NL990001I2 - Geneesmiddel, dat dipyridamol of modipamol en O-acetylsailcylzuur resp. fysiologisch verdraagbare zouten daarvan, bevat, werkwijze voor de bereiding daarvan en toepassing daarvan voor het bestrijden van thrombusvorming. - Google Patents
Geneesmiddel, dat dipyridamol of modipamol en O-acetylsailcylzuur resp. fysiologisch verdraagbare zouten daarvan, bevat, werkwijze voor de bereiding daarvan en toepassing daarvan voor het bestrijden van thrombusvorming.Info
- Publication number
- NL990001I2 NL990001I2 NL990001C NL990001C NL990001I2 NL 990001 I2 NL990001 I2 NL 990001I2 NL 990001 C NL990001 C NL 990001C NL 990001 C NL990001 C NL 990001C NL 990001 I2 NL990001 I2 NL 990001I2
- Authority
- NL
- Netherlands
- Prior art keywords
- modipamol
- acetylsailicylic
- combating
- acid
- thrombus formation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19863627423 DE3627423A1 (de) | 1986-08-13 | 1986-08-13 | Arzneimittel enthaltend dipyridamol oder mopidamol und o-acetylsalicylsaeure bzw. deren physiologisch vertraegliche salze, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung der thrombusbildung |
Publications (2)
Publication Number | Publication Date |
---|---|
NL990001I1 NL990001I1 (nl) | 1999-03-01 |
NL990001I2 true NL990001I2 (nl) | 2000-04-03 |
Family
ID=6307286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL990001C NL990001I2 (nl) | 1986-08-13 | 1999-01-06 | Geneesmiddel, dat dipyridamol of modipamol en O-acetylsailcylzuur resp. fysiologisch verdraagbare zouten daarvan, bevat, werkwijze voor de bereiding daarvan en toepassing daarvan voor het bestrijden van thrombusvorming. |
Country Status (26)
Country | Link |
---|---|
US (1) | US6015577A (de) |
EP (1) | EP0257344B1 (de) |
JP (1) | JP2593879B2 (de) |
KR (1) | KR950009098B1 (de) |
AT (1) | ATE59961T1 (de) |
AU (1) | AU603146B2 (de) |
BR (1) | BR1100593A (de) |
CA (1) | CA1302272C (de) |
CL (1) | CL2004001252A1 (de) |
DD (1) | DD263918A5 (de) |
DE (3) | DE3627423A1 (de) |
DK (1) | DK172236B1 (de) |
ES (1) | ES2020974B3 (de) |
FI (1) | FI873492A (de) |
GR (1) | GR3001695T3 (de) |
HK (1) | HK14494A (de) |
HU (1) | HU202404B (de) |
IE (1) | IE60862B1 (de) |
IL (1) | IL83510A (de) |
NL (1) | NL990001I2 (de) |
NO (2) | NO175132C (de) |
NZ (1) | NZ221424A (de) |
PH (1) | PH27176A (de) |
PT (1) | PT85525B (de) |
SG (1) | SG122593G (de) |
ZA (1) | ZA875947B (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19927689A1 (de) * | 1999-06-17 | 2000-12-21 | Gruenenthal Gmbh | Orale Darreichungsformen zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac |
EP1093814A1 (de) * | 1999-10-22 | 2001-04-25 | Boehringer Ingelheim Pharma KG | Verwendung von Dipyridamole oder Mopidamol zur Herstellung eines Medikaments für die Behandlung und Vorbeugung von fibrinabhängigen Mikrozirkulationstörungen |
US7064130B2 (en) * | 2001-04-20 | 2006-06-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of radical-scavenging compounds for treatment and prevention of NO-dependent microcirculation disorders |
US20040058056A1 (en) * | 2001-07-06 | 2004-03-25 | Shigemasa Osaki | Drug diffusion coatings, applications and methods |
MXPA04003266A (es) * | 2001-10-05 | 2004-07-08 | Combinatorx Inc | Combinaciones para el tratamiento de desodrdenes inmuno-inflamatorios. |
TW200301135A (en) * | 2001-12-27 | 2003-07-01 | Otsuka Maryland Res Inst Inc | Pharmaceutical compositions comprising a multifunctional phosphodiesterase inhibitor and an adenosine uptake inhibitor |
US20030181488A1 (en) * | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof |
DE10209982A1 (de) * | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma | Oral zu applizierende Darreichungsform für schwerlösliche basische Wirkstoffe |
