NO126115B - - Google Patents
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- Publication number
- NO126115B NO126115B NO254368A NO254368A NO126115B NO 126115 B NO126115 B NO 126115B NO 254368 A NO254368 A NO 254368A NO 254368 A NO254368 A NO 254368A NO 126115 B NO126115 B NO 126115B
- Authority
- NO
- Norway
- Prior art keywords
- parts
- water
- coating
- soluble
- tablets
- Prior art date
Links
- 239000011248 coating agent Substances 0.000 claims description 36
- 239000006185 dispersion Substances 0.000 claims description 30
- 238000000576 coating method Methods 0.000 claims description 29
- 229920000642 polymer Polymers 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 11
- 239000007787 solid Substances 0.000 claims description 10
- 239000000945 filler Substances 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 239000000203 mixture Substances 0.000 description 16
- 229920001223 polyethylene glycol Polymers 0.000 description 14
- 239000002202 Polyethylene glycol Substances 0.000 description 11
- 239000000454 talc Substances 0.000 description 9
- 229910052623 talc Inorganic materials 0.000 description 9
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 8
- 239000008298 dragée Substances 0.000 description 8
- 229920002689 polyvinyl acetate Polymers 0.000 description 7
- 239000011118 polyvinyl acetate Substances 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 239000002700 tablet coating Substances 0.000 description 6
- 238000009492 tablet coating Methods 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
- 229930006000 Sucrose Natural products 0.000 description 5
- 239000013543 active substance Substances 0.000 description 5
- 210000004051 gastric juice Anatomy 0.000 description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- 229960004793 sucrose Drugs 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 239000000654 additive Substances 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 4
- 210000000813 small intestine Anatomy 0.000 description 4
- 239000004149 tartrazine Substances 0.000 description 4
- 235000012756 tartrazine Nutrition 0.000 description 4
- 239000004408 titanium dioxide Substances 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 3
- 238000007792 addition Methods 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 3
- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 description 3
- 229940068196 placebo Drugs 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 3
- 229960000943 tartrazine Drugs 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 239000004237 Ponceau 6R Substances 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Chemical class 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- -1 chalk Substances 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000004922 lacquer Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000004584 polyacrylic acid Chemical class 0.000 description 2
- 239000004800 polyvinyl chloride Chemical class 0.000 description 2
- 229920000915 polyvinyl chloride Chemical class 0.000 description 2
- 235000019238 ponceau 6R Nutrition 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229920003080 Povidone K 25 Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 150000001241 acetals Chemical class 0.000 description 1
- FUGCXLNGEHFIOA-UHFFFAOYSA-L acid red 44 Chemical compound [Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=CC2=C1 FUGCXLNGEHFIOA-UHFFFAOYSA-L 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000004815 dispersion polymer Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000010327 methods by industry Methods 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 150000003021 phthalic acid derivatives Chemical class 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001290 polyvinyl ester Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 125000005624 silicic acid group Chemical class 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000009751 slip forming Methods 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- 238000004018 waxing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEB0093227 | 1967-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO126115B true NO126115B (fi) | 1972-12-27 |
