NL990024I2 - Anti-hypertensive mercaptoacyl derivatives of substituted prolines and pharmaceutical preparations. - Google Patents
Anti-hypertensive mercaptoacyl derivatives of substituted prolines and pharmaceutical preparations.Info
- Publication number
- NL990024I2 NL990024I2 NL990024C NL990024C NL990024I2 NL 990024 I2 NL990024 I2 NL 990024I2 NL 990024 C NL990024 C NL 990024C NL 990024 C NL990024 C NL 990024C NL 990024 I2 NL990024 I2 NL 990024I2
- Authority
- NL
- Netherlands
- Prior art keywords
- hypertensive
- pharmaceutical preparations
- substituted prolines
- mercaptoacyl derivatives
- mercaptoacyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93288378A | 1978-08-11 | 1978-08-11 | |
KR1019790002731A KR830002450B1 (en) | 1978-08-11 | 1979-08-10 | Method for preparing mercaptoacyl derivative of substituted proline |
Publications (2)
Publication Number | Publication Date |
---|---|
NL990024I1 NL990024I1 (en) | 1999-11-01 |
NL990024I2 true NL990024I2 (en) | 1999-11-01 |
Family
ID=26626596
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL7906120A NL193374C (en) | 1978-08-11 | 1979-08-10 | Anti-hypertensive mercaptoacyl derivatives of substituted prolines and pharmaceutical preparations. |
NL990024C NL990024I2 (en) | 1978-08-11 | 1999-08-04 | Anti-hypertensive mercaptoacyl derivatives of substituted prolines and pharmaceutical preparations. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL7906120A NL193374C (en) | 1978-08-11 | 1979-08-10 | Anti-hypertensive mercaptoacyl derivatives of substituted prolines and pharmaceutical preparations. |
Country Status (30)
Country | Link |
---|---|
JP (2) | JPS5527199A (en) |
KR (1) | KR830002450B1 (en) |
AR (1) | AR229081A1 (en) |
AT (1) | AT379589B (en) |
AU (1) | AU530690B2 (en) |
BE (1) | BE878191A (en) |
CA (1) | CA1144930A (en) |
CH (1) | CH642064A5 (en) |
CS (1) | CS228118B2 (en) |
DD (1) | DD145749A5 (en) |
DE (1) | DE2932021C2 (en) |
DK (1) | DK154553C (en) |
ES (1) | ES483311A1 (en) |
FI (1) | FI69834C (en) |
FR (1) | FR2435469A1 (en) |
GB (1) | GB2028327B (en) |
GR (1) | GR72420B (en) |
IE (1) | IE48802B1 (en) |
IN (1) | IN152712B (en) |
IT (1) | IT1117782B (en) |
LU (2) | LU81593A1 (en) |
NL (2) | NL193374C (en) |
NZ (1) | NZ191036A (en) |
PH (1) | PH15030A (en) |
PT (1) | PT70049A (en) |
RO (1) | RO78870B (en) |
SE (1) | SE447477B (en) |
SU (1) | SU1066460A3 (en) |
YU (1) | YU41876B (en) |
ZA (1) | ZA793633B (en) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4483861A (en) * | 1978-10-31 | 1984-11-20 | Santen Pharmaceutical Co., Ltd. | Antihypertensive sulfur-containing compounds |
CA1132985A (en) * | 1978-12-22 | 1982-10-05 | John Krapcho | Ketal and thioketal derivatives of mercaptoacyl prolines |
US4347371A (en) * | 1978-12-30 | 1982-08-31 | Santen Pharmaceutical Co., Ltd. | Disulfide compounds |
US4234489A (en) * | 1979-06-25 | 1980-11-18 | E. R. Squibb & Sons, Inc. | Pyroglutamic acid derivatives and analogs |
US4288368A (en) * | 1979-07-30 | 1981-09-08 | E. R. Squibb & Sons, Inc. | Dithioacylproline derivatives |
US4291040A (en) * | 1979-10-22 | 1981-09-22 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines |
US4692458A (en) * | 1980-03-05 | 1987-09-08 | University Of Miami | Anti-hypertensive agents |
AU542211B2 (en) * | 1980-03-07 | 1985-02-14 | Gruppo Lepetit S.P.A. | Mercaptocycloalkyl carbonyl prolines |
SE431331B (en) * | 1980-03-21 | 1984-01-30 | Squibb & Sons Inc | NEW THERAPEUTICALLY ACTIVE SULFUR CONTAINING N-ACYLATED DERIVATIVES OF 4-OXO-L-PROLINE |
US4284624A (en) | 1980-05-02 | 1981-08-18 | E. R. Squibb & Sons, Inc. | Mixed disulfides |
US4390695A (en) * | 1980-06-23 | 1983-06-28 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