US7485322B2 (en) * | 2002-12-24 | 2009-02-03 | Lek Pharmaceuticals D.D. | Modified release pharmaceutical composition |
JP2006516593A (ja) * | 2003-02-07 | 2006-07-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Mmp−9依存性疾患の治療及び予防のためのジピリダモール又はモピダモールの使用 |
DE10306179A1 (de) | 2003-02-13 | 2004-08-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Dipyridamol in Kombination mit Acetylsalicylsäure und einem Angiotensin II-Antagonisten zur Schlaganfall-Prophylaxe |
EP2062580A1 (de) * | 2003-04-24 | 2009-05-27 | Boehringer Ingelheim International GmbH | Verwendung von Dipyridamol oder Mopidamol zur Behandlung und Prävention thromboembolischer Erkrankungen oder Störungen, die von einer übermäßigen Thrombinbildung und/oder einer erhöhten Expression von Thrombinrezeptoren verursacht werden |
US7041286B2 (en) * | 2003-07-23 | 2006-05-09 | Nerenberg Arnold P | Composition for mitigating a pernicious thrombotic event |
TW200517114A (en) * | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
JP2007537184A (ja) * | 2004-05-13 | 2007-12-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗血小板剤に対する耐性を治療するためのジピリダモールの使用 |
PT2559430E (pt) | 2005-03-22 | 2015-10-09 | Stada Arzneimittel Ag | Ibuprofeno solubilizado |
EP1919460A2 (de) * | 2005-08-22 | 2008-05-14 | Novartis AG | Pharmazeutische zusammensetzungen mit einem ph-abhängigen wirkstoff, einem ph-modifikator und einem verzögerungsmittel |
RU2490012C2 (ru) * | 2006-01-27 | 2013-08-20 | Апталис Фарматех Инк | Системы доставки лекарственного средства, содержащие слабощелочной селективный 5-ht3, серотониновый блокатор и органические кислоты |
RU2428176C2 (ru) * | 2006-01-27 | 2011-09-10 | Юранд, Инк. | Системы доставки лекарственного средства, содержащие слабоосновные лекарственные средства и органические кислоты |
US20070184110A1 (en) * | 2006-02-09 | 2007-08-09 | Minutza Leibovici | Dipyridamole extended-release formulations and process for preparing same |
WO2007139753A2 (en) * | 2006-05-22 | 2007-12-06 | Combinatorx, Incorporated | Methods and compositions for the treatment of diseases or conditions associated with increased c-reactive protein, interleukin-6, or interferon-gamma levels |
ITRM20060460A1 (it) * | 2006-08-31 | 2006-11-30 | Univ Roma | Uso di acido acetil salicilico in combinazione con inibitori dei canali mrp4 per il trattamento di pazienti resistenti a detto acido acetil salicilico |
WO2008095263A1 (en) * | 2007-02-09 | 2008-08-14 | Alphapharm Pty Ltd | A dosage form containing two or more active pharmaceutical ingredients in different physical forms |
EP2203174A4 (de) * | 2007-09-19 | 2010-09-29 | Combinatorx Inc | Therapeutische schemata zur behandlung von immunentzündlichen erkrankungen |
NZ586332A (en) * | 2007-12-17 | 2012-07-27 | Zalicus Inc | Therapeutic regimens for the treatment of immunoinflammatory disorders using dipyridamole and prednisolone |
US20090196935A1 (en) * | 2008-02-01 | 2009-08-06 | Ahmed Salah U | Pharmaceutical Capsules Comprising Extended Release Dipyridamole Pellets |
US8133506B2 (en) * | 2008-03-12 | 2012-03-13 | Aptalis Pharmatech, Inc. | Drug delivery systems comprising weakly basic drugs and organic acids |
US20120276206A1 (en) | 2008-03-28 | 2012-11-01 | Boehringer Ingelheim International Gmbh | Method for manufacturing acid pellets |
US20100080846A1 (en) * | 2008-09-25 | 2010-04-01 | Avshalom Ben-Menachem | Dipyridamole and acetylsalicylic acid formulations and process for preparing same |
US20110003005A1 (en) * | 2009-07-06 | 2011-01-06 | Gopi Venkatesh | Methods of Treating PDNV and PONV with Extended Release Ondansetron Compositions |
