NO137012C - Analogifremgangsm}te for fremstilling av terapeutisk aktive pyrazolo (1,5-a)-pyrimidiner - Google Patents

Analogifremgangsm}te for fremstilling av terapeutisk aktive pyrazolo (1,5-a)-pyrimidiner

Info

Publication number
NO137012C
NO137012C NO4476/72A NO447672A NO137012C NO 137012 C NO137012 C NO 137012C NO 4476/72 A NO4476/72 A NO 4476/72A NO 447672 A NO447672 A NO 447672A NO 137012 C NO137012 C NO 137012C
Authority
NO
Norway
Prior art keywords
pyrimidines
preparation
therapeutic active
analogical procedure
active pyrazolo
Prior art date
Application number
NO4476/72A
Other languages
English (en)
Norwegian (no)
Other versions
NO137012B (no
Inventor
Roland Kenith Robins
Brien Darrell Eugene O
Thomas Novinson
Robert Henry Springer
Original Assignee
Icn Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US245870A external-priority patent/US3925385A/en
Application filed by Icn Pharmaceuticals filed Critical Icn Pharmaceuticals
Publication of NO137012B publication Critical patent/NO137012B/no
Publication of NO137012C publication Critical patent/NO137012C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO4476/72A 1971-12-09 1972-12-06 Analogifremgangsm}te for fremstilling av terapeutisk aktive pyrazolo (1,5-a)-pyrimidiner NO137012C (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20653871A 1971-12-09 1971-12-09
US245870A US3925385A (en) 1972-04-20 1972-04-20 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
US27346572A 1972-07-20 1972-07-20
US29984072A 1972-10-24 1972-10-24

Publications (2)

Publication Number Publication Date
NO137012B NO137012B (no) 1977-09-05
NO137012C true NO137012C (no) 1977-12-14

Family

ID=27498614

Family Applications (1)

Application Number Title Priority Date Filing Date
NO4476/72A NO137012C (no) 1971-12-09 1972-12-06 Analogifremgangsm}te for fremstilling av terapeutisk aktive pyrazolo (1,5-a)-pyrimidiner

Country Status (15)

Country Link
JP (1) JPS4864097A (enExample)
BE (1) BE792533A (enExample)
BG (1) BG22401A3 (enExample)
CH (1) CH603652A5 (enExample)
DD (1) DD104530A5 (enExample)
DE (1) DE2257547A1 (enExample)
GB (1) GB1412017A (enExample)
HU (1) HU168530B (enExample)
IE (1) IE37189B1 (enExample)
IL (1) IL40895A (enExample)
LU (1) LU66597A1 (enExample)
NL (1) NL7216539A (enExample)
NO (1) NO137012C (enExample)
RO (1) RO62762A (enExample)
SE (1) SE398751B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
AU557300B2 (en) * 1982-03-16 1986-12-18 Farmitalia Carlo Erba S.P.A. Substituted 1h-pyrazolo(1,5-alpha)pyrimidines and processes for their preparation
ZA831407B (en) * 1982-03-25 1983-11-30 Erba Farmitalia Substituted ethenyl derivatives of 1h-pyrazolo(1,5-a)pyrimidine and process for their preparation
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
DE3533050A1 (de) * 1985-09-17 1987-03-26 Basf Ag 7-amino-azolo(1,5-a)pyrimidine, verfahren zu ihrer herstellung und diese enthaltende fungizide, bzw. deren verwendung als fungizide
CA1330079C (en) * 1988-10-13 1994-06-07 Michihiko Tsujitani Pyrrolo (3,2-e)pyrazolo(1,5-a)pyrimidine derivative and medicine comprising the same
CA2107479C (en) * 1991-04-22 1997-12-16 Makoto Inoue Pyrazolo[1,5-a]pyrimidine derivatives and anti-inflammatory agent containing the same
DE4333705C2 (de) * 1993-10-02 2003-10-30 Guenter Ege Arylmethylsubstituierte Pyrazolo-azine, insbesondere 3-Arylmethylpyrazolo[1,5-a]pyrimidine und Verfahren zur Herstellung von 8-Arylmethyl-pyrazolo[5,1-c][1,2,4]triazinen
DE69523864T2 (de) * 1994-06-21 2002-06-13 Otsuka Pharmaceutical Factory, Inc. PYRAZOLO[1,5-a] PYRIMIDIN-DERIVATE
EP0795555A4 (en) * 1995-09-28 1998-01-07 Otsuka Pharma Co Ltd ANALGESICS
FR2771631B1 (fr) 1997-12-03 2001-02-02 Oreal Compositions de teinture des fibres keratiniques contenant des 3-amino pyrazolo-[1,5-a]-pyrimidines, procede de teinture, nouvelles 3-amino pyrazolo- [1,5-a]-pyrimidines et leur procede de preparation
CA2497440C (en) * 2002-09-04 2011-03-22 Schering Corporation Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
US7161003B1 (en) * 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7119200B2 (en) * 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
ES2222813B1 (es) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
TWI252851B (en) * 2003-07-24 2006-04-11 Ferrer Int 7-substituted 3-nitro-pyrazolo[1,5-a]pyrimidines and compositions and methods related thereto
BR112015025260B1 (pt) 2013-04-25 2021-11-03 Beigene, Ltd Compostos heterocíclicos fundidos como inibidores da proteína quinase, sua composição, combinação e uso
HRP20221262T1 (hr) 2013-09-13 2022-12-09 Beigene Switzerland Gmbh Protutijela anti-pd1 i njihova uporaba kao terapeutskih i dijagnostičkih sredstava
CN110156892B (zh) 2014-07-03 2023-05-16 百济神州有限公司 抗pd-l1抗体及其作为治疗剂及诊断剂的用途
NZ749997A (en) 2016-07-05 2022-11-25 Beigene Ltd Combination of a pd-l antagonist and a raf inhibitor for treating cancer
WO2018033853A2 (en) 2016-08-16 2018-02-22 Beigene, Ltd. Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof
TWI739887B (zh) 2016-08-19 2021-09-21 英屬開曼群島商百濟神州有限公司 使用包含btk抑制劑的組合產品治療癌症
EP3573989A4 (en) 2017-01-25 2020-11-18 Beigene, Ltd. CRYSTALLINE FORMS OF (S) -7- (1- (BUT-2-YNOYL) PIPERIDIN-4-YL) -2- (4-PHENOXYPHENYL) -4, 5, 6, 7-TETRAHY DROPYRAZOLO [1, 5-A ] PYRIMIDINE-3-CARBOXAMIDE, PREPARATION AND ASSOCIATED USES
TWI877099B (zh) 2017-06-26 2025-03-21 英屬開曼群島商百濟神州有限公司 抗ｐｄ－１抗體或其抗原結合片段在製備治療用於患有肝細胞癌（ｈｃｃ）之藥物的用途
WO2019034009A1 (en) 2017-08-12 2019-02-21 Beigene, Ltd. BTK INHIBITOR WITH ENHANCED DOUBLE SELECTIVITY
US11786529B2 (en) 2017-11-29 2023-10-17 Beigene Switzerland Gmbh Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
TWI856111B (zh) 2019-06-10 2024-09-21 瑞士商百濟神州瑞士有限責任公司 一種含有布魯頓氏酪胺酸激酶抑制劑的口服固體錠劑及其製備方法
US11786531B1 (en) 2022-06-08 2023-10-17 Beigene Switzerland Gmbh Methods of treating B-cell proliferative disorder

Also Published As

Publication number Publication date
BG22401A3 (bg) 1977-02-20
IE37189B1 (en) 1977-05-25
DD104530A5 (enExample) 1974-03-12
NL7216539A (enExample) 1973-06-13
HU168530B (enExample) 1976-05-28
GB1412017A (en) 1975-10-29
JPS4864097A (enExample) 1973-09-05
IE37189L (en) 1973-06-09
BE792533A (fr) 1973-06-08
RO62762A (fr) 1978-05-15
IL40895A0 (en) 1973-01-30
DE2257547A1 (de) 1973-06-14
CH603652A5 (enExample) 1978-08-31
SE398751B (sv) 1978-01-16
LU66597A1 (enExample) 1973-03-15
NO137012B (no) 1977-09-05
IL40895A (en) 1976-12-31

Similar Documents

Publication Publication Date Title
NO137012C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive pyrazolo (1,5-a)-pyrimidiner
NO140301C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazo(5,1-f)-as-triaziner
SE402915B (sv) Forfarande for framstellning av imidazo(5,1-f)triazinoner med terapeutisk verkan
NO136843C (no) Analogifremgangsm}te til fremstilling av terapeutisk aktive derivater av 5,6-dihydro-pyrrolo (3,4-b) pyrazin
SE402592B (sv) Forfarande for framstellning av 2-alkyl-3-acyl-pyrazolo(1,5-a)pyridiner
NO136793C (no) Analogifremgangsm}te til fremstilling av terapeutisk virksomme substituerte 1,2,4-triazolderivater.
NO136837C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive pleuromutiliner
NO136045C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive pyridazinoner.
AR193536A1 (es) Procedimiento para la preparacion de compuestos de pirazolo(1,5a)pirimidina
NO139685C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive isoindolin-derivater
SE396388B (sv) Analogiforfrande for framstellning av 2,3-dihydro-oxo-imidazo-/1,2-a/pyrimidiner
NO136251C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive pyridazin-derivater.
FI54121B (fi) Foerfarande foer framstaellning av blodtryckssaenkande imidazo-(1,2-a)-imidazoler -pyrimidiner och diazepiner och deras syraadditionssalter
SE389499B (sv) Analogiforfarande for framstellning av triazolo(4,3-a)(1,4)bensodiazepin-derivat
SE402012B (sv) Analogiforfarande for framstellning av s-triazolo(1,5-a)(1,4)diazepinderivat
SE410604B (sv) Analogiforfarande for framstellning av pyrazolo(3,4-e)(1,4)diazepinforeningar
SE400551B (sv) Forfarande for framstellning av terapeutiskt aktiva 3-amino-5-karbamylbensoesyraderivat
NO136795C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive indoliner
NO153137C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte pyrido(1,2-a)pyrimidiner.
NO139439C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive pyrazolon-(5)-forbindelser
AR192347A1 (es) Procedimiento para la preparacion de 3-amino-imidazo(1,5-a)piridinas
NO139735C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimido(4,5-b)kinolin-4(3h)-on-derivater
NO136574C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive pyrimidinderivater.
SE380804B (sv) Anologiforfarande for framstellning av s-triazolo (1,5-a) (1,4)
FI55845C (fi) Foerfarande foer framstaellning av en 8-d-ribityl-pyrido(2,3-d)pyrimidin