NO118936B - - Google Patents
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- Publication number
- NO118936B NO118936B NO16499866A NO16499866A NO118936B NO 118936 B NO118936 B NO 118936B NO 16499866 A NO16499866 A NO 16499866A NO 16499866 A NO16499866 A NO 16499866A NO 118936 B NO118936 B NO 118936B
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- nicotinic acid
- salicylic acid
- weight
- acid
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 claims description 29
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 27
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 22
- 229960003512 nicotinic acid Drugs 0.000 claims description 11
- 235000001968 nicotinic acid Nutrition 0.000 claims description 11
- 239000011664 nicotinic acid Substances 0.000 claims description 11
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 11
- 229960004889 salicylic acid Drugs 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 208000000112 Myalgia Diseases 0.000 claims description 5
- 208000013465 muscle pain Diseases 0.000 claims description 5
- 230000009965 odorless effect Effects 0.000 claims description 5
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000002674 ointment Substances 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- XBLVHTDFJBKJLG-UHFFFAOYSA-N Ethyl nicotinate Chemical compound CCOC(=O)C1=CC=CN=C1 XBLVHTDFJBKJLG-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000001640 Fibromyalgia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229940048676 diethylamine salicylate Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000008384 inner phase Substances 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- RZKNXPAYKMNEOU-UHFFFAOYSA-N n'-hydroxy-2-nitrobenzenecarboximidamide Chemical compound ON=C(N)C1=CC=CC=C1[N+]([O-])=O RZKNXPAYKMNEOU-UHFFFAOYSA-N 0.000 description 1
- 239000008385 outer phase Substances 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE13050/65A SE327505B (enrdf_load_stackoverflow) | 1965-10-08 | 1965-10-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO118936B true NO118936B (enrdf_load_stackoverflow) | 1970-03-02 |
Family
ID=20296737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO16499866A NO118936B (enrdf_load_stackoverflow) | 1965-10-08 | 1966-10-04 |
Country Status (7)
| Country | Link |
|---|---|
| DE (1) | DE1645932A1 (enrdf_load_stackoverflow) |
| DK (1) | DK111582B (enrdf_load_stackoverflow) |
| FI (1) | FI46808C (enrdf_load_stackoverflow) |
| FR (1) | FR5895M (enrdf_load_stackoverflow) |
| GB (1) | GB1106580A (enrdf_load_stackoverflow) |
| NO (1) | NO118936B (enrdf_load_stackoverflow) |
| SE (1) | SE327505B (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4505896A (en) * | 1979-04-19 | 1985-03-19 | Elorac, Ltd. | Method of treating acne vulgaris and composition |
| JP2622574B2 (ja) * | 1987-04-01 | 1997-06-18 | 花王株式会社 | 入浴剤 |
-
1965
- 1965-10-08 SE SE13050/65A patent/SE327505B/xx unknown
-
1966
- 1966-10-04 NO NO16499866A patent/NO118936B/no unknown
- 1966-10-06 DK DK517966A patent/DK111582B/da unknown
- 1966-10-06 FR FR79033A patent/FR5895M/fr not_active Expired
- 1966-10-07 FI FI264466A patent/FI46808C/fi active
- 1966-10-07 DE DE19661645932 patent/DE1645932A1/de active Pending
- 1966-10-07 GB GB44868/66A patent/GB1106580A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1106580A (en) | 1968-03-20 |
| DK111582B (da) | 1968-09-16 |
| FR5895M (enrdf_load_stackoverflow) | 1968-03-25 |
| DE1645932A1 (de) | 1970-10-29 |
| FI46808B (enrdf_load_stackoverflow) | 1973-04-02 |
| SE327505B (enrdf_load_stackoverflow) | 1970-08-24 |
| FI46808C (fi) | 1973-07-10 |
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