RO78870A - PROCESS FOR THE PREPARATION OF MERCAPTOACILPROLINE DERIVATIVES - Google Patents

PROCESS FOR THE PREPARATION OF MERCAPTOACILPROLINE DERIVATIVES

Info

Publication number
RO78870A
RO78870A RO7998428A RO9842879A RO78870A RO 78870 A RO78870 A RO 78870A RO 7998428 A RO7998428 A RO 7998428A RO 9842879 A RO9842879 A RO 9842879A RO 78870 A RO78870 A RO 78870A
Authority
RO
Romania
Prior art keywords
mercaptoacilproline
derivatives
preparation
mercaptoacilproline derivatives
Prior art date
Application number
RO7998428A
Other languages
French (fr)
Romanian (ro)
Other versions
RO78870B (en
Inventor
Miguel A Ondetti
John Krapcho
Original Assignee
E.R. Squib & Sons Inc,Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E.R. Squib & Sons Inc,Us filed Critical E.R. Squib & Sons Inc,Us
Publication of RO78870A publication Critical patent/RO78870A/en
Publication of RO78870B publication Critical patent/RO78870B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
RO98428A 1978-08-11 1979-08-10 PROCESS FOR THE PREPARATION OF MERCAPTOACILPROLINE DERIVATIVES RO78870B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93288378A 1978-08-11 1978-08-11
KR1019790002731A KR830002450B1 (en) 1978-08-11 1979-08-10 Method for preparing mercaptoacyl derivative of substituted proline

Publications (2)

Publication Number Publication Date
RO78870A true RO78870A (en) 1982-07-06
RO78870B RO78870B (en) 1985-01-30

Family

ID=26626596

Family Applications (1)

Application Number Title Priority Date Filing Date
RO98428A RO78870B (en) 1978-08-11 1979-08-10 PROCESS FOR THE PREPARATION OF MERCAPTOACILPROLINE DERIVATIVES

Country Status (30)

