ES462060A1 - Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.

Info

Publication number
ES462060A1
ES462060A1 ES462060A ES462060A ES462060A1 ES 462060 A1 ES462060 A1 ES 462060A1 ES 462060 A ES462060 A ES 462060A ES 462060 A ES462060 A ES 462060A ES 462060 A1 ES462060 A1 ES 462060A1
Authority
ES
Spain
Prior art keywords
alkyl
group
tetrahydroisoquinoline
pharmaceutical compositions
methods employing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES462060A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES462060A1 publication Critical patent/ES462060A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Un Un procedimiento para la preparación de nuevos derivados de tetrahidroisoquinoleina de fórmula II ***(Ver fórmula I) y sales del mismo, donde R1 es un grupo alquilo C1-6, ciclo alquilo C3-6, fenilo, naftilo, aralquilo, fenilo sustituido o naftilo sustituido; R2 es un grupo ***(Ver fórmula II) donde R6 es un átomo de hidrógeno o un grupo alquilo C1-6, R7 es un átomo de hidrógeno o un grupo alquilo C1-6, fenilo tolilo o bencilo o bien R6 está unido a R7 de manera que el radical NR6R7 es un anillo de r5 6 o 7 miembros, R8 es un átomo de hidrógeno o un grupo alquilo C1-4.
ES462060A 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina. Expired ES462060A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB33283/75A GB1504424A (en) 1975-08-09 1975-08-09 Isoquinoline-derived aminoethers

Publications (1)

Publication Number Publication Date
ES462060A1 true ES462060A1 (es) 1978-06-16

Family

ID=10350917

Family Applications (6)

Application Number Title Priority Date Filing Date
ES450550A Expired ES450550A1 (es) 1975-08-09 1976-08-06 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462059A Expired ES462059A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462058A Expired ES462058A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462060A Expired ES462060A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES77462062A Expired ES462062A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462061A Expired ES462061A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES450550A Expired ES450550A1 (es) 1975-08-09 1976-08-06 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462059A Expired ES462059A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462058A Expired ES462058A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES77462062A Expired ES462062A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.
ES462061A Expired ES462061A1 (es) 1975-08-09 1977-09-01 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinoleina.

Country Status (19)

Country Link
US (1) US4113869A (es)
JP (1) JPS5223083A (es)
AT (2) AT354448B (es)
AU (1) AU498422B2 (es)
BE (1) BE844783A (es)
CA (1) CA1076119A (es)
CH (2) CH622780A5 (es)
DE (1) DE2635276A1 (es)
DK (1) DK357976A (es)
ES (6) ES450550A1 (es)
FR (1) FR2320755A1 (es)
GB (1) GB1504424A (es)
HU (1) HU173560B (es)
IE (1) IE43506B1 (es)
IL (1) IL50176A (es)
NL (1) NL7608856A (es)
NZ (1) NZ181619A (es)
SE (1) SE7608641L (es)
ZA (1) ZA764555B (es)

