NL300247I1 - 2-Halogeen-9-(2-desoxy-2-fluor-bêta-D-arabinofuranosyl)-adeninenucleosiderivaten. - Google Patents

2-Halogeen-9-(2-desoxy-2-fluor-bêta-D-arabinofuranosyl)-adeninenucleosiderivaten.

Info

Publication number
NL300247I1
NL300247I1 NL300247C NL300247C NL300247I1 NL 300247 I1 NL300247 I1 NL 300247I1 NL 300247 C NL300247 C NL 300247C NL 300247 C NL300247 C NL 300247C NL 300247 I1 NL300247 I1 NL 300247I1
Authority
NL
Netherlands
Prior art keywords
arabinofuranosyl
deoxy
fluoro
beta
halogen
Prior art date
Application number
NL300247C
Other languages
English (en)
Other versions
NL300247I2 (nl
Original Assignee
Southern Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Res Inst filed Critical Southern Res Inst
Publication of NL300247I2 publication Critical patent/NL300247I2/nl
Publication of NL300247I1 publication Critical patent/NL300247I1/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL300247C 1989-05-23 2006-11-24 2-Halogeen-9-(2-desoxy-2-fluor-bêta-D-arabinofuranosyl)-adeninenucleosiderivaten. NL300247I1 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/355,358 US5034518A (en) 1989-05-23 1989-05-23 2-fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine nucleosides
PCT/US1990/002927 WO1990014352A1 (en) 1989-05-23 1990-05-23 2-halo-9-(2-deoxy-2-fluoro-b-d-arabinofuranosyl) adenine nucleoside derivatives

Publications (2)

Publication Number Publication Date
NL300247I2 NL300247I2 (nl) 2007-02-01
NL300247I1 true NL300247I1 (nl) 2007-02-01

Family

ID=23397161

Family Applications (1)

Application Number Title Priority Date Filing Date
NL300247C NL300247I1 (nl) 1989-05-23 2006-11-24 2-Halogeen-9-(2-desoxy-2-fluor-bêta-D-arabinofuranosyl)-adeninenucleosiderivaten.

Country Status (10)