Country Link
JP (2) JPS5527199A (en)
KR (1) KR830002450B1 (en)
AR (1) AR229081A1 (en)
AT (1) AT379589B (en)
AU (1) AU530690B2 (en)
BE (1) BE878191A (en)
CA (1) CA1144930A (en)
CH (1) CH642064A5 (en)
CS (1) CS228118B2 (en)
DD (1) DD145749A5 (en)
DE (1) DE2932021C2 (en)
DK (1) DK154553C (en)
ES (1) ES483311A1 (en)
FI (1) FI69834C (en)
FR (1) FR2435469A1 (en)
GB (1) GB2028327B (en)
GR (1) GR72420B (en)
IE (1) IE48802B1 (en)
IN (1) IN152712B (en)
IT (1) IT1117782B (en)
LU (2) LU81593A1 (en)
NL (2) NL193374C (en)
NZ (1) NZ191036A (en)
PH (1) PH15030A (en)
PT (1) PT70049A (en)
RO (1) RO78870B (en)
SE (1) SE447477B (en)
SU (1) SU1066460A3 (en)
YU (1) YU41876B (en)
ZA (1) ZA793633B (en)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
CA1132985A (en) * 1978-12-22 1982-10-05 John Krapcho Ketal and thioketal derivatives of mercaptoacyl prolines
US4347371A (en) * 1978-12-30 1982-08-31 Santen Pharmaceutical Co., Ltd. Disulfide compounds
US4234489A (en) * 1979-06-25 1980-11-18 E. R. Squibb & Sons, Inc. Pyroglutamic acid derivatives and analogs
US4288368A (en) * 1979-07-30 1981-09-08 E. R. Squibb & Sons, Inc. Dithioacylproline derivatives
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
AU542211B2 (en) * 1980-03-07 1985-02-14 Gruppo Lepetit S.P.A. Mercaptocycloalkyl carbonyl prolines
SE431331B (en) * 1980-03-21 1984-01-30 Squibb & Sons Inc NEW THERAPEUTICALLY ACTIVE SULFUR CONTAINING N-ACYLATED DERIVATIVES OF 4-OXO-L-PROLINE
US4284624A (en) 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
US4390695A (en) * 1980-06-23 1983-06-28 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4578474A (en) * 1980-06-23 1986-03-25 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4332726A (en) * 1980-08-25 1982-06-01 E. R. Squibb & Sons, Inc. Purification of mercaptoacyl amino acids
US4307110A (en) * 1980-09-12 1981-12-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 3-substituted proline derivatives
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4312809A (en) 1980-10-31 1982-01-26 E. R. Squibb & Sons, Inc. Lactam derivatives of mercaptoacylamino acids
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4384123A (en) * 1980-12-04 1983-05-17 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4374131A (en) 1981-04-27 1983-02-15 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinyl-alkanoyl compounds
US4416831A (en) 1981-04-27 1983-11-22 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds
US4381297A (en) 1981-05-04 1983-04-26 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4416833A (en) 1981-05-04 1983-11-22 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4497953A (en) * 1981-06-01 1985-02-05 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4377701A (en) * 1981-09-21 1983-03-22 E. R. Squibb & Sons, Inc. 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4703043A (en) * 1982-06-23 1987-10-27 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4567166A (en) * 1982-07-14 1986-01-28 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use
CA2021409A1 (en) * 1989-08-21 1991-02-22 Donald S. Karanewsky Phosphonate substituted amino or imino acids useful as antihypertensives
JPH05344844A (en) * 1992-06-12 1993-12-27 Suzumo Kiko Kk Method for producing roasted rice ball cracker
EP0640594A1 (en) 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor
US5435286A (en) * 1994-05-02 1995-07-25 Cummins Engine Company, Inc. Ball link assembly for vehicle engine drive trains
US7659305B2 (en) 2002-10-31 2010-02-09 Pfizer Inc. Therapeutic proline derivatives
GB0225379D0 (en) * 2002-10-31 2002-12-11 Pfizer Ltd Therapeutic proline derivatives
WO2006038119A1 (en) * 2004-10-08 2006-04-13 Warner-Lambert Company Llc Stereoselective synthesis of n-protected alkoxy prolines
GB0715626D0 (en) * 2007-08-10 2007-09-19 Generics Uk Ltd Crystalline form of zofenopril calcium
EP2245007B1 (en) * 2008-02-27 2020-08-19 Generics [UK] Limited Process for preparing a crystalline form of zofenopril calcium
US8853421B2 (en) 2008-02-27 2014-10-07 Generics [Uk] Limited Crystalline forms of zofenopril calcium
SI23949A (en) 2011-12-19 2013-06-28 Silverstone Pharma The new crystalline salts of zofenopril, the procedure for obtaining them and their use in therapy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340092A2 (en) * 1976-02-09 1977-09-02 Roussel Uclaf Analgesic (N)-thiazolyl-quinoline carboxamides - prepd. from the corresp. quinoline carboxylic acid and (2)-amino-thiazole
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
PH15381A (en) * 1978-02-21 1982-12-17 Squibb & Sons Inc Halogen substituted mercaptoacylamino acids
US4154934A (en) * 1978-08-11 1979-05-15 E. R. Squibb & Sons, Inc. Mercaptoacylamino derivatives of heterocyclic carboxylic acids

Also Published As

Publication number Publication date
JPS5527199A (en) 1980-02-27
CA1144930A (en) 1983-04-19
LU81593A1 (en) 1979-12-07
DE2932021C2 (en) 1994-05-19
JPH0134987B2 (en) 1989-07-21
IT1117782B (en) 1986-02-24
IE48802B1 (en) 1985-05-15
AU530690B2 (en) 1983-07-28
NL990024I2 (en) 1999-11-01
CH642064A5 (en) 1984-03-30
IE791544L (en) 1980-02-11
DK335879A (en) 1980-02-12
BE878191A (en) 1980-02-11
FI792498A7 (en) 1980-02-12
FI69834B (en) 1985-12-31
YU192379A (en) 1983-02-28
NL193374C (en) 1999-08-03
DK154553C (en) 1989-04-17
GB2028327A (en) 1980-03-05
PT70049A (en) 1979-09-01
FI69834C (en) 1986-05-26
KR830001269A (en) 1983-04-29
RO78870B (en) 1985-01-30
IN152712B (en) 1984-03-17
LU90403I2 (en) 2000-07-07
NL990024I1 (en) 1999-11-01
NL193374B (en) 1999-04-01
PH15030A (en) 1982-05-13
AR229081A1 (en) 1983-06-15
ATA541679A (en) 1985-06-15
IT7949954A0 (en) 1979-08-03
DK154553B (en) 1988-11-28
SE7906722L (en) 1980-02-12
AT379589B (en) 1986-01-27
DE2932021A1 (en) 1980-02-21
NL7906120A (en) 1980-02-13
DD145749A5 (en) 1981-01-07
ZA793633B (en) 1980-07-30
SU1066460A3 (en) 1984-01-07
JPH01287069A (en) 1989-11-17
SE447477B (en) 1986-11-17
YU41876B (en) 1988-02-29
GR72420B (en) 1983-11-03
NZ191036A (en) 1984-05-31
FR2435469A1 (en) 1980-04-04
CS228118B2 (en) 1984-05-14
FR2435469B1 (en) 1983-02-11
KR830002450B1 (en) 1983-10-26
ES483311A1 (en) 1980-04-16
AU4919079A (en) 1980-02-14
GB2028327B (en) 1982-11-24