US4578474A (en) * | 1980-06-23 | 1986-03-25 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
US4316905A (en) * | 1980-07-01 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of various 4-substituted prolines |
US4332726A (en) * | 1980-08-25 | 1982-06-01 | E. R. Squibb & Sons, Inc. | Purification of mercaptoacyl amino acids |
US4307110A (en) * | 1980-09-12 | 1981-12-22 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 3-substituted proline derivatives |
US4311705A (en) * | 1980-10-06 | 1982-01-19 | E. R. Squibb & Sons, Inc. | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines |
US4312809A (en) | 1980-10-31 | 1982-01-26 | E. R. Squibb & Sons, Inc. | Lactam derivatives of mercaptoacylamino acids |
US4462943A (en) * | 1980-11-24 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Carboxyalkyl amino acid derivatives of various substituted prolines |
US4384123A (en) * | 1980-12-04 | 1983-05-17 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted prolines |
US4337201A (en) * | 1980-12-04 | 1982-06-29 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted prolines |
US4374131A (en) | 1981-04-27 | 1983-02-15 | E. R. Squibb & Sons, Inc. | Amino and substituted amino phosphinyl-alkanoyl compounds |
US4416831A (en) | 1981-04-27 | 1983-11-22 | E. R. Squibb & Sons, Inc. | Amino and substituted amino phosphinylalkanoyl compounds |
US4381297A (en) | 1981-05-04 | 1983-04-26 | E. R. Squibb & Sons, Inc. | Substituted carbonyl phosphinyl-alkanoyl compounds |
US4416833A (en) | 1981-05-04 | 1983-11-22 | E. R. Squibb & Sons, Inc. | Substituted carbonyl phosphinyl-alkanoyl compounds |
US4497953A (en) * | 1981-06-01 | 1985-02-05 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
US4377701A (en) * | 1981-09-21 | 1983-03-22 | E. R. Squibb & Sons, Inc. | 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid |
US4555506A (en) * | 1981-12-24 | 1985-11-26 | E. R. Squibb & Sons, Inc. | Phosphorus containing compounds and use as hypotensives |
US4452791A (en) * | 1982-03-15 | 1984-06-05 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
US4560680A (en) * | 1982-03-15 | 1985-12-24 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
US4616005A (en) * | 1982-06-23 | 1986-10-07 | E. R. Squibb & Sons, Inc. | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives |
US4703043A (en) * | 1982-06-23 | 1987-10-27 | E. R. Squibb & Sons, Inc. | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive |
US4452790A (en) * | 1982-06-23 | 1984-06-05 | E. R. Squibb & Sons, Inc. | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives |
US4567166A (en) * | 1982-07-14 | 1986-01-28 | E. R. Squibb & Sons, Inc. | Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension |
EP0187037A3 (en) * | 1984-12-21 | 1988-03-23 | Takeda Chemical Industries, Ltd. | Piperidine derivatives, their production and use |
CA2021409A1 (en) * | 1989-08-21 | 1991-02-22 | Donald S. Karanewsky | Phosphonate substituted amino or imino acids useful as antihypertensives |
JPH05344844A (en) * | 1992-06-12 | 1993-12-27 | Suzumo Kiko Kk | Method for producing roasted rice ball cracker |
EP0640594A1 (en) | 1993-08-23 | 1995-03-01 | Fujirebio Inc. | Hydantoin derivative as metalloprotease inhibitor |
US5435286A (en) * | 1994-05-02 | 1995-07-25 | Cummins Engine Company, Inc. | Ball link assembly for vehicle engine drive trains |
US7659305B2 (en) | 2002-10-31 | 2010-02-09 | Pfizer Inc. | Therapeutic proline derivatives |
GB0225379D0 (en) * | 2002-10-31 | 2002-12-11 | Pfizer Ltd | Therapeutic proline derivatives |
WO2006038119A1 (en) * | 2004-10-08 | 2006-04-13 | Warner-Lambert Company Llc | Stereoselective synthesis of n-protected alkoxy prolines |