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DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
US4340600A (en) 1980-05-22 1982-07-20 Smithkline Corporation Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines
US4766131A (en) * 1980-10-17 1988-08-23 Pennwalt Corporation 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics
US4477670A (en) * 1981-02-19 1984-10-16 Hoechst-Roussel Pharmaceuticals Inc. 4-Aryloxy-1,2,3,4-tetrahydroisoquinolines
US4375471A (en) * 1981-02-19 1983-03-01 Hoechst-Roussel Pharmaceuticals Inc. 4-Aryloxy-1,2,3,4-tetrahydroisoquinolines
US4551474A (en) * 1981-02-19 1985-11-05 Hoechst-Roussel Pharmaceuticals Incorporated Methods of alleviating convulsions and pain employing 4-aryloxy-1,2,3,4 tetrahydroisoquinolines
US6562837B1 (en) * 1998-10-21 2003-05-13 Korea Institute Of Science & Technology Use of tetrahydroisoquinoline compounds for the treatment of septicemia
MXPA02004329A (es) * 1999-11-03 2005-08-26 Amr Technology Inc Tetrahidroisoquinolinas 4-fenil-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina.
ES2304984T3 (es) * 1999-11-03 2008-11-01 Amr Technology, Inc. Tetra-hidroisoquinolinas de sustitucion arilica y heteroarilica y su utilizacion para bloquear la recaptacion de norepinefrina, dopamina y serotonina.
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
EP1113007A1 (en) * 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists
CN100430401C (zh) * 2000-07-11 2008-11-05 Amr科技公司 新的4-苯基取代的四氢异喹啉类化合物及其治疗用途
US7314937B2 (en) * 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
CN101119969B (zh) * 2004-07-15 2014-04-09 阿尔巴尼分子研究公司 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用
US20060111394A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US20060111385A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
US20060111393A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
WO2006066197A1 (en) * 2004-12-17 2006-06-22 Janssen Pharmaceutica, N.V. Tetrahydroisoquinoline compounds for treatment of cns disorders
AU2006261162A1 (en) 2005-06-17 2006-12-28 Janssen Pharmaceutica N.V. Naphthyridine compounds
WO2006138604A1 (en) * 2005-06-17 2006-12-28 Janssen Pharmaceutica N.V. Hexahydro-pyrrolo-isoquinoline compounds for the treatment of cns disorders
JP5258561B2 (ja) * 2005-07-15 2013-08-07 アルバニー モレキュラー リサーチ， インコーポレイテッド アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
US7846930B2 (en) * 2007-05-18 2010-12-07 Janssen Pharmaceutica Nv Diaryl-substituted tetrahydroisoquinolines as histamine H3 receptor and serotonin transporter modulators
AR071997A1 (es) * 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
BRPI0923225A2 (pt) 2008-12-02 2016-10-04 Chiralgen Ltd metodo para sintese de acidos nucleicos modificados no atomo de fosforo
ES2662072T3 (es) 2009-05-12 2018-04-05 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y uso de la misma
ES2528404T3 (es) * 2009-05-12 2015-02-10 Bristol-Myers Squibb Company Formas cristalinas de (S)-7-([1,2,4]triazol[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y sus usos
ES2446971T3 (es) * 2009-05-12 2014-03-11 Albany Molecular Research, Inc. Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso
KR101885383B1 (ko) 2009-07-06 2018-08-03 웨이브 라이프 사이언시스 리미티드 신규한 핵산 프로드러그 및 그의 사용 방법
JP5868324B2 (ja) * 2010-09-24 2016-02-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ 不斉補助基
CN103796657B (zh) 2011-07-19 2017-07-11 波涛生命科学有限公司 合成官能化核酸的方法
EP2873674B1 (en) 2012-07-13 2020-05-06 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
EP4219516A3 (en) 2012-07-13 2024-01-10 Wave Life Sciences Ltd. Chiral control
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인

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US3479358A (en) * 1966-09-19 1969-11-18 Warner Lambert Pharmaceutical Hexahydro-9,4a - iminoethano-4a-h-xanthenes and process for their production
US3666763A (en) * 1970-01-06 1972-05-30 Hoffmann La Roche 4-phenyl isoquinolines and process for preparing same
US3947456A (en) * 1970-01-06 1976-03-30 Hoffman-La Roche Inc. Substituted 4-phenyl isoquinolines
US3878215A (en) * 1971-12-01 1975-04-15 Sandoz Ag 2-Alkyl-3-substituted-4-aryl isoquinolines
US3910924A (en) * 1972-04-13 1975-10-07 Otsuka Pharma Co Ltd 3,4-Dihydrocarbostyril derivatives and a process for preparing the same
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US3870722A (en) * 1973-11-02 1975-03-11 Sandoz Ag 2-Methyl-3-substituted-4-aryl isoquinolines
AR206061A1 (es) * 1974-11-15 1976-06-23 Knoll Ag Procedimiento para la produccion de nuevas 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7-, 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-isoquinolinas de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 7- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-6-metoxi-isoquinolinas y de 2-alcanoil (c1-c4)-1, 2, 3, 4-tetrahidro-8-respectivamente 6- o 5-(2-hidroxi-3-alquil (c3-c4)-aminopropoxi)-7-metoxi-isoquinolinas eventualmente metiladas en la posicion 1

Also Published As

Publication number Publication date
IL50176A0 (en) 1976-09-30
ATA586876A (de) 1979-06-15
AT353793B (de) 1979-12-10
CH626611A5 (es) 1981-11-30
IL50176A (en) 1979-10-31
IE43506B1 (en) 1981-03-11
NZ181619A (en) 1979-08-31
DK357976A (da) 1977-02-10
GB1504424A (en) 1978-03-22
SE7608641L (sv) 1977-02-10
BE844783A (fr) 1977-01-31
FR2320755A1 (fr) 1977-03-11
HU173560B (hu) 1979-06-28
ES462059A1 (es) 1978-06-16
AU1670276A (en) 1978-02-16
ES450550A1 (es) 1977-12-16
ES462062A1 (es) 1978-06-16
ES462061A1 (es) 1978-06-16
CA1076119A (en) 1980-04-22
US4113869A (en) 1978-09-12
JPS5223083A (en) 1977-02-21
AT354448B (de) 1979-01-10
CH622780A5 (es) 1981-04-30
FR2320755B1 (es) 1979-09-14
IE43506L (en) 1977-02-09
ATA717378A (de) 1979-05-15
ZA764555B (en) 1977-07-27
DE2635276A1 (de) 1977-02-17
NL7608856A (nl) 1977-02-11
ES462058A1 (es) 1978-06-16
AU498422B2 (en) 1979-03-15

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