Similar Documents

Publication Publication Date Title
RO78870A (en) PROCESS FOR THE PREPARATION OF MERCAPTOACILPROLINE DERIVATIVES
RO77728A (en) PROCESS FOR THE PREPARATION OF PENETHANOLAMINE DERIVATIVES
RO82376A (en) PROCESS FOR THE PREPARATION OF 9-HYDROXYAMINODIMENZOPYRANE DERIVATIVES
RO85815A (en) PROCESS FOR THE PREPARATION OF TIAZOL DERIVATIVES
RO84425A (en) PROCESS FOR THE PREPARATION OF PLEUROMUTILINGLICOSIDE DERIVATIVES
RO79703A (en) PROCEDURE FOR THE PREPARATION OF HYDROTOTIN DERIVATIVES
RO84584A (en) PROCESS FOR THE PREPARATION OF BENZOTIOFEN DERIVATIVES
RO70897A (en) PROCESS FOR THE PREPARATION OF SUBSTITUTE PENNOXYBENZILOXYCARBONYL DERIVATIVES
RO83053A (en) PROCESS FOR THE PREPARATION OF PENETHANOLAMINE DERIVATIVES
RO77729A (en) PROCESS FOR THE PREPARATION OF PENETHANOLAMINE DERIVATIVES
RO79711A (en) PROCESS FOR PREPARATION OF 2-ETHYLAMINO-4-PYRIMIDONE DERIVATIVES
RO77309A (en) PROCESS FOR THE PREPARATION OF AZOLILECETONE DERIVATIVES
RO78491A (en) PROCESS FOR PREPARATION OF DERIVATIVES OF 2-AMINO-PIRIMIDES
RO85070A (en) PROCESS FOR THE PREPARATION OF N-PHENYL-CARBAMATE DERIVATIVES
RO78090A (en) PROCESS FOR PREPARATION OF 1, 2, 3-TIADIAZOL-5-ILUES DERIVATIVES
RO78765A (en) PROCESS FOR THE PREPARATION OF N-TRIFLUOROETHYL N-PHOSPHONOMETHYLGLICINE DERIVATIVES
RO72562A (en) PROCESS FOR THE PREPARATION OF BENZODIOXOL DERIVATIVES
RO84583A (en) PROCESS FOR THE PREPARATION OF PIRANONE DERIVATIVES
RO84100A (en) PROCESS FOR THE PREPARATION OF BENZODIAZOPINE DERIVATIVES
RO77228A (en) PROCESS FOR THE PREPARATION OF MERCAPTOACILPROLINE DERIVATIVES
RO81930A (en) PROCESS FOR THE PREPARATION OF PIRIMIDONE DERIVATIVES
RO82013A (en) PROCESS FOR THE PREPARATION OF CARBOSTIRIL DERIVATIVES
RO70078A (en) PROCESS FOR THE PREPARATION OF DIFENYLAMINE DERIVATIVES
RO78871A (en) PROCESS FOR THE PREPARATION OF URINE DERIVATIVES
RO76867A (en) PROCESS FOR THE PREPARATION OF PENOXIALCANOLAMINE DERIVATIVES