IL58352A - Selective cytotoxically active pharmaceutical compositions containing a glucuronide,a hyperglycemic agent and an alkalinizing agent - Google Patents

Selective cytotoxically active pharmaceutical compositions containing a glucuronide,a hyperglycemic agent and an alkalinizing agent

Info

Publication number
IL58352A
IL58352A IL58352A IL5835279A IL58352A IL 58352 A IL58352 A IL 58352A IL 58352 A IL58352 A IL 58352A IL 5835279 A IL5835279 A IL 5835279A IL 58352 A IL58352 A IL 58352A
Authority
IL
Israel
Prior art keywords
agent
glucuronide
selective
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL58352A
Other languages
English (en)
Original Assignee
Schwimmer Adolph
Schwartz Irwin S
Rubin David
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/951,270 external-priority patent/US4424348A/en
Priority claimed from US05/951,269 external-priority patent/US4584368A/en
Priority claimed from US06/011,619 external-priority patent/US4327074A/en
Application filed by Schwimmer Adolph, Schwartz Irwin S, Rubin David filed Critical Schwimmer Adolph
Publication of IL58352A publication Critical patent/IL58352A/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0491Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004Monosaccharides having only carbon, hydrogen and oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549Sugars, nucleosides, nucleotides or nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18Acyclic radicals, substituted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/924Hydrolases (3) acting on glycosyl compounds (3.2)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Physiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL58352A 1978-10-13 1979-09-28 Selective cytotoxically active pharmaceutical compositions containing a glucuronide,a hyperglycemic agent and an alkalinizing agent IL58352A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/951,270 US4424348A (en) 1978-10-13 1978-10-13 Methods of manufacture of nitrile-containing glucuronic acid conjugates
US05/951,269 US4584368A (en) 1978-10-13 1978-10-13 β-Glucuronidase activity and/or pH-dependent pharmaceuticals and thier methods of production
US06/011,619 US4327074A (en) 1978-10-13 1979-02-12 Method for diagnosis and selective treatment of infections of bacteria having β-glucuronidase activity

Publications (1)

Publication Number Publication Date
IL58352A true IL58352A (en) 1985-11-29

Family

ID=27359461

Family Applications (1)

Application Number Title Priority Date Filing Date
IL58352A IL58352A (en) 1978-10-13 1979-09-28 Selective cytotoxically active pharmaceutical compositions containing a glucuronide,a hyperglycemic agent and an alkalinizing agent

Country Status (12)

Country Link
JP (1) JPS55500837A (enrdf_load_stackoverflow)
AU (1) AU534068B2 (enrdf_load_stackoverflow)
CA (1) CA1148086A (enrdf_load_stackoverflow)
CH (1) CH652724A5 (enrdf_load_stackoverflow)
DE (1) DE2953223T1 (enrdf_load_stackoverflow)
FR (2) FR2440374B1 (enrdf_load_stackoverflow)
GB (1) GB2055044B (enrdf_load_stackoverflow)
IL (1) IL58352A (enrdf_load_stackoverflow)
IT (1) IT1164730B (enrdf_load_stackoverflow)
NL (1) NL7920107A (enrdf_load_stackoverflow)
SE (1) SE461983B (enrdf_load_stackoverflow)
WO (1) WO1980000791A1 (enrdf_load_stackoverflow)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490523A (en) * 1981-11-10 1984-12-25 Ely J. Rubin Mandelonitrile triacetyl glucuronate and process for preparing same
AU594855B2 (en) * 1988-01-15 1990-03-15 Baker Norton Pharmaceuticals, Inc. Glucuronic acid derivatives of opioid antagonists
DE59610819D1 (de) * 1995-03-30 2003-12-18 Werner Kreutz Arzneistoffe zur selektiven bekämpfung von tumorgewebe
WO2014138722A1 (en) * 2013-03-08 2014-09-12 Cognate3 Llc Process for the preparation of a non-corrosive base solution and methods of using same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB788855A (en) * 1953-06-30 1958-01-08 Ernst Theodore Krebs Improvements in or relating to mandelo-nitrile-glucuronosides and method of making the same
US2985664A (en) * 1957-05-29 1961-05-23 Ernst T Krebs Hexuronic acid derivatives
US3758455A (en) * 1970-05-14 1973-09-11 Chugai Pharmaceutical Co Ltd Reof mycophenolic acid glucuronide and the process for the preparation the
DE2212014A1 (de) * 1971-04-21 1972-10-26 Deutsche Akademie der Wissenschaf ten zu Berlin, χ 1199 Berlin Verfahren zur fermentativen Spaltung von Transportformen von Chemotherapeutika, insbesondere Cancerostatica
USRE29465E (en) * 1972-08-14 1977-11-01 Eli Lilly And Company Psoriasis treatment with mycophenolic acid
US3880995A (en) * 1973-05-14 1975-04-29 Lilly Co Eli Treatment of arthritis with mycophenolic acid and derivatives
US3959253A (en) * 1973-07-02 1976-05-25 Merck & Co., Inc. β-D-glucosyluronic acid derivatives
JPS5325534A (en) * 1976-08-24 1978-03-09 Rikagaku Kenkyusho Mandelic acid glucosides and their anti-cancerous preparations

