NL2033639B1 - Polysaccharide Composition with Moisturizing, Repairing and Anti-aging Functions - Google Patents
Polysaccharide Composition with Moisturizing, Repairing and Anti-aging Functions Download PDFInfo
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- NL2033639B1 NL2033639B1 NL2033639A NL2033639A NL2033639B1 NL 2033639 B1 NL2033639 B1 NL 2033639B1 NL 2033639 A NL2033639 A NL 2033639A NL 2033639 A NL2033639 A NL 2033639A NL 2033639 B1 NL2033639 B1 NL 2033639B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present disclosure belongs to the field of skin care products, and particularly discloses a polysaccharide composition with moisturizing, repairing and anti-aging functions. The polysaccharide composition includes Dendrobium officinale Kimura et Migo polysaccharide, Prunus persica (L.) Batsch polysaccharide, Polygonatum odoratum (Mill. ) Druce polysaccharide and Glycyrrhiza uralensis Fisch. polysaccharide, wherein the ratio of the Dendrobium officina/e Kimura et Migo polysaccharide to the Prunus persica (L.) Batsch polysaccharide to the Polygonatum odoratum (Mi/l.) Druce polysaccharide to the Glycyrrhiza ura/ensis Fisch. polysaccharide is 1: (0.3-0.6): (0.5-1): (0.8-1.2). The polysaccharide composition with moisturizing, repairing and anti-aging functions provided by the present disclosure includes the Dendrobium officinale Kimura et Migo polysaccharide, the Prunus persica (L.) Batsch polysaccharide, the Polygonatum odoratum (Mi/l.) Druce polysaccharide and the Glycyrrhiza ura/ensis Fisch. polysaccharide; and the polysaccharide composition has a synergistic effect on expression of aquaporin, and can improve water transmission and/or wetting agent transmission in skin, prevent and/or treat diseases caused by skin barrier damage and prevent and/or treat sicca syndrome, thus achieving the effects of repairing mucosa and relieving skin dryness and aging.
Description
Polysaccharide Composition with Moisturizing, Repairing and Anti-aging Functions
The present disclosure relates to the field of skin care products, and particularly relates to a polysaccharide composition with moisturizing, repairing and anti-aging functions.
With the increase of the age and the influence of the external environment, the moisturizing mechanism of the skin will be damaged, and the moisture content among skin tissue cells will be reduced, resulting in tight arrangement of the cells and dehydrating and hardening of collagen. If the moisture content in the cuticle is reduced to 10% or below, the skin will be dry, lose elasticity and wrinkle, and the skin aging process will be accelerated. Therefore, the moisture is crucial to skin health, and water retention and moisturizing are one of the most important research subjects of skin care cosmetics all the time. Research shows that the sufficient moisture content is an important condition for keeping the skin healthy and delaying aging. The moisturizing cosmetics can maintain the skin moisture by simulating a natural skin moisturizing system through different mechanisms, including reducing percutaneous moisture loss, absorbing external moisture, achieving hydration moisturizing, repairing keratinocytes, etc.
At present, the best moisturizing substance in the nature is hyaluronic acid, which is known as the most ideal natural moisturizing factor by the international cosmetic industry, and is an acidic mucopolysaccharide. However, because the source of hyaluronic acid is special, hyaluronic acid cannot meet the market demand, and it is urgently needed to find a suitable substitute to solve this problem. The natural plant polysaccharide is a good substitute product.
Polysaccharide has good film forming property, and can form a layer of uniform film on the surface of skin to reduce moisture evaporation on the surface of the skin. In addition, in the extracellular matrix, the polysaccharide can work together with other polysaccharide components in the skin and fibrous protein to form an extracellular colloidal matrix containing a large amount of moisture, and moisture can also be provided for the skin. The polysaccharide applied to cosmetics has the advantages that on one hand, the polysaccharide is wide in effect and can achieve the highly efficient skin care and skin beautifying effects in multiple aspects.
