NO132614B - - Google Patents
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- Publication number
- NO132614B NO132614B NO3731/70A NO373170A NO132614B NO 132614 B NO132614 B NO 132614B NO 3731/70 A NO3731/70 A NO 3731/70A NO 373170 A NO373170 A NO 373170A NO 132614 B NO132614 B NO 132614B
- Authority
- NO
- Norway
- Prior art keywords
- polyethylene glycol
- indomethacin
- carrier medium
- suppositories
- mixture
- Prior art date
Links
- 239000000829 suppository Substances 0.000 claims abstract description 16
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims abstract 3
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 229920001223 polyethylene glycol Polymers 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 238000002844 melting Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229940057838 polyethylene glycol 4000 Drugs 0.000 claims description 3
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 229960000905 indomethacin Drugs 0.000 description 12
- 238000007711 solidification Methods 0.000 description 6
- 230000008023 solidification Effects 0.000 description 6
- 238000002425 crystallisation Methods 0.000 description 4
- 230000008025 crystallization Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000002845 discoloration Methods 0.000 description 2
- 230000032050 esterification Effects 0.000 description 2
- 238000005886 esterification reaction Methods 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4487670A | 1970-06-09 | 1970-06-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO132614B true NO132614B (en, 2012) | 1975-09-01 |
| NO132614C NO132614C (en, 2012) | 1975-12-10 |
Family
ID=21934811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO3731/70A NO132614C (en, 2012) | 1970-06-09 | 1970-10-02 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3644630A (en, 2012) |
| AT (1) | AT297936B (en, 2012) |
| BE (1) | BE756975A (en, 2012) |
| CA (1) | CA933864A (en, 2012) |
| CY (1) | CY760A (en, 2012) |
| DK (1) | DK125306B (en, 2012) |
| FI (1) | FI50832C (en, 2012) |
| FR (1) | FR2094129B1 (en, 2012) |
| GB (1) | GB1284192A (en, 2012) |
| IE (1) | IE34730B1 (en, 2012) |
| IL (1) | IL35383A (en, 2012) |
| MY (1) | MY7400233A (en, 2012) |
| NL (1) | NL144482B (en, 2012) |
| NO (1) | NO132614C (en, 2012) |
| SE (1) | SE353657B (en, 2012) |
| ZA (1) | ZA706715B (en, 2012) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3006024C2 (de) * | 1980-02-18 | 1983-08-04 | Solvon Arzneimittel-Vertriebs- Und Lizenzgesellschaft Mbh, 85011 Burgthann | Topisches, Indomethacin enthaltendes Arzneimittel in Salbenform |
| FR2500302B1 (fr) * | 1981-02-25 | 1985-11-15 | Negma Laboratoires | Nouvelles compositions pharmaceutiques d'indometacine |
| GB2272654B (en) * | 1992-11-02 | 1996-12-18 | Minnesota Mining & Mfg | Antistatic coatings |
| RU2169001C2 (ru) * | 1998-03-03 | 2001-06-20 | Щербак Игорь Федорович | Способ получения гомеопатического суппозитория |
| RU2137468C1 (ru) * | 1998-06-04 | 1999-09-20 | ОАО "Нижегородский химико-фармацевтический завод" | Суппозитории ректальные "апроксид" |
| RU2143261C1 (ru) * | 1999-03-24 | 1999-12-27 | Открытое акционерное общество "Московская фармацевтическая фабрика" | Суппозитории, обладающие слабительным действием |
| US20240024284A1 (en) * | 2022-07-20 | 2024-01-25 | Fulton Medicinali S.P.A. | Indomethacin pharmaceutical composition |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL44885C (en, 2012) * | 1935-11-09 | |||
| US3163576A (en) * | 1961-06-12 | 1964-12-29 | Olin Mathieson | Suppository base comprising glycerin and a diester of polyethylene glycol |
| BR6898229D0 (pt) * | 1967-04-11 | 1973-04-17 | Sumitomo Chemical Co | Processo para a producao de derivados do acido 1-cail-3-indolil-alifatico |
-
0
- BE BE756975D patent/BE756975A/xx not_active IP Right Cessation
-
1970
- 1970-06-09 US US44876A patent/US3644630A/en not_active Expired - Lifetime
- 1970-09-29 NL NL707014320A patent/NL144482B/xx not_active IP Right Cessation
- 1970-10-02 GB GB47028/70A patent/GB1284192A/en not_active Expired
- 1970-10-02 DK DK503570AA patent/DK125306B/da not_active IP Right Cessation
- 1970-10-02 ZA ZA706715A patent/ZA706715B/xx unknown
- 1970-10-02 FI FI702689A patent/FI50832C/fi active
- 1970-10-02 FR FR7035698A patent/FR2094129B1/fr not_active Expired
- 1970-10-02 IE IE1269/70A patent/IE34730B1/xx unknown
- 1970-10-02 NO NO3731/70A patent/NO132614C/no unknown
- 1970-10-02 SE SE13383/70A patent/SE353657B/xx unknown
- 1970-10-02 CA CA094710A patent/CA933864A/en not_active Expired
- 1970-10-04 IL IL35383A patent/IL35383A/xx unknown
- 1970-11-13 AT AT1025470A patent/AT297936B/de not_active IP Right Cessation
-
1974
- 1974-10-05 CY CY76074A patent/CY760A/xx unknown
- 1974-12-30 MY MY233/74A patent/MY7400233A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2094129B1 (en, 2012) | 1974-08-23 |
| IE34730B1 (en) | 1975-08-06 |
| MY7400233A (en) | 1974-12-31 |
| BE756975A (fr) | 1971-04-02 |
| NO132614C (en, 2012) | 1975-12-10 |
| FR2094129A1 (en, 2012) | 1972-02-04 |
| SE353657B (en, 2012) | 1973-02-12 |
| FI50832B (en, 2012) | 1976-04-30 |
| US3644630A (en) | 1972-02-22 |
| AT297936B (de) | 1972-04-10 |
| DK125306B (da) | 1973-02-05 |
| CA933864A (en) | 1973-09-18 |
| GB1284192A (en) | 1972-08-02 |
| CY760A (en) | 1974-10-05 |
| NL144482B (nl) | 1975-01-15 |
| IE34730L (en) | 1971-12-09 |
| ZA706715B (en) | 1972-05-31 |
| IL35383A (en) | 1974-07-31 |
| DE2049112A1 (de) | 1971-12-16 |
| FI50832C (fi) | 1976-08-10 |
| NL7014320A (en, 2012) | 1971-12-13 |
| IL35383A0 (en) | 1970-12-24 |
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