NL7409770A - Werkwijze voor de bereiding van niet-immunogene polypeptiden, werkwijze voor de bereiding van geneesmiddelen, die-immunogene polypeptiden be- vatten en de aldus gevormde geneesmiddelen. - Google Patents

Werkwijze voor de bereiding van niet-immunogene polypeptiden, werkwijze voor de bereiding van geneesmiddelen, die-immunogene polypeptiden be- vatten en de aldus gevormde geneesmiddelen.

Info

Publication number
NL7409770A
NL7409770A NL7409770A NL7409770A NL7409770A NL 7409770 A NL7409770 A NL 7409770A NL 7409770 A NL7409770 A NL 7409770A NL 7409770 A NL7409770 A NL 7409770A NL 7409770 A NL7409770 A NL 7409770A
Authority
NL
Netherlands
Prior art keywords
preparation
immunogenic polypeptides
medicinal properties
biocatalyst
polyalkyl
Prior art date
Application number
NL7409770A
Other languages
English (en)
Dutch (nl)
Original Assignee
Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp filed Critical Research Corp
Publication of NL7409770A publication Critical patent/NL7409770A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Peptides Or Proteins (AREA)
NL7409770A 1973-07-20 1974-07-19 Werkwijze voor de bereiding van niet-immunogene polypeptiden, werkwijze voor de bereiding van geneesmiddelen, die-immunogene polypeptiden be- vatten en de aldus gevormde geneesmiddelen. NL7409770A (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38119173A 1973-07-20 1973-07-20

Publications (1)

Publication Number Publication Date
NL7409770A true NL7409770A (nl) 1975-01-22

Family

ID=23504063

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7409770A NL7409770A (nl) 1973-07-20 1974-07-19 Werkwijze voor de bereiding van niet-immunogene polypeptiden, werkwijze voor de bereiding van geneesmiddelen, die-immunogene polypeptiden be- vatten en de aldus gevormde geneesmiddelen.

Country Status (9)

Country Link
JP (1) JPS5623587B2 (OSRAM)
CA (1) CA1033673A (OSRAM)
CH (1) CH616942A5 (OSRAM)
DE (1) DE2433883C2 (OSRAM)
FR (1) FR2313939A1 (OSRAM)
GB (1) GB1469472A (OSRAM)
IL (1) IL45291A0 (OSRAM)
NL (1) NL7409770A (OSRAM)
SE (1) SE441753B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027161A1 (de) * 1979-07-27 1981-04-22 Hoechst Aktiengesellschaft Insulinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985003934A1 (fr) * 1984-03-06 1985-09-12 Takeda Chemical Industries, Ltd. Proteine modifiee chimiquement et son procede de preparation
JPS59204130A (ja) * 1983-04-30 1984-11-19 Nippon Chemiphar Co Ltd 新規プラスミノ−ゲンアクチベ−タ誘導体を含有してなる経口投与薬剤
DE3334407A1 (de) * 1983-09-23 1985-04-04 Hoechst Ag, 6230 Frankfurt In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
JPS61163687U (OSRAM) * 1985-03-28 1986-10-09
JPS62207485A (ja) * 1986-03-07 1987-09-11 大平技研工業株式会社 テレビゲ−ム機
US5037969A (en) * 1986-07-03 1991-08-06 Takeda Chemical Industries, Ltd. Glycosyl derivatives and use thereof
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5578496A (en) * 1991-12-19 1996-11-26 Board Of Regents, Baylor College Of Medicine Detection of autoantibodies associated with the disease myasthenia gravis
AU3423293A (en) * 1991-12-19 1993-07-19 Baylor College Of Medicine Pva or peg conjugates of peptides for epitope-specific immunosuppression
US5618528A (en) * 1994-02-28 1997-04-08 Sterling Winthrop Inc. Biologically compatible linear block copolymers of polyalkylene oxide and peptide units
US6541629B1 (en) * 1999-09-10 2003-04-01 The Procter & Gamble Company Enzyme inhibitors
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
ES2411007T3 (es) * 2001-10-10 2013-07-04 Novo Nordisk A/S Remodelación y glicoconjugación de péptidos
US7056500B2 (en) * 2001-10-18 2006-06-06 Nektar Therapeutics Al, Corporation Polymer conjugates of opioid antagonists
US7452533B2 (en) * 2002-03-26 2008-11-18 Biosynexus Incorporated Antimicrobial polymer conjugate containing lysostaphin and polyethylene glycol
US20040062748A1 (en) * 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
EP1553993B1 (en) * 2002-10-21 2016-03-30 Allvivo, Inc. Surface coating comprising bioactive compound
DE602004030700D1 (de) 2003-09-24 2011-02-03 Kyowa Hakko Kirin Co Ltd Rekombinanter antikörper gegen humanen insulin-like growth factor
WO2005056636A2 (en) 2003-12-03 2005-06-23 Nektar Therapeutics Al, Corporation Method of preparing maleimide functionalized polymers
CA2611836A1 (en) * 2005-06-13 2006-12-21 Nastech Pharmaceutical Company Inc. Transmucosal delivery of peptide derivatives
US7301003B2 (en) * 2005-08-26 2007-11-27 Enzon Pharmaceuticals, Inc. Method of preparing polymers having terminal amine groups
US20160151511A1 (en) * 2014-12-02 2016-06-02 Antriabio, Inc. Proteins and protein conjugates with increased hydrophobicity
US20170342211A1 (en) * 2016-05-31 2017-11-30 Robert Bosch Gmbh Azlactone functionalized substrates for conjugation of biomolecules
DK3463308T3 (da) * 2016-06-01 2022-01-31 Servier Ip Uk Ltd Formuleringer af polyalkylenoxid-asparaginase og fremgangsmåder til fremstilling og anvendelse deraf

