FR2435469B1 - - Google Patents
Info
- Publication number
- FR2435469B1 FR2435469B1 FR7919590A FR7919590A FR2435469B1 FR 2435469 B1 FR2435469 B1 FR 2435469B1 FR 7919590 A FR7919590 A FR 7919590A FR 7919590 A FR7919590 A FR 7919590A FR 2435469 B1 FR2435469 B1 FR 2435469B1
- Authority
- FR
- France
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93288378A | 1978-08-11 | 1978-08-11 | |
| KR1019790002731A KR830002450B1 (en) | 1978-08-11 | 1979-08-10 | Method for preparing mercaptoacyl derivative of substituted proline |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2435469A1 FR2435469A1 (en) | 1980-04-04 |
| FR2435469B1 true FR2435469B1 (en) | 1983-02-11 |
Family
ID=26626596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7919590A Granted FR2435469A1 (en) | 1978-08-11 | 1979-07-30 | MERCAPTOACYL DERIVATIVES OF SUBSTITUTED PROLINES WITH HYPOTENSIVE ACTION |
Country Status (30)
| Country | Link |
|---|---|
| JP (2) | JPS5527199A (en) |
| KR (1) | KR830002450B1 (en) |
| AR (1) | AR229081A1 (en) |
| AT (1) | AT379589B (en) |
| AU (1) | AU530690B2 (en) |
| BE (1) | BE878191A (en) |
| CA (1) | CA1144930A (en) |
| CH (1) | CH642064A5 (en) |
| CS (1) | CS228118B2 (en) |
| DD (1) | DD145749A5 (en) |
| DE (1) | DE2932021C2 (en) |
| DK (1) | DK154553C (en) |
| ES (1) | ES483311A1 (en) |
| FI (1) | FI69834C (en) |
| FR (1) | FR2435469A1 (en) |
| GB (1) | GB2028327B (en) |
| GR (1) | GR72420B (en) |
| IE (1) | IE48802B1 (en) |
| IN (1) | IN152712B (en) |
| IT (1) | IT1117782B (en) |
| LU (2) | LU81593A1 (en) |
| NL (2) | NL193374C (en) |
| NZ (1) | NZ191036A (en) |
| PH (1) | PH15030A (en) |
| PT (1) | PT70049A (en) |
| RO (1) | RO78870B (en) |
| SE (1) | SE447477B (en) |
| SU (1) | SU1066460A3 (en) |
| YU (1) | YU41876B (en) |
| ZA (1) | ZA793633B (en) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4483861A (en) * | 1978-10-31 | 1984-11-20 | Santen Pharmaceutical Co., Ltd. | Antihypertensive sulfur-containing compounds |
| CA1132985A (en) * | 1978-12-22 | 1982-10-05 | John Krapcho | Ketal and thioketal derivatives of mercaptoacyl prolines |
| US4347371A (en) * | 1978-12-30 | 1982-08-31 | Santen Pharmaceutical Co., Ltd. | Disulfide compounds |
| US4234489A (en) * | 1979-06-25 | 1980-11-18 | E. R. Squibb & Sons, Inc. | Pyroglutamic acid derivatives and analogs |
| US4288368A (en) * | 1979-07-30 | 1981-09-08 | E. R. Squibb & Sons, Inc. | Dithioacylproline derivatives |
| US4291040A (en) * | 1979-10-22 | 1981-09-22 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines |
| US4692458A (en) * | 1980-03-05 | 1987-09-08 | University Of Miami | Anti-hypertensive agents |
| AU542211B2 (en) * | 1980-03-07 | 1985-02-14 | Gruppo Lepetit S.P.A. | Mercaptocycloalkyl carbonyl prolines |
| GB2070586A (en) * | 1980-03-21 | 1981-09-09 | Squibb & Sons Inc | Derivatives of Proline or Pipecolic Acid |
| US4284624A (en) | 1980-05-02 | 1981-08-18 | E. R. Squibb & Sons, Inc. | Mixed disulfides |
| US4578474A (en) * | 1980-06-23 | 1986-03-25 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
| US4390695A (en) * | 1980-06-23 | 1983-06-28 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
| US4316905A (en) * | 1980-07-01 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of various 4-substituted prolines |
| US4332726A (en) * | 1980-08-25 | 1982-06-01 | E. R. Squibb & Sons, Inc. | Purification of mercaptoacyl amino acids |
| US4307110A (en) * | 1980-09-12 | 1981-12-22 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 3-substituted proline derivatives |
| US4311705A (en) * | 1980-10-06 | 1982-01-19 | E. R. Squibb & Sons, Inc. | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines |
| US4312809A (en) | 1980-10-31 | 1982-01-26 | E. R. Squibb & Sons, Inc. | Lactam derivatives of mercaptoacylamino acids |
