NO115002B - - Google Patents
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- Publication number
- NO115002B NO115002B NO146638A NO14663862A NO115002B NO 115002 B NO115002 B NO 115002B NO 146638 A NO146638 A NO 146638A NO 14663862 A NO14663862 A NO 14663862A NO 115002 B NO115002 B NO 115002B
- Authority
- NO
- Norway
- Prior art keywords
- insulin
- crystallization
- freeze
- dried
- medium
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 208
- 102000004877 Insulin Human genes 0.000 claims description 104
- 108090001061 Insulin Proteins 0.000 claims description 104
- 229940125396 insulin Drugs 0.000 claims description 104
- 239000013078 crystal Substances 0.000 claims description 48
- 238000002425 crystallisation Methods 0.000 claims description 47
- 230000008025 crystallization Effects 0.000 claims description 46
- 239000000243 solution Substances 0.000 claims description 25
- 239000002609 medium Substances 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 14
- 229910052751 metal Inorganic materials 0.000 claims description 11
- 239000002184 metal Substances 0.000 claims description 11
- 239000000725 suspension Substances 0.000 claims description 11
- 239000012928 buffer substance Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 230000002378 acidificating effect Effects 0.000 claims description 3
- 239000012736 aqueous medium Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000003637 basic solution Substances 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000011081 inoculation Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 27
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 24
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 18
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 16
- 239000002253 acid Substances 0.000 description 13
- 239000011701 zinc Substances 0.000 description 12
- 150000004702 methyl esters Chemical class 0.000 description 11
- 229910052725 zinc Inorganic materials 0.000 description 11
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 9
- 239000011592 zinc chloride Substances 0.000 description 9
- 235000005074 zinc chloride Nutrition 0.000 description 9
- 239000007864 aqueous solution Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 4
- 238000004108 freeze drying Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229910052759 nickel Inorganic materials 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 229910021586 Nickel(II) chloride Inorganic materials 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 229940125717 barbiturate Drugs 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- -1 diethyl barbiturate Chemical compound 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- QMMRZOWCJAIUJA-UHFFFAOYSA-L nickel dichloride Chemical compound Cl[Ni]Cl QMMRZOWCJAIUJA-UHFFFAOYSA-L 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
- B65B31/003—Adding propellants in fluid form to aerosol containers
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Nozzles (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US156045A US3179132A (en) | 1961-11-30 | 1961-11-30 | Apparatus for pressure charging aerosol dispensers with push buttons attached and for automatically controlling the operation of such apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO115002B true NO115002B (en, 2012) | 1968-07-01 |
Family
ID=22557842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO146638A NO115002B (en, 2012) | 1961-11-30 | 1962-11-29 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3179132A (en, 2012) |
| CH (1) | CH398349A (en, 2012) |
| ES (1) | ES282758A1 (en, 2012) |
| GB (1) | GB1018561A (en, 2012) |
| NO (1) | NO115002B (en, 2012) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3273606A (en) * | 1966-09-20 | Method and apparatus for packaging paint and the like in a pressurized dispensing container | ||
| DE1279046B (de) * | 1964-04-14 | 1968-10-03 | Spritztechnik G M B H | Vorrichtung zum Fuellen einer Druckentnahmepackung |
| US3459244A (en) * | 1967-02-15 | 1969-08-05 | Scovill Manufacturing Co | Head for filling aerosol containers |
| DE1551620C3 (de) * | 1967-07-05 | 1975-08-07 | Siebel, Carl Gisbert, 4000 Duesseldorf | Füllkopf zum Füllen einer Druckentnahmepackung mit einem unter Druck stehenden, vorzugsweise verflüssigten Treibgas |
| US4525979A (en) * | 1982-10-19 | 1985-07-02 | The United States Of America As Represented By The Administrator Of The Environmental Protection Agency | Automatic bottle sealing mechanism for liquid sampling apparatus |
| FR2623875B1 (fr) * | 1987-11-30 | 1990-04-27 | Valois | Dispositif pour le remplissage en gaz d'un recipient aerosol au travers d'une pompe sertie sur ce recipient |
| US6152190A (en) * | 1999-04-15 | 2000-11-28 | Summit Packaging Systems, Inc. | Actuator with resilient annular skirt for improved seal during button-on-filling process |
| US6161599A (en) | 1999-04-15 | 2000-12-19 | Summit Packaging Systems, Inc, | Actuator with a longitudinal filling passageway communicating with each formed internal compartment |
| DE20103988U1 (de) * | 2001-03-07 | 2001-07-12 | Seaquist Perfect Dispensing GmbH, 44319 Dortmund | Abfüllkopf zur Befüllung von Behältern mit einem fluidförmigen Medium |
| US7124788B2 (en) * | 2003-07-10 | 2006-10-24 | Precision Valve Corporation | Means and method for filling bag-on-valve aerosol barrier packs |
| US20200360875A1 (en) | 2019-05-14 | 2020-11-19 | Sodastream Industries Ltd. | Carbonation machine and a gas canister for a carbonation machine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2462642A (en) * | 1946-03-11 | 1949-02-22 | Gulf Research Development Co | Apparatus for filling containers of pressure fluids |
| US2708347A (en) * | 1954-01-07 | 1955-05-17 | Boyle Midway Inc | Filling valve mechanism |
| US2857937A (en) * | 1954-05-10 | 1958-10-28 | Oil Equipment Lab Inc | Apparatus for loading pressurized containers |
| US2989993A (en) * | 1958-01-09 | 1961-06-27 | Karl Kiefer Machine Company | Charging device for pressurized containers |
| US3027922A (en) * | 1959-12-09 | 1962-04-03 | Nalbach Eng Co J | Gas injection nozzle assembly |
-
1961
- 1961-11-30 US US156045A patent/US3179132A/en not_active Expired - Lifetime
-
1962
- 1962-11-19 GB GB43668/62A patent/GB1018561A/en not_active Expired
- 1962-11-23 ES ES282758A patent/ES282758A1/es not_active Expired
- 1962-11-29 CH CH1403362A patent/CH398349A/fr unknown
- 1962-11-29 NO NO146638A patent/NO115002B/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH398349A (fr) | 1966-03-15 |
| GB1018561A (en) | 1966-01-26 |
| ES282758A1 (es) | 1963-02-01 |
| US3179132A (en) | 1965-04-20 |
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