For example, the polysaccharide has the effects of moisturizing, resisting oxidation, resisting aging, enhancing immunity, blocking sun, repairing skin tissue, promoting skin blood circulation, resisting acne and the like, can achieve the effects of moisturizing, resisting bacteria and preventing ultraviolet radiation when acting on the surface of the skin, and can promote skin microcirculation, resist oxidation, delay skin aging and repair damaged skin when acting on the inner layer of the skin. On the other hand, the polysaccharide is small in toxic and side effects, small in harm to human bodies and high in safety.
The inventor finds that the composition in the present disclosure has obvious effects in the aspects of hydrating and moisturizing, and the effects can be achieved through the synergistic effect among components, so that the composition can be used for providing the skin hydrating effect for mammals.
The present disclosure aims to provide a polysaccharide compasition with moisturizing, repairing and anti-aging functions to solve the problems in the Background.
In order to achieve above purpose, the present disclosure provides the following technical solution: a polysaccharide composition with moisturizing, repairing and anti-aging functions includes Dendrobium officinale Kimura et Migo polysaccharide, Prunus persica (L.) Batsch polysaccharide, Polygonatum odoratum (Mill) Druce polysaccharide and Glycyrrhiza uralensis
Fisch. polysaccharide, wherein the ratio of the Dendrobium officinale Kimura ef Migo polysaccharide to the Prunus persica (L.) Batsch polysaccharide to the Polygonatum odoratum (Mill) Druce polysaccharide to the Glycyrrhiza uralensis Fisch. polysaccharide is 1: (0.3-0.6): (0.5-1): (0.8-1.2).
Preferably, the ratio of the Dendrobium officinale Kimura et Migo polysaccharide to the
Prunus persica (L.) Batsch polysaccharide to the Polygonatum odoratum (Mill.) Druce polysaccharide to the Glycyrrhiza uralensis Fisch. polysaccharide is 1: (0.3-0.4): (0.6-0.9): (0.8- 1.1).
Preferably, the Dendrobium officinale Kimura et Migo polysaccharide, the Prunus persica (L.) Batsch polysaccharide, the Polygonatum odoratum (Mill) Druce polysaccharide and the
Glycyrrhiza uralensis Fisch. polysaccharide are all large molecular polysaccharide, wherein the
Dendrobium officinale Kimura et Migo polysaccharide is extracted from three-year-old
Dendrobium officinale Kimura et Migo harvested from November to March.
Preferably, a method for extracting the Dendrobium officinale Kimura et Migo polysaccharide includes the steps of: crushing and screening Dendrobium officinale Kimura et
Migo with a 20-40-mesh sieve; putting the powder into water with the amount 10 times that of the powder; adding cellulase and papain; regulating the PH to be 6; performing enzymolysis at the water temperature of 40°C for 3 h; then increasing the temperature to 100°C; performing extraction for 2 h; and performing extraction twice to obtain the Dendrobium officinale Kimura et
Migo polysaccharide.
Preferably, a method for extracting the Prunus persica (L.) Batsch polysaccharide includes the steps of: removing impurities from collected Prunus persica (L.) Batsch; performing rinsing; then performing freeze drying; crushing the Prunus persica (L.) Batsch and screening with the 20-40-mesh sieve; putting the powder into water with the amount 10 times that of the powder; performing extraction at 90°C for 2 h; performing centrifugation and then performing vacuum concentration on supernatant; performing deproteinization on the concentrated solution through a Sevage method; adding an absolute ethyl alcohol solution with the volume 4 times that of deproteinized polysaccharide liquid; placing the mixture overnight at the room temperature; performing centrifugation to obtain a precipitate; and performing vacuum drying to obtain the
Prunus persica {L.) Batsch polysaccharide.
Preferably, a method for extracting and releasing the Polygonatum odoratum (Mill.) Druce polysaccharide includes the steps of: crushing Polygonatum odoratum (Mill) Druce and screening with the 20-40-mesh sieve; performing extraction with an ethanol solution with a volume concentration of 85% at 90°C for 2 h; removing monosaccharide, oligosaccharide and fat; weighing a certain amount of a pre-treated dry sample; putting the sample into a beaker; adding deionized water according to a material-liquid ratio of 1: 40 (g/ml); putting the beaker into an ultrasonic cell disruptor, and performing extraction for 20 min, wherein the ultrasonic power is 400 W; performing high-speed centrifugation, filtration and vacuum concentration on an extracting solution; then precipitating with ethanol with a volume concentration of 85%; and performing freeze drying on the precipitate to obtain the Polygonatum odoratum (Mill) Druce polysaccharide.
Preferably, a method for extracting the Glycyrrhiza uralensis Fisch. polysaccharide includes the steps of: crushing Glycyrrhiza uralensis Fisch. and screening with the 20-40-mesh sieve; putting the powder into water with the amount 10 times that of the powder; performing ultrasonic extraction in a water bath at 45°C for 20 min; performing filtration; putting filter residues into water with the amount 10 times that of the filter residues; repeating ultrasonic extraction twice; combining extraction solutions obtained by three times of extraction; performing reduced pressure concentration on a rotary evaporator to 50 ml; cooling at room temperature; performing centrifugation on the concentrated solution at 5,000 r/min for 5 min; removing impurity precipitates; slowly adding 95% ethanol with the amount 4 times that of the concentration solution; continuously stirring with a glass rod to fully separate out Glycyrrhiza uralensis Fisch. polysaccharide; standing for 24 h; performing centrifugation at 5,000 r/min for 5 min to obtain a Glycyrrhiza uralensis Fisch. polysaccharide precipitate; washing with absolute ethyl alcohol for 2-3 times; and drying at 60°C to obtain the Glycyrrhiza uralensis Fisch. polysaccharide.
Compared with the prior art, the present disclosure has the beneficial effects that the polysaccharide composition with moisturizing, repairing and anti-aging functions provided by the present disclosure includes the Dendrobium officinale Kimura et Migo polysaccharide, the
Prunus persica (L.) Batsch polysaccharide, the Polygonatum odoratum (Mill) Druce polysaccharide and the Glycyrrhiza uralensis Fisch. polysaccharide; and the polysaccharide composition has a synergistic effect on expression of aquaporin, and can improve water transmission and/or wetting agent transmission in skin, prevent and/or treat diseases caused by skin barrier damage and prevent and/or treat sicca syndrome, thus achieving the effects of repairing mucosa and relieving skin dryness and aging.
The technical solutions in the embodiments of the present disclosure will be described clearly and completely hereinafter with reference to the drawings in the embodiments of the present disclosure. Obviously, the described embodiments are only part of the embodiments of the present disclosure, not all of them. Based on the embodiments of the present disclosure, all other embodiments obtained by ordinary technicians in the art without creative work belong to the scope of the present disclosure.
In the following embodiments, Dendrobium officinale Kimura et Migo polysaccharide,
Prunus persica (L.) Batsch polysaccharide, Polygonatum odoratum (Mill) Druce polysaccharide and Glycyrrhiza uralensis Fisch. polysaccharide are all large molecular polysaccharide; and the
Dendrobium officinale Kimura et Migo polysaccharide is extracted from three-year-old
Dendrobium officinale Kimura et Migo harvested from November to March. The preparation methods of the Dendrobium officinale Kimura et Migo polysaccharide, the Prunus persica (L.)
Batsch polysaccharide, the Polygonatum odoratum (Mill.) Druce polysaccharide and the
Glycyrrhiza uralensis Fisch. polysaccharide are as follows:
A method for extracting the Dendrobium officinale Kimura et Migo polysaccharide includes the steps of: crushing and screening Dendrobium officinale Kimura et Migo with a 20-40-mesh sieve; putting the powder into water with the amount 10 times that of the powder; adding cellulase and papain; regulating the PH to be 8; performing enzymolysis at the water temperature of 40°C for 3 h; then increasing the temperature to 100°C; performing extraction for 2 h; and performing extraction twice to obtain the Dendrobium officinale Kimura et Migo polysaccharide.
A method for extracting the Prunus persica (L.) Batsch polysaccharide includes the steps of: removing impurities from collected Prunus persica (L.) Batsch; performing rinsing; then performing freeze drying; crushing the Prunus persica (L.) Batsch and screening with the 20-40- mesh sieve; putting the powder into water with the amount 10 times that of the powder; performing extraction at 90°C for 2 h; performing centrifugation and then performing vacuum concentration on supernatant; performing deproteinization on the concentrated solution through a Sevage method; adding an absolute ethyl alcohol solution with the volume 4 times that of deproteinized polysaccharide liquid; placing the mixture overnight at the room temperature; performing centrifugation to obtain a precipitate; and performing vacuum drying to obtain the
Prunus persica (L.) Batsch polysaccharide.
A method for extracting and releasing the Polygonatum odoratum (Mill.) Druce polysaccharide includes the steps of: crushing Polygonatum odoratum (Mill.) Druce and screening with the 20-40-mesh sieve; performing extraction with an ethanol solution with a volume concentration of 85% at 90°C for 2 h; removing monosaccharide, oligosaccharide and fat; weighing a certain amount of a pre-treated dry sample; putting the sample into a beaker, adding deionized water according to a material-liquid ratio of 1: 40 (g/ml); putting the beaker into an ultrasonic cell disruptor, and performing extraction for 20 min, wherein the ultrasonic power is 400 W; performing high-speed centrifugation, filtration and vacuum concentration on an extracting solution; then precipitating with ethanol with a volume concentration of 85%; and performing freeze drying on the precipitate to obtain the Polygonatum odoratum (Mill) Druce 5 polysaccharide.
A method for extracting the Glycyrrhiza uralensis Fisch. polysaccharide includes the steps of: crushing Glycyrrhiza uralensis Fisch. and screening with the 20-40-mesh sieve; putting the powder into water with the amount 10 times that of the powder; performing ultrasonic extraction in a water bath at 45°C for 20 min; performing filtration; putting filter residues into water with the amount 10 times that of the filter residues; repeating ultrasonic extraction twice; combining extraction solutions obtained by three times of extraction; performing reduced pressure concentration on a rotary evaporator to 50 ml; cooling at room temperature; performing centrifugation on the concentrated solution at 5,000 r/min for 5 min; removing impurity precipitates; slowly adding 95% ethanol with the amount 4 times that of the concentration solution; continuously stirring with a glass rod to fully separate out Glycyrrhiza uralensis Fisch. polysaccharide; standing for 24 h; performing centrifugation at 5,000 r/min for 5 min to obtain a
Glycyrrhiza uralensis Fisch. polysaccharide precipitate; washing with absolute ethyl alcohol for 2-3 times; and drying at 60°C to obtain the Glycyrrhiza uralensis Fisch. polysaccharide.
Embodiment 1:
A polysaccharide composition with moisturizing, repairing and anti-aging functions included
Dendrobium officinale Kimura et Migo polysaccharide, Prunus persica (L.) Batsch polysaccharide, Polygonatum odoratum (Mill) Druce polysaccharide and Glycyrrhiza uralensis
Fisch. polysaccharide, wherein the ratio of the Dendrobium officinale Kimura et Migo polysaccharide to the Prunus persica (L.) Batsch polysaccharide to the Polygonatum odoratum (Mill) Druce polysaccharide to the Glycyrrhiza uralensis Fisch. polysaccharide was 1: 0.4: 0.6: 1.1.
Embodiment 2:
A polysaccharide composition with moisturizing, repairing and anti-aging functions included
Dendrobium officinale Kimura et Migo polysaccharide, Prunus persica (L.) Batsch polysaccharide, Polygonatum odoratum (Mill) Druce polysaccharide and Glycyrrhiza uralensis
Fisch. polysaccharide, wherein the ratio of the Dendrobium officinale Kimura et Migo polysaccharide to the Prunus persica (L.) Batsch polysaccharide to the Polygonatum odoratum (Mill) Druce polysaccharide to the Glycyrrhiza uralensis Fisch. polysaccharide was 1: 0.3: 0.8: 0.9.
