NL7409768A - Prismatic cephalexin monohydrate prodn. - from acylation broths by concentrating recovering dihydrate and drying - Google Patents
Prismatic cephalexin monohydrate prodn. - from acylation broths by concentrating recovering dihydrate and dryingInfo
- Publication number
- NL7409768A NL7409768A NL7409768A NL7409768A NL7409768A NL 7409768 A NL7409768 A NL 7409768A NL 7409768 A NL7409768 A NL 7409768A NL 7409768 A NL7409768 A NL 7409768A NL 7409768 A NL7409768 A NL 7409768A
- Authority
- NL
- Netherlands
- Prior art keywords
- drying
- concentrating
- dihydrate
- prismatic
- prodn
- Prior art date
Links
- 238000001035 drying Methods 0.000 title abstract 3
- 150000004683 dihydrates Chemical class 0.000 title abstract 2
- 230000010933 acylation Effects 0.000 title 1
- 238000005917 acylation reaction Methods 0.000 title 1
- 235000010633 broth Nutrition 0.000 title 1
- 229940047526 cephalexin monohydrate Drugs 0.000 title 1
- YGZIWEZFFBPCLN-UHFFFAOYSA-N n,3-bis(2-chloroethyl)-4-hydroperoxy-2-oxo-1,3,2$l^{5}-oxazaphosphinan-2-amine Chemical compound OOC1CCOP(=O)(NCCCl)N1CCCl YGZIWEZFFBPCLN-UHFFFAOYSA-N 0.000 title 1
- 239000013078 crystal Substances 0.000 abstract 2
- NVIAYEIXYQCDAN-CLZZGJSISA-N 7beta-aminodeacetoxycephalosporanic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](N)[C@@H]12 NVIAYEIXYQCDAN-CLZZGJSISA-N 0.000 abstract 1
- ZGUNAGUHMKGQNY-SSDOTTSWSA-N D-alpha-phenylglycine Chemical compound OC(=O)[C@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-SSDOTTSWSA-N 0.000 abstract 1
- ZAIPMKNFIOOWCQ-MKOUYDOKSA-N N[C@@H](C(=O)NC1[C@@H]2N(C(=C(CS2)C)C(=O)O)C1=O)C1=CC=CC=C1 Chemical compound N[C@@H](C(=O)NC1[C@@H]2N(C(=C(CS2)C)C(=O)O)C1=O)C1=CC=CC=C1 ZAIPMKNFIOOWCQ-MKOUYDOKSA-N 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229940106164 cephalexin Drugs 0.000 abstract 1
- AVGYWQBCYZHHPN-CYJZLJNKSA-N cephalexin monohydrate Chemical compound O.C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 AVGYWQBCYZHHPN-CYJZLJNKSA-N 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 238000006911 enzymatic reaction Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8193973A JPS5621395B2 (enExample) | 1973-07-18 | 1973-07-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7409768A true NL7409768A (en) | 1975-01-21 |
Family
ID=13760445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7409768A NL7409768A (en) | 1973-07-18 | 1974-07-18 | Prismatic cephalexin monohydrate prodn. - from acylation broths by concentrating recovering dihydrate and drying |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS5621395B2 (enExample) |
| BE (1) | BE817780A (enExample) |
| DK (1) | DK386174A (enExample) |
| HU (1) | HU169795B (enExample) |
| NL (1) | NL7409768A (enExample) |
| SE (1) | SE414508B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4893280A (enExample) * | 1972-03-10 | 1973-12-03 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3531481A (en) * | 1969-04-21 | 1970-09-29 | Lilly Co Eli | Method for manufacture of crystalline cephalosporin |
| US3655656A (en) * | 1970-06-04 | 1972-04-11 | Lilly Co Eli | Crystalline cephalexin monohydrate |
| JPS606957B2 (ja) * | 1973-04-10 | 1985-02-21 | ブリストル マイヤ−ズ カンパニ− | 抗生物質誘導体の製造方法 |
-
1973
- 1973-07-18 JP JP8193973A patent/JPS5621395B2/ja not_active Expired
-
1974
- 1974-07-17 SE SE7409334A patent/SE414508B/xx unknown
- 1974-07-17 BE BE6044693A patent/BE817780A/fr not_active IP Right Cessation
- 1974-07-17 DK DK386174A patent/DK386174A/da unknown
- 1974-07-17 HU HUTA1314A patent/HU169795B/hu unknown
- 1974-07-18 NL NL7409768A patent/NL7409768A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5621395B2 (enExample) | 1981-05-19 |
| SE414508B (sv) | 1980-08-04 |
| HU169795B (enExample) | 1977-02-28 |
| BE817780A (fr) | 1975-01-17 |
| JPS5025794A (enExample) | 1975-03-18 |
| DK386174A (enExample) | 1975-03-24 |
| SE7409334L (enExample) | 1975-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BV | The patent application has lapsed |