NL7608856A - Werkwijze ter bereiding van nieuwe tetrahydro- isochinoline derivaten alsmede deze verbindingen bevattende farmaceutische preparaten. - Google Patents
Werkwijze ter bereiding van nieuwe tetrahydro- isochinoline derivaten alsmede deze verbindingen bevattende farmaceutische preparaten.Info
- Publication number
- NL7608856A NL7608856A NL7608856A NL7608856A NL7608856A NL 7608856 A NL7608856 A NL 7608856A NL 7608856 A NL7608856 A NL 7608856A NL 7608856 A NL7608856 A NL 7608856A NL 7608856 A NL7608856 A NL 7608856A
- Authority
- NL
- Netherlands
- Prior art keywords
- tetrahydroisochinoline
- derivatives
- compounds
- preparation
- new
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000003526 tetrahydroisoquinolines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB33283/75A GB1504424A (en) | 1975-08-09 | 1975-08-09 | Isoquinoline-derived aminoethers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7608856A true NL7608856A (nl) | 1977-02-11 |
Family
ID=10350917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7608856A NL7608856A (nl) | 1975-08-09 | 1976-08-09 | Werkwijze ter bereiding van nieuwe tetrahydro- isochinoline derivaten alsmede deze verbindingen bevattende farmaceutische preparaten. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4113869A (de) |
| JP (1) | JPS5223083A (de) |
| AT (2) | AT354448B (de) |
| AU (1) | AU498422B2 (de) |
| BE (1) | BE844783A (de) |
| CA (1) | CA1076119A (de) |
| CH (2) | CH622780A5 (de) |
| DE (1) | DE2635276A1 (de) |
| DK (1) | DK357976A (de) |
| ES (6) | ES450550A1 (de) |
| FR (1) | FR2320755A1 (de) |
| GB (1) | GB1504424A (de) |
| HU (1) | HU173560B (de) |
| IE (1) | IE43506B1 (de) |
| IL (1) | IL50176A (de) |
| NL (1) | NL7608856A (de) |
| NZ (1) | NZ181619A (de) |
| SE (1) | SE7608641L (de) |
| ZA (1) | ZA764555B (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2711655A1 (de) * | 1977-03-17 | 1978-09-21 | Basf Ag | Pyridinyl-aminoalkylaether |
| US4340600A (en) | 1980-05-22 | 1982-07-20 | Smithkline Corporation | Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines |
| US4766131A (en) * | 1980-10-17 | 1988-08-23 | Pennwalt Corporation | 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics |
| US4477670A (en) * | 1981-02-19 | 1984-10-16 | Hoechst-Roussel Pharmaceuticals Inc. | 4-Aryloxy-1,2,3,4-tetrahydroisoquinolines |
| US4375471A (en) * | 1981-02-19 | 1983-03-01 | Hoechst-Roussel Pharmaceuticals Inc. | 4-Aryloxy-1,2,3,4-tetrahydroisoquinolines |
| US4551474A (en) * | 1981-02-19 | 1985-11-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Methods of alleviating convulsions and pain employing 4-aryloxy-1,2,3,4 tetrahydroisoquinolines |
| US6562837B1 (en) * | 1998-10-21 | 2003-05-13 | Korea Institute Of Science & Technology | Use of tetrahydroisoquinoline compounds for the treatment of septicemia |
| PT1246806E (pt) * | 1999-11-03 | 2008-04-03 | Amr Technology Inc | Tetra-hidroisoquinolinas aril- e heteroaril-substituídas e sua utilização no bloqueio da recaptação de norepinefrina, dopamina e serotonina. |
| KR100878855B1 (ko) * | 1999-11-03 | 2009-01-15 | 에이엠알 테크놀로지, 인크. | 4-페닐-치환 테트라히드로이소퀴놀린, 및 노르에피네프린과 도파민과 세로토닌의 재흡수를 차단하기 위한 이의 용도 |
| US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
| EP1113007A1 (de) | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisochinolin-Verbindungen zur Verwendung als Östrogen-Agonisten/-Antagonisten |
| CN100430401C (zh) | 2000-07-11 | 2008-11-05 | Amr科技公司 | 新的4-苯基取代的四氢异喹啉类化合物及其治疗用途 |
| US7314937B2 (en) * | 2002-03-21 | 2008-01-01 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses |
| US7541357B2 (en) * | 2004-07-15 | 2009-06-02 | Amr Technology, Inc. | Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| US20060111393A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
| US20060111385A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
| US20060111394A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
| EP1831173B1 (de) * | 2004-12-17 | 2011-01-26 | Janssen Pharmaceutica NV | Tetrahydroisochinolinverbindungen zur behandlung von zns-erkrankungen |
| US7754882B2 (en) * | 2005-06-17 | 2010-07-13 | Janssen Pharmaceutica Nv | Hexahydro-pyrrolo-isoquinoline compounds |
| DE602006002894D1 (de) | 2005-06-17 | 2008-11-06 | Janssen Pharmaceutica Nv | Naphthyridinverbindungen |
| EP1904069B1 (de) * | 2005-07-15 | 2018-06-13 | Albany Molecular Research, Inc. | Aryl- und heteroarylsubstituierte tetrahydrobenzazepine und verwendung damit zur wiederaufnahmeblockierung von norepinephrin, dopamin und serotonin |
| WO2008144305A1 (en) * | 2007-05-18 | 2008-11-27 | Janssen Pharmaceutica N.V. | Diaryl-substituted tetrahydroisoquinolines as histamine h3 receptor and serotonin transporter modulators |
| AR071997A1 (es) * | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
| ES2446971T3 (es) * | 2009-05-12 | 2014-03-11 | Albany Molecular Research, Inc. | Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso |
| CA2760837C (en) | 2009-05-12 | 2018-04-03 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
| JP5739415B2 (ja) * | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用 |
| IN2012DN00720A (de) | 2009-07-06 | 2015-06-19 | Ontorii Inc | |
| WO2012039448A1 (ja) * | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | 不斉補助基 |
| MX347361B (es) | 2011-07-19 | 2017-04-12 | Wave Life Sciences Ltd | Metodos para la sintesis de acidos nucleicos funcionalizados. |
| EP2872147B1 (de) | 2012-07-13 | 2022-12-21 | Wave Life Sciences Ltd. | Verfahren zur herstellung von chiralen oligonukleotiden |
| EP2872485B1 (de) | 2012-07-13 | 2020-12-16 | Wave Life Sciences Ltd. | Asymmetrische hilfsgruppe |
| AU2013287630B2 (en) | 2012-07-13 | 2017-05-25 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| US10144933B2 (en) | 2014-01-15 | 2018-12-04 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| EP3095460A4 (de) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chirales nukleinsäureadjuvans mit antiallergischer wirkung und antiallergikum |
| CN106068325B (zh) | 2014-01-16 | 2021-07-09 | 波涛生命科学有限公司 | 手性设计 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1058822A (en) * | 1963-07-30 | 1967-02-15 | Ici Ltd | 3-amino-2-hydroxypropoxy heterocyclic derivatives |
| US3479358A (en) * | 1966-09-19 | 1969-11-18 | Warner Lambert Pharmaceutical | Hexahydro-9,4a - iminoethano-4a-h-xanthenes and process for their production |
| US3666763A (en) * | 1970-01-06 | 1972-05-30 | Hoffmann La Roche | 4-phenyl isoquinolines and process for preparing same |
| US3947456A (en) * | 1970-01-06 | 1976-03-30 | Hoffman-La Roche Inc. | Substituted 4-phenyl isoquinolines |
| US3878215A (en) * | 1971-12-01 | 1975-04-15 | Sandoz Ag | 2-Alkyl-3-substituted-4-aryl isoquinolines |
| US3910924A (en) * | 1972-04-13 | 1975-10-07 | Otsuka Pharma Co Ltd | 3,4-Dihydrocarbostyril derivatives and a process for preparing the same |
| US3855227A (en) * | 1972-05-08 | 1974-12-17 | C Hollander | ({31 )-di-o-isopropylidene-2-keto-l-gulonates |
| JPS5239035B2 (de) * | 1972-12-14 | 1977-10-03 | ||
