ATE46163T1 - Verfahren zur dealkylierung von alkaloiden und zwischenprodukte. - Google Patents

Verfahren zur dealkylierung von alkaloiden und zwischenprodukte.

Info

Publication number
ATE46163T1
ATE46163T1 AT85400996T AT85400996T ATE46163T1 AT E46163 T1 ATE46163 T1 AT E46163T1 AT 85400996 T AT85400996 T AT 85400996T AT 85400996 T AT85400996 T AT 85400996T AT E46163 T1 ATE46163 T1 AT E46163T1
Authority
AT
Austria
Prior art keywords
dealkylation
alkaloids
formula
processes
see diagramm
Prior art date
Application number
AT85400996T
Other languages
English (en)
Inventor
Christian Mazet De L Esco Hoff
Cabanette
Christian Vergely
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of ATE46163T1 publication Critical patent/ATE46163T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT85400996T 1984-05-25 1985-05-21 Verfahren zur dealkylierung von alkaloiden und zwischenprodukte. ATE46163T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8408273A FR2564838B1 (fr) 1984-05-25 1984-05-25 Procede de dealkylation d'alcaloides et intermediaires
EP85400996A EP0164290B1 (de) 1984-05-25 1985-05-21 Verfahren zur Dealkylierung von Alkaloiden und Zwischenprodukte

Publications (1)

Publication Number Publication Date
ATE46163T1 true ATE46163T1 (de) 1989-09-15

Family

ID=9304425

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85400996T ATE46163T1 (de) 1984-05-25 1985-05-21 Verfahren zur dealkylierung von alkaloiden und zwischenprodukte.

Country Status (12)

Country Link
EP (1) EP0164290B1 (de)
JP (1) JPS60258183A (de)
AT (1) ATE46163T1 (de)
AU (1) AU577379B2 (de)
CA (1) CA1244825A (de)
DE (1) DE3572819D1 (de)
DK (1) DK160048C (de)
ES (1) ES8603893A1 (de)
FR (1) FR2564838B1 (de)
NO (1) NO164981C (de)
NZ (1) NZ212193A (de)
PT (1) PT80519B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US6067749A (en) 1996-07-11 2000-05-30 Tasmanian Alkaloids Pty. Ltd. Papaver somniferum strain with high concentration of thebaine and oripavine
GB2471802B (en) * 2006-05-25 2011-02-16 Alpharma Chemical process
GB2471801B (en) * 2006-05-25 2011-02-16 Alpharma Process useful in the preparation of morphine antagonists
GB2444052A (en) * 2006-05-25 2008-05-28 Alpharma Aps Processes of preparing morphinan derivatives such as naltrexone and naloxone comprising O- and N-demethylation and reductive alkylation steps
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
US7999104B2 (en) * 2007-06-29 2011-08-16 Brock University Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
WO2009078989A1 (en) * 2007-12-17 2009-06-25 Mallinckrodt Inc. Processes for the preparation of normorphinan salts
US9131649B2 (en) 2008-03-07 2015-09-15 Tasmanian Alkaloids Pty. Ltd Papaver somniferum strain with high concentration of thebaine
US8546572B2 (en) * 2008-03-31 2013-10-01 Sun Pharmaceutical Industries Limited Process for the preparation of morphinane analogues
AU2011263417B2 (en) 2010-06-11 2014-03-27 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
WO2011154826A1 (en) 2010-06-11 2011-12-15 Rhodes Technologies Process for n-dealkylation of tertiary amines
CN103619847A (zh) 2011-05-06 2014-03-05 布鲁克大学 通过金属催化n-脱甲基化/官能化以及分子内基团转移制备吗啡类似物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141807A (en) * 1977-03-01 1979-02-27 Stauffer Chemical Company Photopolymerizable composition stabilized with nitrogen-containing aromatic compounds
DE2727805A1 (de) * 1977-06-21 1979-01-04 Goedecke Ag Verfahren zur herstellung von oxynormorphon
US4390699A (en) * 1981-07-16 1983-06-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 6-Keto-morphinans belonging to the 14-hydroxy-series
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
DE3381560D1 (de) * 1982-09-24 1990-06-21 Poudres & Explosifs Ste Nale Vinylcarmabate und herstellungsverfahren.

Also Published As

Publication number Publication date
JPS60258183A (ja) 1985-12-20
ES543338A0 (es) 1986-01-01
FR2564838A1 (fr) 1985-11-29
NZ212193A (en) 1988-10-28
EP0164290B1 (de) 1989-09-06
DE3572819D1 (en) 1989-10-12
NO852091L (no) 1985-11-26
NO164981B (no) 1990-08-27
CA1244825A (en) 1988-11-15
EP0164290A1 (de) 1985-12-11
AU577379B2 (en) 1988-09-22
PT80519A (fr) 1985-06-01
DK160048C (da) 1991-06-17
PT80519B (pt) 1988-01-22
AU4284385A (en) 1985-11-28
FR2564838B1 (fr) 1986-11-07
DK227685A (da) 1985-11-26
ES8603893A1 (es) 1986-01-01
NO164981C (no) 1990-12-05
DK160048B (da) 1991-01-21
DK227685D0 (da) 1985-05-22

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee