NL9002314A - Immunogene complexen, in het bijzonder iscoms. - Google Patents
Immunogene complexen, in het bijzonder iscoms. Download PDFInfo
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- NL9002314A NL9002314A NL9002314A NL9002314A NL9002314A NL 9002314 A NL9002314 A NL 9002314A NL 9002314 A NL9002314 A NL 9002314A NL 9002314 A NL9002314 A NL 9002314A NL 9002314 A NL9002314 A NL 9002314A
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- NL
- Netherlands
- Prior art keywords
- quil
- fractions
- iscom
- immunogenic complex
- saponin
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- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
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- QBSJHOGDIUQWTH-UHFFFAOYSA-N dihydrolanosterol Natural products CC(C)CCCC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 QBSJHOGDIUQWTH-UHFFFAOYSA-N 0.000 description 1
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- 210000003743 erythrocyte Anatomy 0.000 description 1
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- CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 description 1
- 229940058690 lanosterol Drugs 0.000 description 1
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- XIXADJRWDQXREU-UHFFFAOYSA-M lithium acetate Chemical compound [Li+].CC([O-])=O XIXADJRWDQXREU-UHFFFAOYSA-M 0.000 description 1
- DNVPQKQSNYMLRS-YAPGYIAOSA-N lumisterol Chemical compound C1[C@@H](O)CC[C@@]2(C)[C@H](CC[C@@]3([C@@H]([C@H](C)/C=C/[C@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-YAPGYIAOSA-N 0.000 description 1
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- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 1
- UMWKZHPREXJQGR-UHFFFAOYSA-N n-methyl-n-(2,3,4,5,6-pentahydroxyhexyl)decanamide Chemical compound CCCCCCCCCC(=O)N(C)CC(O)C(O)C(O)C(O)CO UMWKZHPREXJQGR-UHFFFAOYSA-N 0.000 description 1
- UMWKZHPREXJQGR-XOSAIJSUSA-N n-methyl-n-[(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl]decanamide Chemical compound CCCCCCCCCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO UMWKZHPREXJQGR-XOSAIJSUSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL9002314A NL9002314A (nl) | 1990-10-23 | 1990-10-23 | Immunogene complexen, in het bijzonder iscoms. |
| PCT/NL1991/000211 WO1992006710A1 (en) | 1990-10-23 | 1991-10-23 | Immunogenic complexes, in particular iscoms |
| CA002094600A CA2094600C (en) | 1990-10-23 | 1991-10-23 | Immunogenic complexes, in particular iscoms |
| AT91918619T ATE127024T1 (de) | 1990-10-23 | 1991-10-23 | Immunogene komplexe, insbesondere iscoms. |
| DK91918619.7T DK0555276T3 (da) | 1990-10-23 | 1991-10-23 | Immunogene komplekser, især iscomer |
| EP91918619A EP0555276B1 (de) | 1990-10-23 | 1991-10-23 | Immunogene komplexe, insbesondere iscoms |
| DE69112634T DE69112634T2 (de) | 1990-10-23 | 1991-10-23 | Immunogene komplexe, insbesondere iscoms. |
| ES91918619T ES2075964T3 (es) | 1990-10-23 | 1991-10-23 | Complejos inmunogenos, en particular iscomes. |
| US08/039,294 US5620690A (en) | 1990-10-23 | 1991-10-23 | Immunogenic complexes |
| GR950402880T GR3017778T3 (en) | 1990-10-23 | 1995-10-18 | Immunogenic complexes, in particular iscoms. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL9002314A NL9002314A (nl) | 1990-10-23 | 1990-10-23 | Immunogene complexen, in het bijzonder iscoms. |
| NL9002314 | 1990-10-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL9002314A true NL9002314A (nl) | 1992-05-18 |
Family
ID=19857870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL9002314A NL9002314A (nl) | 1990-10-23 | 1990-10-23 | Immunogene complexen, in het bijzonder iscoms. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5620690A (de) |
| EP (1) | EP0555276B1 (de) |
| AT (1) | ATE127024T1 (de) |
| CA (1) | CA2094600C (de) |
| DE (1) | DE69112634T2 (de) |
| DK (1) | DK0555276T3 (de) |
| ES (1) | ES2075964T3 (de) |
| GR (1) | GR3017778T3 (de) |
| NL (1) | NL9002314A (de) |
| WO (1) | WO1992006710A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08502416A (ja) * | 1992-10-30 | 1996-03-19 | シード・キャピタル・インベストメント・（エス・シー・アイ）・ベスローテン・フェンノートシャップ | キラヤ種の培養細胞 |
| NL9301690A (nl) * | 1993-08-12 | 1995-04-18 | Seed Capital Investments | Verbindingen met adjuvans-activiteit. |
| AU1077795A (en) * | 1993-09-30 | 1995-04-18 | Seed Capital Investments (Sci) B.V. | Compounds with adjuvant activity |
| AUPM500494A0 (en) * | 1994-04-12 | 1994-05-05 | Minister For Agriculture & Rural Affairs For The State Of New South Wales, The | Composition for use in increasing mucosal immunity |
