NL7920107A - Van beta-glucuronidase-activiteit en/of ph afhankelijke farmaceutische preparaten, werkwijzen ter bereiding daarvan en toepassing daarvan voor de selectieve behandeling van ziekten. - Google Patents
Van beta-glucuronidase-activiteit en/of ph afhankelijke farmaceutische preparaten, werkwijzen ter bereiding daarvan en toepassing daarvan voor de selectieve behandeling van ziekten. Download PDFInfo
- Publication number
- NL7920107A NL7920107A NL7920107A NL7920107A NL7920107A NL 7920107 A NL7920107 A NL 7920107A NL 7920107 A NL7920107 A NL 7920107A NL 7920107 A NL7920107 A NL 7920107A NL 7920107 A NL7920107 A NL 7920107A
- Authority
- NL
- Netherlands
- Prior art keywords
- glucuronic acid
- glucuronide
- compound
- aglycone
- administered
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 107
- 230000000694 effects Effects 0.000 title claims description 83
- 102000053187 Glucuronidase Human genes 0.000 title claims description 75
- 108010060309 Glucuronidase Proteins 0.000 title claims description 75
- 238000011282 treatment Methods 0.000 title claims description 36
- 238000002360 preparation method Methods 0.000 title claims description 14
- 201000010099 disease Diseases 0.000 title description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 3
- 239000000825 pharmaceutical preparation Substances 0.000 title description 3
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- 229940097043 glucuronic acid Drugs 0.000 claims description 57
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 claims description 54
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 claims description 51
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- ZKSZEJFBGODIJW-UHFFFAOYSA-N passiedulin Natural products OC1C(O)C(O)C(CO)OC1OC(C#N)C1=CC=CC=C1 ZKSZEJFBGODIJW-UHFFFAOYSA-N 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- BMXNUTUYWQWEFA-UHFFFAOYSA-N prunasin Natural products OCC1OC(O)C(O)C(O)C1OC(C#N)c2ccccc2 BMXNUTUYWQWEFA-UHFFFAOYSA-N 0.000 description 1
- 235000014774 prunus Nutrition 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229960000581 salicylamide Drugs 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 231100000161 signs of toxicity Toxicity 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001573 trophoblastic effect Effects 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Optics & Photonics (AREA)
- General Physics & Mathematics (AREA)
- Physiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95127078 | 1978-10-13 | ||
| US95126978 | 1978-10-13 | ||
| US05/951,270 US4424348A (en) | 1978-10-13 | 1978-10-13 | Methods of manufacture of nitrile-containing glucuronic acid conjugates |
| US05/951,269 US4584368A (en) | 1978-10-13 | 1978-10-13 | β-Glucuronidase activity and/or pH-dependent pharmaceuticals and thier methods of production |
| US1161979 | 1979-02-12 | ||
| US06/011,619 US4327074A (en) | 1978-10-13 | 1979-02-12 | Method for diagnosis and selective treatment of infections of bacteria having β-glucuronidase activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7920107A true NL7920107A (nl) | 1980-08-29 |
Family
ID=27359461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7920107A NL7920107A (nl) | 1978-10-13 | 1979-10-02 | Van beta-glucuronidase-activiteit en/of ph afhankelijke farmaceutische preparaten, werkwijzen ter bereiding daarvan en toepassing daarvan voor de selectieve behandeling van ziekten. |