Family
ID=6986833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO254368A NO126115B (fi) | 1967-06-28 | 1968-06-27 |
Country Status (13)
| Country | Link |
|---|---|
| AT (1) | AT292922B (fi) |
| BE (1) | BE717236A (fi) |
| BR (1) | BR6800174D0 (fi) |
| CH (1) | CH509804A (fi) |
| DE (1) | DE1617351A1 (fi) |
| DK (2) | DK126023B (fi) |
| FI (1) | FI49473C (fi) |
| FR (1) | FR1588833A (fi) |
| GB (1) | GB1213348A (fi) |
| LU (1) | LU56347A1 (fi) |
| NL (1) | NL6809061A (fi) |
| NO (1) | NO126115B (fi) |
| SE (2) | SE373751B (fi) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK152831B (da) * | 1976-09-17 | 1988-05-24 | Richter Gedeon Vegyeszet | Fremgangsmaade ved fremstilling af biologisk aktive praeparater med reguleret afgivelse af aktivt stof samt polymerbaseret vaeskeformigt overtraekspraeparat til anvendelse ved fremgangsmaaden |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE418247B (sv) * | 1975-11-17 | 1981-05-18 | Haessle Ab | Sett att framstella kroppar med reglerad frigoring av en aktiv komponent |
| JPS58502097A (ja) * | 1981-12-18 | 1983-12-08 | キイ・フア−マシユ−テイカルズ・インコ−ポレイテツド | ポリビニルアルコ−ルおよびポリエチレングリコ−ルの拡張性格子 |
| US4428926A (en) | 1981-12-18 | 1984-01-31 | Key Pharmaceuticals, Inc. | Sustained release propranolol system |
| US4428925A (en) | 1981-12-18 | 1984-01-31 | Key Pharmaceuticals, Inc. | Sustained release glycerol trinitrate |
| US4432965A (en) * | 1982-07-09 | 1984-02-21 | Key Pharmaceuticals, Inc. | Quinidine sustained release dosage formulation |
| DE3405378A1 (de) * | 1984-02-15 | 1985-08-22 | Röhm GmbH, 6100 Darmstadt | Arzneimittelueberzug |
| ZA86252B (en) * | 1985-01-30 | 1986-09-24 | Warner Lambert Co | Coated dosage forms |
| EP0298768B1 (en) * | 1987-07-09 | 1994-05-11 | The Wellcome Foundation Limited | Flavoured film-coated tablet |
| ATE192335T1 (de) * | 1990-12-20 | 2000-05-15 | Warner Jenkinson Co Inc | Filmbildende zusammensetzungen aus feuchtem pulver |
| US5436011A (en) * | 1993-04-16 | 1995-07-25 | Bristol-Myers Squibb Company | Solid pharmaceutical dosage form and a method for reducing abrasion |
| US20030175342A1 (en) * | 2002-03-14 | 2003-09-18 | Karl Kolter | Coated pharmaceutical single-unit delayed-release forms, based on polyvinyl acetate |
-
1967
- 1967-06-28 DE DE19671617351 patent/DE1617351A1/de active Pending
-
1968
- 1968-06-25 FI FI177468A patent/FI49473C/fi active
- 1968-06-25 CH CH941968A patent/CH509804A/de not_active IP Right Cessation
- 1968-06-26 GB GB3047568A patent/GB1213348A/en not_active Expired
- 1968-06-26 DK DK303668A patent/DK126023B/da not_active IP Right Cessation
- 1968-06-26 LU LU56347D patent/LU56347A1/xx unknown
- 1968-06-27 SE SE439171A patent/SE373751B/xx unknown
- 1968-06-27 SE SE872768A patent/SE366479B/xx unknown
- 1968-06-27 FR FR1588833D patent/FR1588833A/fr not_active Expired
- 1968-06-27 BE BE717236D patent/BE717236A/xx not_active IP Right Cessation
- 1968-06-27 NL NL6809061A patent/NL6809061A/xx unknown
- 1968-06-27 BR BR20017468A patent/BR6800174D0/pt unknown
- 1968-06-27 NO NO254368A patent/NO126115B/no unknown
- 1968-06-27 AT AT620268A patent/AT292922B/de not_active IP Right Cessation
-
1971
- 1971-01-27 DK DK35371A patent/DK127712B/da not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK152831B (da) * | 1976-09-17 | 1988-05-24 | Richter Gedeon Vegyeszet | Fremgangsmaade ved fremstilling af biologisk aktive praeparater med reguleret afgivelse af aktivt stof samt polymerbaseret vaeskeformigt overtraekspraeparat til anvendelse ved fremgangsmaaden |
Also Published As
| Publication number | Publication date |
|---|---|
| DK127712B (da) | 1973-12-24 |
| CH509804A (de) | 1971-07-15 |
| SE373751B (fi) | 1975-02-17 |
| FI49473B (fi) | 1975-04-01 |
| DK126023B (da) | 1973-06-04 |
| GB1213348A (en) | 1970-11-25 |
| NL6809061A (fi) | 1968-12-30 |
| SE366479B (fi) | 1974-04-29 |
| FR1588833A (fi) | 1970-03-16 |
| DE1617351A1 (fi) | 1972-01-05 |
| BE717236A (fi) | 1968-12-27 |
| FI49473C (fi) | 1975-07-10 |
| LU56347A1 (fi) | 1968-10-04 |
| AT292922B (de) | 1971-09-10 |
| BR6800174D0 (pt) | 1973-02-13 |
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