Experimental embodiment:
An experimental product 1 obtained in the Embodiment 1 and an experimental product 2 obtained in the Embodiment 2 were taken to be experimented with a contrast product 1 and a contrast product 2, the contrast product 1 in the Experimental Embodiment was hyaluronic acid with small molecular weight of 1%, and the contrast product 2 was hyaluronic acid with medium molecular weight of 1%. An experimental method included the steps of: screening suitable subjects, cleaning inner sides of forearms, and marking test areas; making the subjects to statically sit under a constant temperature and humidity condition for 20 min, and measuring the initial values of the skin cuticle moisture content and the skin percutaneous moisture loss amount; smearing to-be-tested samples with a concentration of (2.00.1) mg/cm? in the test areas according to a sample random distribution table; and measuring the skin cuticle moisture content and the skin percutaneous moisture loss amount after the polysaccharide composition was used for1h, 2h, 4h, 6h, 8 hand 12 h. The results are shown in the following Table 1 and
Table 2.
Table 1: Rate of change in skin cuticle moisture content
Experimental Experimental Contrast Contrast Blank [sert | ette | pet | te | on
The Table 1 was a table showing the change in moisture content of different samples over time. As shown in the table, the hydrating effects of the experimental product 1 and the experimental product 2 were obviously superior to that of the hyaluronic acid with medium molecular weight of 1% and slightly superior to that of the hyaluronic acid with small molecular weight of 1%, and the hydrating duration of the experimental product 1 and the experimental product 2 was obviously longer than that of the hyaluronic acid with medium molecular weight of 1% and the hyaluronic acid with small molecular weight of 1%.
Table 2: Rate of change in skin cuticle moisture content
Experimental Experimental Contrast Contrast Blank
EEE | ans | on
The Table 2 was a table showing the change in percutaneous moisture loss of different samples over time. As shown in the table, the moisture retention effects of the experimental product 1 and the experimental product 2 were obviously superior to that of the hyaluronic acid with medium molecular weight of 1% and slightly superior to that of the hyaluronic acid with small molecular weight of 1%, and the moisture retention duration of the experimental product 1 and the experimental product 2 was obviously longer than that of the hyaluronic acid with medium molecular weight of 1% and the hyaluronic acid with small molecular weight of 1%.
Although embodiments of the present disclosure have been shown and described, it can be understood for those skilled in the art that a variety of changes, modifications, substitutions and modifications can be made to these embodiments without departing from the principles and spirit of the present disclosure. The scope of the present disclosure is defined by the appended claims and their equivalents.
Claims (7)
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4179971B2 (en) * | 2003-11-17 | 2008-11-12 | 小川香料株式会社 | Moisturizing plant extract and external preparation, cosmetic, bath preparation and detergent containing the extract |
CN103230548A (en) * | 2013-05-06 | 2013-08-07 | 孙永权 | Traditional Chinese medicine composition for treating pulmonary heart disease |
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2022
- 2022-11-30 NL NL2033639A patent/NL2033639B1/en active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4179971B2 (en) * | 2003-11-17 | 2008-11-12 | 小川香料株式会社 | Moisturizing plant extract and external preparation, cosmetic, bath preparation and detergent containing the extract |
CN103230548A (en) * | 2013-05-06 | 2013-08-07 | 孙永权 | Traditional Chinese medicine composition for treating pulmonary heart disease |
Non-Patent Citations (1)
Title |
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DATABASE GNPD [online] MINTEL; 12 May 2021 (2021-05-12), ANONYMOUS: "Toner", XP093052362, retrieved from https://www.gnpd.com/sinatra/recordpage/8655403/ Database accession no. 8655403 * |
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