NO151964B - Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-fenyl-3-(4-pipieridyl)-propaner - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-fenyl-3-(4-pipieridyl)-propaner Download PDF

Info

Publication number
NO151964B
NO151964B NO793943A NO793943A NO151964B NO 151964 B NO151964 B NO 151964B NO 793943 A NO793943 A NO 793943A NO 793943 A NO793943 A NO 793943A NO 151964 B NO151964 B NO 151964B
Authority
NO
Norway
Prior art keywords
percent
per cent
alloy
manganese
zinc
Prior art date
Application number
NO793943A
Other languages
English (en)
Other versions
NO151964C (no
NO793943L (no
Inventor
Alain Champseix
Gerard Le Fur
Original Assignee
Pharmindustrie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmindustrie filed Critical Pharmindustrie
Publication of NO793943L publication Critical patent/NO793943L/no
Publication of NO151964B publication Critical patent/NO151964B/no
Publication of NO151964C publication Critical patent/NO151964C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

Kobberlegering inneholdende mangan og aluminium, med høy motstandsevne mot ka vi tas jon - erosjonskorrosjon i sjøvann.
Foreliggende oppfinnelse angår kobberlegeringer som inneholder mangan og aluminium og som har høy motstandsevne mot kavitasjon-erosjonskorrosjon i sjø-vann.
Det er kjent en legering som består
av 1—5 pst. jern, 1—6 pst. nikkel, 6—9 pst. aluminium, 10—15 pst. mangan og resten i det vesentlige kobber. Dessuten er det kjent en monofase smilegering inneholdende mindre enn 5 pst. jern, mindre enn 6 pst. nikkel, mellom 5 og 20 pst. mangan,
1—7 pst. aluminium og 0,01—0,2 pst. arsen,
antimon eller fosfor, og resten kobber. Arsen, antimon eller fosfor øker korrosjonsmotstandsevnen ved å hindre at aluminium ekstraheres fra legeringen. Slike kjente legeringer har særlig en sammensetning mellom 5 og 13 pst. mangan og forsøk er utført med en legering på 12 pst. mangan.
Det er videre kjent en legering som
har 8,5—10 pst. mangan, 8,5—10,5 pst. aluminium, 2,5—5 pst. jern, 2—3 pst. nikkel, mindre enn 0,25 pst. forurensninger, slik som sink, bly og silicium, og resten kobber.
Slike legeringer har god motstandsevne mot korrosjon, og kavitasjon-erosjonskorrosjon i sjøvann.
Det norske patent nr. 107 218 tilhøren-de samme oppfinner, vedrører en legering med følgende sammensetning:
1— 9 pst. jern
0— 7 pst. nikkel + kobolt
3—14 pst. nikkel + kobolt -{- jern
3— 9 pst. aluminium 1— 7 pst. sink
17—21 pst. mangan,
idet resten er kobber og vanlige forurensninger.
Denne legering har et temmelig kon-stant manganinnhold, idet en variasjon på fra 17 til 21 pst. ikke har stor innvirkning på legeringens karakteristika.
Ovenstående legerings fordel består i at den har gode egenskaper, både mekaniske og korrosjons-messige, hvilket gjør den egnet til f. eks. skipspropellere, og en annen fordel består i at man kan korrigere smeiten ikke bare ved å variere aluminiuminnholdet, men også sinkinnholdet.
Man vil således se at et nytt område for kobberlegeringer inneholdende mangan og aluminium gir meget gode egenskaper og gir muligheter for en enda bedre korri-gering og modifisering av det smeltede bad.
Foreliggende oppfinnelse foreslår å anvende et manganinnhold på 10—16 pst. i stedet for de ovenfor angitte 17—21 pst., som er beskyttet ifølge ovennevnte patent. En slik legering gir gode mekaniske og korrosjonsmotstandsdyktige egenskaper og det blir derved oppnådd en enda bedre korreksjons-mulighet for det smeltede bad, nemlig ved ikke bare å variere aluminium og sinkinnholdet, men også manganinnholdet. For en legering inneholdende 17—21 pst. mangan vil den maksimale variasjon av manganinnholdet bare være omkring 20 pst. av den minimale mengde tilsatt, mens en legering inneholdende 10—16 pst. vil gi muligheter for en 60 pst. variasjon i forhold til minimalmengden mangan.
Aluminium er svært avgjørende når det gjelder påvirkning på forskjellige karakteristika for legeringen, som f. eks. hårdheten.
Sink har en såkalt aluminiumekvivalent på omkring 0,3 til 0,4 og mangan har en ekvivalent på 0,1 til 0,2, hvilket betyr at en variasjon på 1 pst. sink har omkring samme virkning på nevnte karakteristika som 0,3 til 0,4 pst. aluminium og 1 pst. mangan vil ha samme innvirkning som 0,1 til 0,2 pst. aluminium. Dette betyr at man får stor frihet ved variasjon av de ønskede karakteristika for forskjellig an-vendelse av legeringene.
