NL2033558A - Dynamic axial compression system - Google Patents
Dynamic axial compression system Download PDFInfo
- Publication number
- NL2033558A NL2033558A NL2033558A NL2033558A NL2033558A NL 2033558 A NL2033558 A NL 2033558A NL 2033558 A NL2033558 A NL 2033558A NL 2033558 A NL2033558 A NL 2033558A NL 2033558 A NL2033558 A NL 2033558A
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- NL
- Netherlands
- Prior art keywords
- filler
- axial compression
- tube
- compression system
- columnar
- Prior art date
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6004—Construction of the column end pieces
- G01N30/6021—Adjustable pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
- B01D15/206—Packing or coating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Reciprocating Pumps (AREA)
- Details Of Reciprocating Pumps (AREA)
- Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
Abstract
Disclosed is a dynamic axial compression system. The dynamic axial compression system comprises a column tube, a first pump body, an organic solvent storage tank and a filler collecting tank, wherein the column tube is used for accommodating filler, and a plurality of filler openings are formed in the bottom of the side wall of the column tube along the circumferential direction; an inlet of the first pump body communicates with the organic solvent storage tank, and part of the filler openings communicate with an outlet of the first pump body; and the other part of the filler openings communicate with the filler collecting tank. According to the dynamic axial compression system, the replacement efficiency of filler in the column tube is improved.
Description
DYNAMIC AXIAL COMPRESSION SYSTEM
[0001] The present disclosure relates to the technical field of dynamic axial compression columns, in particular to a dynamic axial compression system.
[0002] The dynamic axial compression column system is mainly used for separation and purification of target substances and is suitable for separation and purification production of hectogram-level and kilogram- level target products. The chromatographic column filled through dynamic axial compression completely meets the requirements of continuity, uniformity, stability, compactness and the like of a bed layer. The dynamic axial compression column system can constantly and uninterruptedly apply pressure to the filler in the column tube, so that column head collapse and column bed loosening are effectively avoided.
The dynamic axial compression column system is widely applied to the industrial preparative liquid chromatography field.
[0003] Along with continuous development of the medical industry, more and more pharmaceutical companies need to deal with a larger quantity of target objects every day. A column tube used in a conventional dynamic axial compression column is usually forged. The machining period is long, the cost is high, the column tube is troublesome to mount and dismount, and the replacement speed of filler in the conventional dynamic axial compression column is low. Comprehensively, the conventional dynamic axial compression column is long in discharging time and low in production efficiency.
[0004] The present disclosure aims to provide a dynamic axial compression system to solve the problems in the prior art and improve the replacement efficiency of the filler in a dynamic axial compression column.
[0005] In order to achieve the purpose, the present disclosure provides the following scheme.
[0006] The present disclosure provides a dynamic axial compression system. The dynamic axial compression system comprises a column tube, a first pump body, an organic solvent storage tank and a filler collecting tank, wherein the column tube is used for accommodating filler, and a plurality of filler openings are formed in the bottom of the side wall of the column tube along the circumferential direction; an inlet of the first pump body communicates with the organic solvent storage tank, and part of the filler openings communicate with an outlet of the first pump body; and the other part of the filler openings communicate with the filler collecting tank.
[0007] Preferably, a filler inlet is formed in the top of the side wall of the column tube, a second pump body is further arranged on a connecting pipeline of the filler inlet and the filler collecting tank, and the second pump body is used for pumping the filler and an organic solvent in the column tube into the filler collecting tank; and the first pump body and the second pump body are both arranged at an unloading station and are both pneumatic diaphragm pumps.
[0008] Preferably, the dynamic axial compression system further comprises a supporting assembly used for supporting the column tube, wherein a driving device is fixedly arranged on the column tube, and the driving device is used for driving a piston in the column tube to move along the axial direction of the column tube; an end cap is sealed and detachably connected with the bottom of the column tube, and the end cap is higher than the bottom of the supporting assembly; a sample inlet is formed in the piston, a feeding pipe is arranged on the sample inlet, the feeding pipe penetrates through a supporting plate, a sample outlet is formed in the end cap, and a discharging pipe is connected to the sample outlet.