EP2361615A1 (de) | 2010-02-19 | 2011-08-31 | Alfred E. Tiefenbacher GmbH & Co. KG | Tablette mit verlängerter Dipyridamolfreisetzung |
WO2012162492A1 (en) * | 2011-05-24 | 2012-11-29 | Teva Pharmaceutical Industries Ltd. | Compressed core comprising organic acids for a pharmaceutical composition |
CN103239724A (zh) * | 2013-05-27 | 2013-08-14 | 成都自豪药业有限公司 | 抗血栓形成的联合用药物及其药物组合物 |
WO2018236899A1 (en) * | 2017-06-19 | 2018-12-27 | The Cleveland Clinic Foundation | TREATMENT OF A DISEASE AND PROMOTION OF WEIGHT LOSS BY INHIBITING THE TMA / FMO3 / TMAO PATHWAY |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2368280A1 (fr) * | 1976-10-20 | 1978-05-19 | Theramex | Nouvelle composition therapeutique presentant une activite anti-agregante plaquettaire, et son procede de preparation |
FR2368272A1 (fr) * | 1976-10-20 | 1978-05-19 | Theramex | Compositions therapeutiques solides pour combattre l'agregation plaquettaire |
LU77353A1 (de) * | 1977-05-16 | 1979-01-19 | ||
DE3000979A1 (de) * | 1980-01-12 | 1981-07-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue dipyridamol-retardformen und verfahren zu ihrer herstellung |
FR2513118A1 (fr) * | 1981-09-18 | 1983-03-25 | Rocador Sa | Composition pharmaceutique a base de dipyridamol et de sel d'aluminium de l'acide acetylsalicylique pour combattre l'agregation plaquettaire |
DE3576119D1 (de) * | 1984-07-21 | 1990-04-05 | Hoechst Ag | Kombinationspraeparat aus pyrimido-pyrimidinen und o-acetylsalicylsaeure bzw. deren pharmakologisch vertraeglichen salzen und dessen verwendung. |
-
1986
- 1986-08-13 DE DE19863627423 patent/DE3627423A1/de not_active Withdrawn
-
1987
- 1987-07-31 DE DE2002199015 patent/DE10299015I2/de active Active
- 1987-07-31 AT AT87111104T patent/ATE59961T1/de active
- 1987-07-31 DE DE8787111104T patent/DE3767408D1/de not_active Expired - Lifetime
- 1987-07-31 ES ES87111104T patent/ES2020974B3/es not_active Expired - Lifetime
- 1987-07-31 EP EP87111104A patent/EP0257344B1/de not_active Expired - Lifetime
- 1987-08-11 CA CA000544180A patent/CA1302272C/en not_active Expired - Lifetime
- 1987-08-11 PH PH35653A patent/PH27176A/en unknown
- 1987-08-11 DD DD87305901A patent/DD263918A5/de not_active IP Right Cessation
- 1987-08-12 DK DK421187A patent/DK172236B1/da not_active IP Right Cessation
- 1987-08-12 AU AU76795/87A patent/AU603146B2/en not_active Expired
- 1987-08-12 IL IL83510A patent/IL83510A/xx not_active IP Right Cessation
- 1987-08-12 NO NO873370A patent/NO175132C/no not_active IP Right Cessation
- 1987-08-12 IE IE215287A patent/IE60862B1/en not_active IP Right Cessation
- 1987-08-12 NZ NZ221424A patent/NZ221424A/xx unknown
- 1987-08-12 PT PT85525A patent/PT85525B/pt unknown
- 1987-08-12 ZA ZA875947A patent/ZA875947B/xx unknown
- 1987-08-12 JP JP62201688A patent/JP2593879B2/ja not_active Expired - Lifetime
- 1987-08-12 HU HU873652A patent/HU202404B/hu unknown
- 1987-08-12 FI FI873492A patent/FI873492A/fi not_active Application Discontinuation
- 1987-08-13 KR KR87008873A patent/KR950009098B1/ko not_active IP Right Cessation
-
1991
- 1991-03-29 GR GR91400406T patent/GR3001695T3/el unknown
-
1993
- 1993-11-11 SG SG122593A patent/SG122593G/en unknown
-
1994
- 1994-02-24 HK HK144/94A patent/HK14494A/xx not_active IP Right Cessation
-
1995
- 1995-04-12 US US08/421,351 patent/US6015577A/en not_active Expired - Lifetime
-
1997
- 1997-05-13 BR BR1100593-9A patent/BR1100593A/pt active IP Right Grant
-
1999
- 1999-01-06 NL NL990001C patent/NL990001I2/nl unknown
- 1999-07-01 NO NO1999014C patent/NO1999014I1/no unknown
-
2004
- 2004-05-24 CL CL200401252A patent/CL2004001252A1/es unknown
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