Sink nedsetter legeringens smeltepunkt, hvilket betyr en fabrikasjonsfordel.
Den overraskende karakter av foreliggende oppfinnelse vil fremgå av at man til nå i sammenlignbare legeringer inneholdende relativt mye mangan, overhodet ikke har brukt sink. I denne anledning skal det bemerkes at man kjenner en legering inneholdende 1—5 pst. jern, 1—6 pst. nikkel, 69 pst. aluminium, 10—15 pst. mangan og resten kobber. I publikasjonen fra «British Standards Institution»: B. S. 1400: 1961: «Schedule of Copper Alloy Ingots and Copper Alloy Castings», sidene 65—68, vedrørende mangan-aluminium-kobber-legeringer, er det en forutsetning at sink ikke er tilstede.
Fransk patent nr. 1 126 069 beskriver
legeringer med et meget lavere manganinnhold enn i henhold til foreliggende oppfinnelse eller ovenstående patent, nemlig 8 pst. Aluminiuminnholdet skal være minst 8 pst. for å oppnå de nødvendige mekaniske karakteristika. Det stilles i henhold til det franske patent helt andre krav enn
til foreliggende legering, bl. a. skal jern-innholdet være 3 ganger nikkelinnholdet. De fordeler som frembringes i henhold til foreliggende oppfinnelse fåes således ikke i henhold til det franske patent.
Foreliggende oppfinnelse er således
basert på den overraskende idé at korrosjonsmotstandsevnen, og særlig motstands-evnen mot kavitasjon-erosjonskorrosjon av slike legeringer i sjøvann, særlig ved høye relative vannhastigheter kan forbedres ved slike kjente manganinnhold (ca. 10—16
pst.), mens det opprettholdes gode mekaniske egenskaper, slik som strekkstyrke, 0,2 pst. flytegrense, total forlengelse, inn-snøring ved brudd og utmattingsstyrke under dreiebøyning både i luft og i sjøvann
uten økning av smeltepunkt, og mens det opprettholdes god sveisbarhet, deformer-ingsevne i varm tilstand og ekstruderings-evne hvis en slik legering fremstilles med følgende sammensetning:
1— 9 pst. jern,
0— 7 pst. nikkel + kobolt,
3— 9 pst. aluminium,
3—14 pst. nikkel + kobolt + jern,
10—16 pst. mangan,
1— 7 pst. sink,
10—16 pst. mangan,
resten kobber og vanlige forurensnin-
ger.
Det har videre vist seg at sink kan erstatte en del av aluminium med hensyn til innvirkning på mekanisk karakteris-
tikk og på utfelling av jernrik fase under størkning av den smeltede legering, hvilket influerer bl. a. på korrosjonsmotstandsevnen. Dette betyr at under fremstilling av det smeltede bad av legeringen, kan ikke bare aluminium (og eventuelt mangan), men også sink anvendes for å korrigere forholdene og sammensetningen og endelig legeringens karakteristikk. Dette øker fri-heten ved fremstillingen. Innvirkningen av aluminium er så utpreget at aluminium-prosenten er sterkt kritisk, og at små av-vikelser i aluminiuminnhold har stor innvirkning. Sink er mindre kritisk i denne henseende.
Det har vist seg at sink har en såkalt aluminiumekvivalent på ca. 0,3—0,4. Det fremgår av dette at det kan tilsettes langt mere sink uten store forandringer i karak-teristikken enn aluminium ville medføre.
Sink har et langt lavere smeltepunkt
enn mangan, som. har lavere aluminiumekvivalent enn sink, nemlig ca. 0,1—0,2. Således er mindre sink enn mangan nød-vendig for samme effekt, og mink er ikke bare mere økonomisk enn mangan, men med det lave smeltepunkt for sink er det mulig å fremstille det smeltede bad hur-tigere og med mindre varmeenergi, særlig med hensyn til badets endelige korreksjo-ner.
Den overraskende karakter ved foreliggende oppfinnelse kan forklares fra det faktum at inntil nå ble det i sammenlignbare legeringer med forholdsvis høyt manganinnhold ikke anvendt noe sink i det hele tatt, slik som i den ovenfor angitte legering med 1—5 pst. jern, 1—6 pst. nikkel, 6—9 pst. aluminium, 10—15 pst. mangan, resten kobber. I publikasjonen British Standards Institution: B. S. 1400: 1961:
Schedule of Copper Alloy Ingots and Cop-
per Alloy Castings, sidene 65—68, tas for
mangan-aluminiumkobberlegeringer totalt fravær av sink som basis.
Oppfinnelsen vil i det følgende bli be-skrevet ved hjelp av eksempler:
