FI894349A0 - Foerfarande foer framstaellning av en farmakologiskt aktiv nitratester. - Google Patents

Foerfarande foer framstaellning av en farmakologiskt aktiv nitratester.

Info

Publication number
FI894349A0
FI894349A0 FI894349A FI894349A FI894349A0 FI 894349 A0 FI894349 A0 FI 894349A0 FI 894349 A FI894349 A FI 894349A FI 894349 A FI894349 A FI 894349A FI 894349 A0 FI894349 A0 FI 894349A0
Authority
FI
Finland
Prior art keywords
nitrates
framework
active
pharmacological activation
pharmacological
Prior art date
Application number
FI894349A
Other languages
English (en)
Other versions
FI894349A (fi
Inventor
Jan Bron
Geert Jan Sterk
Der Werf Jan Fetze Van
Hendrik Timmerman
Original Assignee
Cedona Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedona Pharm Bv filed Critical Cedona Pharm Bv
Publication of FI894349A0 publication Critical patent/FI894349A0/fi
Publication of FI894349A publication Critical patent/FI894349A/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/08—Esters of nitric acid having nitrate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI894349A 1988-09-15 1989-09-14 Foerfarande foer framstaellning av en farmakologiskt aktiv nitratester. FI894349A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8802276A NL8802276A (nl) 1988-09-15 1988-09-15 Geneesmiddel met relaxerende werking, dat als aktieve stof een nitraatester bevat.

Publications (2)

Publication Number Publication Date
FI894349A0 true FI894349A0 (fi) 1989-09-14
FI894349A FI894349A (fi) 1990-03-16

Family

ID=19852906

Family Applications (1)

Application Number Title Priority Date Filing Date
FI894349A FI894349A (fi) 1988-09-15 1989-09-14 Foerfarande foer framstaellning av en farmakologiskt aktiv nitratester.

Country Status (13)

Country Link
US (1) US5049694A (fi)
EP (1) EP0359335A3 (fi)
JP (1) JPH02134316A (fi)
KR (1) KR900004331A (fi)
AU (1) AU638413B2 (fi)
DK (1) DK453089A (fi)
FI (1) FI894349A (fi)
IL (1) IL91602A0 (fi)
NL (1) NL8802276A (fi)
NO (1) NO171904C (fi)
NZ (1) NZ230631A (fi)
PT (1) PT91701B (fi)
ZA (1) ZA896982B (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
NL9001955A (nl) * 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.
JP3454531B2 (ja) * 1991-11-07 2003-10-06 三共株式会社 ニトロキシアルキルアミド誘導体
US5646181A (en) * 1992-07-02 1997-07-08 Research Foundation Of State University Of New York Method and compositions for treating impotence
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
WO1994021248A1 (de) * 1993-03-15 1994-09-29 Byk Nederland Bv Verwendung von substituierten alkylnitraten zur behandlung des krankhaft erhöhten augeninnendruckes
ES2065291B1 (es) * 1993-07-30 1995-10-01 Prodesfarma Sa "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"
WO1995009831A1 (en) * 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
WO1995019952A1 (de) * 1994-01-19 1995-07-27 Byk Nederland Bv Nitroxy-gruppen enthaltende benzylaminderivate und ihre verwendung zur behandlung von cardiovasculären erkrankungen sowie erhöhtem augeninnendruck
US5925658A (en) * 1995-03-02 1999-07-20 Sankyo Company, Limited Optically active thiazolidinone derivative
US6310052B1 (en) 1996-06-04 2001-10-30 Queen's University At Kingston Nitrate esters and their use for neurological conditions
US7115661B1 (en) 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
IL120531A (en) * 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
US6056966A (en) * 1998-05-18 2000-05-02 Baker Norton Pharmaceuticals, Inc. Method and compositions for treating impotence
AU2003265769A1 (en) * 2002-05-02 2003-11-17 Ciphergen Biosystems, Inc. Biochips with surfaces coated with polysaccharide based hydrogels
JP4891982B2 (ja) * 2008-12-15 2012-03-07 スガツネ工業株式会社 ２軸ヒンジ装置及び携帯機器
CN103739499B (zh) * 2011-10-24 2016-09-07 尼科斯科学爱尔兰公司 醌基一氧化氮供体化合物

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2139364A (en) * 1937-03-22 1938-12-06 Shell Dev Alpha-substituted glycerol nitrates
NL49919C (fi) * 1938-02-10
US2294849A (en) * 1938-08-20 1942-09-01 Sharples Chemicals Inc Manufacture of nitric acid esters
US2549687A (en) * 1947-11-21 1951-04-17 Duriron Co Heat exchanger
GB713329A (en) * 1951-01-08 1954-08-11 Nat Res Dev Improvements in or relating to production of nitric acid esters of higher alcohols and glycols
US2683164A (en) * 1951-12-21 1954-07-06 Trojan Powder Co Preparation of 1, 2, 6-hexanetriol trinitrate
US2742492A (en) * 1954-07-29 1956-04-17 Ethyl Corp Nitrate formulations
NL98269C (fi) * 1956-02-24
NL110701C (fi) * 1960-03-14
US3428667A (en) * 1962-09-20 1969-02-18 Aerojet General Co N,n-dinitramines of certain organic compounds and process
US3419571A (en) * 1966-04-06 1968-12-31 Warner Lambert Pharmaceutical Method for relieving coronary insufficiency
US3409620A (en) * 1967-02-06 1968-11-05 Mario Biazzi Sa Dr Ing Continuous manufacture in vacuum of nitric esters and/or organic nitro compounds
US3470231A (en) * 1967-05-29 1969-09-30 Us Navy Method of stabilizing nitric acid esters
US3853891A (en) * 1971-06-16 1974-12-10 Sandoz Ag N-(n-(cyanoalkyl)-n-nitroso)amino-aminoalcohol
US4336408A (en) * 1977-11-25 1982-06-22 Thiokol Corporation 2-Hydroxymethyl-1,3-propanediol preparation
JPS56113748A (en) * 1980-02-13 1981-09-07 Kowa Co Aminoethanol derivative and its preparation
US4417903A (en) * 1982-10-15 1983-11-29 Ethyl Corporation Diesel fuel composition
DE3305690A1 (de) * 1983-02-18 1984-08-30 Heinrich Mack Nachf., 7918 Illertissen Glycerinmononitrate zur behandlung der angina pectoris
US4479905A (en) * 1983-09-19 1984-10-30 Ethyl Corporation Nitration process
DE3443998A1 (de) * 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3512627A1 (de) * 1985-04-06 1986-10-09 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
NO171904C (no) 1993-05-19
ZA896982B (en) 1990-06-27
DK453089A (da) 1990-03-16
NO893686D0 (no) 1989-09-14
AU4133089A (en) 1990-03-22
EP0359335A3 (en) 1991-03-06
NO893686L (no) 1990-03-16
PT91701A (pt) 1990-03-30
IL91602A0 (en) 1990-04-29
NL8802276A (nl) 1990-04-02
NO171904B (no) 1993-02-08
NZ230631A (en) 1993-01-27
KR900004331A (ko) 1990-04-12
AU638413B2 (en) 1993-07-01
DK453089D0 (da) 1989-09-14
PT91701B (pt) 1995-06-30
EP0359335A2 (en) 1990-03-21
JPH02134316A (ja) 1990-05-23
US5049694A (en) 1991-09-17
FI894349A (fi) 1990-03-16

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Legal Events

Date Code Title Description
FD Application lapsed
MM Patent lapsed

Owner name: CEDONA PHARMACEUTICALS B.V.