GB0715626D0 (en) | 2007-08-10 | 2007-09-19 | Generics Uk Ltd | Crystalline form of zofenopril calcium |
US8853421B2 (en) | 2008-02-27 | 2014-10-07 | Generics [Uk] Limited | Crystalline forms of zofenopril calcium |
JP5530369B2 (en) * | 2008-02-27 | 2014-06-25 | ジェネリクス・[ユーケー]・リミテッド | New crystal form |
SI23949A (en) | 2011-12-19 | 2013-06-28 | Silverstone Pharma | The new crystalline salts of zofenopril, the procedure for obtaining them and their use in therapy |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2340092A2 (en) * | 1976-02-09 | 1977-09-02 | Roussel Uclaf | Analgesic (N)-thiazolyl-quinoline carboxamides - prepd. from the corresp. quinoline carboxylic acid and (2)-amino-thiazole |
AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
US4116962A (en) * | 1976-12-03 | 1978-09-26 | E. R. Squibb & Sons, Inc. | Pyrrolidine and piperidine-2-carboxylic acid derivatives |
US4113715A (en) * | 1977-01-17 | 1978-09-12 | E. R. Squibb & Sons, Inc. | Amino acid derivatives |
US4108886A (en) * | 1977-03-11 | 1978-08-22 | E. R. Squibb & Sons, Inc. | Thiopropanoylamino acid derivatives |
PH15381A (en) * | 1978-02-21 | 1982-12-17 | Squibb & Sons Inc | Halogen substituted mercaptoacylamino acids |
US4154934A (en) * | 1978-08-11 | 1979-05-15 | E. R. Squibb & Sons, Inc. | Mercaptoacylamino derivatives of heterocyclic carboxylic acids |
-
1979
- 1979-07-16 CA CA000331877A patent/CA1144930A/en not_active Expired
- 1979-07-17 NZ NZ191036A patent/NZ191036A/en unknown
- 1979-07-18 GR GR59635A patent/GR72420B/el unknown
- 1979-07-18 IN IN524/DEL/79A patent/IN152712B/en unknown
- 1979-07-18 ZA ZA00793633A patent/ZA793633B/en unknown
- 1979-07-24 AU AU49190/79A patent/AU530690B2/en not_active Expired
- 1979-07-30 FR FR7919590A patent/FR2435469A1/en active Granted
- 1979-08-01 PH PH22842A patent/PH15030A/en unknown
- 1979-08-03 IT IT49954/79A patent/IT1117782B/en active Protection Beyond IP Right Term
- 1979-08-07 DE DE2932021A patent/DE2932021C2/en not_active Expired - Lifetime
- 1979-08-07 YU YU1923/79A patent/YU41876B/en unknown
- 1979-08-08 AT AT0541679A patent/AT379589B/en not_active IP Right Cessation
- 1979-08-09 CS CS795462A patent/CS228118B2/en unknown
- 1979-08-09 DD DD79214896A patent/DD145749A5/en not_active IP Right Cessation
- 1979-08-10 SU SU792800304A patent/SU1066460A3/en active
- 1979-08-10 PT PT70049A patent/PT70049A/en unknown
- 1979-08-10 BE BE0/196688A patent/BE878191A/en not_active IP Right Cessation
- 1979-08-10 RO RO98428A patent/RO78870B/en unknown
- 1979-08-10 JP JP10272279A patent/JPS5527199A/en active Granted
- 1979-08-10 IE IE1544/79A patent/IE48802B1/en active Protection Beyond IP Right Term
- 1979-08-10 NL NL7906120A patent/NL193374C/en active Protection Beyond IP Right Term
- 1979-08-10 CH CH737579A patent/CH642064A5/en not_active IP Right Cessation
- 1979-08-10 SE SE7906722A patent/SE447477B/en active Protection Beyond IP Right Term
- 1979-08-10 FI FI792498A patent/FI69834C/en not_active IP Right Cessation
- 1979-08-10 AR AR277678A patent/AR229081A1/en active
- 1979-08-10 KR KR1019790002731A patent/KR830002450B1/en active
- 1979-08-10 DK DK335879A patent/DK154553C/en not_active IP Right Cessation
- 1979-08-10 LU LU81593A patent/LU81593A1/en active Protection Beyond IP Right Term
- 1979-08-10 GB GB7927867A patent/GB2028327B/en not_active Expired
- 1979-08-10 ES ES483311A patent/ES483311A1/en not_active Expired
-
1988
- 1988-12-21 JP JP63323204A patent/JPH01287069A/en active Pending
-
1999
- 1999-06-04 LU LU90403C patent/LU90403I2/en unknown
- 1999-08-04 NL NL990024C patent/NL990024I2/en unknown
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