Eksempel 1.
Følgende elementer ble smeltet sam-men i en egnet ovn:
6.6 pst. jern,
2.7 pst. nikkel,
6,7 pst. aluminium,
11,7 pst. mangan,
1,8 pst. sink,
resten kobber og vanlige forurensninger.
Legeringen ble støpt i en sandform bundet med sement. Undersøkelser av en prøve av denne legering ga følgende ver-dier: strekkstyrke: 67 kg/mm<2>, forlengelse ved brudd: 30 pst. (l/d=5), innsnøring ved brudd: 34,4 pst.
Eksempel 2.
I en egnet ovn ble det fremstilt en legering som hadde følgende sammensetning:
6.0 pst. jern,
2,7 pst. nikkel,
6,4 pst. aluminium,
12,2 pst. mangan,
5,2 pst. sink,
resten kobber og vanlige forurensninger.
En prøve ga en
strekkstyrke på: 72,7 kg/mm<2>
og en
forlengelse ved brudd på 25,5 pst. (l/d=5).
Eksempel 3.
Det ble fremstilt en legering med føl-gende sammensetning:
3,2 pst. jern,
2,7 pst. nikkel,
8.1 pst. aluminium,
11,9 pst. mangan,
3,6 pst. sink,
resten kobber og vanlige forurensninger.
Det ble undersøkt en prøve som ga følgende resultater: strekkstyrke: 80,7 kg/mm<2 >forlengelse ved brudd: 19,5 pst. (l/d=5) innsnøring ved brudd: 17 pst.
Eksempel 4.
Det ble fremstilt en legering med føl-gende sammensetning:
6.8 pst. jern,
0,14 pst. nikkel,
7,1 pst. aluminium,
10,8 pst. mangan,
4.9 pst. sink,
resten kobber og vanlige forurensninger.
En prøve ga:
strekkstyrke: 68,3 kg/mm<2>, forlengelse ved brudd: 30 pst. (l/d=5), innsnøring ved brudd: 38 pst.
Eksempel 5.
Det ble fremstilt en legering med føl-gende sammensetning:
6.6 pst. jern,
5.0 pst. nikkel,
5,8 pst. aluminium,
15.4 pst. mangan,
4,3 pst. sink,
resten kobber og vanlige forurensninger.
En prøve ga:
strekkstyrke: 72,3 kg/mm<2>, forlengelse ved brudd: 16 pst. (l/d=5), innsnøring ved brudd: 15,4 pst.
Eksempel 6.
Det ble fremstilt en legering med føl-gende sammensetning:
6,5 pst. jern,
2.7 pst. nikkel,
6,5 pst. aluminium,
11.5 pst. mangan,
4.1 pst. sink,
resten kobber og vanlige forurensninger.
Undersøkelse av en prøve ga følgende resultater: strekkstyrke: 67,9 kg/mm<2>, 0,2 pst. flytegrense: 29,6 kg/mm<2>, forlengelse ved brudd: 25 pst. (l/d=5).
Denne legering ble med hensyn på korrosjonsmotstandsevne og kavitasjon-erosjons-korrosjonsmotstandsevne i sjøvann ved en hastighet på 38 meter/sek., sammenlignet med følgende kjente mangan - aluminium-kobberlegering: jern 2,74 pst., nikkel 2,03 pst., aluminium 8,45 pst., mangan 12,04 pst., resten kobber og forurensninger.
Aluminiumekvivalent 10,25, strekkstyrke: 68,5 kg/mm<2>, 0,2 pst. flytegrense: 30,8 kg/mm<2>
forlengelse ved brudd: 18,3 pst. (l/d=5).
Det fremgikk fra sammenligningen at korrosjonsmotstandsevnen for legeringen, ifølge foreliggende oppfinnelse, eksempel 6, var ca. 60 pst. høyere enn for den nevnte kjente legering. Kavitasjon-erosjons-korrosjonsmotstandsevnen var ca. 100 pst. bedre enn for den nevnte kjente legering.
Eksempel 7.
Det ble fremstilt en legering med føl-gende sammensetning: 2,7 pst. jern,
2,9 pst. nikkel, 6,7 pst. aluminium,
12,2 pst. mangan, 4.4 pst. sink,
resten kobber og vanlige forurensninger.
Undersøkelse av en prøve ga: strekkstyrke: 72,6 kg/mm<2>, 0,2 pst. flytegrense: 31,7 kg/mm<2>, forlengelse ved brudd: 22,9 pst. (l/d=5).
Legeringen ble undersøkt som angitt under eksempel 6, og sammenlignet med den kjente legering angitt i det nevnte eksempel. Korrosjonsmotstandsevnen for legeringen ifølge oppfinnelsen var ca. 15 pst. bedre enn for den nevnte kjente legering. Kavitasj on-erosj ons-korros j onsmot-standsevnen var også i dette tilfelle ca. 100 pst. bedre enn for den nevnte kjente legering.
Legeringen ifølge eksempel 7 ble eks-trudert og en prøve av denne ekstruderte legering hadde en strekkstyrke på 65 kg/ mm<2>, en 0,2 pst. flytegrense på 42 kg/mm<2> og en forlengelse ved brudd på 32 pst. (l/d=5).
Eksempel 8.
Det ble fremstilt en legering med føl-gende sammensetning: 4.5 pst. jern, 2,1 pst. nikkel, 0,8 pst. kobolt, 6,4 pst. aluminium, 12,1 pst. mangan, 4,9 pst. sink, resten kobber og forurensninger. Undersøkelse av en prøve ga: strekkstyrke: 71,8 kg/mm<2>
forlengelse ved brudd 26,5 pst. (l/d=5)
Alle prosentsatser for legeringsbe-standdeler angitt i foreliggende beskrivelse og i påstandene, er angitt i vektprosent.

