DK0555276T3 - Immunogene komplekser, især iscomer - Google Patents
Immunogene komplekser, især iscomerInfo
- Publication number
- DK0555276T3 DK0555276T3 DK91918619.7T DK91918619T DK0555276T3 DK 0555276 T3 DK0555276 T3 DK 0555276T3 DK 91918619 T DK91918619 T DK 91918619T DK 0555276 T3 DK0555276 T3 DK 0555276T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- iscoms
- immunogenic
- quil
- fractions
- Prior art date
Links
- 230000002163 immunogen Effects 0.000 title abstract 6
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 abstract 3
- 239000001397 quillaja saponaria molina bark Substances 0.000 abstract 3
- 229930182490 saponin Natural products 0.000 abstract 3
- 150000007949 saponins Chemical class 0.000 abstract 3
- 229930182558 Sterol Natural products 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003432 sterols Chemical class 0.000 abstract 1
- 235000003702 sterols Nutrition 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL9002314A NL9002314A (nl) | 1990-10-23 | 1990-10-23 | Immunogene complexen, in het bijzonder iscoms. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0555276T3 true DK0555276T3 (da) | 1995-09-18 |
Family
ID=19857870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91918619.7T DK0555276T3 (da) | 1990-10-23 | 1991-10-23 | Immunogene komplekser, især iscomer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5620690A (da) |
| EP (1) | EP0555276B1 (da) |
| AT (1) | ATE127024T1 (da) |
| CA (1) | CA2094600C (da) |
| DE (1) | DE69112634T2 (da) |
| DK (1) | DK0555276T3 (da) |
| ES (1) | ES2075964T3 (da) |
| GR (1) | GR3017778T3 (da) |
| NL (1) | NL9002314A (da) |
| WO (1) | WO1992006710A1 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08502416A (ja) * | 1992-10-30 | 1996-03-19 | シード・キャピタル・インベストメント・（エス・シー・アイ）・ベスローテン・フェンノートシャップ | キラヤ種の培養細胞 |
| NL9301690A (nl) * | 1993-08-12 | 1995-04-18 | Seed Capital Investments | Verbindingen met adjuvans-activiteit. |
| WO1995009179A1 (en) * | 1993-09-30 | 1995-04-06 | Seed Capital Investments (Sci) B.V. | Compounds with adjuvant activity |
| AUPM500494A0 (en) * | 1994-04-12 | 1994-05-05 | Minister For Agriculture & Rural Affairs For The State Of New South Wales, The | Composition for use in increasing mucosal immunity |
| AUPM873294A0 (en) * | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| UA56132C2 (uk) * | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| GB9620795D0 (en) * | 1996-10-05 | 1996-11-20 | Smithkline Beecham Plc | Vaccines |
| SE9600648D0 (sv) * | 1996-02-21 | 1996-02-21 | Bror Morein | Receptorbimdande enhet |
| AUPO517897A0 (en) * | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
| ATE435661T1 (de) * | 1997-08-29 | 2009-07-15 | Antigenics Inc | Adjuvant qs-21 enthaltende zusammensetzungen mit polysorbate oder cyclodextrin als hilfsmittel |
| GB9817052D0 (en) * | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| US7713942B2 (en) | 2001-04-04 | 2010-05-11 | Nordic Vaccine Technology A/S | Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides |
| JP2004528321A (ja) | 2001-04-04 | 2004-09-16 | ノルディック ワクチン テクノロジー アクティーゼルスカブ | ステロールおよびサポニンを含むポリヌクレオチド結合複合体 |
| SE0202110D0 (sv) * | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
| AU2003269839B2 (en) * | 2002-10-02 | 2006-07-27 | Nordic Vaccine A/S | Composition for vaccination |
| SE0300795D0 (sv) | 2003-03-24 | 2003-03-24 | Isconova Ab | Composition comprising iscom particles and live micro-organisms |
| SE0301998D0 (sv) * | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
| CA2592627C (en) * | 2005-01-20 | 2014-02-25 | Isconova Ab | Vaccine composition comprising a fibronectin binding protein or a fibronectin binding peptide |
| US8921052B2 (en) * | 2005-04-14 | 2014-12-30 | Panasonic Healthcare Co., Ltd. | Hemoglobin derivative measurement method, and reagent composition, measurement kit, analysis device and analysis system for use in the method |
| MX2011007494A (es) | 2009-01-13 | 2011-08-12 | Transgene Sa | Uso de una fraccion de la mitocondria de acidos nucleicos de saccharomyces cerevisiae para la estimulacion inmune. |
| PT2750683T (pt) * | 2011-10-03 | 2018-06-26 | Mx Adjuvac Ab | Nanopartículas, processo de preparação e seu uso como transportadores para moléculas hidrofóbicas anfipáticas no domínio da medicina, incluindo tratamento de cancro e compostos relacionados a alimentos |
| EP3344291A4 (en) | 2015-09-03 | 2019-04-10 | Novavax, Inc. | VACCINE COMPOSITIONS WITH IMPROVED STABILITY AND IMMUNOGENICITY |