| AUPM873294A0 (en) * | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| GB9620795D0 (en) * | 1996-10-05 | 1996-11-20 | Smithkline Beecham Plc | Vaccines |
| UA56132C2 (uk) * | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| SE9600648D0 (sv) * | 1996-02-21 | 1996-02-21 | Bror Morein | Receptorbimdande enhet |
| AUPO517897A0 (en) * | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
| US6645495B1 (en) * | 1997-08-29 | 2003-11-11 | Antigenics, Inc. | Compositions of saponin adjuvants and excipients |
| GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| DK1377320T3 (da) * | 2001-04-04 | 2009-02-09 | Nordic Vaccine Technology As | Polynukleotidbindingskomplekser omfattende steroler og saponiner |
| US7713942B2 (en) | 2001-04-04 | 2010-05-11 | Nordic Vaccine Technology A/S | Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides |
| SE0202110D0 (sv) * | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
| AU2003269839B2 (en) * | 2002-10-02 | 2006-07-27 | Nordic Vaccine A/S | Composition for vaccination |
| SE0300795D0 (sv) | 2003-03-24 | 2003-03-24 | Isconova Ab | Composition comprising iscom particles and live micro-organisms |
| SE0301998D0 (sv) * | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
| PL1838341T3 (pl) | 2005-01-20 | 2014-04-30 | Isconova Ab | Kompozycja szczepionki obejmująca białko wiążące fibronektynę lub peptyd wiążący fibronektynę |
| WO2006112339A1 (ja) * | 2005-04-14 | 2006-10-26 | Matsushita Electric Industrial Co., Ltd. | ヘモグロビン誘導体の測定方法、それに用いる試薬組成物、測定キット、分析デバイス、及び分析システム |
| BRPI1006179A2 (pt) | 2009-01-13 | 2016-02-23 | Transgène S A | uso de uma fração de ácidos nucleicos mitocondriais, composição adjuvante, composição de vacina, e, kit da parte |
| ES2673957T5 (es) | 2011-10-03 | 2021-12-15 | Croda Int Plc | Nanopartículas, procedimiento para la preparación y utilización de las mismas como portadoras de moléculas anfipáticas o hidrofóbicas en el campo de la medicina, incluyendo el tratamiento del cáncer, y compuestos de tipo alimentario |
| US10426829B2 (en) | 2015-09-03 | 2019-10-01 | Novavax, Inc. | Vaccine compositions having improved stability and immunogenicity |
| KR20210004959A (ko) | 2018-03-19 | 2021-01-13 | 노바백스, 인코포레이티드 | 다가 인플루엔자 나노입자 백신 |
| US10953089B1 (en) | 2020-01-27 | 2021-03-23 | Novavax, Inc. | Coronavirus vaccine formulations |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| SE8205892D0 (sv) * | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| SE8405493D0 (sv) * | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
| DK166762B1 (da) * | 1986-01-14 | 1993-07-12 | Nederlanden Staat | Fremgangsmaade til fremstilling af immunogenkomplekser og farmaceutisk sammensaetning indeholdende saadanne komplekser |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| CA1331443C (en) * | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
| NZ230747A (en) * | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| US4981684A (en) * | 1989-10-24 | 1991-01-01 | Coopers Animal Health Limited | Formation of adjuvant complexes |
| US5273965A (en) * | 1992-07-02 | 1993-12-28 | Cambridge Biotech Corporation | Methods for enhancing drug delivery with modified saponins |
-
1990
- 1990-10-23 NL NL9002314A patent/NL9002314A/nl not_active Application Discontinuation
-
1991
- 1991-10-23 EP EP91918619A patent/EP0555276B1/de not_active Expired - Lifetime
- 1991-10-23 US US08/039,294 patent/US5620690A/en not_active Expired - Lifetime
- 1991-10-23 ES ES91918619T patent/ES2075964T3/es not_active Expired - Lifetime
- 1991-10-23 AT AT91918619T patent/ATE127024T1/de not_active IP Right Cessation
- 1991-10-23 DK DK91918619.7T patent/DK0555276T3/da active
- 1991-10-23 WO PCT/NL1991/000211 patent/WO1992006710A1/en active IP Right Grant
- 1991-10-23 CA CA002094600A patent/CA2094600C/en not_active Expired - Lifetime
- 1991-10-23 DE DE69112634T patent/DE69112634T2/de not_active Expired - Lifetime
-
1995
- 1995-10-18 GR GR950402880T patent/GR3017778T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0555276A1 (de) | 1993-08-18 |
| CA2094600C (en) | 1998-12-08 |
| CA2094600A1 (en) | 1992-04-24 |
| DK0555276T3 (da) | 1995-09-18 |
| DE69112634T2 (de) | 1996-02-08 |
| US5620690A (en) | 1997-04-15 |
| GR3017778T3 (en) | 1996-01-31 |
| ATE127024T1 (de) | 1995-09-15 |
| WO1992006710A1 (en) | 1992-04-30 |
| DE69112634D1 (de) | 1995-10-05 |
| ES2075964T3 (es) | 1995-10-16 |
| EP0555276B1 (de) | 1995-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1B | A search report has been drawn up | ||
| BV | The patent application has lapsed |