NL6816210A - Iron complex with alkali-modified dextran treatment of anaemia - Google Patents

Iron complex with alkali-modified dextran treatment of anaemia

Info

Publication number
NL6816210A
NL6816210A NL6816210A NL6816210A NL6816210A NL 6816210 A NL6816210 A NL 6816210A NL 6816210 A NL6816210 A NL 6816210A NL 6816210 A NL6816210 A NL 6816210A NL 6816210 A NL6816210 A NL 6816210A
Authority
NL
Netherlands
Prior art keywords
alkali
complex
dextran
anaemia
modified dextran
Prior art date
Application number
NL6816210A
Other versions
NL156708B (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to NL6816210A priority Critical patent/NL156708B/en
Publication of NL6816210A publication Critical patent/NL6816210A/en
Publication of NL156708B publication Critical patent/NL156708B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(A) Modified dextran contng. at least 1 terminal unit of formula (I) or (II), or a salt or lactone thereof. (B) A complex of the above, esp. with Fe(OH)3. The Fe complex is useful for treating iron-deficiency anaemia. Stable, conc. solns. can be obtd. with LD50 (mice, i.v.) > 2 g./kg. The modified dextran is prepd. from a partially depolymerised dextran of mean mol. wt. 500-50,000, pref. 1,000-10,000, by treatment with alkali at a pH is not 8 and at 40-80 deg. until no more alkali is consumed. The salt of the product is pptd. by a solvent and purified by means of an anion-exchange resin. The Fe3+ complex is prepd. by reactg. the dextran deriv. with colloidal Fe(OH)3 at 50-130 deg.
NL6816210A 1968-11-14 1968-11-14 PROCESS FOR PREPARING A COMPLEX OF A DEXTRAND DERIVATIVE AND FERRIHYDROXIDE. NL156708B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL6816210A NL156708B (en) 1968-11-14 1968-11-14 PROCESS FOR PREPARING A COMPLEX OF A DEXTRAND DERIVATIVE AND FERRIHYDROXIDE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL6816210A NL156708B (en) 1968-11-14 1968-11-14 PROCESS FOR PREPARING A COMPLEX OF A DEXTRAND DERIVATIVE AND FERRIHYDROXIDE.

Publications (2)

Publication Number Publication Date
NL6816210A true NL6816210A (en) 1970-05-19
NL156708B NL156708B (en) 1978-05-16

Family

ID=19805146

Family Applications (1)

Application Number Title Priority Date Filing Date
NL6816210A NL156708B (en) 1968-11-14 1968-11-14 PROCESS FOR PREPARING A COMPLEX OF A DEXTRAND DERIVATIVE AND FERRIHYDROXIDE.

Country Status (1)

Country Link
NL (1) NL156708B (en)

Also Published As

Publication number Publication date
NL156708B (en) 1978-05-16

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Legal Events

Date Code Title Description
VJC Lapsed due to non-payment of the due maintenance fee for the patent or patent application
NL80 Abbreviated name of patent owner mentioned of already nullified patent

Owner name: FISONS