Claims (4)

1. Kobberlegering inneholdende mangan og aluminium, med høy motstandsevne mot kavitasjon-erosjonskorrosjon i sjø-mann og med gode mekaniske egenskaper, karakterisert ved at den har føl-gende sammensetning: 1— 9 pst. jern, 0— 7 pst. nikkel + kobolt, 3— 9 pst. aluminium, 3—14 pst. nikkel -f- kobolt + jern, 1— 7 pst. sink, 10—16 pst. mangan, resten kobber og vanlige forurensninger.
2. Legering ifølge påstand 1, karakterisert ved at den har følgende sammensetning: 2— 7 pst. jern, 1—5 pst. nikkel, 5— 8 pst. aluminium, 10—16 pst. mangan, 1,6—5,5 pst. sink, resten kobber og vanlige forurensninger.
3. Legering ifølge påstand 1 eller 2, karakterisert ved at sinkinnholdet er høyere enn 3,5 pst.
4. Legering som angitt i påstand 1 eller 2, karakterisert ved at alumi-niumekvivalenten beregnet som pst. Al + 0,15 x pst.Mn -|- 0,35 x pst.Zn, ligger mellom 7 og 13.
NO793943A 1978-12-05 1979-12-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-fenyl-3-(4-pipieridyl)-propaner NO151964C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7834185A FR2443246A1 (fr) 1978-12-05 1978-12-05 Nouveaux medicaments a base de derives de la phenyl-1 (piperidyl-4)-3 propanone-1