Country Status (12)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4490523A (en) * | 1981-11-10 | 1984-12-25 | Ely J. Rubin | Mandelonitrile triacetyl glucuronate and process for preparing same |
| AU594855B2 (en) * | 1988-01-15 | 1990-03-15 | Baker Norton Pharmaceuticals, Inc. | Glucuronic acid derivatives of opioid antagonists |
| DE59610819D1 (de) * | 1995-03-30 | 2003-12-18 | Werner Kreutz | Arzneistoffe zur selektiven bekämpfung von tumorgewebe |
| WO2014138722A1 (en) * | 2013-03-08 | 2014-09-12 | Cognate3 Llc | Process for the preparation of a non-corrosive base solution and methods of using same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB788855A (en) * | 1953-06-30 | 1958-01-08 | Ernst Theodore Krebs | Improvements in or relating to mandelo-nitrile-glucuronosides and method of making the same |
| US2985664A (en) * | 1957-05-29 | 1961-05-23 | Ernst T Krebs | Hexuronic acid derivatives |
| US3758455A (en) * | 1970-05-14 | 1973-09-11 | Chugai Pharmaceutical Co Ltd | Reof mycophenolic acid glucuronide and the process for the preparation the |
| DE2212014A1 (de) * | 1971-04-21 | 1972-10-26 | Deutsche Akademie der Wissenschaf ten zu Berlin, χ 1199 Berlin | Verfahren zur fermentativen Spaltung von Transportformen von Chemotherapeutika, insbesondere Cancerostatica |
| USRE29465E (en) * | 1972-08-14 | 1977-11-01 | Eli Lilly And Company | Psoriasis treatment with mycophenolic acid |
| US3880995A (en) * | 1973-05-14 | 1975-04-29 | Lilly Co Eli | Treatment of arthritis with mycophenolic acid and derivatives |
| US3959253A (en) * | 1973-07-02 | 1976-05-25 | Merck & Co., Inc. | β-D-glucosyluronic acid derivatives |
| JPS5325534A (en) * | 1976-08-24 | 1978-03-09 | Rikagaku Kenkyusho | Mandelic acid glucosides and their anti-cancerous preparations |
-
1979
- 1979-09-24 AU AU51120/79A patent/AU534068B2/en not_active Ceased
- 1979-09-28 IL IL58352A patent/IL58352A/xx unknown
- 1979-10-02 JP JP50180979A patent/JPS55500837A/ja active Pending
- 1979-10-02 WO PCT/US1979/000809 patent/WO1980000791A1/en unknown
- 1979-10-02 DE DE792953223T patent/DE2953223T1/de active Granted
- 1979-10-02 GB GB8015763A patent/GB2055044B/en not_active Expired
- 1979-10-02 NL NL7920107A patent/NL7920107A/nl unknown
- 1979-10-02 CH CH4668/80A patent/CH652724A5/de not_active IP Right Cessation
- 1979-10-10 FR FR7925183A patent/FR2440374B1/fr not_active Expired
- 1979-10-11 IT IT50529/79A patent/IT1164730B/it active
- 1979-10-12 CA CA000337483A patent/CA1148086A/en not_active Expired
-
1980
- 1980-04-30 FR FR8009746A patent/FR2449284A1/fr not_active Withdrawn
- 1980-06-12 SE SE8004369A patent/SE461983B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IT1164730B (it) | 1987-04-15 |
| CH652724A5 (de) | 1985-11-29 |
| FR2449284A1 (fr) | 1980-09-12 |
| AU534068B2 (en) | 1984-01-05 |
| SE8004369L (sv) | 1980-06-12 |
| CA1148086A (en) | 1983-06-14 |
| AU5112079A (en) | 1981-04-16 |
| JPS55500837A (enrdf_load_stackoverflow) | 1980-10-23 |
| FR2440374A1 (fr) | 1980-05-30 |
| GB2055044A (en) | 1981-02-25 |
| DE2953223T1 (de) | 1980-11-27 |
| WO1980000791A1 (en) | 1980-05-01 |
| FR2440374B1 (fr) | 1986-03-21 |
| IL58352A (en) | 1985-11-29 |
| GB2055044B (en) | 1983-04-20 |
| DE2953223C2 (enrdf_load_stackoverflow) | 1989-05-18 |
| IT7950529A0 (it) | 1979-10-11 |
| SE461983B (sv) | 1990-04-23 |
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