Also Published As

Publication number Publication date
IT1164730B (it) 1987-04-15
CH652724A5 (de) 1985-11-29
FR2449284A1 (fr) 1980-09-12
AU534068B2 (en) 1984-01-05
SE8004369L (sv) 1980-06-12
CA1148086A (en) 1983-06-14
AU5112079A (en) 1981-04-16
JPS55500837A (enrdf_load_stackoverflow) 1980-10-23
FR2440374A1 (fr) 1980-05-30
GB2055044A (en) 1981-02-25
DE2953223T1 (de) 1980-11-27
WO1980000791A1 (en) 1980-05-01
FR2440374B1 (fr) 1986-03-21
NL7920107A (nl) 1980-08-29
GB2055044B (en) 1983-04-20
DE2953223C2 (enrdf_load_stackoverflow) 1989-05-18
IT7950529A0 (it) 1979-10-11
SE461983B (sv) 1990-04-23

Similar Documents

Publication Publication Date Title
IL55274A0 (en) Pinene derivatives, their preparation and pharmaceutical compositions containing them
IL51086A (en) 4 (phenoxy-phenoxy) methyl 1,3-dioxolane derivatives,their manufacture and insecticidal and acaricidal compositions containing them
NZ190299A (en) 1,2,4-trizole -3,5- diamines and pharmaceutical compositions
IL57708A0 (en) Aminopropoxyindole derivatives,their preparation and pharmaceutical compositions containing them
NZ190745A (en) Mercapto-substituted -2,3,4,5-tetrahydro-1h-3-benzazepines and pharmaceutical compositions
HK6185A (en) 1-benzoyl-2-pyrrolidinone derivative,processes for its preparation and medicaments containing it
HU177796B (en) Insecticide compositions containing substituted benzoyl-urea derivatives as active agent,and process for producing the active agent
IT7926662A0 (it) Composizione farmaceutica contenente 3,4-di-idro-3-osso-2-chinossaline.
DE2960024D1 (en) Substituted diphenylmethyl-imidazoles, their preparation and medicaments containing them
IL57297A0 (en) 4-amino-2-piperidinoquinazoline derivatives,their preparation and pharmaceutical compositions containing them
IL58352A (en) Selective cytotoxically active pharmaceutical compositions containing a glucuronide,a hyperglycemic agent and an alkalinizing agent
NZ189881A (en) 4,5-diaryl-2-(substituted-thio)-pyrroles and pharmaceutical compositions
DE3263167D1 (en) Physiologically active substance fa-5859, its derivative; their production and antidiabetic agents containing said compounds
HU177937B (en) Insecticide compositions containing n,n-dimethyl-o-pyrazolyl-carbamoic-acid-esters and process for producing the active agents
IL56816A0 (en) N-phenylaniline derivatives,their preparation and pharmaceutical compositions containing them
IL58620A (en) Aryltrifluoroethanol derivatives,their preparation and pharmaceutical compositions containing them
IL57245A (en) Alpha-imidazolyl methyl dibenzyl ethers,their preparation and pharmaceutical compositions comprising therapeutically active substituted dibenzyl ethers
IL57720A0 (en) Phenylpiperidine derivatives,their preparation and pharmaceutical compositions containing them
IL57219A (en) 10-methoxy-daunorubicin,10-methoxy-doxorubicin,their derivatives,preparation thereof,and pharmaceutical compositions comprising them
IL56913A (en) Sprio-steroid-oxazolidinone derivatives,their preparation and pharmaceutical compositions containing them
IL56890A0 (en) 2-amino-carbazole derivatives,their preparation and pharmaceutical compositions containing them
DE2963868D1 (en) Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them
NZ192082A (en) 10-cyano-5h-dibenz(b,f)azepine-5-carboxamide and pharmaceutical compositions
IL56349A0 (en) 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
IL56529A0 (en) Azathianaphthalene derivatives, their manufacture and pharmaceutical compositions containing them