| US3872125A (en) * | 1973-03-03 | 1975-03-18 | Sandoz Ag | 3-substituted-4-aryl isoquinolines |
| US3870722A (en) * | 1973-11-02 | 1975-03-11 | Sandoz Ag | 2-Methyl-3-substituted-4-aryl isoquinolines |
| AR206061A1 (es) * | 1974-11-15 | 1976-06-23 | Knoll Ag | Procedimiento para la produccion de nuevas 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7-, 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-isoquinolinas de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-6-metoxi-isoquinolinas y de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-7-metoxi-isoquinolinas eventualmente metiladas en la posicion 1 |
-
1975
- 1975-08-09 GB GB33283/75A patent/GB1504424A/en not_active Expired
-
1976
- 1976-07-28 IE IE1668/76A patent/IE43506B1/en unknown
- 1976-07-29 ZA ZA764555A patent/ZA764555B/xx unknown
- 1976-07-29 NZ NZ181619A patent/NZ181619A/xx unknown
- 1976-07-30 SE SE7608641A patent/SE7608641L/xx not_active Application Discontinuation
- 1976-07-30 IL IL50176A patent/IL50176A/xx unknown
- 1976-07-30 BE BE169475A patent/BE844783A/xx unknown
- 1976-08-02 US US05/710,446 patent/US4113869A/en not_active Expired - Lifetime
- 1976-08-05 CH CH1002076A patent/CH622780A5/de not_active IP Right Cessation
- 1976-08-05 DE DE19762635276 patent/DE2635276A1/de not_active Withdrawn
- 1976-08-06 DK DK357976A patent/DK357976A/da not_active Application Discontinuation
- 1976-08-06 AT AT586876A patent/AT354448B/de not_active IP Right Cessation
- 1976-08-06 ES ES450550A patent/ES450550A1/es not_active Expired
- 1976-08-06 CA CA258,633A patent/CA1076119A/en not_active Expired
- 1976-08-09 AU AU16702/76A patent/AU498422B2/en not_active Expired
- 1976-08-09 FR FR7624258A patent/FR2320755A1/fr active Granted
- 1976-08-09 NL NL7608856A patent/NL7608856A/xx not_active Application Discontinuation
- 1976-08-09 JP JP51094721A patent/JPS5223083A/ja active Pending
- 1976-08-09 HU HU76BE1265A patent/HU173560B/hu unknown
-
1977
- 1977-09-01 ES ES77462062A patent/ES462062A1/es not_active Expired
- 1977-09-01 ES ES462059A patent/ES462059A1/es not_active Expired
- 1977-09-01 ES ES462058A patent/ES462058A1/es not_active Expired
- 1977-09-01 ES ES462060A patent/ES462060A1/es not_active Expired
- 1977-09-01 ES ES462061A patent/ES462061A1/es not_active Expired
-
1978
- 1978-10-05 AT AT717378A patent/AT353793B/de not_active IP Right Cessation
-
1981
- 1981-01-27 CH CH52281A patent/CH626611A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CH622780A5 (de) | 1981-04-30 |
| ES462058A1 (es) | 1978-06-16 |
| AT353793B (de) | 1979-12-10 |
| SE7608641L (sv) | 1977-02-10 |
| HU173560B (hu) | 1979-06-28 |
| ZA764555B (en) | 1977-07-27 |
| IE43506B1 (en) | 1981-03-11 |
| ES462059A1 (es) | 1978-06-16 |
| IL50176A0 (en) | 1976-09-30 |
| ES450550A1 (es) | 1977-12-16 |
| DK357976A (da) | 1977-02-10 |
| ATA586876A (de) | 1979-06-15 |
| BE844783A (fr) | 1977-01-31 |
| CA1076119A (en) | 1980-04-22 |
| US4113869A (en) | 1978-09-12 |
| DE2635276A1 (de) | 1977-02-17 |
| ES462060A1 (es) | 1978-06-16 |
| NZ181619A (en) | 1979-08-31 |
| IL50176A (en) | 1979-10-31 |
| FR2320755B1 (de) | 1979-09-14 |
| AU1670276A (en) | 1978-02-16 |
| GB1504424A (en) | 1978-03-22 |
| IE43506L (en) | 1977-02-09 |
| ES462061A1 (es) | 1978-06-16 |
| AU498422B2 (en) | 1979-03-15 |
| FR2320755A1 (fr) | 1977-03-11 |
| AT354448B (de) | 1979-01-10 |
| ATA717378A (de) | 1979-05-15 |
| CH626611A5 (de) | 1981-11-30 |
| JPS5223083A (en) | 1977-02-21 |
| ES462062A1 (es) | 1978-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BV | The patent application has lapsed |