Publications (3)

Publication Number Publication Date
NO793943L NO793943L (no) 1980-06-06
NO151964B true NO151964B (no) 1985-04-01
NO151964C NO151964C (no) 1985-07-10

Family

ID=9215691

Family Applications (1)

Application Number Title Priority Date Filing Date
NO793943A NO151964C (no) 1978-12-05 1979-12-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-fenyl-3-(4-pipieridyl)-propaner

Country Status (10)

Country Link
US (1) US4294841A (no)
EP (1) EP0012643B1 (no)
JP (1) JPS55113715A (no)
CA (1) CA1137485A (no)
DE (1) DE2962158D1 (no)
DK (1) DK508479A (no)
ES (3) ES486596A0 (no)
FR (1) FR2443246A1 (no)
NO (1) NO151964C (no)
PT (1) PT70503A (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3276313D1 (en) * 1981-09-24 1987-06-19 Beecham Wuelfing Gmbh & Co Kg Sulphonamides
DE3309595A1 (de) * 1983-03-17 1984-09-20 Basf Ag, 6700 Ludwigshafen Neue aminopropanolderivate von 1-(2-hydroxy-phenyl)-3-phenyl-propanolen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
MA20246A1 (fr) * 1983-10-14 1985-07-01 Lafon Labor Procede de preparation de nouveaux derives de 1-(acetylaminophenyl)-2 aminopropanone.
FR2560873B1 (fr) * 1984-03-09 1986-09-26 Rhone Poulenc Sante Medicaments a base de derives de la piperidine, nouveaux derives de la piperidine et leurs procedes de preparation
US4642348A (en) * 1984-04-10 1987-02-10 A. H. Robins Company, Incorporated N-(amino)alkyl)-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-positions
JPH0165782U (no) * 1987-10-22 1989-04-27
JPH0165783U (no) * 1987-10-22 1989-04-27
US5821252A (en) * 1988-10-21 1998-10-13 Hoechst Aktiengesellschaft Method of blocking nerve conduction by treatment with branched-chain esters of 2- 4-(2-piperidine-ethoxy)-benzoyl!-benzoic acid and pharmaceutically acceptable salts thereof
US5153206A (en) * 1988-12-02 1992-10-06 Pfizer Inc. Arylpiperidine derivatives
JP2969359B2 (ja) * 1989-01-13 1999-11-02 武田薬品工業株式会社 環状アミン化合物
US5243048A (en) * 1989-09-08 1993-09-07 The Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines
US5266572A (en) * 1989-09-08 1993-11-30 The Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines
US5109002A (en) * 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines
FR2678265B1 (fr) * 1991-06-27 1994-01-14 Synthelabo Derives de 4-(2-phenylethyl)piperidine, leur preparation et leur application en therapeutique.
WO1994001403A1 (en) * 1992-07-08 1994-01-20 Shell Internationale Research Maatschappij B.V. Piperidine derivatives
GB9226111D0 (en) * 1992-12-15 1993-02-10 Smithkline Beecham Plc Madicaments
ATE171446T1 (de) * 1993-05-26 1998-10-15 Syntex Inc 1-phenylalkanone als 5-ht4 rezeptor ligande
KR100403246B1 (ko) * 1995-09-28 2004-02-11 가켄 세이야쿠 가부시키가이샤 ４-메틸렌피페리딘의제조방법
EP2865381A1 (en) 2006-05-18 2015-04-29 Pharmacyclics, Inc. ITK inhibitors for treating blood cell malignancies
WO2013010885A1 (en) 2011-07-15 2013-01-24 Basf Se Fungicidal alkyl- and aryl-substituted 2-[2-chloro-4-(dihalo-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2833776A (en) * 1958-05-06 Aryl-substituted psperidylpropanols
GB395231A (en) * 1932-06-27 1933-07-13 Goodyear Tire & Rubber Hydrogenation of heterocyclic compounds
US3637712A (en) * 1970-01-26 1972-01-25 Bristol Myers Co Piperidylpropanol compounds
US4181803A (en) * 1973-12-14 1980-01-01 Eisai Co., Ltd. Propiophenone derivatives and preparation thereof

