NO164981C - Fremgangsmaate for fremstilling av dealkylerte 14-hydroksy-morfinan-alkaloider. - Google Patents
Fremgangsmaate for fremstilling av dealkylerte 14-hydroksy-morfinan-alkaloider.Info
- Publication number
- NO164981C NO164981C NO852091A NO852091A NO164981C NO 164981 C NO164981 C NO 164981C NO 852091 A NO852091 A NO 852091A NO 852091 A NO852091 A NO 852091A NO 164981 C NO164981 C NO 164981C
- Authority
- NO
- Norway
- Prior art keywords
- dealkylated
- hydroxy
- procedure
- preparation
- formula
- Prior art date
Links
- BLUMEJOOWLSPSE-OWCLPIDISA-N (1S,9R,10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-10-ol Chemical class C1CCC[C@@]2(O)[C@]3([H])NCC[C@@]21C1=CC=CC=C1C3 BLUMEJOOWLSPSE-OWCLPIDISA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000020335 dealkylation Effects 0.000 abstract 1
- 238000006900 dealkylation reaction Methods 0.000 abstract 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Chemical group 0.000 abstract 1
- 239000001257 hydrogen Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8408273A FR2564838B1 (fr) | 1984-05-25 | 1984-05-25 | Procede de dealkylation d'alcaloides et intermediaires |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO852091L NO852091L (no) | 1985-11-26 |
| NO164981B NO164981B (no) | 1990-08-27 |
| NO164981C true NO164981C (no) | 1990-12-05 |
Family
ID=9304425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO852091A NO164981C (no) | 1984-05-25 | 1985-05-24 | Fremgangsmaate for fremstilling av dealkylerte 14-hydroksy-morfinan-alkaloider. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0164290B1 (da) |
| JP (1) | JPS60258183A (da) |
| AT (1) | ATE46163T1 (da) |
| AU (1) | AU577379B2 (da) |
| CA (1) | CA1244825A (da) |
| DE (1) | DE3572819D1 (da) |
| DK (1) | DK160048C (da) |
| ES (1) | ES8603893A1 (da) |
| FR (1) | FR2564838B1 (da) |
| NO (1) | NO164981C (da) |
| NZ (1) | NZ212193A (da) |
| PT (1) | PT80519B (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4795813A (en) * | 1981-08-17 | 1989-01-03 | The Florida Board Of Regents On Behalf Of The Florida State University | Synthesis of derivatives of codeine and other 3-O-alkylmorphines |
| US6067749A (en) | 1996-07-11 | 2000-05-30 | Tasmanian Alkaloids Pty. Ltd. | Papaver somniferum strain with high concentration of thebaine and oripavine |
| GB2471802B (en) * | 2006-05-25 | 2011-02-16 | Alpharma | Chemical process |
| GB2444052A (en) * | 2006-05-25 | 2008-05-28 | Alpharma Aps | Processes of preparing morphinan derivatives such as naltrexone and naloxone comprising O- and N-demethylation and reductive alkylation steps |
| GB2438401A (en) * | 2006-05-25 | 2007-11-28 | Alpharma Aps | Preparation of morphinan derivatives comprising N-demethylation, reductive amination and O-demethylation steps |
| US7999104B2 (en) | 2007-06-29 | 2011-08-16 | Brock University | Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids |
| US8962841B2 (en) | 2007-06-29 | 2015-02-24 | Brock University | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids |
| CA2709872C (en) * | 2007-12-17 | 2016-06-14 | Peter X. Wang | Processes for the preparation of normorphinan salts |
| US9131649B2 (en) | 2008-03-07 | 2015-09-15 | Tasmanian Alkaloids Pty. Ltd | Papaver somniferum strain with high concentration of thebaine |
| WO2009122436A2 (en) * | 2008-03-31 | 2009-10-08 | Sun Pharmaceutical Industries Ltd. | An improved process for the preparation of morphinane analogues |
| AU2011263416B2 (en) | 2010-06-11 | 2014-04-10 | Rhodes Technologies | Process for N-dealkylation of tertiary amines |
| CA2802295C (en) | 2010-06-11 | 2016-09-20 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| AU2012253188B2 (en) * | 2011-05-06 | 2016-12-22 | Brock University | Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4141807A (en) * | 1977-03-01 | 1979-02-27 | Stauffer Chemical Company | Photopolymerizable composition stabilized with nitrogen-containing aromatic compounds |