Country Link
US (1) US5034518A (nl)
EP (1) EP0473708B1 (nl)
JP (1) JP3160288B2 (nl)
AT (1) ATE147751T1 (nl)
AU (1) AU5831590A (nl)
DE (2) DE122006000060I2 (nl)
ES (1) ES2098266T3 (nl)
HK (1) HK1007561A1 (nl)
NL (1) NL300247I1 (nl)
WO (1) WO1990014352A1 (nl)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5384310A (en) * 1989-05-23 1995-01-24 Southern Research Institute 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
AU1254892A (en) * 1990-12-18 1992-07-22 Sloan-Kettering Institute For Cancer Research Novel synthesis of 2'-"up" fluorinated 2''-deoxy-arabinofuranosylpurines
DE4141454A1 (de) * 1991-11-25 1993-05-27 Schering Ag Neues verfahren zur herstellung von 2-fluorpurin-derivaten
WO1993023058A1 (en) * 1992-05-19 1993-11-25 The Scripps Research Institute Use of 2-halo adenine derivatives as therapeutic agents against chronic myelogenous leukemia
US5817641A (en) * 1994-07-21 1998-10-06 Thomas Jefferson University Treatment of enterotoxigenic diarrhea with 2-substituted adenosine derivatives
ES2276515T3 (es) 1998-02-25 2007-06-16 Emory University 2'-fluoronucleosidos.
EP1411954B1 (en) * 2000-10-18 2010-12-15 Pharmasset, Inc. Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
CA2381367A1 (en) * 2001-04-12 2002-10-12 Hironori Komatsu Method for purifying 5'-protected 2'-deoxypurine nucleosides
AU2002322325A1 (en) 2001-06-22 2003-01-08 Emory University Beta-2'-or 3'-halonucleosides
CA2500091A1 (en) * 2002-09-27 2004-04-08 Bioenvision, Inc. Methods and compositions for the treatment of lupus using clofarabine
AU2003276988B2 (en) * 2002-09-27 2009-11-05 Bioenvision, Inc. Methods and compositions for the treatment of autoimmune disorders using clofarabine
WO2004035034A2 (en) * 2002-10-16 2004-04-29 Ilex Products, Inc. Clofarabine and taxane chemotherapy combination
DE602005015466D1 (de) * 2004-08-23 2009-08-27 Hoffmann La Roche Antivirale 4'-azidonucleoside
US8895531B2 (en) * 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
ES2392948T3 (es) * 2006-10-10 2012-12-17 Janssen Products, L.P. Intermedio para inhibidores nucleosídicos de VHC
US20090274686A1 (en) * 2008-05-02 2009-11-05 Yat Sun Or Nucleoside phosphonate derivatives
CN102311472B (zh) 2010-07-09 2014-09-03 神隆(昆山)生化科技有限公司 2-氯-9-(2’-脱氧-2’-氟-β-D-阿拉伯呋喃糖基)-腺嘌呤的制备
CN103665075A (zh) * 2013-12-26 2014-03-26 南通康鑫药业有限公司 一种氯法拉滨的合成方法
EP2937420A1 (en) 2014-04-23 2015-10-28 Synbias Pharma AG Method for the synthesis of clofarabine
WO2018085307A1 (en) * 2016-11-03 2018-05-11 Wu Laurence I Prodrugs of clofarabine
JP7378764B2 (ja) * 2018-10-04 2023-11-14 国立大学法人 鹿児島大学 抗ｂ型肝炎ウイルス剤
US20220008450A1 (en) * 2018-10-04 2022-01-13 Daikin Industries, Ltd. Anti-hepatitis b virus agent
GB201816825D0 (en) 2018-10-16 2018-11-28 Phoremost Ltd Target for anti-cancer therapy
JP2020176082A (ja) * 2019-04-17 2020-10-29 ダイキン工業株式会社 核酸アナログ及び抗ｂ型肝炎ウイルス剤
US20220251134A1 (en) 2019-06-14 2022-08-11 Southern Research Institute 2,4,7-substituted-7-deaza-2'-deoxy-2'-fluoroarabinosyl nucleoside and nucleotide pro-drugs and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS542993A (en) * 1977-06-10 1979-01-10 Agency Of Ind Science & Technol Thermochemical production of hydrogen using wate as raw material
US4210745A (en) * 1978-01-04 1980-07-01 The United States Of America As Represented By The Department Of Health, Education And Welfare Procedure for the preparation of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4188378A (en) * 1978-01-04 1980-02-12 The United States Of America As Represented By The Department Of Health, Education And Welfare Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4357324A (en) * 1981-02-24 1982-11-02 The United States Of America As Represented By The Department Of Health And Human Services Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
NZ226672A (en) * 1987-10-30 1991-07-26 Hoffmann La Roche 6-amino-9-(2,3-dideoxy-2-fluoro-b-d-threopentofuranosyl)-9h-purine derivatives and pharmaceutical compositions
ATE128141T1 (de) * 1988-03-16 1995-10-15 Scripps Research Inst Als therapeutische mittel verwendbare substituierte adeninderivate.

Also Published As

Publication number Publication date
ATE147751T1 (de) 1997-02-15
JPH05502014A (ja) 1993-04-15
NL300247I2 (nl) 2007-02-01
US5034518A (en) 1991-07-23
DE122006000060I1 (de) 2007-04-05
EP0473708A1 (en) 1992-03-11
AU5831590A (en) 1990-12-18
JP3160288B2 (ja) 2001-04-25
ES2098266T3 (es) 1997-05-01
EP0473708A4 (en) 1992-04-22
DE69029733D1 (de) 1997-02-27
HK1007561A1 (en) 1999-04-16
EP0473708B1 (en) 1997-01-15
DE122006000060I2 (de) 2010-10-21
DE69029733T2 (de) 1997-07-17
WO1990014352A1 (en) 1990-11-29

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