Also Published As

Publication number Publication date
DK508479A (da) 1980-06-06
ES493441A0 (es) 1981-07-01
US4294841A (en) 1981-10-13
EP0012643B1 (fr) 1982-02-17
ES8105980A1 (es) 1981-07-01
EP0012643A3 (en) 1980-10-01
ES8106499A1 (es) 1981-07-01
ES493440A0 (es) 1981-07-01
ES8104230A1 (es) 1981-03-16
ES486596A0 (es) 1981-03-16
FR2443246B1 (no) 1982-04-30
JPS55113715A (en) 1980-09-02
JPS6230988B2 (no) 1987-07-06
NO151964C (no) 1985-07-10
FR2443246A1 (fr) 1980-07-04
PT70503A (fr) 1979-12-01
EP0012643A2 (fr) 1980-06-25
DE2962158D1 (en) 1982-03-25
CA1137485A (fr) 1982-12-14
NO793943L (no) 1980-06-06

Similar Documents

Publication Publication Date Title
NO151964B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-fenyl-3-(4-pipieridyl)-propaner
US5376192A (en) High strength, high toughness aluminum-copper-magnesium-type aluminum alloy
US7550110B2 (en) Al-Zn-Mg-Cu alloys and products with improved ratio of static mechanical characteristics to damage tolerance
US20090074606A1 (en) Low density titanium alloy, golf club head, and process for prouducing low density titanium alloy part
JPH0372147B2 (no)
KR101536402B1 (ko) 고강도이면서 냉간 압연성이 우수한 타이타늄 합금재
EP1078108A1 (en) Aluminium alloy for use in a brazed assembly
US4584173A (en) Aluminium alloys
US3297437A (en) Copper base alloys containing manganese and aluminium
US6106643A (en) Hot working high-chromium alloy
CA1076396A (en) Matrix-stiffened heat and corrosion resistant alloy
NO149914B (no) Fremgangsmaate til fremstilling av en stabil, steril vandig opploesning av cisplatina (ii)diamindiklorid paa enhetsdoseform
EP3196321B1 (en) Economically alloyed titanium alloy with predictable properties
JPS61104043A (ja) 耐熱高強度アルミニウム合金粉末焼成品
NO144699B (no) Fremgangsmaate for fremstilling av et plateformet produkt.
US3323913A (en) Copper base alloys containing manganese, aluminum and zinc
JP4180868B2 (ja) 成形性に優れた展伸用マグネシウム薄板およびその製造方法
JPH0246662B2 (no)
RU2576286C2 (ru) Сплав на основе алюминия
US3488188A (en) Copper-nickel alloys
US3079252A (en) Copper-base alloys
US2003297A (en) Aluminum alloy
JP7473423B2 (ja) 成形性に優れたＡｌ－Ｍｇ－Ｓｉ系アルミニウム合金板
CN105349855A (zh) 一种耐腐蚀耐磨铝管及其制备方法
US1556953A (en) Alloy