| AU2019238171A1 (en) | 2018-03-19 | 2020-09-24 | Novavax, Inc. | Multivalent influenza nanoparticle vaccines |
| US10953089B1 (en) | 2020-01-27 | 2021-03-23 | Novavax, Inc. | Coronavirus vaccine formulations |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8205892D0 (sv) * | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| SE8405493D0 (sv) * | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
| DE3775783D1 (de) * | 1986-01-14 | 1992-02-20 | Nederlanden Staat | Verfahren zur herstellung immunologischer komplexe und diese enthaltende pharmazeutische zusammensetzung. |
| CA1331443C (en) * | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| NZ230747A (en) * | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| US4981684A (en) * | 1989-10-24 | 1991-01-01 | Coopers Animal Health Limited | Formation of adjuvant complexes |
| US5273965A (en) * | 1992-07-02 | 1993-12-28 | Cambridge Biotech Corporation | Methods for enhancing drug delivery with modified saponins |
-
1990
- 1990-10-23 NL NL9002314A patent/NL9002314A/nl not_active Application Discontinuation
-
1991
- 1991-10-23 US US08/039,294 patent/US5620690A/en not_active Expired - Lifetime
- 1991-10-23 DK DK91918619.7T patent/DK0555276T3/da active
- 1991-10-23 EP EP91918619A patent/EP0555276B1/en not_active Expired - Lifetime
- 1991-10-23 WO PCT/NL1991/000211 patent/WO1992006710A1/en active IP Right Grant
- 1991-10-23 CA CA002094600A patent/CA2094600C/en not_active Expired - Lifetime
- 1991-10-23 DE DE69112634T patent/DE69112634T2/de not_active Expired - Lifetime
- 1991-10-23 ES ES91918619T patent/ES2075964T3/es not_active Expired - Lifetime
- 1991-10-23 AT AT91918619T patent/ATE127024T1/de not_active IP Right Cessation
-
1995
- 1995-10-18 GR GR950402880T patent/GR3017778T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2075964T3 (es) | 1995-10-16 |
| EP0555276A1 (en) | 1993-08-18 |
| NL9002314A (nl) | 1992-05-18 |
| US5620690A (en) | 1997-04-15 |
| WO1992006710A1 (en) | 1992-04-30 |
| DE69112634T2 (de) | 1996-02-08 |
| GR3017778T3 (en) | 1996-01-31 |
| CA2094600C (en) | 1998-12-08 |
| EP0555276B1 (en) | 1995-08-30 |
| CA2094600A1 (en) | 1992-04-24 |
| ATE127024T1 (de) | 1995-09-15 |
| DE69112634D1 (de) | 1995-10-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0555276T3 (da) | Immunogene komplekser, især iscomer | |
| DK602989A (da) | Saponinadjuvans | |
| ZA837603B (en) | Immunogenic protein or peptide complex,method of producing said complex and the use thereof as an immune stimulant and as a vaccine | |
| BR9306984A (pt) | Análogo de antígeno de peptídeo de um antígeno de peptídeo nativo vacina anticorpo processo para vacinar um hospedeiro necessitando deste tratamento estojo diagnóstico processos para preparar um análogo de um antiígeno de um antígeno de peptídeo nativo para preparar uma vacina para analisar uma amostra para um antígeno de peptídeo nativo e para analisar uma amostra para um anticorpo | |
| PT584348E (pt) | Vacina genetica para virus da imunodeficiencia | |
| NZ219113A (en) | Hiv peptide containing epitope of the env protein | |
| GB9626484D0 (en) | Helicobacter pylori antigenic protein preparation and immunoassays | |
| NZ331651A (en) | BSW17 peptide immunogens for vaccination against and treatment of allergy | |
| DK0489153T3 (da) | Vaccinepræparater indeholdende liposomer | |
| HUP9903770A2 (hu) | Eljárások és készítmények többepitópos antigének konformációjának megváltoztatására immunválasz kiváltása céljából | |
| AU1800597A (en) | Novel methods of vaccination and vaccines therefore comprising a nucleic acid encoding a first epitope and a peptide containing a second epitope | |
| DK1267924T3 (da) | Immunterapeutiske metoder og sammensætninger | |
| ATE162550T1 (de) | Ospc-antigen-impfstoffe immunogene zusammensetzung zur vorbeugung und behandlung von lyme-krankheit und rekombinante verfahren zur herstellung von derartige antigene | |
| ATE188484T1 (de) | Immunologisch mit hla homologe hiv protein epitope | |
| IL76271A0 (en) | Cross-reactive and protective epitopes of circumsporozoite proteins | |
| IL106407A0 (en) | Antigens,vaccines containing them and their preparation | |
| DE69229043D1 (de) | Das durch den monoklonalen menschlichen antikörper 81av78 erkannte antigen ctaa 81av78 | |
| EP1020516A3 (en) | Leptospira vaccine antigens for the prevention of leptospirosis | |
| ZA9601216D (en) | Novel Antigen. | |
| MX9708226A (es) | Vacunas que contienen una saponina y un esterol. |