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE337223B (OSRAM) * 1967-05-23 1971-08-02 Pharmacia Ab
US3619371A (en) * 1967-07-03 1971-11-09 Nat Res Dev Production of a polymeric matrix having a biologically active substance bound thereto
US3674767A (en) * 1967-07-14 1972-07-04 Nat Res Dev Novel polymeric materials containing triazinyl groups

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027161A1 (de) * 1979-07-27 1981-04-22 Hoechst Aktiengesellschaft Insulinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung

Also Published As

Publication number Publication date
CH616942A5 (en) 1980-04-30
FR2313939B1 (OSRAM) 1979-05-18
FR2313939A1 (fr) 1977-01-07
CA1033673A (en) 1978-06-27
JPS5042087A (OSRAM) 1975-04-16
JPS5623587B2 (OSRAM) 1981-06-01
DE2433883A1 (de) 1976-02-05
DE2433883C2 (de) 1986-03-27
GB1469472A (en) 1977-04-06
SE441753B (sv) 1985-11-04
IL45291A0 (en) 1974-10-22
SE7409366L (OSRAM) 1975-01-21

Similar Documents

Publication Publication Date Title
NL7409770A (nl) Werkwijze voor de bereiding van niet-immunogene polypeptiden, werkwijze voor de bereiding van geneesmiddelen, die-immunogene polypeptiden be- vatten en de aldus gevormde geneesmiddelen.
IE39406L (en) Bile acid binding compositions
NL7505551A (nl) Werkwijze voor de bereiding van synthetische polyesters, alsmede de geheel of ten dele uit deze polyesters bestaande gevormde voortbreng- sels.
DE3688213D1 (de) Polymer, seine herstellung und verwendung.
AT341215B (de) Verfahren zur herstellung stabiler, lagerfahiger, nichtwasseriger polymerdispersionen
ATA976075A (de) Verfahren zur herstellung wasserloslicher, hochmolekularer polymerisate
BG27910A3 (bg) Метод за получаване на линейни полимири
ES428648A1 (es) Procedimiento para la obtencion de cuerpos moldeados de po-liuretano.
ES447679A1 (es) Procedimiento para la obtencion de polimerizados de estirenoexpndibles conteniendo compuestos de halogeno.
NL7501516A (nl) Werkwijze voor de bereiding van pyrido(1,2,3-de)- benzoxazinecarbonzuren en de lagere alkyl- s ervan, alsmede dergelijke zuren en esters.
ES394117A1 (es) Procedimiento de preparacion de principios medicinales ac- tivos.
BE826875A (fr) Nouveaux complexes metalliferes utilisables comme stabilisants de matieres organiques et leur preparation
NL7411531A (nl) Koolzuurderivaten van 2-mercapto 4.5-dichloor- thiazolen, alsmede werkwijze voor de bereiding en toepassing ervan als herbiciden.
NL7411889A (nl) Werkwijze voor de bereiding van kunsthars- massa's.
NL7514553A (nl) Werkwijze voor de bereiding van tandpasta's.
BE832247A (fr) Complexes de l'o-chloranile et du 5,6,11,12-tetraselenotetracene, utilisables comme elements conducteurs organiques
NL7611554A (nl) Werkwijze voor het bereiden van polycarbonaat- polymeren alsmede gevormd voortbrengsel, geheel of ten dele bestaande uit aldus verkregen poly- carbonaatpolymeer.
NL181358C (nl) Werkwijze voor de bereiding van 3,6-dichloorpicolinezuur.
RO68748A (ro) Procedeu pentru prepararea unor derivati de 1-sulfonil-2,5(6)-benzimidizol substituiti
ES457416A1 (es) Un procedimiento para la preparacion de poli(tetrametilen- eter)glicol.
FR2290203B1 (OSRAM)
NL7506105A (nl) Werkwijze voor de bereiding van (alpha).(alpha).(alpha).(alpha)'.(alpha)'.(alpha)'- -hexakisaryl 1.3- respectievelijk -1.4-dimethyl- benzenen.
JPS5377300A (en) Improved proces for preparation of ring-opening polymer
NL7613787A (nl) Werkwijze voor de bereiding van gestabiliseerde lineaire, grootmoleculige polyesters.
JPS5240600A (en) Improved process for preparing ring-opening polymer