular pressure
ES2065291B1 (es) * 1993-07-30 1995-10-01 Prodesfarma Sa "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"
EP0722434B1 (en) * 1993-10-06 1998-07-29 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
CA2181581A1 (en) * 1994-01-19 1995-07-20 Jan Bron Nitroxy group-containing benzylamine derivatives and their use for treating cardiovascular diseases, as well as increased intra-ocular pressure
US5925658A (en) * 1995-03-02 1999-07-20 Sankyo Company, Limited Optically active thiazolidinone derivative
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
US7115661B1 (en) 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
US6310052B1 (en) 1996-06-04 2001-10-30 Queen's University At Kingston Nitrate esters and their use for neurological conditions
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
IL120531A (en) * 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
US6056966A (en) * 1998-05-18 2000-05-02 Baker Norton Pharmaceuticals, Inc. Method and compositions for treating impotence
AU2003265769A1 (en) * 2002-05-02 2003-11-17 Ciphergen Biosystems, Inc. Biochips with surfaces coated with polysaccharide based hydrogels
JP4891982B2 (ja) * 2008-12-15 2012-03-07 スガツネ工業株式会社 ２軸ヒンジ装置及び携帯機器
EP2722326A1 (en) * 2011-10-24 2014-04-23 Nicox S.A. Quinone based nitric oxide donating compounds

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2139364A (en) * 1937-03-22 1938-12-06 Shell Dev Alpha-substituted glycerol nitrates
NL49919C (da) * 1938-02-10
US2294849A (en) * 1938-08-20 1942-09-01 Sharples Chemicals Inc Manufacture of nitric acid esters
US2549687A (en) * 1947-11-21 1951-04-17 Duriron Co Heat exchanger
GB713329A (en) * 1951-01-08 1954-08-11 Nat Res Dev Improvements in or relating to production of nitric acid esters of higher alcohols and glycols
US2683164A (en) * 1951-12-21 1954-07-06 Trojan Powder Co Preparation of 1, 2, 6-hexanetriol trinitrate
US2742492A (en) * 1954-07-29 1956-04-17 Ethyl Corp Nitrate formulations
NL98269C (da) * 1956-02-24
NL110701C (da) * 1960-03-14
US3428667A (en) * 1962-09-20 1969-02-18 Aerojet General Co N,n-dinitramines of certain organic compounds and process
US3419571A (en) * 1966-04-06 1968-12-31 Warner Lambert Pharmaceutical Method for relieving coronary insufficiency
US3409620A (en) * 1967-02-06 1968-11-05 Mario Biazzi Sa Dr Ing Continuous manufacture in vacuum of nitric esters and/or organic nitro compounds
US3470231A (en) * 1967-05-29 1969-09-30 Us Navy Method of stabilizing nitric acid esters
US3853891A (en) * 1971-06-16 1974-12-10 Sandoz Ag N-(n-(cyanoalkyl)-n-nitroso)amino-aminoalcohol
US4336408A (en) * 1977-11-25 1982-06-22 Thiokol Corporation 2-Hydroxymethyl-1,3-propanediol preparation
JPS56113748A (en) * 1980-02-13 1981-09-07 Kowa Co Aminoethanol derivative and its preparation
US4417903A (en) * 1982-10-15 1983-11-29 Ethyl Corporation Diesel fuel composition
DE3305690A1 (de) * 1983-02-18 1984-08-30 Heinrich Mack Nachf., 7918 Illertissen Glycerinmononitrate zur behandlung der angina pectoris
US4479905A (en) * 1983-09-19 1984-10-30 Ethyl Corporation Nitration process
DE3443998A1 (de) * 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3512627A1 (de) * 1985-04-06 1986-10-09 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
DK453089D0 (da) 1989-09-14
NO171904B (no) 1993-02-08
NZ230631A (en) 1993-01-27
JPH02134316A (ja) 1990-05-23
KR900004331A (ko) 1990-04-12
NO893686L (no) 1990-03-16
PT91701B (pt) 1995-06-30
AU638413B2 (en) 1993-07-01
EP0359335A2 (en) 1990-03-21
FI894349A0 (fi) 1989-09-14
IL91602A0 (en) 1990-04-29
NO893686D0 (no) 1989-09-14
NL8802276A (nl) 1990-04-02
EP0359335A3 (en) 1991-03-06
PT91701A (pt) 1990-03-30
DK453089A (da) 1990-03-16
US5049694A (en) 1991-09-17
FI894349A (fi) 1990-03-16
AU4133089A (en) 1990-03-22
ZA896982B (en) 1990-06-27

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