| DE2727805A1 (de) * | 1977-06-21 | 1979-01-04 | Goedecke Ag | Verfahren zur herstellung von oxynormorphon |
| US4390699A (en) * | 1981-07-16 | 1983-06-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | 6-Keto-morphinans belonging to the 14-hydroxy-series |
| US4472253A (en) * | 1981-08-17 | 1984-09-18 | The Florida Board Of Regents On Behalf Of The Florida State University | Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative |
| FR2533561B1 (fr) * | 1982-09-24 | 1986-07-25 | Poudres & Explosifs Ste Nale | Procede de preparation des carbamates vinyliques et nouveaux carbamates vinyliques |
-
1984
- 1984-05-25 FR FR8408273A patent/FR2564838B1/fr not_active Expired
-
1985
- 1985-05-21 EP EP85400996A patent/EP0164290B1/fr not_active Expired
- 1985-05-21 DE DE8585400996T patent/DE3572819D1/de not_active Expired
- 1985-05-21 AT AT85400996T patent/ATE46163T1/de not_active IP Right Cessation
- 1985-05-21 ES ES543338A patent/ES8603893A1/es not_active Expired
- 1985-05-22 CA CA000482102A patent/CA1244825A/en not_active Expired
- 1985-05-22 DK DK227685A patent/DK160048C/da not_active IP Right Cessation
- 1985-05-23 PT PT80519A patent/PT80519B/pt not_active IP Right Cessation
- 1985-05-24 NZ NZ212193A patent/NZ212193A/xx unknown
- 1985-05-24 JP JP60113016A patent/JPS60258183A/ja active Pending
- 1985-05-24 NO NO852091A patent/NO164981C/no unknown
- 1985-05-24 AU AU42843/85A patent/AU577379B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DK160048B (da) | 1991-01-21 |
| PT80519B (pt) | 1988-01-22 |
| EP0164290A1 (fr) | 1985-12-11 |
| ES543338A0 (es) | 1986-01-01 |
| ES8603893A1 (es) | 1986-01-01 |
| DK227685D0 (da) | 1985-05-22 |
| AU577379B2 (en) | 1988-09-22 |
| FR2564838A1 (fr) | 1985-11-29 |
| JPS60258183A (ja) | 1985-12-20 |
| DK227685A (da) | 1985-11-26 |
| NO164981B (no) | 1990-08-27 |
| FR2564838B1 (fr) | 1986-11-07 |
| NZ212193A (en) | 1988-10-28 |
| CA1244825A (en) | 1988-11-15 |
| ATE46163T1 (de) | 1989-09-15 |
| AU4284385A (en) | 1985-11-28 |
| NO852091L (no) | 1985-11-26 |
| PT80519A (fr) | 1985-06-01 |
| DK160048C (da) | 1991-06-17 |
| DE3572819D1 (en) | 1989-10-12 |
| EP0164290B1 (fr) | 1989-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO164981C (no) | Fremgangsmaate for fremstilling av dealkylerte 14-hydroksy-morfinan-alkaloider. | |
| FI852974A0 (fi) | Nya n-hydroxylgruppen skyddande grupper och framstaellningsfoerfarande foer 3-acylamino-1-hydroxi-2-azetidinoner. | |
| GR3003548T3 (da) | ||
| DE69031534D1 (de) | Verfahren zur Herstellung von optisch aktiven Zyklobutannukleosiden | |
| ATE21105T1 (de) | 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate. | |
| KR840001175A (ko) | [3H]-이미다조 [5,1-d]-1,2,3,5- 테트라진-4-온 유도체의 제조방법 | |
| HUT40638A (en) | Process for producing 1,2-dithiolane-3-pentanoic acid | |
| DK0402339T3 (da) | Fremgangsmåde til fremstilling af carbonatestere | |
| ES8104323A1 (es) | Un procedimiento para obtener 2,6-diaminonebularinas | |
| SE8501679L (sv) | Stereokontrollerat acetoxiazetidinon-forfarande | |
| BR8705870A (pt) | Processo para a producao de um uretano,composto e composicao curavel | |
| CA1273347C (da) | ||
| GB8907008D0 (en) | Intermediates useful for the synthesis for delphinidin chloride | |
| ES8202561A1 (es) | Un procedimiento para la produccion de 11,12-carbonato de eritromicilamina | |
| DE3260782D1 (en) | Method for the preparation of 1,1'-diacetals | |
| JPS55133325A (en) | Manufacture of pentadienol | |
| JPS54109943A (en) | Preparation of phenylglycine derivative | |
| ES521004A0 (es) | Un procedimiento para preparar p-clorofenoxiacetil-piperonilpiperacina. | |
| ATE26259T1 (de) | Verfahren zur herstellung von 3-cyano-4aminoacetophenonen. | |
| ZA874579B (en) | Process for preparing 2-methyl-2(methylthio)propionaldehyde 0-(methylcarbomoyl)oxime as a water-wet cake | |
| ES8306757A1 (es) | "procedimiento para la obtencion de derivados del acido penicilanico con accion inhibidora sobre las 8 -lactamasas". | |
| JPS54141715A (en) | Synthesis of saccharose by carbon dioxide |