[0009] Preferably, the column tube is divided into a plurality of sub- column tubes along the axial direction, and every two adjacent sub- column tubes are sealed and detachably connected; and the filler inlet is formed in the side wall of the uppermost sub-column tube, and the filler openings are formed in the side wall of the lowermost sub-column tube.
[0010] Preferably, the number of the sub-column tubes is two, the two sub-column tubes are respectively an upper column tube and a lower column tube, and the supporting assembly is fixedly connected with the upper column tube; the dynamic axial compression system further comprises an end cap storage rack and a piston storage rack, the end cap storage rack can be arranged below the end cap, a gap exists between the end cap and the end cap storage rack, and the end cap storage rack is lifted by a forklift to support the end cap or a combination of the end cap and the lower column tube; and the piston storage rack can be arranged below the upper column tube, and the piston storage rack is lifted by the forklift to support the piston.
[0011] Preferably, the supporting assembly comprises a plurality of supporting rods, the supporting rods are arranged along the circumferential direction of the column tube, a lug plate is fixedly arranged on the side, close to the column tube, of the supporting rod, and the lug plates are welded to the side wall of the column tube.
[0012] Preferably, the driving device is a hydraulic cylinder, the supporting plate is fixedly arranged on the top of the column tube, the hydraulic cylinder is fixedly arranged on the supporting plate and located above the supporting plate, and the bottom of a hydraulic rod of the hydraulic cylinder is fixedly connected with the piston; the top surface of the piston is provided with at least one vertical guide rod, guide avoiding holes corresponding to the guide rods are formed in the supporting plate, the guide rod penetrates through the corresponding guide avoiding hole, and the guide rods are in sliding fit with the supporting plate.
[0013] Preferably, scales are arranged on the guide rod, and the number of the guide rods is two.
[0014] Preferably, a plurality of handles are uniformly arranged on the side wall of the end cap in the circumferential direction, and a sight glass is arranged on the supporting plate.
[0015] Preferably, a lighting support is arranged above the sight glass, and a lighting lamp facing the sight glass is fixedly arranged on the lighting support.
[0016] Compared with the prior art, the present disclosure has the following technical effects.
[0017] According to the dynamic axial compression system in the present disclosure, the replacement efficiency of the filler is improved, so that the production efficiency of liquid chromatography is improved. According to the dynamic axial compression system in the present disclosure, the supporting structure is simplified, the equipment weight is reduced, and the maintenance time is shortened, so that the production efficiency of liquid chromatography is effectively improved.
[0018] To more clearly illustrate the embodiment of the present disclosure or the technical scheme in the prior art, the following briefly introduces the attached figures to be used in the embodiment.
Apparently, the attached figures in the following description show merely some embodiments of the present disclosure, and those skilled in the art may still derive other drawings from these attached figures without creative efforts.
[0019] FIG. 1 is a partial structural schematic diagram | of a dynamic axial compression system in the first embodiment of the present disclosure;
[0020] FIG. 2 is a partial structural schematic diagram Il of a dynamic axial compression system in the first embodiment of the present disclosure;
[0021] FIG. 3 is a partial structural schematic diagram Ill of a dynamic axial compression system in the first embodiment of the present disclosure; and
[0022] FIG. 4 is a partial structural schematic diagram IV of a dynamic axial compression system in the first embodiment of the present disclosure.
[0023] Reference signs: 100, dynamic axial compression system; 1, hydraulic cylinder; 2, guide rod; 3, supporting plate; 4, feeding pipe; 5, sight glass; 6, lug plate; 7, supporting rod; 8, upper column tube; 9, lower column tube; 10, filler inlet; 11, end cap; 12, handle; 13, first air source switch valve; 14, first air pressure adjusting valve; 15, first air pressure gauge; 16, first oil pressure gauge; 17, second oil pressure gauge; 18, pressure retaining valve; 19, direction switching valve; 20, first connecting pipe; 21, second connecting pipe; 22, end cap storage rack; 23, piston; 24, cylinder connecting base; 25, bolt; 26, first control panel; 27, first pneumatic diaphragm pump; 28, second pneumatic diaphragm pump; 29, second air pressure gauge; 30, second air pressure adjusting valve; 31, second air source switch valve; 32, third air source switch valve; 33, third air pressure adjusting valve; 34, third air pressure gauge; 35, second control panel; and 36, filler opening.
[0024] The following clearly and completely describes the technical scheme in the embodiments of the present disclosure with reference to the attached figures in the embodiments of the present disclosure.
Apparently, the described embodiments are merely a part rather than all of the embodiments of the present disclosure. Based on the embodiment in the present disclosure, all other embodiments obtained by the ordinary technical staff in the art under the premise of without contributing creative labour belong to the scope protected by the present disclosure.
[0025] The present disclosure aims to provide a dynamic axial compression system to solve the problems in the prior art and improve the replacement efficiency of filler in a dynamic axial compression column.
[0026] To make the foregoing objective, features and advantages of the present disclosure clearer and more comprehensible, the present disclosure is further described in detail below with reference to the attached figures and specific embodiments.
[0027] Embodiment
[0028] As shown in FIG. 1 to FIG. 4, the embodiment provides a dynamic axial compression system 100, comprising a supporting plate 3, an upper column tube 8, a lower column tube 9, an end cap 11, a hydraulic cylinder 1, a first pneumatic diaphragm pump 27, a second pneumatic diaphragm pump 28, a piston 23 and three supporting rods 7.
[0029] Wherein, the supporting plate 3 is in fastening connection with the top of the upper column tube 8 through bolts, the bottom of the upper column tube 8 is in sealed and detachable connection with the top of the lower column tube 9 through bolts, the end cap 11 is in sealed and detachable connection with the bottom of the lower column tube 9 through bolts, the three supporting rods 7 are uniformly arranged along the circumferential direction of the upper column tube 8, a lug plate 6 is fixedly arranged on the side, close to the upper column tube 8, of the supporting rod 7, the lug plates 6 are welded to the side wall of the upper column tube 8, and the end cap 11 is higher than the bottom of the supporting rod 7.
[0030] The hydraulic cylinder 1 is fixedly arranged above the supporting plate 3 and is fixedly connected with the supporting plate 3 through a plurality of bolts 25; and a hydraulic rod avoiding hole corresponding to a hydraulic rod of the hydraulic cylinder 1 is formed in the supporting plate 3, and the hydraulic rod penetrates through the hydraulic rod avoiding hole. The bottom of the hydraulic rod of the hydraulic cylinder 1 is fixedly connected with the piston 23. Specifically, the free end of the hydraulic rod is connected with a cylinder connecting base 24, the cylinder connecting base 24 is fixedly connected with the piston 23 through a connecting clamping ring, the hydraulic rod can drive the piston 23 to ascend and descend in the upper column tube 8, a sample inlet is formed in the piston 23, a feeding pipe 4 is arranged on the sample inlet, the feeding pipe 4 penetrates through the supporting plate 3, a sample outlet is formed in the end cap 11, and a discharge pipe is connected to the sample outlet.
[0031] Two filler inlets 10 are formed in the side wall of the upper column tube 8, and a plurality of filler openings 36 are formed in the bottom of the side wall of the lower column tube 9 along the circumferential direction, an inlet of the first pneumatic diaphragm pump 27 communicates with an organic solvent storage tank, a part of the filler openings 36 communicate with a first connecting pipe 20, the first connecting pipe 20 communicates with an outlet of the first pneumatic diaphragm pump 27, the other part of the filler openings 36 communicate with the second connecting pipe 21, and the second connecting pipe 21 communicates with an inlet of the second pneumatic diaphragm pump 28. When the filler needs to be replaced, the first pneumatic diaphragm pump 27 and the second pneumatic diaphragm pump 28 are started, and the first pneumatic diaphragm pump 27 pumps an organic solvent into the lower column tube 9 to uninterruptedly flush the compacted filler, so that the filler is loosened; the second pneumatic diaphragm pump 28 continuously pumps the filler in the lower column tube 9, so that quick filler replacement is realized, and the replacement efficiency of the filler is greatly improved. It should be noted that the filler is distributed in the lower column tube 9 and the upper column tube 8, and the height of the filler is preferably higher than that of the lower column tube 9.
[0032] Two vertical guide rods 2 are arranged on the top surface of the piston 23, and scales are arranged on the guide rod 2, so that the position of the piston 23 can be conveniently observed; and guide avoiding holes corresponding to the guide rods 2 are formed in the supporting plate 3, the guide rod 2 penetrates through the corresponding guide avoiding hole, and the guide rods 2 are in sliding fit with the supporting plate 3.
[0033] A plurality of handles 12 are uniformly arranged on the side wall of the end cap 11 in the circumferential direction, a threaded hole in the end cap 11 can be aligned with a threaded hole in the lower column tube 9 conveniently during installation, a sight glass 5 is arranged on the supporting plate 3, and the state in the upper column tube 8 can be observed through the sight glass 5. The edge of the piston 23 is attached to the inner side wall of the upper column tube 8, and the piston 23 is in sliding fit with the upper column tube 8. An upper frit (not shown in the figure) is fixedly arranged on the bottom surface of the piston 23, a lower frit (not shown in the figure) is fixedly arranged above the end cap 11, and the lower frit is lower than the filler openings 36.
[0034] In the embodiment, the dynamic axial compression system 100 further comprises a first air source, an air-driven hydraulic pump, an oil tank and a first control panel 26. The air-driven hydraulic pump communicates with the first air source through a pipeline. An oil inlet of the air-driven hydraulic pump communicates with an oil outlet of the oil tank. An oil outlet of the air-driven hydraulic pump, a first oil port of the hydraulic cylinder 1, a second oil port of the hydraulic cylinder 1 and an oil return port of the oil tank are connected through a direction switching valve 19. The direction switching valve 19 is a four-way valve. When the oil outlet of the air-driven hydraulic pump communicates with the first oil port of the hydraulic cylinder 1, the second oil port of the hydraulic cylinder 1 communicates with the oil return port of the oil tank. When the oil outlet of the air-driven hydraulic pump communicates with the second oil port of the hydraulic cylinder 1, the first oil port of the hydraulic cylinder 1 communicates with the oil return port of the oil tank. A first air source switch valve 13, a first air pressure adjusting valve 14 and a first air pressure gauge 15 are arranged on the first air source, and the direction switching valve 19, the first air source switch valve 13, the first air pressure adjusting valve 14 and the first air pressure gauge 15 are respectively arranged on the first control panel 26. In addition, a pressure retaining valve 18, a first oil pressure gauge 16 and a second oil pressure gauge 17 are further arranged on the first control panel 26. The pressure retaining valve 18 is used for maintaining pressure for an oil way system of the hydraulic oil pump. The first oil pressure gauge 16 is used for displaying the oil pressure of the oil outlet of the air-driven hydraulic pump. The second oil pressure gauge 17 is used for displaying the oil pressure of the pressure retaining valve 18. The arrangement of the pressure retaining valve 18, the first oil pressure gauge 16 and the second oil pressure gauge 17 is common arrangement in a hydraulic oil circuit system. The connecting structure and the working principle are not repeated here.
[0035] When the system is used, the first air source is opened by opening the first air source switch valve 13, and high-pressure gas in the first air source enters the air-driven hydraulic pump to drive the air-driven hydraulic pump to work. When the air-driven hydraulic pump works, oil in the oil tank is pumped into the hydraulic cylinder 1. The direction switching valve 19 is controlled to control the air-driven hydraulic pump to pump the oil in the oil tank into the first oil port or the second oil port of a hydraulic cylinder 1, so that control over the hydraulic cylinder 1 is achieved, namely, ascending or descending of the hydraulic rod of the hydraulic cylinder 1 is controlled and switched. Therefore, the movement direction of the piston 23 is controlled. In the normal working process, the piston 23 is controlled to descend through the hydraulic cylinder 1 to compact the filler. After separation is finished, the piston 23 is controlled to ascend through the hydraulic cylinder 1 to relieve the pressure of the piston 23 on the filler. In the process of adjusting and controlling the hydraulic cylinder 1, the air pressure of the first air source is adjusted through the first air pressure adjusting valve 14, the air pressure of the first air source is observed in real time through the first air pressure gauge 15. The oil pressure in the oil way system is observed in real time through the first oil pressure gauge 16 and the second oil pressure gauge 17, and proper adjustment is carried out through the pressure retaining valve 18. It needs to be noted that in the embodiment, the first air source switch valve 13, the first air pressure adjusting valve 14, the first air pressure gauge 15, the direction switching valve 19, the pressure retaining valve 18, the first oil pressure gauge 16 and the second oll pressure gauge 17 are arranged only in order to control and adjust the action of the hydraulic cylinder 1. In order to show the use process of the hydraulic cylinder 1 and the working process of the dynamic axial compression system 100 in the embodiment, the control and adjustment of the hydraulic cylinder and the connection and working principles of related oil ways, oil pressure gauges, valves and the like belong to the well-known and very mature prior art in the field. Therefore, the specific connection relation, the working principle and the using process of the first air source switch valve 13, the first air pressure adjusting valve 14, the first air pressure gauge 15, the direction switching valve 19, the pressure retaining valve 18, the first oil pressure gauge 16, the second oil pressure gauge 17 and the like which are used for controlling the hydraulic cylinder 1 are not repeated in the embodiment.
[0036] The first pneumatic diaphragm pump 27 and the pneumatic diaphragm pump 28 are both arranged at an unloading station, the unloading station is a frame rack, and the second control panel 35 is arranged on the top of the unloading station. The first pneumatic diaphragm pump 27 communicates with a second air source, the pneumatic diaphragm pump 28 communicates with a third air source, and the first air source, the second air source and the third air source are respectively air compression systems. A second air pressure gauge 29, a second air pressure adjusting valve 30 and a second air source switch valve 31 are arranged on the second air source. A third air source switch valve 32, a third air pressure adjusting valve 33 and a third air pressure gauge 34 are arranged on the third air source. The second air pressure gauge 29, the second air pressure adjusting valve 30, the second air source switch valve 31, the third air source switch valve 32, the third air pressure adjusting valve 33 and the third air pressure gauge 34 are all arranged on the second control panel 35.
[0037] In the embodiment, the dynamic axial compression system 100 further comprises an end cap storage rack 22 and a piston storage rack.
The end cap storage rack 22 and the piston storage rack are stored when the dynamic axial compression system 100 works normally. When the end cap 11 needs to be detached, the end cap storage rack 22 is placed under the end cap 11, the end cap storage rack 22 is lifted by a forklift, the top of the end cap storage rack 22 makes contact with the bottom surface of the end cap 11, and then bolts between the end cap 11 and the lower column tube 9 are detached. After the bolts are detached, the end cap storage rack 22 is put down by the forklift. Therefore, the end cap 11 can be conveniently detached.
[0038] When the lower column tube 9 needs to be detached, the end cap storage rack 22 is lifted by the forklift, the top of the end cap storage rack 22 makes contact with the bottom surface of the end cap 11, and then the bolts between the upper column tube 8 and the lower column tube 9 are detached. After the bolts are detached, the end cap storage rack 22 is put down by the forklift, and therefore the lower column tube 9 and the end cap 11 are detached conveniently.
[0039] When the piston 23 needs to be detached, firstly, the lower column tube 9 is detached according to the method, and then the piston storage rack is lifted by the forklift. The direction switching valve 19 is opened, the oil outlet of the air-driven hydraulic pump is connected with the first oil port of the hydraulic cylinder, and the hydraulic rod drives the piston 23 to move downwards in the axial direction until the top of the piston storage rack makes contact with the bottom surface of the piston 23. Then, the connecting clamping ring between the piston 23 and the hydraulic rod is detached. After the connecting clamping ring is detached, the piston storage rack is put down by the forklift, so that the piston 23 is detached conveniently.
[0040] Embodiment II
[0041] The embodiment provides a dynamic axial compression system 100. The dynamic axial compression system 100 in the embodiment is basically the same as the dynamic axial compression system 100 provided in the first embodiment in structure and working principle. The difference lies in that, in the embodiment, a lighting support is further arranged above a sight glass 5, a lighting lamp facing the sight glass 5 is fixedly arranged on the lighting support, and the lighting lamp can be a dry battery type flashlight or connected with a 24V power supply.
[0042] In the description of the present disclosure, it needs to be illustrated that the indicative direction or position relations of the terms such as "centre", "top", "bottom", "vertical’, "inside" and "outside" are direction or position relations illustrated based on the attached figures, just for facilitating the description of the present disclosure and simplifying the description, but not for indicating or hinting that the indicated device or element must be in a specific direction and is constructed and operated in the specific direction, the terms cannot be understood as the restriction of the present disclosure. Moreover, the terms such as "first"
and "second" are just used for distinguishing the description, but cannot be understood to indicate or hint relative importance.
[0043] Specific examples are used for illustration of the principles and implementation methods of the present disclosure. The description of the above-mentioned embodiments is used to help illustrate the method and the core principles of the present disclosure; and meanwhile, those skilled in the art can make various modifications in terms of specific embodiments and scope of application in accordance with the teachings of the present disclosure. In conclusion, the content of this specification shall not be construed as a limitation to the present disclosure.
Claims (10)
Applications Claiming Priority (1)
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CN202111398379.2A CN113975854A (en) | 2021-11-19 | 2021-11-19 | Dynamic axial compression system |
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NL2033558A true NL2033558A (en) | 2023-06-12 |
NL2033558B1 NL2033558B1 (en) | 2023-06-28 |
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NL2033558A NL2033558B1 (en) | 2021-11-19 | 2022-11-18 | Dynamic axial compression system |
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CN (1) | CN113975854A (en) |
BE (1) | BE1029890B1 (en) |
NL (1) | NL2033558B1 (en) |
Citations (4)
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US20080264837A1 (en) * | 2007-04-25 | 2008-10-30 | Bio-Rad Laboratories, Inc. | Chromatography column with pack, unpack, and clean-in-place features |
EP1643244B2 (en) * | 2004-09-07 | 2015-09-09 | Asahi Kasei Bioprocess, Inc. | Hoist-free chromatography method |
US20190270034A1 (en) * | 2016-06-10 | 2019-09-05 | Repligen Corporation | Chromatography Column Packing Medium Recovery |
CN214344591U (en) * | 2021-01-11 | 2021-10-08 | 厦门昊琦科学仪器有限公司 | Hydraulic drive formula developments chromatography device |
Family Cites Families (7)
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CA2305039C (en) * | 1994-10-03 | 2002-02-12 | Amersham Pharmacia Biotech Ab | Access valve devices, their use in separation apparatus, and corresponding methods |
US8066876B2 (en) * | 2009-11-23 | 2011-11-29 | Agilent Technologies, Inc. | Apparatus and methods for packing chromatography columns |
JP4968489B2 (en) * | 2010-03-29 | 2012-07-04 | 栗田工業株式会社 | Chromatographic packing device |
CN104307207B (en) * | 2013-12-17 | 2016-07-06 | 源创精科生物科技(长沙)有限公司 | A kind of full-automatic chromatographic column |
CN209155185U (en) * | 2018-09-12 | 2019-07-26 | 镇江瑞华生物科技有限公司 | A kind of detachable multilayer chromatography chromatography column apparatus |
CN113117380B (en) * | 2019-12-31 | 2023-01-10 | 江苏汉邦科技股份有限公司 | Novel chromatographic column and discharging method |
CN216571665U (en) * | 2021-11-19 | 2022-05-24 | 江苏汉邦科技有限公司 | Dynamic axial compression system |
-
2021
- 2021-11-19 CN CN202111398379.2A patent/CN113975854A/en active Pending
-
2022
- 2022-11-18 NL NL2033558A patent/NL2033558B1/en active
- 2022-11-21 BE BE20225937A patent/BE1029890B1/en active IP Right Grant
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1643244B2 (en) * | 2004-09-07 | 2015-09-09 | Asahi Kasei Bioprocess, Inc. | Hoist-free chromatography method |
US20080264837A1 (en) * | 2007-04-25 | 2008-10-30 | Bio-Rad Laboratories, Inc. | Chromatography column with pack, unpack, and clean-in-place features |
US20190270034A1 (en) * | 2016-06-10 | 2019-09-05 | Repligen Corporation | Chromatography Column Packing Medium Recovery |
CN214344591U (en) * | 2021-01-11 | 2021-10-08 | 厦门昊琦科学仪器有限公司 | Hydraulic drive formula developments chromatography device |
Also Published As
Publication number | Publication date |
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NL2033558B1 (en) | 2023-06-28 |
BE1029890A1 (en) | 2023-05-30 |
BE1029890B1 (en) | 2023-10-27 |
CN113975854A (en) | 2022-01-28 |
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