| US4462943A (en) * | 1980-11-24 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Carboxyalkyl amino acid derivatives of various substituted prolines |
| US4384123A (en) * | 1980-12-04 | 1983-05-17 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted prolines |
| US4337201A (en) * | 1980-12-04 | 1982-06-29 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted prolines |
| US4374131A (en) | 1981-04-27 | 1983-02-15 | E. R. Squibb & Sons, Inc. | Amino and substituted amino phosphinyl-alkanoyl compounds |
| US4416831A (en) | 1981-04-27 | 1983-11-22 | E. R. Squibb & Sons, Inc. | Amino and substituted amino phosphinylalkanoyl compounds |
| US4381297A (en) | 1981-05-04 | 1983-04-26 | E. R. Squibb & Sons, Inc. | Substituted carbonyl phosphinyl-alkanoyl compounds |
| US4416833A (en) | 1981-05-04 | 1983-11-22 | E. R. Squibb & Sons, Inc. | Substituted carbonyl phosphinyl-alkanoyl compounds |
| US4497953A (en) * | 1981-06-01 | 1985-02-05 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
| US4377701A (en) * | 1981-09-21 | 1983-03-22 | E. R. Squibb & Sons, Inc. | 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid |
| US4555506A (en) * | 1981-12-24 | 1985-11-26 | E. R. Squibb & Sons, Inc. | Phosphorus containing compounds and use as hypotensives |
| US4452791A (en) * | 1982-03-15 | 1984-06-05 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
| US4560680A (en) * | 1982-03-15 | 1985-12-24 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
| US4703043A (en) * | 1982-06-23 | 1987-10-27 | E. R. Squibb & Sons, Inc. | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive |
| US4452790A (en) * | 1982-06-23 | 1984-06-05 | E. R. Squibb & Sons, Inc. | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives |
| US4616005A (en) * | 1982-06-23 | 1986-10-07 | E. R. Squibb & Sons, Inc. | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives |
| US4567166A (en) * | 1982-07-14 | 1986-01-28 | E. R. Squibb & Sons, Inc. | Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension |
| EP0187037A3 (en) * | 1984-12-21 | 1988-03-23 | Takeda Chemical Industries, Ltd. | Piperidine derivatives, their production and use |
| AU632596B2 (en) * | 1989-08-21 | 1993-01-07 | E.R. Squibb & Sons, Inc. | Phosphonate substituted amino or imino acids useful as antihypertensives |
| JPH05344844A (en) * | 1992-06-12 | 1993-12-27 | Suzumo Kiko Kk | Method for producing roasted rice ball cracker |
| EP0640594A1 (en) | 1993-08-23 | 1995-03-01 | Fujirebio Inc. | Hydantoin derivative as metalloprotease inhibitor |
| US5435286A (en) * | 1994-05-02 | 1995-07-25 | Cummins Engine Company, Inc. | Ball link assembly for vehicle engine drive trains |
| GB0225379D0 (en) * | 2002-10-31 | 2002-12-11 | Pfizer Ltd | Therapeutic proline derivatives |
| US7659305B2 (en) | 2002-10-31 | 2010-02-09 | Pfizer Inc. | Therapeutic proline derivatives |
| WO2006038119A1 (en) * | 2004-10-08 | 2006-04-13 | Warner-Lambert Company Llc | Stereoselective synthesis of n-protected alkoxy prolines |
| GB0715626D0 (en) | 2007-08-10 | 2007-09-19 | Generics Uk Ltd | Crystalline form of zofenopril calcium |
| NZ622549A (en) * | 2008-02-27 | 2015-10-30 | Generics Uk Ltd | Novel crystalline form of zofenopril calcium |
| US8853421B2 (en) | 2008-02-27 | 2014-10-07 | Generics [Uk] Limited | Crystalline forms of zofenopril calcium |
| SI23949A (en) | 2011-12-19 | 2013-06-28 | Silverstone Pharma | The new crystalline salts of zofenopril, the procedure for obtaining them and their use in therapy |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2340092A2 (en) * | 1976-02-09 | 1977-09-02 | Roussel Uclaf | Analgesic (N)-thiazolyl-quinoline carboxamides - prepd. from the corresp. quinoline carboxylic acid and (2)-amino-thiazole |
| AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
| US4116962A (en) * | 1976-12-03 | 1978-09-26 | E. R. Squibb & Sons, Inc. | Pyrrolidine and piperidine-2-carboxylic acid derivatives |
| US4113715A (en) * | 1977-01-17 | 1978-09-12 | E. R. Squibb & Sons, Inc. | Amino acid derivatives |
| US4108886A (en) * | 1977-03-11 | 1978-08-22 | E. R. Squibb & Sons, Inc. | Thiopropanoylamino acid derivatives |
| PH15381A (en) * | 1978-02-21 | 1982-12-17 | Squibb & Sons Inc | Halogen substituted mercaptoacylamino acids |
| US4154934A (en) * | 1978-08-11 | 1979-05-15 | E. R. Squibb & Sons, Inc. | Mercaptoacylamino derivatives of heterocyclic carboxylic acids |
-
1979
- 1979-07-16 CA CA000331877A patent/CA1144930A/en not_active Expired
- 1979-07-17 NZ NZ191036A patent/NZ191036A/en unknown
- 1979-07-18 GR GR59635A patent/GR72420B/el unknown
- 1979-07-18 ZA ZA00793633A patent/ZA793633B/en unknown
- 1979-07-18 IN IN524/DEL/79A patent/IN152712B/en unknown
- 1979-07-24 AU AU49190/79A patent/AU530690B2/en not_active Expired
- 1979-07-30 FR FR7919590A patent/FR2435469A1/en active Granted
- 1979-08-01 PH PH22842A patent/PH15030A/en unknown
- 1979-08-03 IT IT49954/79A patent/IT1117782B/en active Protection Beyond IP Right Term
- 1979-08-07 DE DE2932021A patent/DE2932021C2/en not_active Expired - Lifetime
- 1979-08-07 YU YU1923/79A patent/YU41876B/en unknown
- 1979-08-08 AT AT0541679A patent/AT379589B/en not_active IP Right Cessation
- 1979-08-09 DD DD79214896A patent/DD145749A5/en not_active IP Right Cessation
- 1979-08-09 CS CS795462A patent/CS228118B2/en unknown
- 1979-08-10 GB GB7927867A patent/GB2028327B/en not_active Expired
- 1979-08-10 KR KR1019790002731A patent/KR830002450B1/en active
- 1979-08-10 LU LU81593A patent/LU81593A1/en active Protection Beyond IP Right Term
- 1979-08-10 PT PT70049A patent/PT70049A/en unknown
- 1979-08-10 JP JP10272279A patent/JPS5527199A/en active Granted
- 1979-08-10 SU SU792800304A patent/SU1066460A3/en active
- 1979-08-10 AR AR277678A patent/AR229081A1/en active
- 1979-08-10 ES ES483311A patent/ES483311A1/en not_active Expired
- 1979-08-10 NL NL7906120A patent/NL193374C/en active Protection Beyond IP Right Term
- 1979-08-10 IE IE1544/79A patent/IE48802B1/en active Protection Beyond IP Right Term
- 1979-08-10 DK DK335879A patent/DK154553C/en not_active IP Right Cessation
- 1979-08-10 SE SE7906722A patent/SE447477B/en active Protection Beyond IP Right Term
- 1979-08-10 FI FI792498A patent/FI69834C/en not_active IP Right Cessation
- 1979-08-10 RO RO98428A patent/RO78870B/en unknown
- 1979-08-10 CH CH737579A patent/CH642064A5/en not_active IP Right Cessation
- 1979-08-10 BE BE0/196688A patent/BE878191A/en not_active IP Right Cessation
-
1988
- 1988-12-21 JP JP63323204A patent/JPH01287069A/en active Pending
-
1999
- 1999-06-04 LU LU90403C patent/LU90403I2/en unknown
- 1999-08-04 NL NL990024C patent/NL990024I2/en unknown
Also Published As
Similar Documents
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property | ||
| CP | Supplementary protection certificate (spc) filed |
Free format text: PRODUCT NAME: ZOFENOPRIL CALCIUM; NAT. REGISTRATION NO/DATE: NL 24 268 19990329; FIRST REGISTRATION: GB - PL 16 239/0 002 19980730 Spc suppl protection certif: 99C0025 Filing date: 19990707 |
|
| CA | Change of address | ||
| CR | Request for supplementary protection certificate laid open to the public (eec regulation of 18 june 1992) |
Free format text: 99C0025, 19990707 |
|
| CP | Supplementary protection certificate (spc) filed | ||
| CY | Supplementary certificate of protection granted (eec regulation of 18 june 1992) |
Free format text: 99C0025, 19990707, EXPIRES: 20040729 |